The transfusion dilemma-Weighing the known and newly proposed risks of blood transfusions against the uncertain benefits

Best Practice and Research: Clinical Anaesthesiology

Volumn 27, Issue 1, 2013, Pages 17-35

  Refaai, Majed A ^a   Blumberg, Neil ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

blood components; transfusion; transfusion reaction

Indexed keywords

ADRENALIN; ANTIVITAMIN K; CITRATE SODIUM; DIPHENHYDRAMINE; DOPAMINE; FRESH FROZEN PLASMA; FUROSEMIDE; HEMOGLOBIN; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; PARACETAMOL; STEROID; THROMBOCYTE ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC REACTION; ANAPHYLAXIS; ANGIONEUROTIC EDEMA; BACKACHE; BACTERIUM CONTAMINATION; BLOOD CLOTTING DISORDER; BLOOD GROUP INCOMPATIBILITY; BLOOD SAMPLING; BLOOD SMEAR; BLOOD STORAGE; BLOOD TRANSFUSION; BRONCHOSPASM; CHEST TIGHTNESS; CHILL; CONGESTIVE HEART FAILURE; CRYOPRECIPITATE; DRUG EFFICACY; DYSPNEA; EDEMA; ERYTHROCYTE TRANSFUSION; FEVER; FLUID RESUSCITATION; HEMOGLOBIN BLOOD LEVEL; HEMOGLOBINURIA; HEMORRHAGIC SHOCK; HUMAN; HYPERKALEMIA; HYPOTENSION; HYPOTHERMIA; IMMUNOMODULATION; INFECTION RISK; LUNG EDEMA; NAUSEA; NEGLIGENCE; PATIENT MONITORING; PLASMA TRANSFUSION; PRIORITY JOURNAL; REPEAT PROCEDURE; REVIEW; RISK ASSESSMENT; RISK REDUCTION; SHOCK; SUBSTITUTION THERAPY; TACHYCARDIA; THERAPEUTIC ERROR; THORAX PAIN; THROMBOCYTE TRANSFUSION; TISSUE OXYGENATION; TRANSFUSION RELATED ACUTE LUNG INJURY; TREATMENT DURATION; URTICARIA; VIRAL CONTAMINATION; VITAL SIGN; VOMITING;

EID: 84876255839     PISSN: 15216896     EISSN: 1532169X     Source Type: Journal    
DOI: 10.1016/j.bpa.2012.12.006     Document Type: Review

References (104)

1. L.T. Goodnough Risks of blood transfusion Crit Care Med 31 12 Suppl 2003 Dec S678 S686 PubMed PMID: 14724466. eng
2. R.H. Walker Special report: transfusion risks Am J Clin Pathol 88 3 1987 Sep 374 378 PubMed PMID: 3630978. eng
3. Health care cost and utilization project (HCUP) facts and Figures Soh-bcitU 2005 Exhibit 3.1. Most Frequent Procedures at http://www.hcup-us.ahrq. gov/reports.jsp [accessed 06.05.08]
4. H. Wandt, K. Schaefer-Eckart, and K. Wendelin Therapeutic platelet transfusion versus routine prophylactic transfusion in patients with haematological malignancies: an open-label, multicentre, randomised study Lancet 380 9850 2012 Oct 1309 1316 PubMed PMID: 22877506. eng
5. N. Blumberg, J.M. Heal, and G.L. Phillips Platelets-to transfuse or not to transfuse Lancet 380 9850 2012 Oct 1287 1289 PubMed PMID: 22877505. eng
6. N. Blumberg, H. Zhao, and H. Wang The intention-to-treat principle in clinical trials and meta-analyses of leukoreduced blood transfusions in surgical patients Transfusion 47 4 2007 Apr 573 581 PubMed PMID: 17381614. eng
7. Leukocyte reduction and ultraviolet B irradiation of platelets to prevent alloimmunization and refractoriness to platelet transfusions. The Trial to Reduce Alloimmunization to Platelets Study Group N Engl J Med 337 26 1997 Dec 1861 1869 PubMed PMID: 9417523. eng
8. A.T. Tinmouth, L.A. McIntyre, and R.A. Fowler Blood conservation strategies to reduce the need for red blood cell transfusion in critically ill patients CMAJ 178 1 2008 Jan 49 57 PubMed PMID: 18166731. Pubmed Central PMCID: PMC2151112. eng
9. E.F. Bell, R.G. Strauss, and J.A. Widness Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants Pediatrics 115 6 2005 Jun 1685 1691 PubMed PMID: 15930233. Pubmed Central PMCID: PMC2866196. eng
10. J.L. Carson, A. Duff, and J.A. Berlin Perioperative blood transfusion and postoperative mortality JAMA 279 3 1998 Jan 199 205 PubMed PMID: 9438739. eng
11. P.C. Hébert, G. Wells, and M.A. Blajchman A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group N Engl J Med 340 6 1999 Feb 409 417 PubMed PMID: 9971864. eng
12. H. Kirpalani, R.K. Whyte, and C. Andersen The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants J Pediatr 149 3 2006 Sep 301 307 PubMed PMID: 16939737. eng
13. J. Lacroix, P.C. Hébert, and J.S. Hutchison Transfusion strategies for patients in pediatric intensive care units N Engl J Med 356 16 2007 Apr 1609 1619 PubMed PMID: 17442904. eng
14. J.L. Carson, M.L. Terrin, and H. Noveck Liberal or restrictive transfusion in high-risk patients after hip surgery N Engl J Med 365 26 2011 Dec 2453 2462 PubMed PMID: 22168590. Pubmed Central PMCID: PMC3268062. eng
15. P.M. Van Dijk, and J.W. Kleine The transfusion reaction in anesthesiological practice Acta Anaesthesiol Belg 27 4 1976 247 254 PubMed PMID: 829394. eng
16. P.J. Schmidt Transfusion mortality; with special reference to surgical and intensive care facilities J Fla Med Assoc. 67 2 1980 Feb 151 153 PubMed PMID: 7359107. eng
17. K. Sazama Reports of 355 transfusion-associated deaths: 1976 through 1985 Transfusion 30 7 1990 Sep 583 590 PubMed PMID: 2402771. eng
18. J.V. Linden, K. Wagner, and A.E. Voytovich Transfusion errors in New York State: an analysis of 10 years' experience Transfusion 40 10 2000 Oct 1207 1213 PubMed PMID: 11061857. eng
19. P.I. Tartter, S. Quintero, and D.M. Barron Perioperative blood transfusion associated with infectious complications after colorectal cancer operations Am J Surg 152 5 1986 Nov 479 482 PubMed PMID: 3777324. eng
20. P.I. Tartter, K. Mohandas, and P. Azar Randomized trial comparing packed red cell blood transfusion with and without leukocyte depletion for gastrointestinal surgery Am J Surg 176 5 1998 Nov 462 466 PubMed PMID: 9874434. eng
21. J.A. van Hilten, L.M. van de Watering, and J.H. van Bockel Effects of transfusion with red cells filtered to remove leucocytes: randomised controlled trial in patients undergoing major surgery BMJ 328 7451 2004 May 1281 PubMed PMID: 15142885. Pubmed Central PMCID: PMC420164. eng
22. S.V. Rao, J.G. Jollis, and R.A. Harrington Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes JAMA 292 13 2004 Oct 1555 1562 PubMed PMID: 15467057. eng
23. K.R. Nilsson, S.M. Berenholtz, and E. Garrett-Mayer Association between venous thromboembolism and perioperative allogeneic transfusion Arch Surg 142 2 2007 Feb 126 132 discussion 33. PubMed PMID: 17309963
24. A.A. Khorana, C.W. Francis, and N. Blumberg Blood transfusions, thrombosis, and mortality in hospitalized patients with cancer Arch Intern Med 168 21 2008 Nov 2377 2381 PubMed PMID: 19029504. Pubmed Central PMCID: PMC2775132. eng
25. L.M. van de Watering, J. Hermans, and J.G. Houbiers Beneficial effects of leukocyte depletion of transfused blood on postoperative complications in patients undergoing cardiac surgery: a randomized clinical trial Circulation 97 6 1998 Feb 562 568 PubMed PMID: 9494026. eng
26. N. Blumberg, J.M. Heal, and J.L. Liesveld Platelet transfusion and survival in adults with acute leukemia Leuk: Off J Leuk Soc Am, Leuk Res Fund, U.K. 22 3 2008 Mar 631 635 PubMed PMID: 17805333. Epub 2007/09/07. eng
27. N. Blumberg, K.F. Gettings, and C. Turner An association of soluble CD40 ligand (CD154) with adverse reactions to platelet transfusions Transfusion 46 10 2006 Oct 1813 1821 PubMed PMID: 17002639. eng
28. S.Y. Khan, M.R. Kelher, and J.M. Heal Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury Blood 108 7 2006 Oct 1 2455 2462 PubMed PMID: 16772606. Pubmed Central PMCID: 1895564. Epub 2006/06/15. eng
29. Y.M. Bilgin, L.M. van de Watering, and L. Eijsman Double-blind, randomized controlled trial on the effect of leukocyte-depleted erythrocyte transfusions in cardiac valve surgery Circulation 109 22 2004 Jun 2755 2760 PubMed PMID: 15148271. eng
30. T.D. Vo, J. Cowles, and J.M. Heal Platelet washing to prevent recurrent febrile reactions to leucocyte-reduced transfusions Transfus Med 11 1 2001 Feb 45 47 PubMed PMID: 11328571. eng
31. N. Blumberg, J.M. Heal, and J.M. Rowe A randomized trial of washed red blood cell and platelet transfusions in adult acute leukemia [ISRCTN76536440] BMC Blood Disord 4 1 2004 Dec 10 6 PubMed PMID: 15588315. Pubmed Central PMCID: 544564. Epub 2004/12/14. Eng
32. D. Goldfinger Acute hemolytic transfusion reactions-a fresh look at pathogenesis and considerations regarding therapy Transfusion 17 2 1977 Mar-Apr 85 98 PubMed PMID: 850938. eng
33. A.A. Pineda, S.M. Brzica, and H.F. Taswell Hemolytic transfusion reaction. Recent experience in a large blood bank Mayo Clin Proc 53 6 1978 Jun 378 390 PubMed PMID: 651382. eng
34. P. Kopko, M. Silva, and I. Shulman AABB survey of transfusion-related acute lung injury policies and practices in the United States Transfusion 47 9 2007 Sep 1679 1685 PubMed PMID: 17725734. eng
35. R.D. Davenport The role of cytokines in hemolytic transfusion reactions Immunol Invest 24 1-2 1995 Jan-Feb 319 331 PubMed PMID: 7713593. eng
36. G.I. Ingram The bleeding complications of blood transfusion Transfusion 5 1965 Jan-Feb 1 5 PubMed PMID: 14255496. eng
37. AABB technical manual 16th ed. and AABB standards for blood banks and transfusion services 25th ed. 2008 AABB Press Bethesda, MD
38. R.L. Bick, W.R. Schmalhorst, and L. Fekete Disseminated intravascular coagulation and blood component therapy Transfusion 16 4 1976 Jul-Aug 361 365 PubMed PMID: 951733. eng
39. J.P. Miller, and J.P. AuBuchon Leukocyte-reduced and cytomegalovirus- reduced-risk blood components Transfusion therapy: clinical principles and practice, ed 1999 AABB Press Bethesda MD
40. G. Stack, J.V. Judge, and E.L. Snyder T.L. Simon, E.C. Rossi, G.S. Moss, Febrile and non-immune transfusion reactions 2nd ed. 1996 Williams & Wilkins Baltimore
41. N.M. Heddle, L. Klama, and J. Singer The role of the plasma from platelet concentrates in transfusion reactions N Engl J Med 331 10 1994 Sep 625 628 PubMed PMID: 8052271. eng
42. R.P. Phipps, J. Kaufman, and N. Blumberg Platelet derived CD154 (CD40 ligand) and febrile responses to transfusion Lancet 357 9273 2001 Jun 23 2023 2024 PubMed PMID: 11438137. Epub 2001/07/05. eng
43. A.A. Pineda, V.W. Zylstra, and D.E. Clare Viability and functional integrity of washed platelets Transfusion 29 6 1989 Jul-Aug 524 527 PubMed PMID: 2749876. eng
44. S.G. Sandler, R. Eckrich, and D. Malamut Hemagglutination assays for the diagnosis and prevention of IgA anaphylactic transfusion reactions Blood 84 6 1994 Sep 2031 2035 PubMed PMID: 8081004. eng
45. R.D. Davenport E.P.D. Mintz, Management of transfusion reactions 1999 AABB Press Bethesda, MD
46. R.D. Davenport, K.L. Burnie, and R.M. Barr Transfusion management of patients with IgA deficiency and anti-IgA during liver transplantation Vox Sang 63 4 1992 247 250 PubMed PMID: 1481472. eng
47. W.J. Savage, A.A. Tobian, and J.H. Savage Atopic predisposition of recipients in allergic transfusion reactions to apheresis platelets Transfusion 51 11 2011 Nov 2337 2342 PubMed PMID: 21569041. eng
48. W.J. Savage, J.H. Savage, and A.A. Tobian Allergic agonists in apheresis platelet products are associated with allergic transfusion reactions Transfusion 52 3 2012 Mar 575 581 PubMed PMID: 21883267. eng
49. M.A. Popovsky, and S.B. Moore Mechanism of transfusion-related acute lung injury Blood 77 10 1991 May 2299 PubMed PMID: 1709383. eng
50. M.A. Popovsky, H.C. Chaplin, and S.B. Moore Transfusion-related acute lung injury: a neglected, serious complication of hemotherapy Transfusion 32 6 1992 Jul-Aug 589 592 PubMed PMID: 1502715. eng
51. C.C. Silliman, L.K. Boshkov, and Z. Mehdizadehkashi Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors Blood 101 2 2003 Jan 454 462 PubMed PMID: 12393667. eng
52. R. Fasano, and N.L. Luban Blood component therapy Pediatr Clin North Am. 55 2 2008 Apr 421 445 ix. PubMed PMID: 18381094. eng
53. M.A. Popovsky, and S.B. Moore Diagnostic and pathogenetic considerations in transfusion-related acute lung injury Transfusion 25 6 1985 Nov-Dec 573 577 PubMed PMID: 4071603. eng
54. A.F. Eder, and L.A. Chambers Noninfectious complications of blood transfusion Arch Pathol Lab Med 131 5 2007 May 708 718 PubMed PMID: 17488156. eng
55. M. Goldman, K.E. Webert, and D.M. Arnold Proceedings of a consensus conference: towards an understanding of TRALI Transfus Med Rev 19 1 2005 Jan 2 31 PubMed PMID: 15830325. eng
56. M.A. Popovsky Transfusion and the lung: circulatory overload and acute lung injury Vox Sang 87 Suppl 2 2004 Jul 62 65 PubMed PMID: 15209881. eng
57. Chester Andrzejewski Jr., M.A. Popovsky, and Theresa C. Stec Hemotherapy bedside biovigilance involving vital sign values and characteristics of patients with suspected transfusion reactions associated with fluid challenges: can some cases of transfusion-associated circulatory overload have proinflammatory aspects? Transfusion 52 2012 2310 2320
58. N. Blumberg, J.M. Heal, and K.F. Gettings An association between decreased cardiopulmonary complications (transfusion-related acute lung injury and transfusion-associated circulatory overload) and implementation of universal leukoreduction of blood transfusions Transfusion 50 12 2010 Dec 2738 2744 PubMed PMID: 20561296. Pubmed Central PMCID: PMC2944002. eng
59. A. Insunza, I. Romon, and M.L. Gonzalez-Ponte Implementation of a strategy to prevent TRALI in a regional blood centre Transfus Med 14 2 2004 Apr 157 164 PubMed PMID: 15113380. eng
60. M.A. Popovsky, A.M. Audet, and C. Andrzejewski Transfusion-associated circulatory overload in orthopedic surgery patients: a multi-institutional study Immunohematology 12 2 1996 87 89 PubMed PMID: 15387748. eng
61. A.I. BRAUDE Transfusion reactions from contaminated blood; their recognition and treatment N Engl J Med 258 26 1958 Jun 1289 1293 PubMed PMID: 13552963. eng
62. M.E. Brecher Bacterial contamination of blood products 2002 Lippincott, Williams and Wilkins Baltimore, Md
63. M.E. Brecher, and S.N. Hay Bacterial contamination of blood components Clin Microbiol Rev. 18 1 2005 Jan 195 204 PubMed PMID: 15653826. Pubmed Central PMCID: PMC544173. eng
64. University Health System Consortium UHC technology assessment. Platelet transfusion guidelines 1998 http://www.uhc.org
65. E.K. Chiu, K.Y. Yuen, and A.K. Lie A prospective study of symptomatic bacteremia following platelet transfusion and of its management Transfusion 34 11 1994 Nov-Dec 950 954 PubMed PMID: 7974703. eng
66. P. Ness, H. Braine, and K. King Single-donor platelets reduce the risk of septic platelet transfusion reactions Transfusion 41 7 2001 Jul 857 861 PubMed PMID: 11452152. eng
67. J.F. Hardy, P. de Moerloose, and C.M. Samama The coagulopathy of massive transfusion Vox Sang 89 3 2005 Oct 123 127 PubMed PMID: 16146503. eng
68. W.F. Rosse, D. Gallagher, and T.R. Kinney Transfusion and alloimmunization in sickle cell disease. The Cooperative Study of Sickle Cell Disease Blood 76 7 1990 Oct 1431 1437 PubMed PMID: 2207318. eng
69. G. Ramsey, and P. Larson Loss of red cell alloantibodies over time Transfusion 28 2 1988 Mar-Apr 162 165 PubMed PMID: 3354044. eng
70. P. Gresele, C.P. Page, and V. Fuster Platelets in thrombotic and non-thrombotic disorders: pathophysiology, pharmacology and therapeutics 1st ed. 2002 Cambridge University Press
71. N. Lubenow, P. Eichler, and D. Albrecht Very low platelet counts in post-transfusion purpura falsely diagnosed as heparin-induced thrombocytopenia. Report of four cases and review of literature Thromb Res. 100 3 2000 Nov 115 125 PubMed PMID: 11108897. eng
72. C.D. Hillyer, K. Hillyer, and F. Strobl Handbook of transfusion medicine 1st ed. 2001 Academic Press p. 328
73. A.V. Hoffbrand, P.A.H. Moss, and J.E. Pettit Essential haematology: 5th Edition 2006 Blackwell Publishing
74. Y. Kohgo, T. Ohtake, and K. Ikuta Iron accumulation in alcoholic liver diseases Alcohol Clin Exp Res. 29 11 Suppl. 2005 Nov 189S 193S PubMed PMID: 16344607. eng
75. G. Jean, S. Terzoli, and R. Mauri Cirrhosis associated with multiple transfusions in thalassaemia Arch Dis Child 59 1 1984 Jan 67 70 PubMed PMID: 6696498. Pubmed Central PMCID: PMC1628419. eng
76. W.A. Suarez, S.A. Snyder, and B.B. Berman Preclinical cardiac dysfunction in transfusion-dependent children and young adults detected with low-dose dobutamine stress echocardiography J Am Soc Echocardiogr 11 10 1998 Oct 948 956 PubMed PMID: 9804099. eng
77. C. Borgna-Pignatti, S. Rugolotto, and P. De Stefano Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine Haematologica 89 10 2004 Oct 1187 1193 PubMed PMID: 15477202. eng
78. H. Moayeri, and Z. Oloomi Prevalence of growth and puberty failure with respect to growth hormone and gonadotropins secretion in beta-thalassemia major Arch Iran Med 9 4 2006 Oct 329 334 PubMed PMID: 17061604. eng
79. M.R. Gamberini, M. Fortini, and V. De Sanctis Diabetes mellitus and impaired glucose tolerance in thalassaemia major: incidence, prevalence, risk factors and survival in patients followed in the Ferrara Center Pediatr Endocrinol Rev. 2 Suppl. 2 2004 Dec 285 291 PubMed PMID: 16462713. eng
80. M.D. Cappellini, M. Bejaoui, and L. Agaoglu Prospective evaluation of patient-reported outcomes during treatment with deferasirox or deferoxamine for iron overload in patients with beta-thalassemia Clin Ther 29 5 2007 May 909 917 PubMed PMID: 17697909. eng
81. R.H. Osborne, R. De Abreu Lourenço, and A. Dalton Quality of life related to oral versus subcutaneous iron chelation: a time trade-off study Value Health 10 6 2007 Nov-Dec 451 456 PubMed PMID: 17970927. eng
82. T.E. Delea, O. Sofrygin, and S.K. Thomas Cost effectiveness of once-daily oral chelation therapy with deferasirox versus infusional deferoxamine in transfusion-dependent thalassaemia patients: US healthcare system perspective Pharmacoeconomics 25 4 2007 329 342 PubMed PMID: 17402805. eng
83. K. Anderson Broadening the spectrum of patient groups at risk for transfusion-associated GVHD: implications for universal irradiation of cellular blood components Transfusion 43 12 2003 Dec 1652 1654 PubMed PMID: 14641857. eng
84. D. Triulzi, R. Duquesnoy, and L. Nichols Fatal transfusion-associated graft-versus-host disease in an immunocompetent recipient of a volunteer unit of red cells Transfusion 46 6 2006 Jun 885 888 PubMed PMID: 16734803. eng
85. L.D. Petz, L. Calhoun, and P. Yam Transfusion-associated graft-versus-host disease in immunocompetent patients: report of a fatal case associated with transfusion of blood from a second-degree relative, and a survey of predisposing factors Transfusion 33 9 1993 Sep 742 750 PubMed PMID: 8105567. eng
86. L.M. Williamson, D. Stainsby, and H. Jones The impact of universal leukodepletion of the blood supply on hemovigilance reports of posttransfusion purpura and transfusion-associated graft-versus-host disease Transfusion 47 8 2007 Aug 1455 1467 PubMed PMID: 17655590. eng
87. N. Blumberg Deleterious clinical effects of transfusion immunomodulation: proven beyond a reasonable doubt Transfusion 45 2 Suppl. 2005 Aug 33S 39S discussion 9S-40S. PubMed PMID: 16086785. eng
88. A. Tinmouth, D. Fergusson, and I.C. Yee Clinical consequences of red cell storage in the critically ill Transfusion 46 11 2006 Nov 2014 2027 PubMed PMID: 17076859. eng
89. L. Gianotti, T. Pyles, and J.W. Alexander Impact of blood transfusion and burn injury on microbial translocation and bacterial survival Transfusion 32 4 1992 May 312 317 PubMed PMID: 1585434. eng
90. M.M. Heiss, W. Mempel, and K.W. Jauch Beneficial effect of autologous blood transfusion on infectious complications after colorectal cancer surgery Lancet 342 8883 1993 Nov 1328 1333 PubMed PMID: 7901637. eng
91. J.A. Weinberg, G. McGwin, and R.L. Griffin Age of transfused blood: an independent predictor of mortality despite universal leukoreduction J Trauma 65 2 2008 Aug 279 282 discussion 82-4. PubMed PMID: 18695462. eng
92. P.C. Hébert, E. Yetisir, and C. Martin Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases? Crit Care Med 29 2 2001 Feb 227 234 PubMed PMID: 11246298. eng
93. K.J. Deans, P.C. Minneci, and A.F. Suffredini Randomization in clinical trials of titrated therapies: unintended consequences of using fixed treatment protocols Crit Care Med 35 6 2007 Jun 1509 1516 PubMed PMID: 17440420. eng
94. N. Blumberg, and J.M. Heal Universal leukocyte reduction of blood transfusions Clin Infect Dis 45 8 2007 Oct 1014 1015 PubMed PMID: 17879917. eng
95. F.K. Widmann Informed consent for blood transfusion: brief historical survey and summary of a conference Transfusion 30 5 1990 Jun 460 470 PubMed PMID: 2360239. eng
96. G. Stack, and E.L. Snyder Cytokine generation in stored platelet concentrates Transfusion 34 1 1994 Jan 20 25 PubMed PMID: 8273124. eng
97. N. Blumberg, and J.M. Heal C.D. Hillyer, Transfusion immunomodulation 2007 Churchill Livingstone Elsevier Philadelphia, PA 701
98. M.A. Blajchman, L. Bardossy, and R. Carmen Allogeneic blood transfusion-induced enhancement of tumor growth: two animal models showing amelioration by leukodepletion and passive transfer using spleen cells Blood 81 7 1993 Apr 1880 1882 PubMed PMID: 8461473. eng
99. N. Blumberg, J.M. Heal, and P. Murphy Association between transfusion of whole blood and recurrence of cancer Br Med J (Clin Res Ed) 293 6546 1986 Aug 530 533 PubMed PMID: 3092902. Pubmed Central PMCID: PMC1341306. eng
100. R.D. Davenport, and S.L. Kunkel Cytokine roles in hemolytic and nonhemolytic transfusion reactions Transfus Med Rev. 8 3 1994 Jul 157 168 PubMed PMID: 8081078. eng
101. N. Blumberg, and J.M. Heal Evidence for plasma-mediated immunomodulation-transfusions of plasma-rich blood components are associated with a greater risk of acquired immunodeficiency syndrome than transfusions of red blood cells alone Transplant Proc. 20 6 1988 Dec 1138 1142 PubMed PMID: 3144070. eng
102. M.T. Gladwin, and E. Vichinsky Pulmonary complications of sickle cell disease N Engl J Med 359 21 2008 Nov 2254 2265 PubMed PMID: 19020327. eng
103. J. Villagra, S. Shiva, and L.A. Hunter Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin Blood 110 6 2007 Sep 2166 2172 PubMed PMID: 17536019. Pubmed Central PMCID: PMC1976348. eng
104. E.A. Hod, G.M. Brittenham, and G.B. Billote Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron Blood 118 25 2011 Dec 6675 6682 PubMed PMID: 22021369. Pubmed Central PMCID: PMC3242722. eng