Optimization of reorganization energy drives evolution of the designed Kemp eliminase KE07

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1834, Issue 5, 2013, Pages 908-917

  Labas, A ^a,b   Szabo, E ^a,b   Mones, L ^c,d   Fuxreiter, M ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Computational enzyme design; Computer simulation; Enzymatic catalysis; Enzymatic evolution; Kemp eliminase; Reorganization energy

Indexed keywords

KE07 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COMPUTER AIDED DESIGN; ENERGY; ENZYME ACTIVATION; ENZYME ACTIVITY; PRIORITY JOURNAL;

CATALYSIS; CATALYTIC DOMAIN; ENZYMES; EVOLUTION, CHEMICAL; MODELS, MOLECULAR;

EID: 84876286601     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2013.01.005     Document Type: Article

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