-
1
-
-
33748671369
-
The 7TM G-Protein-coupled receptor target family
-
Jacoby, E.; Bouhelal, R.; Gerspacher, M.; Seuwen, K. The 7TM G-Protein-coupled receptor target family. Chem. Med. Chem. 2006, 1, 760-782.
-
(2006)
Chem. Med. Chem.
, vol.1
, pp. 760-782
-
-
Jacoby, E.1
Bouhelal, R.2
Gerspacher, M.3
Seuwen, K.4
-
2
-
-
61649096359
-
G-Protein-coupled receptor-focused drug discovery using a target class platform approach
-
Heilker, R.; Wolff, M.; Tautermann, C.S.; Bieler, M. G-Protein-coupled receptor-focused drug discovery using a target class platform approach. Drug Discov. Today 2009, 14, 231-240.
-
(2009)
Drug Discov. Today
, vol.14
, pp. 231-240
-
-
Heilker, R.1
Wolff, M.2
Tautermann, C.S.3
Bieler, M.4
-
3
-
-
78650121289
-
A fluorescent ligand-binding alternative using Tag-lite® technology
-
Zwier, J.M.; Roux, T.; Cottet, M.; Durroux, T.; Douzon, S.; Bdioui, S.; Gregor, N.; Bourrier, E.; Oueslati, N.; Nicolas, L.; et al. A fluorescent ligand-binding alternative using Tag-lite® technology. J. Biomol. Screen. 2010, 15, 1248-1259.
-
(2010)
J. Biomol. Screen.
, vol.15
, pp. 1248-1259
-
-
Zwier, J.M.1
Roux, T.2
Cottet, M.3
Durroux, T.4
Douzon, S.5
Bdioui, S.6
Gregor, N.7
Bourrier, E.8
Oueslati, N.9
Nicolas, L.10
-
4
-
-
0038623824
-
Measuring intracellular calcium fluxes in high throughput mode
-
Chambers, C.; Smith, F.; Williams, C.; Marcos, S.; Liu, Z.H.; Hayter, P.; Ciaramella, G.; Keighley, W.; Gribbon, P.; Sewing, A. Measuring intracellular calcium fluxes in high throughput mode. Comb. Chem. High Throughput Screen. 2003, 6, 355-362.
-
(2003)
Comb. Chem. High Throughput Screen.
, vol.6
, pp. 355-362
-
-
Chambers, C.1
Smith, F.2
Williams, C.3
Marcos, S.4
Liu, Z.H.5
Hayter, P.6
Ciaramella, G.7
Keighley, W.8
Gribbon, P.9
Sewing, A.10
-
5
-
-
27844597919
-
Functional assays for screening GPCR targets
-
Thomsen, W.; Frazer, J.; Unett, D. Functional assays for screening GPCR targets. Curr. Opin. Biotechnol. 2005, 16, 655-665.
-
(2005)
Curr. Opin. Biotechnol.
, vol.16
, pp. 655-665
-
-
Thomsen, W.1
Frazer, J.2
Unett, D.3
-
6
-
-
65949124866
-
Current screens based on the AlphaScreen technology for deciphering cell signalling pathways
-
Taouji, S.; Dahan, S.; Bosse, R.; Chevet, E. Current screens based on the AlphaScreen technology for deciphering cell signalling pathways. Curr. Genomics 2009, 10, 93-101.
-
(2009)
Curr. Genomics
, vol.10
, pp. 93-101
-
-
Taouji, S.1
Dahan, S.2
Bosse, R.3
Chevet, E.4
-
7
-
-
0141758332
-
Biosensor profiling of molecular interactions in pharmacology
-
Cooper, M.A. Biosensor profiling of molecular interactions in pharmacology. Curr. Opin. Pharmacol. 2003, 3, 557-562.
-
(2003)
Curr. Opin. Pharmacol.
, vol.3
, pp. 557-562
-
-
Cooper, M.A.1
-
8
-
-
42949124474
-
The application of cell-based label-free technology in drug discovery
-
Xi, B.; Yu, N.; Wang, X.; Xu, X.; Abassi, Y. The application of cell-based label-free technology in drug discovery. Biotechnol. J. 2008, 3, 484-495.
-
(2008)
Biotechnol. J.
, vol.3
, pp. 484-495
-
-
Xi, B.1
Yu, N.2
Wang, X.3
Xu, X.4
Abassi, Y.5
-
9
-
-
77956486698
-
Label-free whole-cell assays: Expanding the scope of GPCR screening
-
Scott, C.W.; Peters, M.F. Label-free whole-cell assays: Expanding the scope of GPCR screening. Drug Discov. Today 2010, 15, 704-716.
-
(2010)
Drug Discov. Today
, vol.15
, pp. 704-716
-
-
Scott, C.W.1
Peters, M.F.2
-
10
-
-
78649343774
-
Label-free receptor assays Drug Discov
-
Fang, Y. Label-free receptor assays. Drug Discov. Today Technol. 2010, 7, 5-11.
-
(2010)
Today Technol
, vol.7
, pp. 5-11
-
-
Fang, Y.1
-
11
-
-
79952089580
-
Label-free cell-based assays using photonic crystal optical biosensors
-
Shamah, S.M.; Cunningham, B.T. Label-free cell-based assays using photonic crystal optical biosensors. Analyst 2011, 136, 1090-1102.
-
(2011)
Analyst
, vol.136
, pp. 1090-1102
-
-
Shamah, S.M.1
Cunningham, B.T.2
-
12
-
-
84879193022
-
Cellular screening for 7TM receptors using label-free detection
-
Cooper, M.A., Mayr, L.M., Eds.; John Wiley & Sons, Ltd.: Hoboken, NJ, USA
-
Jerman, J.C.; Brown, J.; Rocheville, M. Cellular screening for 7TM receptors using label-free detection. In Label-Free Technologies: For Drug Discovery; Cooper, M.A., Mayr, L.M., Eds.; John Wiley & Sons, Ltd.: Hoboken, NJ, USA, 2011; pp. 205-222.
-
(2011)
Label-Free Technologies: For Drug Discovery
, pp. 205-222
-
-
Jerman, J.C.1
Brown, J.2
Rocheville, M.3
-
13
-
-
80755139203
-
Review of transducer principles for label-free biomolecular interaction analysis
-
Nirschl, M.; Reuter, F.; Voros, J. Review of transducer principles for label-free biomolecular interaction analysis. Biosensors 2011, 1, 70-92.
-
(2011)
Biosensors
, vol.1
, pp. 70-92
-
-
Nirschl, M.1
Reuter, F.2
Voros, J.3
-
14
-
-
33746918047
-
Label-free profiling of ligands for endogenous GPCRs using a cell-based high-throughput screening technology
-
Li, G.; Ferrie, A.M.; Fang, Y. Label-free profiling of ligands for endogenous GPCRs using a cell-based high-throughput screening technology. JALA 2006, 11, 181-187.
-
(2006)
JALA
, vol.11
, pp. 181-187
-
-
Li, G.1
Ferrie, A.M.2
Fang, Y.3
-
15
-
-
33845877164
-
Label-free cell-based assays with optical biosensors in drug discovery
-
Fang, Y. Label-free cell-based assays with optical biosensors in drug discovery. Assay Drug Dev. Technol. 2006, 4, 583-595.
-
(2006)
Assay Drug Dev. Technol.
, vol.4
, pp. 583-595
-
-
Fang, Y.1
-
16
-
-
33751231711
-
Optical biosensors: Where next and how soon? Drug Discov
-
Cooper, M.A. Optical biosensors: Where next and how soon? Drug Discov. Today 2006, 11, 1061-1067.
-
(2006)
Today
, vol.11
, pp. 1061-1067
-
-
Cooper, M.A.1
-
17
-
-
80053371048
-
High-throughput analysis of biomolecular interactions and cellular responses with resonant waveguide grating biosensors
-
Cooper, M.A., Ed.; Cambridge University Press: Cambridge, UK
-
Fang, Y.; Fang, J.; Tran, E.; Xinying, X.; Hallstrom, M.; Frutos, A.G. High-throughput analysis of biomolecular interactions and cellular responses with resonant waveguide grating biosensors. In Label-Free Biosensors: Techniques and Applications; Cooper, M.A., Ed.; Cambridge University Press: Cambridge, UK, 2009; pp. 206-222.
-
(2009)
Label-Free Biosensors: Techniques and Applications
, pp. 206-222
-
-
Fang, Y.1
Fang, J.2
Tran, E.3
Xinying, X.4
Hallstrom, M.5
Frutos, A.G.6
-
18
-
-
34547578768
-
Label-free impedance biosensors: Opportunities and challenges
-
Daniels, J.S.; Pourmand, N. Label-free impedance biosensors: Opportunities and challenges. Electroanalysis 2007, 19, 1239-1257.
-
(2007)
Electroanalysis
, vol.19
, pp. 1239-1257
-
-
Daniels, J.S.1
Pourmand, N.2
-
19
-
-
84856403899
-
Dynamic and label-free cell-based assays using the xCELLigence system
-
Cooper, M.A., Mayr, L.M., Eds.; John Wiley & Sons, Ltd.: Hoboken, NJ, USA
-
Abassi, Y.A.; Sieler, A.; Watzele, M.; Wang, X.; Xu, X. Dynamic and label-free cell-based assays using the xCELLigence system. In Label-Free Technologies: For Drug Discovery; Cooper, M.A., Mayr, L.M., Eds.; John Wiley & Sons, Ltd.: Hoboken, NJ, USA, 2011; pp. 71-81.
-
(2011)
Label-Free Technologies: For Drug Discovery
, pp. 71-81
-
-
Abassi, Y.A.1
Sieler, A.2
Watzele, M.3
Wang, X.4
Xu, X.5
-
20
-
-
0022559399
-
Use of electric fields to monitor the dynamical aspect of cell behavior in tissue culture
-
Giaever, I.; Keese, C.R. Use of electric fields to monitor the dynamical aspect of cell behavior in tissue culture. IEEE Trans. Biomed. Eng. 1986, 33, 242-247.
-
(1986)
IEEE Trans. Biomed. Eng.
, vol.33
, pp. 242-247
-
-
Giaever, I.1
Keese, C.R.2
-
21
-
-
0027754169
-
A morphological biosensor for mammalian cells
-
Giaever, I.; Keese, C.R. A morphological biosensor for mammalian cells. Nature 1993, 366, 591-592.
-
(1993)
Nature
, vol.366
, pp. 591-592
-
-
Giaever, I.1
Keese, C.R.2
-
22
-
-
4644360563
-
Application of real-time cell electronic sensing (RT-CES) technology to cell-based assays
-
Solly, K.; Wang, X.; Xu, X.; Strulovici, B.; Zheng, W. Application of real-time cell electronic sensing (RT-CES) technology to cell-based assays. Assay Drug Dev. Technol. 2004, 2, 363-372.
-
(2004)
Assay Drug Dev. Technol.
, vol.2
, pp. 363-372
-
-
Solly, K.1
Wang, X.2
Xu, X.3
Strulovici, B.4
Zheng, W.5
-
23
-
-
84879193193
-
Electrical impedance technology applied to cell-based assays
-
Cooper, M.A., Ed.; Cambridge University Press: Cambridge, UK
-
McGuinness, R.; Verdonk, E. Electrical impedance technology applied to cell-based assays. In Label-Free Biosensors: Techniques and Applications; Cooper, M.A., Ed.; Cambridge University Press: Cambridge, UK, 2009; pp. 251-277.
-
(2009)
Label-Free Biosensors: Techniques and Applications
, pp. 251-277
-
-
McGuinness, R.1
Verdonk, E.2
-
24
-
-
33748747144
-
Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components
-
Head, B.P.; Patel, H.H.; Roth, D.M.; Murray, F.; Swaney, J.S.; Niesman, I.R.; Farquhar, M.G.; Insel, P.A. Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components. J. Biol. Chem. 2006, 281, 26391-26399.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 26391-26399
-
-
Head, B.P.1
Patel, H.H.2
Roth, D.M.3
Murray, F.4
Swaney, J.S.5
Niesman, I.R.6
Farquhar, M.G.7
Insel, P.A.8
-
25
-
-
0035798556
-
Role of the cytoskeleton in mediating cAMP-dependent protein kinase inhibition of the epithelial Na+/H+ exchanger NHE3
-
Szaszi, K.; Kurashima, K.; Kaibuchi, K.; Grinstein, S.; Orlowski, J. Role of the cytoskeleton in mediating cAMP-dependent protein kinase inhibition of the epithelial Na+/H+ exchanger NHE3. J. Biol. Chem. 2001, 276, 40761-40768.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 40761-40768
-
-
Szaszi, K.1
Kurashima, K.2
Kaibuchi, K.3
Grinstein, S.4
Orlowski, J.5
-
26
-
-
35348821843
-
Function, structure and therapeutic potential of complement C5a receptors
-
Monk, P.N.; Scola, A.M.; Madala, P.; Fairlie, D.P. Function, structure and therapeutic potential of complement C5a receptors. Br. J. Pharmacol. 2007, 152, 429-448.
-
(2007)
Br. J. Pharmacol.
, vol.152
, pp. 429-448
-
-
Monk, P.N.1
Scola, A.M.2
Madala, P.3
Fairlie, D.P.4
-
27
-
-
78650289203
-
Role of C5 activation products in sepsis
-
Ward, P.A. Role of C5 activation products in sepsis. Sci. World J. 2010, 10, 2395-2402.
-
(2010)
Sci. World J.
, vol.10
, pp. 2395-2402
-
-
Ward, P.A.1
-
28
-
-
77951084459
-
Complement factor C5a in acute exacerbation of chronic obstructive pulmonary disease
-
Marc, M.M.; Kristan, S.S.; Rozman, A.; Kern, I.; Flezar, M.; Kosnik, M.; Korosec, P. Complement factor C5a in acute exacerbation of chronic obstructive pulmonary disease. Scand. J. Immunol. 2010, 71, 386-391.
-
(2010)
Scand. J. Immunol.
, vol.71
, pp. 386-391
-
-
Marc, M.M.1
Kristan, S.S.2
Rozman, A.3
Kern, I.4
Flezar, M.5
Kosnik, M.6
Korosec, P.7
-
29
-
-
79960196841
-
Complement C5a inhibition reduces atherosclerosis in ApoE-/- mice
-
Manthey, H.D.; Thomas, A.C.; Shiels, I.A.; Zernecke, A.; Woodruff, T.M.; Rolfe, B.; Taylor, S.M. Complement C5a inhibition reduces atherosclerosis in ApoE-/- mice. FASEB J. 2010, 25, 2447-2455.
-
(2010)
FASEB J
, vol.25
, pp. 2447-2455
-
-
Manthey, H.D.1
Thomas, A.C.2
Shiels, I.A.3
Zernecke, A.4
Woodruff, T.M.5
Rolfe, B.6
Taylor, S.M.7
-
30
-
-
0024600632
-
Analysis of the interaction of human C5a and C5a des Arg with human monocytes and neutrophils: Flow cytometric and chemotaxis studies
-
Yancey, K.B.; Lawley, T.J.; Dersookian, M.; Harvath, L. Analysis of the interaction of human C5a and C5a des Arg with human monocytes and neutrophils: Flow cytometric and chemotaxis studies. J. Invest. Dermatol. 1989, 92, 184-189.
-
(1989)
J. Invest. Dermatol.
, vol.92
, pp. 184-189
-
-
Yancey, K.B.1
Lawley, T.J.2
Dersookian, M.3
Harvath, L.4
-
31
-
-
0344154671
-
Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes
-
Chenoweth, D.E.; Hugli, T.E. Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes. Proc. Natl. Acad. Sci. USA 1978, 75, 3943-3947.
-
(1978)
Proc. Natl. Acad. Sci. USA
, vol.75
, pp. 3943-3947
-
-
Chenoweth, D.E.1
Hugli, T.E.2
-
32
-
-
0028850938
-
Cellular expression of the C5a anaphylatoxin receptor (C5aR): Demonstration of C5aR on nonmyeloid cells of the liver and lung
-
Haviland, D.; McCoy, R.; Whitehead, W.; Akama, H.; Molmenti, E.; Brown, A.; Haviland, J.; Parks, W.; Perlmutter, D.; Wetsel, R. Cellular expression of the C5a anaphylatoxin receptor (C5aR): Demonstration of C5aR on nonmyeloid cells of the liver and lung. J. Immunol. 1995, 154, 1861-1869.
-
(1995)
J. Immunol.
, vol.154
, pp. 1861-1869
-
-
Haviland, D.1
McCoy, R.2
Whitehead, W.3
Akama, H.4
Molmenti, E.5
Brown, A.6
Haviland, J.7
Parks, W.8
Perlmutter, D.9
Wetsel, R.10
-
33
-
-
0018887370
-
A differential effect of C5a and C5a des Arg in the induction of pulmonary inflammation
-
Larsen, G.L.; McCarthy, K.; Webster, R.O.; Henson, J.; Henson, P.M. A differential effect of C5a and C5a des Arg in the induction of pulmonary inflammation. Am. J. Pathol. 1980, 100, 179-192.
-
(1980)
Am. J. Pathol.
, vol.100
, pp. 179-192
-
-
Larsen, G.L.1
McCarthy, K.2
Webster, R.O.3
Henson, J.4
Henson, P.M.5
-
34
-
-
0028072084
-
Development of C5a receptor antagonists Differential loss of functional responses
-
Konteatis, Z.; Siciliano, S.; van Riper, G.; Molineaux, C.; Pandya, S.; Fischer, P.; Rosen, H.; Mumford, R.; Springer, M. Development of C5a receptor antagonists. Differential loss of functional responses. J. Immunol. 1994, 153, 4200-4205.
-
(1994)
J. Immunol.
, vol.153
, pp. 4200-4205
-
-
Konteatis, Z.1
Siciliano, S.2
van Riper, G.3
Molineaux, C.4
Pandya, S.5
Fischer, P.6
Rosen, H.7
Mumford, R.8
Springer, M.9
-
35
-
-
77954013043
-
Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS
-
Halili, M.A.; Andrews, M.R.; Labzin, L.I.; Schroder, K.; Matthias, G.; Cao, C.; Lovelace, E.; Reid, R.C.; Le, G.T.; Hume, D.A.; et al. Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. J. Leukoc. Biol. 2010, 87, 1103-1114.
-
(2010)
J. Leukoc. Biol.
, vol.87
, pp. 1103-1114
-
-
Halili, M.A.1
Andrews, M.R.2
Labzin, L.I.3
Schroder, K.4
Matthias, G.5
Cao, C.6
Lovelace, E.7
Reid, R.C.8
Le, G.T.9
Hume, D.A.10
-
36
-
-
43749088520
-
Conopressin-T from Conus tulipa reveals an antagonist switch in Vasopressin-like peptides
-
Dutertre, S.; Croker, D.; Daly, N.L.; Andersson, A.; Muttenthaler, M.; Lumsden, N.G.; Craik, D.J.; Alewood, P.F.; Guillon, G.; Lewis, R.J. Conopressin-T from Conus tulipa reveals an antagonist switch in Vasopressin-like peptides. J. Biol. Chem. 2008, 283, 7100-7108.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 7100-7108
-
-
Dutertre, S.1
Croker, D.2
Daly, N.L.3
Andersson, A.4
Muttenthaler, M.5
Lumsden, N.G.6
Craik, D.J.7
Alewood, P.F.8
Guillon, G.9
Lewis, R.J.10
-
37
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford, M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248-254.
-
(1976)
Anal. Biochem.
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
38
-
-
0033650981
-
Scintillation proximity binding assay
-
Proudfoot, A.E.I., Wells, T.N.C., Power, C.A., Eds.; Humana Press: Totowa, NJ, USA
-
Alouani, S. Scintillation proximity binding assay. In Chemokine Protocols; Proudfoot, A.E.I., Wells, T.N.C., Power, C.A., Eds.; Humana Press: Totowa, NJ, USA, 2000; Volume 138, pp. 135-141.
-
(2000)
Chemokine Protocols
, vol.138
, pp. 135-141
-
-
Alouani, S.1
-
39
-
-
85056062287
-
The use of AlphaScreen technology in HTS: Current status
-
Eglen, R.M.; Reisine, T.; Roby, P.; Rouleau, N.; Illy, C.; Bosse, R.; Bielefeld, M. The use of AlphaScreen technology in HTS: Current status. Curr. Chem. Genomics 2008, 1, 2-10.
-
(2008)
Curr. Chem. Genomics
, vol.1
, pp. 2-10
-
-
Eglen, R.M.1
Reisine, T.2
Roby, P.3
Rouleau, N.4
Illy, C.5
Bosse, R.6
Bielefeld, M.7
-
40
-
-
0018850996
-
The effect of hemodialysis and C5a des Arg on neutrophil subpopulations
-
Klempner, M.S.; Gallin, J.I.; Balow, J.E.; van Kammen, D.P. The effect of hemodialysis and C5a des Arg on neutrophil subpopulations. Blood 1980, 55, 777-783.
-
(1980)
Blood
, vol.55
, pp. 777-783
-
-
Klempner, M.S.1
Gallin, J.I.2
Balow, J.E.3
van Kammen, D.P.4
-
41
-
-
0019500177
-
Response of human neutrophils to C5a: A role for the oligosaccharide moiety of human C5a des Arg-74 but not of C5a in biologic activity
-
Gerard, C.; Chenoweth, D.E.; Hugli, T.E. Response of human neutrophils to C5a: A role for the oligosaccharide moiety of human C5a des Arg-74 but not of C5a in biologic activity. J. Immunol. 1981, 127, 1978-1982.
-
(1981)
J. Immunol.
, vol.127
, pp. 1978-1982
-
-
Gerard, C.1
Chenoweth, D.E.2
Hugli, T.E.3
-
42
-
-
0021952732
-
Chemotactic responses of human peripheral blood monocytes to the complement-derived peptides C5a and C5a des Arg
-
Marder, S.R.; Chenoweth, D.E.; Goldstein, I.M.; Perez, H.D. Chemotactic responses of human peripheral blood monocytes to the complement-derived peptides C5a and C5a des Arg. J. Immunol. 1985, 134, 3325-3331.
-
(1985)
J. Immunol.
, vol.134
, pp. 3325-3331
-
-
Marder, S.R.1
Chenoweth, D.E.2
Goldstein, I.M.3
Perez, H.D.4
-
43
-
-
0022556792
-
The chemoattractant des-Arg74-C5a regulates the expression of its own receptor on a monocyte-like cell line
-
Barker, M.D.; Jose, P.J.; Williams, T.J.; Burton, D.R. The chemoattractant des-Arg74-C5a regulates the expression of its own receptor on a monocyte-like cell line. Biochem. J. 1986, 236, 621-624.
-
(1986)
Biochem. J.
, vol.236
, pp. 621-624
-
-
Barker, M.D.1
Jose, P.J.2
Williams, T.J.3
Burton, D.R.4
-
44
-
-
0023781639
-
Human C5a and C5a des Arg exhibit chemotactic activity for fibroblasts
-
Senior, R.M.; Griffin, G.L.; Perez, H.D.; Webster, R.O. Human C5a and C5a des Arg exhibit chemotactic activity for fibroblasts. J. Immunol. 1988, 141, 3570-3574.
-
(1988)
J. Immunol.
, vol.141
, pp. 3570-3574
-
-
Senior, R.M.1
Griffin, G.L.2
Perez, H.D.3
Webster, R.O.4
-
45
-
-
0028318754
-
The degradation product of the C5a anaphylatoxin C5a des Arg retains basophil-activating properties
-
Bürgi, B.; Brunner, T.; Dahinden, C.A. The degradation product of the C5a anaphylatoxin C5a des Arg retains basophil-activating properties. Eur. J. Immunol. 1994, 24, 1583-1589.
-
(1994)
Eur. J. Immunol.
, vol.24
, pp. 1583-1589
-
-
Bürgi, B.1
Brunner, T.2
Dahinden, C.A.3
-
46
-
-
0029885592
-
The human mast cell line HMC-1 expresses C5a receptors and responds to C5a but not to C5a(desArg)
-
Werfel, T.; Oppermann, M.; Butterfield, J.H.; Begemann, G.; Elsner, J.; Gotze, O.; Zwirner, J. The human mast cell line HMC-1 expresses C5a receptors and responds to C5a but not to C5a(desArg). Scand. J. Immunol. 1996, 44, 30-36.
-
(1996)
Scand. J. Immunol.
, vol.44
, pp. 30-36
-
-
Werfel, T.1
Oppermann, M.2
Butterfield, J.H.3
Begemann, G.4
Elsner, J.5
Gotze, O.6
Zwirner, J.7
-
47
-
-
0033609445
-
Receptor activation by human C5a des Arg74 but not intact C5a is dependent on an interaction between Glu199 of the receptor and Lys68 of the ligand
-
Crass, T.; Bautsch, W.; Cain, S.A.; Pease, J.E.; Monk, P.N. Receptor activation by human C5a des Arg74 but not intact C5a is dependent on an interaction between Glu199 of the receptor and Lys68 of the ligand. Biochemistry 1999, 38, 9712-9717.
-
(1999)
Biochemistry
, vol.38
, pp. 9712-9717
-
-
Crass, T.1
Bautsch, W.2
Cain, S.A.3
Pease, J.E.4
Monk, P.N.5
-
48
-
-
10644276245
-
Kinetics of G-protein-coupled receptor signalling and desensitization
-
Krasel, C.; Vilardaga, J.P.; Bunemann, M.; Lohse, M.J. Kinetics of G-protein-coupled receptor signalling and desensitization. Biochem. Soc. Trans. 2004, 32, 1029-1031.
-
(2004)
Biochem. Soc. Trans.
, vol.32
, pp. 1029-1031
-
-
Krasel, C.1
Vilardaga, J.P.2
Bunemann, M.3
Lohse, M.J.4
-
49
-
-
0025731025
-
The regulation of actin polymerization in differentiating U937 cells correlates with increased membrane levels of the pertussis-toxin-sensitive G-protein Gi2
-
Sheth, B.; Banks, P.; Burton, D.R.; Monk, P.N. The regulation of actin polymerization in differentiating U937 cells correlates with increased membrane levels of the pertussis-toxin-sensitive G-protein Gi2. Biochem. J. 1991, 275, 809-811.
-
(1991)
Biochem. J.
, vol.275
, pp. 809-811
-
-
Sheth, B.1
Banks, P.2
Burton, D.R.3
Monk, P.N.4
-
50
-
-
20044381682
-
Macrophages induce the inflammatory response in the pulmonary arthus reaction through Gαi2 activation that controls C5aR and Fc receptor cooperation
-
Skokowa, J.; Ali, S.R.; Felda, O.; Kumar, V.; Konrad, S.; Shushakova, N.; Schmidt, R.E.; Piekorz, R.P.; Nurnberg, B.; Spicher, K.; et al. Macrophages induce the inflammatory response in the pulmonary arthus reaction through Gαi2 activation that controls C5aR and Fc receptor cooperation. J. Immunol. 2005, 174, 3041-3050.
-
(2005)
J. Immunol.
, vol.174
, pp. 3041-3050
-
-
Skokowa, J.1
Ali, S.R.2
Felda, O.3
Kumar, V.4
Konrad, S.5
Shushakova, N.6
Schmidt, R.E.7
Piekorz, R.P.8
Nurnberg, B.9
Spicher, K.10
-
51
-
-
34248169999
-
Receptors for the anaphylatoxins C3a and C5a are expressed in human atherosclerotic coronary plaques
-
Oksjoki, R.; Laine, P.; Helske, S.; Vehmaan-Kreula, P.; Mäyränpää, M.I.; Gasque, P.; Kovanen, P.T.; Pentikäinen, M.O. Receptors for the anaphylatoxins C3a and C5a are expressed in human atherosclerotic coronary plaques. Atherosclerosis 2007, 195, 90-99.
-
(2007)
Atherosclerosis
, vol.195
, pp. 90-99
-
-
Oksjoki, R.1
Laine, P.2
Helske, S.3
Vehmaan-Kreula, P.4
Mäyränpää, M.I.5
Gasque, P.6
Kovanen, P.T.7
Pentikäinen, M.O.8
-
52
-
-
0028670476
-
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras
-
Koch, W.J.; Hawes, B.E.; Allen, L.F.; Lefkowitz, R.J. Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras. Proc. Natl. Acad. Sci. USA 1994, 91, 12706-12710.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 12706-12710
-
-
Koch, W.J.1
Hawes, B.E.2
Allen, L.F.3
Lefkowitz, R.J.4
-
53
-
-
0033606980
-
Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with Gαi
-
Mochizuki, N.; Ohba, Y.; Kiyokawa, E.; Kurata, T.; Murakami, T.; Ozaki, T.; Kitabatake, A.; Nagashima, K.; Matsuda, M. Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with Gαi. Nature 1999, 400, 891-894
-
(1999)
Nature
, vol.400
, pp. 891-894
-
-
Mochizuki, N.1
Ohba, Y.2
Kiyokawa, E.3
Kurata, T.4
Murakami, T.5
Ozaki, T.6
Kitabatake, A.7
Nagashima, K.8
Matsuda, M.9
-
54
-
-
0033932559
-
5-HT(1A) receptor agonist-antagonist binding affinity difference as a measure of intrinsic activity in recombinant and native tissue systems
-
Watson, J.; Collin, L.; Ho, M.; Riley, G.; Scott, C.; Selkirk, J.V.; Price, G.W. 5-HT(1A) receptor agonist-antagonist binding affinity difference as a measure of intrinsic activity in recombinant and native tissue systems. Br. J. Pharmacol. 2000, 130, 1108-1114.
-
(2000)
Br. J. Pharmacol.
, vol.130
, pp. 1108-1114
-
-
Watson, J.1
Collin, L.2
Ho, M.3
Riley, G.4
Scott, C.5
Selkirk, J.V.6
Price, G.W.7
-
55
-
-
0034090285
-
Opioid and cannabinoid receptors share a common pool of GTP-binding proteins in cotransfected cells, but not in cells which endogenously coexpress the receptors
-
Shapira, M.; Vogel, Z.; Sarne, Y. Opioid and cannabinoid receptors share a common pool of GTP-binding proteins in cotransfected cells, but not in cells which endogenously coexpress the receptors. Cell Mol. Neurobiol. 2000, 20, 291-304.
-
(2000)
Cell Mol. Neurobiol.
, vol.20
, pp. 291-304
-
-
Shapira, M.1
Vogel, Z.2
Sarne, Y.3
-
56
-
-
23944501304
-
Heterodimerization of G protein-coupled receptors: Specificity and functional significance
-
Prinster, S.C.; Hague, C.; Hall, R.A. Heterodimerization of G protein-coupled receptors: Specificity and functional significance. Pharmacol. Rev. 2005, 57, 289-298.
-
(2005)
Pharmacol. Rev.
, vol.57
, pp. 289-298
-
-
Prinster, S.C.1
Hague, C.2
Hall, R.A.3
-
57
-
-
0041571471
-
C5L2, a nonsignaling C5a binding protein
-
Okinaga, S.; Slattery, D.; Humbles, A.; Zsengeller, Z.; Morteau, O.; Kinrade, M.B.; Brodbeck, R.M.; Krause, J.E.; Choe, H.-R.; Gerard, N.P.; et al. C5L2, a nonsignaling C5a binding protein. Biochemistry 2003, 42, 9406-9415.
-
(2003)
Biochemistry
, vol.42
, pp. 9406-9415
-
-
Okinaga, S.1
Slattery, D.2
Humbles, A.3
Zsengeller, Z.4
Morteau, O.5
Kinrade, M.B.6
Brodbeck, R.M.7
Krause, J.E.8
Choe, H.-R.9
Gerard, N.P.10
-
58
-
-
24644496122
-
Characteristics of dynamic mass redistribution of epidermal growth factor receptor signaling in living cells measured with label-free optical biosensors
-
Fang, Y.; Ferrie, A.M.; Fontaine, N.H.; Yuen, P.K. Characteristics of dynamic mass redistribution of epidermal growth factor receptor signaling in living cells measured with label-free optical biosensors. Anal. Chem. 2005, 77, 5720-5725.
-
(2005)
Anal. Chem.
, vol.77
, pp. 5720-5725
-
-
Fang, Y.1
Ferrie, A.M.2
Fontaine, N.H.3
Yuen, P.K.4
-
59
-
-
36048969417
-
Non-invasive optical biosensor for probing cell signaling
-
Fang, Y. Non-invasive optical biosensor for probing cell signaling. Sensors 2007, 7, 2316-2329.
-
(2007)
Sensors
, vol.7
, pp. 2316-2329
-
-
Fang, Y.1
-
60
-
-
77956657852
-
Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements
-
Schroder, R.; Janssen, N.; Schmidt, J.; Kebig, A.; Merten, N.; Hennen, S.; Muller, A.; Blattermann, S.; Mohr-Andra, M.; Zahn, S.; et al. Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements. Nat. Biotechnol. 2010, 28, 943-949.
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 943-949
-
-
Schroder, R.1
Janssen, N.2
Schmidt, J.3
Kebig, A.4
Merten, N.5
Hennen, S.6
Muller, A.7
Blattermann, S.8
Mohr-Andra, M.9
Zahn, S.10
-
61
-
-
70349758970
-
A 100K well screen for a muscarinic receptor using the Epic label-free system-a reflection on the benefits of the label-free approach to screening seven-transmembrane receptors
-
Dodgson, K.; Gedge, L.; Murray, D.C.; Coldwell, M. A 100K well screen for a muscarinic receptor using the Epic label-free system-a reflection on the benefits of the label-free approach to screening seven-transmembrane receptors. J. Recept. Signal Transduct. Res. 2009, 29, 163-172.
-
(2009)
J. Recept. Signal Transduct. Res.
, vol.29
, pp. 163-172
-
-
Dodgson, K.1
Gedge, L.2
Murray, D.C.3
Coldwell, M.4
-
62
-
-
24944547571
-
Why drugs fail-a study on side effects in new chemical entities
-
Schuster, D.; Laggner, C.; Langer, T. Why drugs fail-a study on side effects in new chemical entities. Curr. Pharm. Des. 2005, 11, 3545-3559.
-
(2005)
Curr. Pharm. Des.
, vol.11
, pp. 3545-3559
-
-
Schuster, D.1
Laggner, C.2
Langer, T.3
|