Association of the I148M/PNPLA3 variant with elevated alanine transaminase levels in normal-weight and overweight/obese Mexican children

Gene

Volumn 520, Issue 2, 2013, Pages 185-188

  Larrieta Carrasco, Elena ^a   León Mimila, Paola ^b   Villarreal Molina, Teresa ^c   Villamil Ramírez, Hugo ^b   Romero Hidalgo, Sandra ^c   Jacobo Albavera, Leonor ^b   Gutiérrez Vidal, Roxana ^b   López Contreras, Blanca E ^b   Guillén Pineda, Luz E ^a   Sánchez Muñoz, Fausto ^d   Bojalil, Rafael ^d   Mejía Domínguez, Ana M ^e   Méndez Sánchez, Nahúm ^f   Domínguez López, Aaron ^a   Aguilar Salinas, Carlos A ^a   Canizales Quinteros, Samuel ^a,b  

^a INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^b INSTITUTO NACIONAL DE MEDICINA GENÓMICA   (Mexico)

^c INMEGEN   (Mexico)

^d INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

^e Banco de Sangre   (Mexico)

^f Hospital Medica Sur   (Mexico)

Author keywords

Alanine transaminases; I148M PNPLA3; Mexican children; NAFLD; Obesity

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

ANTHROPOMETRIC PARAMETERS; ARTICLE; BODY MASS; CHILD; CONTROLLED STUDY; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; LIVER INJURY; MAJOR CLINICAL STUDY; MALE; OBESITY; PNPLA3 GENE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD;

AGE OF ONSET; ALANINE TRANSAMINASE; AMINO ACID SUBSTITUTION; CASE-CONTROL STUDIES; CHILD; FEMALE; GENETIC ASSOCIATION STUDIES; HUMANS; IDEAL BODY WEIGHT; ISOLEUCINE; LIPASE; LIVER DISEASES; MALE; MEMBRANE PROTEINS; METHIONINE; MEXICO; OBESITY; OVERWEIGHT; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84876320981     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2013.03.038     Document Type: Article

References (37)

1. Alisi A., Cianfarani S., Manco M., Agostoni C., Nobili V. Non-alcoholic fatty liver disease and metabolic syndrome in adolescents: pathogenetic role of genetic background and intrauterine environment. Ann. Med. 2012, 44:29-40.
2. Brouwers M.C., Cantor R.M., Kono N. Heritability and genetic loci of fatty liver in familial combined hiperlipidemia. J. Lipid Res. 2006, 47:2799-2807.
3. Burgert T.S., et al. Alanine aminotransferase levels and fatty liver in childhood obesity: associations with insulin resistance, adiponectin, and visceral fat. J. Clin. Endocrinol. Metab. 2006, 91:4287-4294.
4. Carter-Kent C., et al. Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study. Hepatology 2009, 50:1113-1120.
5. CDC/NCHS CDC Growth Charts: United States http://www.cdc.gov/growthcharts.
6. Chambers J.C., et al. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat. Genet. 2011, 43:1131-1138.
7. Chan D.F., et al. Hepatic steatosis in obese Chinese children. Int. J. Obes. Relat. Metab. Disord. 2004, 28:1257-1263.
8. Chavez-Tapia N.C., Sanchez-Avila F., Vasquez-Fernandez F. Non-alcoholic fatty-liver disease in pediatric populations. J. Pediatr. Endocrinol. Metab. 2007, 20:1059-1073.
9. Day C.P. Genetic and environmental susceptibility to non-alcoholic fatty liver disease. Dig. Dis. 2010, 28:255-260.
10. Feldstein A.E., Charatcharoenwitthaya P., Treeprasertsuk S., Benson J.T., Enders F.B., Angulo P. The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20years. Gut 2009, 58:1538-1544.
11. Fishbein M.H., Mogren C., Gleason T., Stevens W.R. Relationship of hepatic steatosis to adipose tissue distribution in pediatric nonalcoholic fatty liver disease. J. Pediatr. Gastroenterol. Nutr. 2006, 42:83-88.
12. Flores-Calderón J., Gómez-Díaz R.A., Rodríguez-Gómez G., Morán-Villota S. Frequency of increased aminotransferases levels and associated metabolic abnormalities in obese and overweight children of an elementary school in Mexico City. Ann. Hepatol. 2005, 4:279-283.
13. Fraser A., Longnecker M.P., Lawlor D.A. Prevalence of elevated alanine aminotransferase among US adolescents and associated factors: NHANES 1999-2004. Gastroenterology 2007, 133:1814-1820.
14. Giudice E.M., et al. The association of PNPLA3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat. PLoS One 2011, 6:e27933.
15. Goran M.I., et al. Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents. Diabetes 2010, 59:3127-3130.
16. Hotta K., et al. Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease. BMC Med. Genet. 2010, 11:172.
17. Johansson L.E., Lindblad U., Larsson C.A., Råstam L., Ridderstråle M. Polymorphisms in the adiponutrin gene are associated with increased insulin secretion and obesity. Eur. J. Endocrinol. 2008, 159:577-583.
18. Kollerits B., et al. A common variant in the adiponutrin gene influences liver enzyme values. J. Med. Genet. 2010, 47:116-119.
19. Kotronen A., et al. A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans. Diabetologia 2009, 52:1056-1060.
20. Kuczmarski R.J., et al. 2000 CDC growth charts for the United States: methods and development. Vital Health Stat. 2002, 11(246):1-190.
21. Lin Y.C., Chang P.F., Hu F.C., Yang W.S., Chang M.H., Ni Y.H. A common variant in the PNPLA3 gene is a risk factor for non-alcoholic fatty liver disease in obese Taiwanese children. J. Pediatr. 2011, 158:740-744.
22. Makkonen J., Pietiläinen K.H., Rissanen A., Kaprio J., Yki-Järvinen H. Genetic factors contribute to variation in serum alanine aminotransferase activity independent of obesity and alcohol: a study in monozygotic and dizygotic twins. J. Hepatol. 2009, 50:1035-1042.
23. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28:412-419.
24. Olaiz-Fernández G., et al. Encuesta Nacional de Salud y Nutrición 2006 2006, Instituto Nacional de Salud Pública, Cuernavaca, México.
25. Pratt D.S., Kaplan M.M. Evaluation of abnormal liver-enzyme results in asymptomatic patients. N. Engl. J. Med. 2000, 342:1266-1271.
26. Romeo S., et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat. Genet. 2008, 40:1461-1465.
27. Romeo S., et al. The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life. J. Hepatol. 2010, 53:335-338.
28. Santoro N., et al. A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents. Hepatology 2010, 52:1281-1290.
29. Schwimmer J.B., McGreal N., Deutsch R., Finegold M.J., Lavine J.E. Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents. Pediatrics 2005, 115:e561-e565.
30. Schwimmer J.B., Deutsch R., Kahen T., Lavine J.E., Stanley C., Behling C. Prevalence of fatty liver in children and adolescents. Pediatrics 2006, 118:1388-1393.
31. Sharp D.B., Santos L.A., Cruz M.L. Fatty liver in adolescents on the U.S.-Mexico border. J. Am. Acad. Nurse Pract. 2009, 21:225-230.
32. Sookoian S., Castaño G.O., Burgueño A.L., Gianotti T.F., Rosselli M.S., Pirola C.J. A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity. J. Lipid Res. 2009, 50:2111-2116.
33. Strauss R.S., Barlow S.E., Dietz W.H. Prevalence of abnormal serum aminotransferase values in overweight and obese adolescents. J. Pediatr. 2000, 136:727-733.
34. Tazawa Y., Noguchi H., Nishinomiya F., Takada G. Serum alanine aminotransferase activity in obese children. Acta Paediatr. 1997, 86:238-241.
35. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2003, 26:S5-S20. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus.
36. Villarreal-Molina M.T., et al. The ATP-binding cassette transporter A1 R230C variant affects HDL cholesterol levels and BMI in the Mexican population: association with obesity and obesity-related comorbidities. Diabetes 2007, 56:1881-1887.
37. Zain S.M., et al. A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease. Hum. Genet. 2012, 131:1145-1152.