Characterization of the sensitization profile to lupin in peanut-allergic children and assessment of cross-reactivity risk

Pediatric Allergy and Immunology

Volumn 24, Issue 3, 2013, Pages 270-275

  Ballabio, Cinzia ^a   Peñas, Elena ^a   Uberti, Francesca ^a   Fiocchi, Alessandro ^b   Duranti, Marcello ^a   Magni, Chiara ^a   Restani, Patrizia ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Melloni Hospital   (Italy)

Author keywords

Cross reactivity; Lupin allergy; Peanut allergy; Sensitization pattern

Indexed keywords

ALLERGEN; ALPHA CONGLUTIN; BETA CONGLUTIN; DELTA CONGLUTIN; GAMMA CONGLUTIN; GLOBULIN; IMMUNOGLOBULIN E; UNCLASSIFIED DRUG; VEGETABLE PROTEIN;

ALLERGY TEST; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS REACTION; FEMALE; FRESH FOOD SKIN PRICK TEST; HUMAN; IMMUNE RESPONSE; IMMUNOBLOTTING; IMMUNOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LUPIN; MALE; PEANUT ALLERGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRICK TEST; PRIORITY JOURNAL; RISK ASSESSMENT; SENSITIZATION;

ALLERGENS; ARACHIS HYPOGAEA; CHILD; CROSS REACTIONS; FEMALE; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN E; ITALY; LUPINUS; MALE; NUT HYPERSENSITIVITY; PROTEIN BINDING; SEED STORAGE PROTEINS; SKIN TESTS;

EID: 84876423458     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/pai.12054     Document Type: Article

References (30)

1. Duranti M, Consonni A, Magni C, Sessa F, Scarafoni A. The major proteins of lupin seed: characterisation and molecular properties for use as functional and nutraceutical ingredients. Trends Food Sci Tech 2008: 19: 624-33.
2. Bertoglio JC, Calvo MA, Hancke JL, et al. Hypoglycaemic effect of γ-conglutin, a white lupin seed protein, in healthy volunteers. Fitoterapia 2011: 82: 933-8.
3. Bettzieche A, Brandsch C, Schmidt M, Weisse K, Eder K, Stangl GI. Differing effect of protein isolates from different cultivars of blue lupin on plasma lipoproteins of hypercholesterolemic rats. Biosci Biotechnol Biochem 2008: 72: 3114-21.
4. Lovati MR, Manzoni C, Castiglioni S, Magni M, Duranti M. Lupin seed γ-conglutin lowers blood glucose in hyperglycaemic rats and increases glucose consumption of Hep G2 cells. Br J Nutr 2011: 28: 1-7.
5. Scarafoni A, Magni C, Duranti M. Molecular nutraceutics as a mean to investigate the positive effects of legume seed proteins on human health. Trends Food Sci Technol 2007: 18: 454-63.
6. Sirtori CR, Lovati MR, Manzoni C, et al. Proteins of white lupin seed, a naturally isoflavone-poor legume, reduce cholesterolemia in rats and increase LDL receptor activity in HepG2cells. J Nutr 2004: 134: 18-23.
7. Prieto A, Razzak E, Lindo DP, Alvarez-Perea A, Rueda M, Baeza ML. Recurrent anaphylaxis due to lupin flour: primary sensitisation through inhalation. J Investig Allergol Clin Immunol 2010: 20: 76-9.
8. Radcliffe M, Scadding G, Brown HM. Lupin flour anaphylaxis. Lancet 2005: 365: 1360.
9. Ballabio C, Magni C, Restani P, et al. IgE-mediated cross-reactivity among leguminous seed proteins in peanut allergic children. Plant Foods Hum Nutr 2010: 65: 396-402.
10. Fæste CK, Lovik M, Wilker HG, Egaas E. A case of peanut cross-allergy to lupin flour in a hot-dog bread. Int Arch Allergy Immunol 2004: 136: 36-9.
11. Fiocchi A, Sarratud P, Terracciano L, et al. Assessment of the tolerance to lupin-enriched pasta in peanut-allergic children. Clin Exp Allergy 2009: 39: 1045-51.
12. Moneret-Vautrin DA, Gueril L, Kanny G, Flabbee J, Fremont S, Morisset M. Cross-allergenicity of peanut and lupin: the risk of lupin allergy in patients allergic to peanuts. J Allergy Clin Immunol 1999: 104: 883-8.
13. Quaresima RR, Viseu R, Martins LM, Tomaz E, Inacio F. Allergic primary sensitisation to lupin seed. Allergy 2007: 62: 1472-3.
14. Shaw J, Roberts G, Grimshaw K, White S, Hourihane Lupin allergy in peanut-allergic children and teenagers. Allergy 2008: 63: 370-3.
15. Gayraud J, Mairesse M, Fontaine JF, et al. The prevalence of sensitisation to lupin flour in France and Belgium: a prospective study in 5366 patients, by the Allergy Vigilance Network. Eur Ann Allergy Clin Immunol 2009: 41: 17-22.
16. European Commission. Directive 2006/142/EC of 22 December 2006, amending Annex IIIa of Directive 2000/13/EC of the European Parliament and of the Council listing the ingredients which must under all circumstances appear on the labelling of foodstuffs. Off J Eur Union 2006: 368: 110-11.
17. Magni C, Herndl A, Sironi E, et al. One- and two-dimensional electrophoretic identification of IgE-binding polypeptides of Lupinus albus and other legume seeds. J Agric Food Chem 2005: 53: 4567-71.
18. Goggin DE, Mir G, Smith WB, Stuckey M, Smith PM. Proteomic analysis of lupin seed proteins to identify conglutin β as an allergen, Lup an 1. J Agric Food Chem 2008: 56: 6370-7.
19. Guillamón E, Rodríguez J, Burbano C, et al. Characterization of lupin major allergens (Lupinus albus L.). Mol Nutr Food Res 2010: 54: 1668-76.
20. Holden L, Sletten GBG, Lindvik H, Fæste CK, Dooper MBW. Characterization of IgE binding to lupin, peanut and almond with sera from lupin-allergic patients. Int Arch Allergy Immunol 2008: 146: 267-76.
21. Peeters K, Nordlee J, Penninks A, et al. Lupine allergy: not simply cross-reactivity with peanut or soy. J Allergy Clin Immunol 2007: 120: 647-3.
22. Magni C, Scarafoni A, Herndl A, et al. Combined 2D electrophoretic approaches for the study of white lupin mature seed storage proteome. Phytochemistry 2007: 68: 997-1007.
23. Sironi E, Sessa F, Duranti M. A simple procedure of lupin seed protein fractionation for selective food applications. Eur Food Res Technol 2005: 221: 145-50.
24. Bock SA. In vivo diagnosis: skin testing and oral food challenge procedure. In: Metcalfe DD, Sampson HA, Simon RA, eds. Food allergy: adverse reactions to food and food additives. Cambridge MA: Blackwell Science, 2nd edn, 1997: 151-66.
25. Dreborg S. Diagnosis of food allergy: test in vivo and in vitro. Pediatr Allergy Immunol 2001: 16: 24-30.
26. Restani P, Velonà T, Plebani A, et al. Evaluation by SDS-PAGE and immunoblotting of residual antigenicity in hydrolysed protein formulas. Clin Exp Allergy 1995: 25: 651-8.
27. Sampson HA. Food allergy. Part 2: diagnosis and management. J Allergy Clin Immunol 1999: 103: 981-9.
28. Magni C, Ballabio C, Restani P, et al. Molecular insight into IgE-mediated reactions to sesame (Sesamum indicum, L.) seed proteins. Ann Allergy Asthma Immunol 2010: 105: 458-64.
29. Magni C, Ballabio C, Restani P, et al. Two-dimensional electrophoresis and western-blotting analyses with anti Ara h 3 basic subunit IgG evidence the cross-reacting polypeptides of Arachis hypogaea, Glycine max and Lupinus albus seed proteomes. J Agric Food Chem 2005: 53: 2275-81.
30. Novembre E, Moriondo M, Bernardini R, Azzari C, Rossi ME, Vierucci A. Lupin allergy in a child. J Allergy Clin Immunol 1999: 103: 1214-16.