Morin protects heart from beta-adrenergic-stimulated myocardial infarction: An electrocardiographic, biochemical, and histological study in rats

Journal of Physiology and Biochemistry

Volumn 68, Issue 3, 2012, Pages 433-446

  Pogula, Bharath Kumar ^a   Maharajan, Mari Kannan ^b   Oddepalli, Divya Rekha ^a   Boini, Lavanya ^a   Arella, Mounika ^a   Sabarimuthu, Darlin Quine ^c  

^a Jayamukhi College of Pharmacy   (India)

^b Sri Padmavathi School of Pharmacy   (India)

^c GOVERNMENT ARTS COLLEGE   (India)

Author keywords

Electrocardiogram; Histopathology; Isoproterenol; Lipid peroxidation; Lipid profile; Morin

Indexed keywords

CHOLESTEROL; CREATINE KINASE MB; FATTY ACID; HIGH DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; ISOPRENALINE; LACTATE DEHYDROGENASE; LOW DENSITY LIPOPROTEIN; MORIN; PHOSPHOLIPID; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL; TROPONIN I; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; ECG ABNORMALITY; ELECTROCARDIOGRAPHY; HEART INFARCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE INJURY; HEART MUSCLE NECROSIS; HEART PROTECTION; HEART RATE; HEART WEIGHT; HISTOLOGY; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; NONHUMAN; PREMEDICATION; RAT;

ADRENERGIC BETA-AGONISTS; ANIMALS; ANTIOXIDANTS; BIOLOGICAL MARKERS; ELECTROCARDIOGRAPHY; FLAVONOIDS; ISOPROTERENOL; LIPID PEROXIDATION; MALE; MYOCARDIAL INFARCTION; MYOCARDIUM; RATS; RATS, WISTAR;

RATTUS; RATTUS NORVEGICUS;

EID: 84871269278     PISSN: 11387548     EISSN: 18778755     Source Type: Journal    
DOI: 10.1007/s13105-012-0157-z     Document Type: Article

References (50)

1. Anandan R, Mathew S, Sankar TV, Viswanathan Nair PG (2007) Protective effect of n-3 polyunsaturated fatty acids concentrate on isoproterenol-induced myocardial infarction in rats. Prostaglandins Leukot Essent Fatty Acids 76:153-158
2. Becker LB (2004) New cause platelet aggregation. Concepts in reactive oxygen species and cardiovascular reperfusion physiology. Cardiovas Res 61:461-470
3. Blois MS (1958) Antioxidant determinations by the use of a stable free radical. Nature 181:1199-1200
4. Buring JE, O'Connor GT, Goldhaber SZ, Rosner B, Herbert PN, Blum CB, Breslow JL, Hennekens CH (1992) Decreased HDL2 and HDL3 cholesterol, Apo A-I and Apo A-II, and increased risk of myocardial infarction. Circulation 85:22-29
5. Chagoya de Sanchez V, Hernandez-Munoz R, Lopez-Barrera F et al (1997) Sequential changes of energy metabolism and mitochondrial function in myocardial infarction induced by isoproterenol in rats: A long-term and integrative study. Can J Physiol Pharmacol 75:1300-1311
6. Chien KR, Sherman SC, Mittnacht S Jr, Farber JL (1980) Microsomal membrane structure and function subsequent to calcium activation of an endogenous phospholipase. Arch Biochem Biophys 205:614-622
7. Cotran RS, Kumar V, Robbins SL (eds) (1994) Robbins pathologic basis of disease. 5th ed. Philadelphia: WB Saunders
8. Crass MF 3rd, Shipp JC, Pieper GM (1975) Effects of catecholamines on myocardial endogenous substrates and contractility. Am J Physiol 228:618-627
9. Ebenezar KK, Sathish V, Devaki T (2003) Effect of Larginine and L-lysine on lysosomal hydrolases and membrane bound phosphatases in experimentally induced myocardial infarction in rats. Mol Cell Biochem 247:163-169
10. Falholt K, Lund B, Falholt W (1973) An easy colorimetric micromethod for routine determination of free fatty acids in plasma. Clin Chim Acta 46:105-111
11. Fang SH, Hou YC, ChangWC, Hsiu SL, Chao PD, Chiang BL (2003) Morin sulfates/glucuronides exert anti-inflammatory activity on activated macrophages and decreased the incidence of septic shock. Life Sci 74:743-756
12. Franson R, Waite M, Weglicki W (1972) Phospholipase A activity of lysosomes of rat myocardial tissue. Biochemistry 11:472-476
13. Gálvez J, Coelho G, Crespo ME, Cruz T, Rodríguez-Cabezas ME, Concha A, Gonzalez M, Zarzuelo A (2001) Intestinal anti-inflammatory activity of morin on chronic experimental colitis in the rat. Aliment Pharmacol Ther 15:2027-2039
14. Hearse DJ (1979) Cellular damage during myocardial ischaemia: Metabolic changes leading to enzyme leakage. In: Hearse DJ, De Leiris J, Loisance D (eds) Enzymes in cardiology. Wiley, New York, pp 1-21
15. Iwase Y, Takemura Y, Ju-ichi M, Mukainaka T, Ichiishi E, Ito C, Furukawa H, Yano M, Tokuda H, Nishino H (2001) Inhibitory effect of flavonoid derivatives on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors. Cancer Lett 173:105-109
16. Jackson G (2001) Haemodynamic and metabolic agents in the treatment of stable angina: Publication review. Coron Artery Dis 12:S22-S24
17. Jain KS, Kathiravan MK, Somani RS, Shishoo CJ (2007) The biology and chemistry of hyperlipidemia. Bioorgan Med Chem 15:4674-4699
18. Jiang ZY, Hunt JV, Wolff SP (1992) Ferrous ion oxidation in the presence of xylenol orange for detection SP of lipid hydroperoxide in low density lipoprotein. Anal Biochem 202:384-389
19. Kannan MM, Quine SD (2011) Ellagic acid ameliorates isoproterenol induced oxidative stress: Evidence from electrocardiological, biochemical and histological study. Eur J Pharmacol 659:45-52
20. Karthick M, Stanely Mainzen Prince P (2006) Preventive effect of rutin, a bioflavonoid, on lipid peroxides and antioxidants in isoproterenol-induced myocardial infarction in rats. J Pharm Pharmacol 58:701-707
21. Karthikeyan K, Bai BR, Devaraj SN (2007) Cardioprotective effect of grape seed proanthocyanidins on isoproterenolinduced myocardial injury in rats. Int J Cardiol 115:326-333
22. Katz AM, Messineo FC (1981) Lipid-membrane interactions and the pathogenesis of ischemic damage in the myocardium. Circ Res 48:1-16
23. Kela AK, Reddy LP, Thombre DP (1980) E.C.G. findings in normal rats and after administration of isoproterenol. Indian J Physiol Pharmacol 24:84-90
24. Kitagawa S, Sakamoto H, Tano H (2004) Inhibitory effects of flavonoids on free radical-induced hemolysis and their oxidative effects on hemoglobin. Chem Pharm Bull (Tokyo) 52:999-1001
25. Kok LD, Wong YP, Wu TW, Chan HC, Kwok TT, Fung KP (2000) Morin hydrate: A potential antioxidant in minimizing the free-radicals-mediated damage to cardiovascular cells by anti-tumor drugs. Life Sci 67:91-99
26. Lee SF, Lin JK (1997) Inhibitory effects of phytopolyphenols on TPA-induced transformation, PKC activation, and c-Jun expression in mouse fibroblast cells. Nutr Cancer 28:177-183
27. Mendoza-Wilson AM, Santacruz-Ortega H, Balandrán-Quintana RR (2011) Relationship between structure, properties, and the radical scavenging activity of morin. J Mol Struct 995:134-141
28. Nirmala C, Puvanakrishnan R (1996) Protective role of curcumin against isoproterenol induced myocardial infarction in rats. Mol Cell Biochem 159:85-93
29. Nishizawa M, Kohno M, Nishimura M, Kitagawa A, Niwano Y (2005) Non-reductive scavenging of 1,1-diphenyl-2-picryl hydrazyl (DPPH) by peroxyradical: A useful method for quantitative analysis of peroxyradical. Chem Pharm Bull (Tokyo) 53:714-716
30. Panda VS, Naik SR (2008) Cardioprotective activity of Ginkgo biloba Phytosomes in isoproterenol-induced myocardial necrosis in rats: A biochemical and histoarchitectural evaluation. Exp Toxicol Pathol 60:397-404
31. Paritha IA, Devi CS (1997) Effect of a-tocopherol on isoproterenol- induced changes in lipid and lipoprotein profile in rats. Indian J Pharmacol 29:399-404
32. Parveen A, Babbar R, Agarwal S, Kotwani A, Fahim M. Mechanistic clues in the cardioprotective effect of Terminalia arjuna bark extract in isoproterenol-induced chronic heart failure in rats. Cardiovasc Toxicol 11:48-57
33. Punithavathi VR, Stanley Mainzen Prince P (2010) Pretreatment with a combination of quercetin and alpha-tocopherol ameliorates adenosine triphosphatases and lysosomal enzymes in myocardial infarcted rats. Life Sci 86:178-184
34. Ravichandran LV, Puvanakrishnan R, Joseph KT (1990) Alterations in the heart lysosomal stability in isoproterenol induced myocardial infarction in rats. Biochem Int 22:387-396
35. Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C (1999) Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Bio Med 26:1231-1237
36. Sabeena Farvin KH, Anandan R, Kumar SH, Shiny KS, Sankar TV, Thankappan TK (2004) Effect of squalene on tissue defense system in isoproterenol-induced myocardial infarction in rats. Pharmacol Res 50:231-236
37. Salter AM, White DA (1996) Effects of dietary fat on cholesterol metabolism: Regulation of plasma LDL concentrations. Nutr Res Rev 9:241-257
38. Sharma SK, Mishra HK, Sharma H, Goel A, Sreenivas V, Gulati V, Tahir M (2008) Obesity, and not obstructive sleep apnea, is responsible for increased serum hs-CRP levels in patients with sleep-disordered breathing in Delhi. Sleep Med 9:149-156
39. Siddhuraju P (2007) Antioxidant activity of polyphenolic compounds extracted from defatted raw and dry heated Tamarindus indica seed coat. LWT-Food Sci and Technol 40:982-990
40. Stanely Mainzen Prince P, Priya S (2010) Preventive effects of rutin on lysosomal enzymes in isoproterenol induced cardio toxic rats: Biochemical, histological and in vitro evidences. Eur J Pharmacol 649:229-235
41. Sumitra M, Manikandan P, Kumar DA, Natarajan A, Balakrishna K, Manohar BM, Puvanakrishna R (2001) Experimental myocardial necrosis in rats: Role of arjunolic acid on platelet aggregation, coagulation and antioxidant status. Mol Cell Biochem 277:135-142
42. Sushama Kumari S, Varghese A, Muraleedharan D, Menon VP (1990) Protective action of aspirin in experimental myocardial infarction induced by isoproterenol in rats and its effect on lipid peroxidation. Indian J Exp Biol 28:480-485
43. Vik-Mo H, Mjøs OD (1981) Influence of free fatty acids on myocardial oxygen consumption and ischemic injury. Am J Cardiol 48:361-365
44. Vogel HG (ed) (2002) Drug discovery and evaluation-pharmacological assays, 2nd edn. Springer, Berlin, pp 759-867
45. Whitmer JT, Idell-Wenger JA, Rovetto MJ, Neely JR (1978) Control of fatty acid metabolism in ischemic and hypoxic hearts. J Biol Chem 253:4305-4309
46. Wu TW, Zeng LH, Wu J, Fung KP (1993) Morin hydrate is a plant-derived and antioxidant-based hepatoprotector. Life Sci 53:PL213-218
47. Yen GC, Duh PD, Tsai CL (1993) The relationship between antioxidant activity and maturity of peanut hulls. J Agric Food Chem 41:67-70
48. Zeng LH, Fung KP, Wu TW (1994) Morin hydrate protects cultured rat glomerular mesangial cells against oxyradical damage. Life Sci 55:PL351-357
49. Zhu M, Phillipson JD, Greengrass PM, Bowery NE, Cai Y (1997) Plant polyphenols: Biologically active compounds or non-selective binders to protein? Phytochemistry 44:441-447
50. Zilversmit DB, Davis AK (1950) Microdetermination of plasma phospholipids by trichloroacetic acid precipitation. J Lab Clin Med 35:155-160