Randomization in clinical trials of titrated therapies: Unintended consequences of using fixed treatment protocols

Critical Care Medicine

Volumn 35, Issue 6, 2007, Pages 1509-1516

  Deans, Katherine J ^a,d   Minneci, Peter C ^a,d   Suffredini, Anthony F ^a   Danner, Robert L ^a   Hoffman, William D ^d   Ciu, Xizhong ^a   Klein, Harvey G ^b   Schechter, Alan N ^c   Banks, Steven M ^a   Eichacker, Peter Q ^a   Natanson, Charles ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Practice misalignment; Randomization; Treatment dose

Indexed keywords

ADULT RESPIRATORY DISTRESS SYNDROME; AIRWAY PRESSURE; ARTICLE; ARTIFICIAL VENTILATION; CLINICAL PRACTICE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DISEASE SEVERITY; GROUPS BY AGE; HEMOGLOBIN BLOOD LEVEL; HUMAN; INTENSIVE CARE; ISCHEMIC HEART DISEASE; METHODOLOGY; MORTALITY; PATIENT CARE; PATIENT COMPLIANCE; PATIENT SAFETY; PRIORITY JOURNAL; PUBLICATION; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; TIDAL VOLUME; TITRIMETRY; TRANSFUSION; TREATMENT INDICATION;

EID: 34249288679     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000266584.40715.A6     Document Type: Article

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