Very low platelet counts in post-transfusion purpura falsely diagnosed as heparin-induced thrombocytopenia: Report of four cases and review of literature

Thrombosis Research

Volumn 100, Issue 3, 2000, Pages 115-125

  Lubenow, Norbert ^a,f   Eichler, Petra ^a   Albrecht, Dorothea ^a   Carlsson, Lena E ^a   Kothmann, Jürgen ^b   Rossocha, Wulf Rüdiger ^c   Hahn, Manfred ^d   Quitmann, Henning ^e   Greinacher, Andreas ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b Department of Neurology   (Germany)

^c St Vinzenz Hospital   (Germany)

^d Klinikum Duisburg   (Germany)

^e UNIVERSITY OF DUISBURG ESSEN   (Germany)

^f Institut fur Immunologie und Transfusionsmedizin   (Germany)

Author keywords

Differential diagnosis; Heparin induced thrombocytopenia; HIT; Platelets; Post transfusion purpura; PTP

Indexed keywords

ALLOANTIBODY; DANAPAROID; FC RECEPTOR; HEPARIN; HLA ANTIGEN CLASS 1; HYDROCORTISONE; IMMUNOGLOBULIN; THROMBOCYTE ANTIBODY;

ADULT; AGED; ARTICLE; BLOOD TRANSFUSION; CASE REPORT; CLINICAL FEATURE; DIAGNOSTIC ERROR; DIFFERENTIAL DIAGNOSIS; DRUG INDUCED DISEASE; ERYTHROCYTE CONCENTRATE; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEPARINIZATION; HUMAN; MALE; PLASMAPHERESIS; PRIORITY JOURNAL; PURPURA; RETROPERITONEAL HEMORRHAGE; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; THROMBOSIS; TREATMENT OUTCOME;

ACUTE DISEASE; AGED; BLOOD PLATELETS; BLOOD TRANSFUSION; DIAGNOSIS, DIFFERENTIAL; DIAGNOSTIC ERRORS; FEMALE; HEPARIN; HUMANS; ISOANTIBODIES; MALE; MIDDLE AGED; PLATELET COUNT; PURPURA; THROMBOCYTOPENIA;

EID: 0034324768     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(00)00311-X     Document Type: Article

References (91)

1. Post-transfusionelle Purpura: Klinische und immunologische Untersuchungen bei 38 Patientinnen
2. Post-transfusion purpura: A survey of 12 Danish cases with special reference to immunoglobulin G subclasses of the platelet antibodies
3. The alloimmune thrombocytopenias: Neonatal alloimmune thrombocytopenic purpura and post-transfusion purpura
4. Posttransfusion Purpura
5. Post-transfusion purpura and isoimmune neonatal thrombocytopenia in the same family
6. Posttransfusional immunologic thrombocytopenia. A case report
7. Serological and genetical studies on a platelet antigen (Zw)
8. A new syndrome of post-transfusion immunologic purpura
9. Thrombocytopenia with a circulating agglutinin, platelet lysin and clot retraction inhibitor
10. Post-transfusion purpura (PTP) responding to high dose intravenous IgG: Further observations on pathogenesis
11. Post-transfusion purpura: Enigma of alloimmunisation
12. Post-transfusion purpura: Conversion of PLA1-negative platelets to the PLA1-positive phenotype by stored plasma is not due to the presence of soluble PLA1 antigen
13. Platelet serology: Prospects and problems in platelet serology
14. Immunoreactions involving platelets. V. Post-transfusion purpura due to a complement-fixing antibody against genetically controlled platelet antigen. A proposed mechanism for thrombocytopenia and its relevance in 'autoimmunity
15. Elution of anti-Zwa (-PlA1) from autologous platelets after normalization of platelet count in post-transfusion purpura
16. Interaction of two GPIIb/IIIa monoclonal antibodies with platelet Fc receptor (FcRII)
17. Platelet activation by CD9 monoclonal antibodies is mediated by the Fc gamma II receptor
18. Mechanism of platelet aggregation induced by a monoclonal antibody requiring Fc portion
19. The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: A transgenic mouse model
20. Anti-GPIIb/IIIa (CD41) monoclonal antibody-induced platelet activation requires Fc receptor-dependent cell-cell interaction
21. Further observation on post-transfusion purpura (PTP)
22. Post transfusion purpura
23. Post-transfusion purpura (PTP) associated with anti-HPA-1a, anti-HPA-2b and anti-HPA-3a antibodies
24. Autoreactive platelet antibody in post transfusion purpura
25. Post-transfusion purpura associated with an autoantibody directed against a previously undefined platelet antigen
26. Autoantibody in post-transfusion purpura
27. Pan-reactive platelet antibodies in post-transfusion purpura
28. Analysis of immunoglobulin class, IgG subclass and titre of HPA-1a antibodies in alloimmunized mothers giving birth to babies with or without neonatal alloimmune thrombocytopenia
29. Fetal bleeding in neonatal alloimmune thrombocytopenia mediated by anti-PlA1 is not associated with inhibition of fibrinogen binding to platelets GPIIb/IIIa
30. Identification of a human heavy chain antibody fragment directed against human platelet alloantigen 1a by a phage display library
31. b (Pl(A2)). The significance of IgG3 antibodies in PTP
32. Post-transfusion purpura associated with alloimmunization against the platelet specific antigen, Baka
33. Post-transfusion purpura associated with anti-Baka and anti-PlA2 platelet antibodies and delayed haemolytic transfusion reaction
34. b, a new platelet-specific antigen associated with post-transfusion purpura
35. b
36. Post-transfusion purpura with antiplatelet antibody specific for the platelet antigen, Pen (a)
37. Posttransfusion purpura due to an alloantibody reactive with glycoprotein Ia/IIa (anti-HPA-5b)
38. Platelet and neutrophil alloantigens: Their nature and role in immune-mediated cytopenias
39. Systematic screening for genetic polymorphism in human platelet glycoprotein Ibalpha
40. Genetic susceptibility and anti-human platelet antigen 5b alloimmunization role of HLA class II and TAP genes
41. HLA antigens and maternal antibodies in allo-immune neonatal thrombocytopenia
42. The immune response to the HPA-1a antigen: Association with HLA-DRw 52 a
43. a is strongly associated with HLA-B 8 and DR 3
44. HLA-B 8 antigen and anti-Pl(a1) alloimmunisation
45. An immune response gene linked to MHC in man
46. HLA-DRw52a is involved in alloimmunisation against PL-A1 antigen
47. a antigen, resulting in neonatal alloimmune thrombocytopenia or posttransfusion purpura, is associated with the supertypic DRw 52 antigen including DR 3 and Drw 6
48. Platelets as immunogens
49. Monoclonal antibody-specific immobilization of platelet antigens (MAIPA): A new tool for the identification of platelet-reactive antibodies
50. The platelet adhesion immunofluorescence test: A modification of the platelet suspension immunofluorescence test
51. Clinical aspects and typing of platelet alloantigens
52. Rapid typing for human platelet antigen systems -1, -2, -3 and -5 by PCR amplification with sequence-specific primers
53. Genotyping of the human platelet antigen systems 1 through 5 by multiplex polymerase chain reaction and ligation-based typing
54. Platelet and neutrophil alloantigen genotyping in clinical practice
55. A platelet monoclonal antibody inhibition assay for detection of glycoprotein IIb/IIIa-related platelet alloantibodies
56. Investigation of human platelet alloantigens and glycoproteins using non-radioactive immunoprecipitation
57. Genomic RFLP typing of human platelet alloantigens Zw (PlA), Ko, Bak, and Br (HPA-1, 2, 3, 5)
58. A monoclonal antibody (SZ21) specific for platelet GPIIIa distinguishes P1A1 from P1A2
59. Heparin-induced thrombocytopenia: Towards consensus
60. Heparin-induced thrombocytopenia in patients treated with low molecular weight heparin or unfractionated heparin
61. Pathogenicity of IgA and/or IgM antibodies to heparin-PF4 complexes in patients with heparin-induced thrombocytopenia
62. Heparin-induced immune thrombocytopenia
63. A rapid and sensitive test for diagnosing heparin-associated thrombocytopenia
64. Heparin-induced thrombocytopenia: Laboratory studies
65. A diagnostic test for heparin-induced thrombocytopenia
66. Plasma P-selectin is increased in thrombotic consumptive platelet disorders
67. Heparin-induced thrombocytopenia: Mechanism of interaction of the heparin-dependent antibody with platelets
68. Heparin-associated thrombocytopenia: No association of immune response with HLA
69. Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia
70. Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin-induced platelet activation test, and platelet factor 4/heparin enzyme-linked immunosorbent assay
71. DNA typing of human platelet antigen systems 1,2,3 and 5 in B-lymphoblastoid cell lines of the International Histocompatibility Workshop
72. First workshop for detection of heparin-induced antibodies: Validation of the heparin-induced platelet-activation test (HIPA) in comparison with a PF4/heparin ELISA
73. A case of 'auto-immune thrombocytopenic purpura' serologically similar to post-transfusion purpura
74. The alloimmune thrombocytopenic syndromes
75. The mechanism of platelet aggregation induced by HLA-related antibodies
76. Platelet activation by cross-linking HLA class I molecules and Fc receptor
77. Transient reversal of thrombocytopenia in idiopathic thrombocytopenic purpura by high-dose intravenous gammaglobulin
78. High-dose intravenous immunoglobulin for post-transfusion purpura
79. High-dose IgG for post-transfusion purpura-revisited
80. Effect of intravenous immunoglobulin in immune thrombocytopenia
81. Posttransfusion purpura. A survey of 13 cases
82. Post-transfusion purpura as the main manifestation of a trilineal transfusion reaction, responsive to steroids: Flow-cytometric investigation of granulocyte and platelet antibodies
83. Post-transfusion purpura: Response to steroids and association with red blood cell and lymphocytotoxic antibodies
84. Case report: Post-transfusion purpura
85. Post-transfusion purpura: The therapeutic value of P1(a1)-negative platelets
86. Posttransfusion purpura due to HPA-1a immunization in a male patient: Response to subsequent multiple HPA-1a-incompatible red-cell transfusions
87. Posttransfusion purpura. Therapeutic failure of P1(A1)-negative platelet transfusion
88. The therapeutic value of HPA-1a-negative platelet transfusion in post-transfusion purpura complicated by life-threatening haemorrhage
89. Heparin-induced thrombocytopenia (HIT): An overview of 230 patients treated with Orgaran (Org 10172)
90. Recombinant hirudin (lepirudin) provides safe and effective anticoagulation in patients with heparin-induced thrombocytopenia: A prospective study
91. Lepirudin (recombinant hirudin) for parenteral anticoagulation in patients with heparin-induced thrombocytopenia