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Volumn 6, Issue 11, 2011, Pages

The association of PNPLA3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; LIVER ENZYME;

EID: 82155164171     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027933     Document Type: Article
Times cited : (81)

References (41)
  • 1
    • 84873097480 scopus 로고    scopus 로고
    • Iaso-Iotf website
    • Available: Accessed Jul 1
    • Iaso-Iotf website. Available: http://www.iaso.org/iotf/obesity/?map=children Accessed Jul 1.
  • 2
    • 34249715820 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis in children
    • Roberts EA, (2007) Non-alcoholic steatohepatitis in children. Clin Liver Dis 11: 155-72.
    • (2007) Clin Liver Dis , vol.11 , pp. 155-172
    • Roberts, E.A.1
  • 3
    • 34548306754 scopus 로고    scopus 로고
    • Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future
    • Wieckowska A, McCullough AJ, Feldstein AE, (2007) Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future. Hepatology 46: 582-9.
    • (2007) Hepatology , vol.46 , pp. 582-589
    • Wieckowska, A.1    McCullough, A.J.2    Feldstein, A.E.3
  • 4
    • 70350241227 scopus 로고    scopus 로고
    • The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years
    • Feldstein AE, Charatcharoenwitthaya P, Treeprasertsuk S, Benson JT, Enders FB, et al. (2009) The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut 58: 1538-44.
    • (2009) Gut , vol.58 , pp. 1538-1544
    • Feldstein, A.E.1    Charatcharoenwitthaya, P.2    Treeprasertsuk, S.3    Benson, J.T.4    Enders, F.B.5
  • 5
    • 33745107554 scopus 로고    scopus 로고
    • Mechanisms of Disease: hepatic steatosis in type 2 diabetes-pathogenesis and clinical relevance
    • Roden M, (2006) Mechanisms of Disease: hepatic steatosis in type 2 diabetes-pathogenesis and clinical relevance. Nat Clin Pract Endocrinol Metab 2: 335-48.
    • (2006) Nat Clin Pract Endocrinol Metab , vol.2 , pp. 335-348
    • Roden, M.1
  • 6
    • 30044431801 scopus 로고    scopus 로고
    • From fat to inflammation
    • Day CP, (2006) From fat to inflammation. Gastroenterology 130: 207-10.
    • (2006) Gastroenterology , vol.130 , pp. 207-210
    • Day, C.P.1
  • 7
    • 50249151997 scopus 로고    scopus 로고
    • Waist circumference correlates with liver fibrosis in children with non-alcoholic steatohepatitis
    • Manco M, Bedogni G, Marcellini M, Devito R, Ciampalini P, et al. (2008) Waist circumference correlates with liver fibrosis in children with non-alcoholic steatohepatitis. Gut 57: 1283-7.
    • (2008) Gut , vol.57 , pp. 1283-1287
    • Manco, M.1    Bedogni, G.2    Marcellini, M.3    Devito, R.4    Ciampalini, P.5
  • 8
    • 4344595660 scopus 로고    scopus 로고
    • The potential role of genes in nonalcoholic fatty liver disease
    • Day CP, (2004) The potential role of genes in nonalcoholic fatty liver disease. Clin Liver Dis 8: 673-91.
    • (2004) Clin Liver Dis , vol.8 , pp. 673-691
    • Day, C.P.1
  • 9
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, et al. (2008) Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 40: 1461-5.
    • (2008) Nat Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3    Pertsemlidis, A.4    Cox, D.5    Pennacchio, L.A.6
  • 10
    • 53049090077 scopus 로고    scopus 로고
    • Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
    • Yuan X, Waterworth D, Perry JR, Lim N, Song K, et al. (2008) Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet 83: 520-8.
    • (2008) Am J Hum Genet , vol.83 , pp. 520-528
    • Yuan, X.1    Waterworth, D.2    Perry, J.R.3    Lim, N.4    Song, K.5
  • 12
    • 77949895032 scopus 로고    scopus 로고
    • A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis
    • He S, McPhaul C, Li JZ, Garuti R, Kinch L, et al. (2010) A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. J Biol Chem 285: 6706-15.
    • (2010) J Biol Chem , vol.285 , pp. 6706-6715
    • He, S.1    McPhaul, C.2    Li, J.Z.3    Garuti, R.4    Kinch, L.5
  • 13
    • 77950607738 scopus 로고    scopus 로고
    • Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease
    • Valenti L, Al-Serri A, Daly AK, Galmozzi E, Rametta R, et al. (2010) Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease. Hepatology 51: 1209-17.
    • (2010) Hepatology , vol.51 , pp. 1209-1217
    • Valenti, L.1    Al-Serri, A.2    Daly, A.K.3    Galmozzi, E.4    Rametta, R.5
  • 14
    • 77956630787 scopus 로고    scopus 로고
    • PNPLA3 variants specifically confer increased risk for histologic non-alcoholic fatty liver disease but not metabolic disease
    • GIANT Consortium
    • Speliotes EK, Butler JL, Palmer CD, Voight BF, GIANT Consortium (2010) PNPLA3 variants specifically confer increased risk for histologic non-alcoholic fatty liver disease but not metabolic disease. Hepatology 52: 904-12.
    • (2010) Hepatology , vol.52 , pp. 904-912
    • Speliotes, E.K.1    Butler, J.L.2    Palmer, C.D.3    Voight, B.F.4
  • 15
    • 77957936457 scopus 로고    scopus 로고
    • I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease
    • Valenti L, Alisi A, Galmozzi E, Bartuli A, Del Menico B, et al. (2010) I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease. Hepatology 52: 1274-80.
    • (2010) Hepatology , vol.52 , pp. 1274-1280
    • Valenti, L.1    Alisi, A.2    Galmozzi, E.3    Bartuli, A.4    Del Menico, B.5
  • 16
    • 77956636268 scopus 로고    scopus 로고
    • The association of genetic variability in patatin-like phospholipasedomain-containing protein 3 (PNPLA3) with histological severity of non-alcoholic fatty liver disease
    • Rotman Y, Koh C, Zmuda JM, Kleiner DE, Liang TJ, et al. (2010) The association of genetic variability in patatin-like phospholipasedomain-containing protein 3 (PNPLA3) with histological severity of non-alcoholic fatty liver disease. Hepatology 52: 894-903.
    • (2010) Hepatology , vol.52 , pp. 894-903
    • Rotman, Y.1    Koh, C.2    Zmuda, J.M.3    Kleiner, D.E.4    Liang, T.J.5
  • 17
    • 77957941549 scopus 로고    scopus 로고
    • Patatin-like phospholipase domain-containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease
    • Browning JD, Cohen JC, Hobbs HH, (2010) Patatin-like phospholipase domain-containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease. Hepatology 52: 1189-92.
    • (2010) Hepatology , vol.52 , pp. 1189-1192
    • Browning, J.D.1    Cohen, J.C.2    Hobbs, H.H.3
  • 18
    • 74249093842 scopus 로고    scopus 로고
    • Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent
    • Romeo S, Sentinelli F, Dash S, Yeo GS, Savage DB, et al. (2010) Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent. Int J Obes 34: 190-4.
    • (2010) Int J Obes , vol.34 , pp. 190-194
    • Romeo, S.1    Sentinelli, F.2    Dash, S.3    Yeo, G.S.4    Savage, D.B.5
  • 19
    • 0025333948 scopus 로고
    • The LMS method for constructing normalized growth standards
    • Cole TJ, (1990) The LMS method for constructing normalized growth standards. Eur J Clin Nutr 44: 45-60.
    • (1990) Eur J Clin Nutr , vol.44 , pp. 45-60
    • Cole, T.J.1
  • 20
    • 0017261757 scopus 로고
    • Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty
    • Tanner JM, Whitehouse RH, (1976) Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child 51: 170-9.
    • (1976) Arch Dis Child , vol.51 , pp. 170-179
    • Tanner, J.M.1    Whitehouse, R.H.2
  • 21
    • 0004165071 scopus 로고
    • Antropometric standardization reference manual; Human Kinetic Books, Champaign, IL
    • Lohman TG, Roche AF, Martorell R, (1988) Antropometric standardization reference manual; Human Kinetic Books, Champaign, IL.
    • (1988)
    • Lohman, T.G.1    Roche, A.F.2    Martorell, R.3
  • 22
    • 0034089687 scopus 로고    scopus 로고
    • Prevalence of abnormal serum aminotransferase values in overweight and obese adolescents
    • Strauss RS, Barlow SE, Dietz WH, (2000) Prevalence of abnormal serum aminotransferase values in overweight and obese adolescents. J Pediatr 136: 727-33.
    • (2000) J Pediatr , vol.136 , pp. 727-733
    • Strauss, R.S.1    Barlow, S.E.2    Dietz, W.H.3
  • 23
    • 0032821965 scopus 로고    scopus 로고
    • Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp
    • Matsuda M, DeFronzo RA, (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22: 1462-70.
    • (1999) Diabetes Care , vol.22 , pp. 1462-1470
    • Matsuda, M.1    DeFronzo, R.A.2
  • 24
    • 1642284417 scopus 로고    scopus 로고
    • Validation of insulin sensitivity indices from oral glucose tolerance test parameters in obese children and adolescents
    • Yeckel CW, Weiss R, Dziura J, Taksali SE, Dufour S, et al. (2004) Validation of insulin sensitivity indices from oral glucose tolerance test parameters in obese children and adolescents. J Clin Endocrinol Metab 89: 1096-101.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 1096-1101
    • Yeckel, C.W.1    Weiss, R.2    Dziura, J.3    Taksali, S.E.4    Dufour, S.5
  • 25
    • 77954157546 scopus 로고    scopus 로고
    • On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women's Genome Health Study
    • Paré G, Cook NR, Ridker PM, Chasman DI, (2010) On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women's Genome Health Study. PLoS Genet 6: e1000981.
    • (2010) PLoS Genet , vol.6
    • Paré, G.1    Cook, N.R.2    Ridker, P.M.3    Chasman, D.I.4
  • 26
    • 77955308935 scopus 로고    scopus 로고
    • The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life
    • Romeo S, Sentinelli F, Cambuli VM, Incani M, Congiu T, et al. (2010) The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life. J Hepatol 53: 335-8.
    • (2010) J Hepatol , vol.53 , pp. 335-338
    • Romeo, S.1    Sentinelli, F.2    Cambuli, V.M.3    Incani, M.4    Congiu, T.5
  • 27
    • 70350550096 scopus 로고    scopus 로고
    • Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene
    • Kantartzis K, Peter A, Machicao F, Machann J, Wagner S, et al. (2009) Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. Diabetes 58: 2616-23.
    • (2009) Diabetes , vol.58 , pp. 2616-2623
    • Kantartzis, K.1    Peter, A.2    Machicao, F.3    Machann, J.4    Wagner, S.5
  • 28
    • 77957970113 scopus 로고    scopus 로고
    • A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents
    • Santoro N, Kursawe R, D'Adamo E, Dykas DJ, Zhang CK, et al. (2010) A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents. Hepatology 52: 1281-90.
    • (2010) Hepatology , vol.52 , pp. 1281-1290
    • Santoro, N.1    Kursawe, R.2    D'Adamo, E.3    Dykas, D.J.4    Zhang, C.K.5
  • 29
    • 38349193106 scopus 로고    scopus 로고
    • Waist-to-height ratio, a useful index to identify high metabolic risk in overweight children
    • Obesity Study Group of the Italian Society of Pediatric Endocrinology and Diabetology
    • Maffeis C, Banzato C, Talamini G, Obesity Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (2008) Waist-to-height ratio, a useful index to identify high metabolic risk in overweight children. J Pediatr 52: 207-13.
    • (2008) J Pediatr , vol.52 , pp. 207-213
    • Maffeis, C.1    Banzato, C.2    Talamini, G.3
  • 30
    • 0033767814 scopus 로고    scopus 로고
    • Waist circumference and waist-to-height ratio are better predictors of cardiovascular disease risk factors in children than body mass index
    • Savva SC, Tornaritis M, Savva ME, Kourides Y, Panagi A, et al. (2000) Waist circumference and waist-to-height ratio are better predictors of cardiovascular disease risk factors in children than body mass index. Int J Obes Relat Metab Disord 24: 1453-8.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 1453-1458
    • Savva, S.C.1    Tornaritis, M.2    Savva, M.E.3    Kourides, Y.4    Panagi, A.5
  • 31
    • 0036364517 scopus 로고    scopus 로고
    • Waist-to-height ratio is the best predictor of cardiovascular disease risk factors in Japanese schoolchildren
    • Hara M, Saitou E, Iwata F, Okada T, Harada K, (2002) Waist-to-height ratio is the best predictor of cardiovascular disease risk factors in Japanese schoolchildren. J Atheroscler Thromb 9: 127-32.
    • (2002) J Atheroscler Thromb , vol.9 , pp. 127-132
    • Hara, M.1    Saitou, E.2    Iwata, F.3    Okada, T.4    Harada, K.5
  • 32
    • 33744487870 scopus 로고    scopus 로고
    • A study of central fatness using waist-to-height ratios in UK children and adolescents over two decades supports the simple message-'keep your waist circumference to less than half your height'
    • McCarthy HD, Ashwell M, (2006) A study of central fatness using waist-to-height ratios in UK children and adolescents over two decades supports the simple message-'keep your waist circumference to less than half your height'. Int J Obes 30: 988-92.
    • (2006) Int J Obes , vol.30 , pp. 988-992
    • McCarthy, H.D.1    Ashwell, M.2
  • 33
    • 26944474885 scopus 로고    scopus 로고
    • Six reasons why the waist-to-height ratio is a rapid and effective global indicator for health risks of obesity and how its use could simplify the international public health message on obesity
    • Ashwell M, Hsieh SD, (2005) Six reasons why the waist-to-height ratio is a rapid and effective global indicator for health risks of obesity and how its use could simplify the international public health message on obesity. Int J Food Sci Nutr 56: 303-7.
    • (2005) Int J Food Sci Nutr , vol.56 , pp. 303-307
    • Ashwell, M.1    Hsieh, S.D.2
  • 34
    • 33845886915 scopus 로고    scopus 로고
    • Abdominal obesity and metabolic syndrome
    • Després JP, Lemieux I, (2006) Abdominal obesity and metabolic syndrome. Nature 444: 881-7.
    • (2006) Nature , vol.444 , pp. 881-887
    • Després, J.P.1    Lemieux, I.2
  • 35
    • 0038365556 scopus 로고    scopus 로고
    • Waist-to-height ratio, a simple and practical index for assessing central fat distribution and metabolic risk in Japanese men and women
    • Hsieh SD, Yoshinaga H, Muto T, (2003) Waist-to-height ratio, a simple and practical index for assessing central fat distribution and metabolic risk in Japanese men and women. Int J Obes Relat Metab Disord 27: 610-6.
    • (2003) Int J Obes Relat Metab Disord , vol.27 , pp. 610-616
    • Hsieh, S.D.1    Yoshinaga, H.2    Muto, T.3
  • 36
    • 49649096375 scopus 로고    scopus 로고
    • Visceral fat: a key mediator of steatohepatitis in metabolic liver disease
    • van der Poorten D, Milner KL, Hui J, Hodge A, Trenell MI, et al. (2008) Visceral fat: a key mediator of steatohepatitis in metabolic liver disease. Hepatology 48: 449-57.
    • (2008) Hepatology , vol.48 , pp. 449-457
    • van der Poorten, D.1    Milner, K.L.2    Hui, J.3    Hodge, A.4    Trenell, M.I.5
  • 37
    • 34948864852 scopus 로고    scopus 로고
    • Lack of Fas antagonism by Met in human fatty liver disease
    • Zou C, Ma J, Wang X, Guo L, Zhu Z, et al. (2007) Lack of Fas antagonism by Met in human fatty liver disease. Nat Med 13: 1078-85.
    • (2007) Nat Med , vol.13 , pp. 1078-1085
    • Zou, C.1    Ma, J.2    Wang, X.3    Guo, L.4    Zhu, Z.5
  • 38
    • 33745904468 scopus 로고    scopus 로고
    • In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    • Wieckowska A, Zein NN, Yerian LM, Lopez AR, McCullough AJ, et al. (2006) In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 44: 27-33.
    • (2006) Hepatology , vol.44 , pp. 27-33
    • Wieckowska, A.1    Zein, N.N.2    Yerian, L.M.3    Lopez, A.R.4    McCullough, A.J.5
  • 39
  • 40
    • 41049083146 scopus 로고    scopus 로고
    • Insulin resistance and body fat distribution in south asian men compared to caucasian men
    • Chandalia M, Lin P, Seenivasan T, Livingston EH, Snell PG, et al. (2007) Insulin resistance and body fat distribution in south asian men compared to caucasian men. PLoS ONE 8: e812.
    • (2007) PLoS ONE , vol.8
    • Chandalia, M.1    Lin, P.2    Seenivasan, T.3    Livingston, E.H.4    Snell, P.G.5
  • 41
    • 37349053742 scopus 로고    scopus 로고
    • Impact of fatty liver disease on health care utilization and costs in a general population: a 5-year observation
    • Baumeister SE, Völzke H, Marschall P, John U, Schmidt CO, et al. (2008) Impact of fatty liver disease on health care utilization and costs in a general population: a 5-year observation. Gastroenterology 134: 85-94.
    • (2008) Gastroenterology , vol.134 , pp. 85-94
    • Baumeister, S.E.1    Völzke, H.2    Marschall, P.3    John, U.4    Schmidt, C.O.5


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