Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants

Pediatrics

Volumn 115, Issue 6, 2005, Pages 1685-1691

  Bell, Edward F ^a   Strauss, Ronald G ^a   Widness, John A ^a   Mahoney, Larry T ^a   Mock, Donald M ^c,d   Seward, Victoria J ^a   Cress, Gretchen A ^a   Johnson, Karen J ^a   Kromer, Irma J ^a   Zimmerman, M Bridget ^b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Anemia; Brain; Erythrocyte; Preterm infants; Transfusions

Indexed keywords

ARTICLE; BRAIN HEMORRHAGE; CONTROLLED STUDY; ENCEPHALOMALACIA; ERYTHROCYTE TRANSFUSION; FEMALE; HEMATOCRIT; HUMAN; HUMAN EXPERIMENT; INFANT; MALE; PREMATURITY; PRIORITY JOURNAL; STATISTICAL ANALYSIS; ANEMIA; APNEA; BLOOD; BLOOD DONOR; CHRONIC BRAIN DISEASE; CLINICAL TRIAL; COMORBIDITY; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; ECHOENCEPHALOGRAPHY; ECHOGRAPHY; LENGTH OF STAY; LUNG DYSPLASIA; MONITORING; NEWBORN; PATENT DUCTUS ARTERIOSUS; PRACTICE GUIDELINE; RANDOMIZED CONTROLLED TRIAL; RETROLENTAL FIBROPLASIA; RISK; STANDARD; STATISTICS; SURVIVAL; TREATMENT OUTCOME; VERY LOW BIRTH WEIGHT;

OXYGEN;

ANEMIA; APNEA; BLOOD DONORS; BRAIN DAMAGE, CHRONIC; BRONCHOPULMONARY DYSPLASIA; CEREBRAL HEMORRHAGE; COMORBIDITY; DUCTUS ARTERIOSUS, PATENT; ECHOENCEPHALOGRAPHY; ERYTHROCYTE TRANSFUSION; HEMATOCRIT; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; INFANT, VERY LOW BIRTH WEIGHT; LENGTH OF STAY; LEUKOMALACIA, PERIVENTRICULAR; MONITORING, PHYSIOLOGIC; OXYGEN; PRACTICE GUIDELINES; RETINOPATHY OF PREMATURITY; RISK; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 27744595770     PISSN: 00314005     EISSN: 00314005     Source Type: Journal    
DOI: 10.1542/peds.2004-1884     Document Type: Article

References (32)

1. Strauss RG. Transfusion therapy in neonates. Am J Dis Child. 1991;145:904-911
2. Sacher RA, Luban NLC, Strauss RG. Current practice and guidelines for the transfusion of cellular blood components in the newborn. Transfus Med Rev. 1989;3:39-54
3. Widness JA, Seward VJ, Kromer IJ, Burmeister LF, Bell EF, Strauss RG. Changing patterns of red blood cell transfusion in very low birth weight infants. J Pediatr. 1996;129:680-687
4. Alagappan A, Shattuck KE, Malloy MH. Impact of transfusion guidelines on neonatal transfusions. J Perinatol. 1998;18:92-97
5. Maier RF, Sonntag J, Walka MM, Liu G, Metze BC, Obladen M. Changing practices of red blood cell transfusions in infants with birth weight less than 1000 g. J Pediatr. 2000;136:220-224
6. Franz AR, Pohlandt F. Red blood cell transfusions in very and extremely low birthweight infants under restrictive transfusion guidelines: is exogenous erythropoietin necessary? Arch Dis Child Fetal Neonatal Ed. 2001;84:F96-F100
7. Maier RF, Obladen M, Messinger D, Wardrop CAJ. Factors related to transfusion in very low birthweight infants treated with erythropoietin. Arch Dis Child Fetal Neonatal Ed. 1996;74:F182-F186
8. Ringer SA, Richardson DK, Sacher RA, Keszler M, Churchill WH. Variations in transfusion practice in neonatal intensive care. Pediatrics. 1998;101:194-200
9. Bednarek FJ, Weisberger S, Richardson DK, Frantz ID III, Shah B, Rubin LP. Variations in blood transfusions among newborn intensive care units. J Pediatr. 1998;133:601-607
10. Stockman JA III, Clark DA. Weight gain: a response to transfusion in selected preterm infants. Am J Dis Child. 1984;138:828-830
11. Alverson DA, Isken VH, Cohen RS. Effect of booster blood transfusions on oxygen utilization in infants with bronchopulmonary dysplasia. J Pediatr. 1988;113:722-726
12. Hudson I, Cooke A, Holland B, et al. Red cell volume and cardiac output in anaemic preterm infants. Arch Dis Child. 1990;65:672-675
13. Lachance C, Chessex P, Fouron JC, Widness JA, Bard H. Myocardial, erythropoietic, and metabolic adaptations to anemia of prematurity. J Pediatr. 1994;125:278-282
14. Alkalay AL, Galvis S, Ferry DA, Simmons CF, Krueger RC Jr. Hemodynamic changes in anemic premature infants: are we allowing the hematocrits to fall too low? Pediatrics. 2003;112:838-845
15. Joshi A, Gerhardt T, Shandloff P, Bancalari E. Blood transfusion effect on the respiratory pattern of preterm infants. Pediatrics. 1987;80:79-84
16. Stute H, Greiner B, Linderkamp O. Effect of blood transfusion on cardiorespiratory abnormalities in preterm infants. Arch Dis Child Fetal Neonatal Ed. 1995;72:F194-F196
17. DeMaio JG, Harris MC, Deuber C, Spitzer AR. Effect of blood transfusion on apnea frequency in growing premature infants. J Pediatr. 1989;114:1039-1041
18. Sasidharan P, Heimler R. Transfusion-induced changes in the breathing pattern of healthy preterm anemic infants. Pediatr Pulmonol. 1992;12:170-173
19. Bifano EM, Smith F, Borer J. Relationship between determinants of oxygen delivery and respiratory abnormalities in preterm infants with anemia. J Pediatr. 1992;120:292-296
20. James L, Greenough A, Naik S. The effect of blood transfusion on oxygenation in premature ventilated neonates. Eur J Pediatr. 1997;156:139-141
21. Blank JP, Sheagren TG, Vajaria J, Mangurten HH, Benawra RS, Puppala BL. The role of RBC transfusion in the premature infant. Am J Dis Child. 1984;138:831-833
22. Ross MP, Christensen RD, Rothstein G, et al. A randomized trial to develop criteria for administering erythrocyte transfusions to anemic preterm infants 1 to 3 months of age. J Perinatol. 1989;9:246-253
23. Meyer J, Sive A, Jacobs P. Empiric red cell transfusion in asymptomatic preterm infants. Acta Paediatr. 1993;82:30-34
24. Brooks SE, Marcus DM, Gillis D, Pirie E, Johnson MH, Bhatia J. The effect of blood transfusion protocol on retinopathy of prematurity: a prospective, randomized study. Pediatrics. 1999;104:514-518
25. Johnson KJ, Cress GA, Connolly NW, Burmeister LF, Widness JA. Neonatal laboratory blood sampling: comparison of results from arterial catheters with those from an automated capillary device. Neonatal Netw. 2000;19(1):27-34
26. Strauss RG, Burmeister LF, Johnson K, et al. AS-1 red cells for neonatal transfusions: a randomized trial assessing donor exposure and safety. Transfusion. 1996;36:873-878
27. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978;92:529-534
28. Mahoney LT, Coryell KG, Lauer RM. The newborn transitional circulation: a two-dimensional Doppler echocardiographic study. J Am Coll Cardiol. 1985;6:623-629
29. Murray D, Vandewalker G, Matherne GP, Mahoney LT. Pulsed Doppler and two-dimensional echocardiography: comparison of halothane and isoflurane on cardiac function in infants and small children. Anesthesiology. 1987;67:211-217
30. Georgieff MK, Landon MB, Mills MM, et al. Abnormal iron distribution in infants of diabetic mothers: spectrum and maternal antecedents. J Pediatr. 1990;117:455-461
31. Snedecor GW, Cochran WG. Statistical Methods. 6th ed. Ames, IA: Iowa State University Press; 1967:111-114
32. Hunt CR, Corwin MJ, Baird T, et al. Cardiorespiratory events detected by home memory monitoring and one-year neurodevelopmental outcome. J Pediatr. 2004;145:465-471