Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove

PLoS Pathogens

Volumn 6, Issue 7, 2010, Pages 1-14

  Sanville, Bradley ^a   Dolan, Michael A ^a   Wollenberg, Kurt ^a   Yan, Yuhe ^a   Martin, Carrie ^a   Yeung, Man Lung ^a   Strebel, Klaus ^a   Buckler White, Alicia ^a   Kozak, Christine A ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTIDINE DEAMINASE; GENOMIC DNA; PROTEIN APOBEC3; RNA; UNCLASSIFIED DRUG; ANTIRETROVIRUS AGENT; APOBEC3 PROTEIN, MOUSE; APOBEC3G PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; CLUSTER ANALYSIS; CODON; CONTROLLED STUDY; EVOLUTIONARY ADAPTATION; EXON; GENE EXPRESSION; GENE INSERTION SEQUENCE; IN VITRO STUDY; LONG TERMINAL REPEAT; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; XENOTROPIC VIRUS; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETIC SELECTION; GENETICS; HUMAN; MOLECULAR EVOLUTION; MOLECULAR GENETICS; WILD ANIMAL;

FRIEND MURINE LEUKEMIA VIRUS; GAMMARETROVIRUS; MOUSE MAMMARY TUMOR VIRUS; MUS;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, WILD; ANTI-RETROVIRAL AGENTS; BASE SEQUENCE; CYTIDINE DEAMINASE; EVOLUTION, MOLECULAR; HUMANS; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; SELECTION, GENETIC; SEQUENCE HOMOLOGY, NUCLEIC ACID;

EID: 77957656529     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000974     Document Type: Article

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