Maternal vitamin D supplementation to meet the needs of the breastfed infant: A systematic review

Journal of Human Lactation

Volumn 29, Issue 2, 2013, Pages 163-170

  Thiele, Doria K ^a,b   Senti, Jeanine L ^b   Anderson, Cindy M ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH DAKOTA   (United States)

Author keywords

25 hydroxyvitamin D; breast milk; breastfeeding; cholecalciferol; human milk; infant; lactation; vitamin D; vitamin D deficiency

Indexed keywords

25 HYDROXYVITAMIN D; 25-HYDROXYVITAMIN D; DRUG DERIVATIVE; VITAMIN; VITAMIN D;

BLOOD; BREAST FEEDING; DOSE RESPONSE; DRUG EFFECT; FEMALE; HUMAN; LACTATION; MOTHER; REVIEW; VITAMIN D DEFICIENCY; ANALOGS AND DERIVATIVES; DRUG EFFECTS;

BREAST FEEDING; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; LACTATION; MOTHERS; VITAMIN D; VITAMIN D DEFICIENCY; VITAMINS;

EID: 84876252003     PISSN: 08903344     EISSN: 15525732     Source Type: Journal    
DOI: 10.1177/0890334413477916     Document Type: Review

References (70)

1. Hillman LS. Mineral and vitamin D adequacy in infants fed human milk or formula between 6 and 12 months of age. J Pediatr. 1990 ; 117 (2)(pt 2). S134 - S142
2. Specker BL. Do North American women need supplemental vitamin D during pregnancy or lactation?. Am J Clin Nutr. 1994 ; 59 (2). 484S - 490S
3. Ala-Houhala M, Koskinen T, Parviainen MT, Visakorpi JK. 25-hydroxyvitamin D and vitamin D in human milk: effects of supplementation and season. Am J Clin Nutr. 1988 ; 48 (4). 1057-1060
4. Greer FR, Hollis BW, Cripps DJ, Tsang RC. Effects of maternal ultraviolet B irradiation on vitamin D content of human milk. J Pediatr. 1984 ; 105 (3). 431-433
5. Specker BL, Tsang RC, Hollis BW. Effect of race and diet on human-milk vitamin D and 25-hydroxyvitamin D. Am J Dis Child. 1985 ; 139 (11). 1134-1137
6. Basile LA, Taylor SN, Wagner CL, Horst RL, Hollis BW. The effect of high-dose vitamin D supplementation on serum vitamin D levels and milk calcium concentration in lactating women and their infants. Breastfeed Med. 2006 ; 1 (1). 27-35
7. Hollis BW, Wagner CL. Vitamin D requirements during lactation: high-dose maternal supplementation as therapy to prevent hypovitaminosis D for both the mother and the nursing infant. Am J Clin Nutr. 2004 ; 80 (6). 1752S - 1758S
8. Saadi HF, Dawodu A, Afandi B, et al. Effect of combined maternal and infant vitamin D supplementation on vitamin D status of exclusively breastfed infants. Matern Child Nutr. 2009 ; 5 (1). 25-32
9. Wagner CL, Hulsey TC, Fanning D, Ebeling M, Hollis BW. High-dose vitamin D3 supplementation in a cohort of breastfeeding mothers and their infants: a 6-month follow-up pilot study. Breastfeed Med. 2006 ; 1 (2). 59-70
10. Camargo CA, Ingham T, Wickens K, et al. Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma. Pediatrics. 2011 ; 127 (1). e180 - e187
11. Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001 ; 358 (9292). 1500-1503
12. Karatekin G, Kaya A, Salihoglu O, Balci H, Nuhoglu A. Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Eur J Clin Nutr. 2009 ; 63 (4). 473-477
13. Lagishetty V, Liu NQ, Hewison M. Vitamin D metabolism and innate immunity. Mol Cell Endocrinol. 2011 ; 347 (1-2). 97-105
14. Peroni DG, Piacentini GL, Cametti E, Chinellato I, Boner AL. Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children. Br J Dermatol. 2011 ; 164 (5). 1078-1082
15. Waterhouse JC, Perez TH, Albert PJ. Reversing bacteria-induced vitamin D receptor dysfunction is key to autoimmune disease. Ann N Y Acad Sci. 2009 ; 1173: 757-765
16. Akbar NA, Zacharek MA. Vitamin D: immunomodulation of asthma, allergic rhinitis, and chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg. 2011 ; 19 (3). 224-228
17. Wagner CL, Greer FR. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics. 2008 ; 122 (5). 1142-1152
18. Merewood A, Mehta SD, Grossman X, et al. Vitamin D status among 4-month-old infants in New England: a prospective cohort study. J Hum Lact. 2012 ; 28 (2). 159-166
19. Mulligan ML, Felton SK, Riek AE, Bernal-Mizrachi C. Implications of vitamin D deficiency in pregnancy and lactation. Am J Obstet Gynecol. 2010 ; 202 (5). 429.e1-429.e9
20. Adams JS, Hewison M. Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase. Arch Biochem Biophys. 2012 ; 523 (1). 95-102
21. Liu NQ, Hewison M. Vitamin D, the placenta and pregnancy. Arch Biochem Biophys. 2012 ; 523 (1). 37-47
22. Welsh J. Vitamin D metabolism in mammary gland and breast cancer. Mol Cell Endocrinol. 2011 ; 347 (1-2). 55-60
23. Holick MF. Vitamin D: evolutionary, physiological and health perspectives. Curr Drug Targets. 2011 ; 12 (1). 4-18
24. Winzenberg T, Jones G.. Vitamin D and bone health in childhood and adolescence. Calcif Tissue Int. 2013 ; 92 (2). 140-150
25. Wagner CL, Taylor SN, Johnson DD, Hollis BW. The role of vitamin D in pregnancy and lactation: emerging concepts. Womens Health (Lond Engl). 2012 ; 8 (3). 323-340
26. Hollis BW, Wagner CL. Vitamin D and pregnancy: skeletal effects, nonskeletal effects, and birth outcomes. Calcif Tissue Int. 2013 ; 92 (2). 128-139
27. Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL. Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res. 2011 ; 26 (10). 2341-2357
28. Thandrayen K, Pettifor JM. Maternal vitamin D status: implications for the development of infantile nutritional rickets. Rheum Dis Clin North Am. 2012 ; 38 (1). 61-79
29. Hollis BW, Wagner CL. The vitamin D requirement during human lactation: The facts and IOM's "utter" failure. Public Health Nutr. 2011 ; 14 (4). 748-749
30. Wagner CL, Taylor SN, Hollis BW. Does vitamin D make the world go "round"?. Breastfeed Med. 2008 ; 3 (4). 239-250
31. Vitamin D: screening and supplementation during pregnancy. Obstet Gynecol. 2011 ; 118 (1). 197-198
32. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academies Press ; 2011 :
33. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006 ; 84 (1). 18-28
34. Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr. 2005 ; 135 (2). 317-322
35. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011 ; 96 (7). 1911-1930
36. Holick MF. Vitamin D deficiency. N Engl J Med. 2007 ; 357 (3). 266-281
37. Rosen CJ, Adams JS, Bikle DD, et al. The nonskeletal effects of vitamin D: an endocrine society scientific statement. Endocr Rev. 2012 ; 33 (3). 456-492
38. Gloth FM, Tobin JD, Sherman SS, Hollis BW. Is the recommended daily allowance for vitamin D too low for the homebound elderly?. J Am Geriatr Soc. 1991 ; 39 (2). 137-141
39. Lips P, Wiersinga A, van Ginkel FC, et al. The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects. J Clin Endocrinol Metab. 1988 ; 67 (4). 644-650
40. Gloth FM, Gundberg CM, Hollis BW, Haddad JG, Tobin JD. Vitamin D deficiency in homebound elderly persons. JAMA. 1995 ; 274 (21). 1683-1686
41. Vieth R, Ladak Y, Walfish PG. Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D. J Clin Endocrinol Metab. 2003 ; 88 (1). 185-191
42. Bischoff-Ferrari HA, Dietrich T, Orav EJ, Dawson-Hughes B. Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med. 2004 ; 116 (9). 634-639
43. Heaney RP, Dowell MS, Hale CA, Bendich A. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr. 2003 ; 22 (2). 142-146
44. Heaney RP, Recker RR, Grote J, Horst RL, Armas LA. Vitamin D(3) is more potent than vitamin D(2) in humans. J Clin Endocrinol Metab. 2011 ; 96 (3). E447 - E452
45. Basile LA, Taylor SN, Wagner CL, Quinones L, Hollis BW. Neonatal vitamin D status at birth at latitude 32 degrees 72: evidence of deficiency. J Perinatol. 2007 ; 27 (9). 568-571
46. Hollis BW. Vitamin D requirement during pregnancy and lactation. J Bone Miner Res. 2007 ; 22: V39 - V44
47. Hollis BW. Nutrition: US recommendations fail to correct vitamin D deficiency. Nat Rev Endocrinol. 2009 ; 5 (10). 534-536
48. Lee JM, Smith JR, Philipp BL, Chen TC, Mathieu J, Holick MF. Vitamin D deficiency in a healthy group of mothers and newborn infants. Clin Pediatr (Phila). 2007 ; 46 (1). 42-44
49. Merewood A, Mehta SD, Grossman X, et al. Widespread vitamin D deficiency in urban Massachusetts newborns and their mothers. Pediatrics. 2010 ; 125 (4). 640-647
50. Robinson CJ, Alanis MC, Wagner CL, Hollis BW, Johnson DD. Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia. Am J Obstet Gynecol. 2010 ; 203 (4). 366.e1-366.e6
51. Collins-Fulea C, Klima K, Wegienka GR. Prevalence of low vitamin D levels in an urban midwestern obstetric practice. J Midwifery Womens Health. 2012 ; 57 (5). 439-444
52. Dror DK, King JC, Durand DJ, Allen LH. Association of modifiable and nonmodifiable factors with vitamin D status in pregnant women and neonates in Oakland, CA. J Am Diet Assoc. 2011 ; 111 (1). 111-116
53. Liang L, Chantry C, Styne DM, Stephensen CB. Prevalence and risk factors for vitamin D deficiency among healthy infants and young children in Sacramento, California. Eur J Pediatr. 2010 ; 169 (11). 1337-1344
54. Agarwal N, Faridi MM, Aggarwal A, Singh O. Vitamin D status of term exclusively breastfed infants and their mothers from india. Acta Paediatr. 2010 ; 99 (11). 1671-1674
55. Greer FR. 25-hydroxyvitamin D: functional outcomes in infants and young children. Am J Clin Nutr. 2008 ; 88 (2). 529S - 533S
56. Siafarikas A, Piazena H, Feister U, Bulsara MK, Meffert H, Hesse V. Randomised controlled trial analysing supplementation with 250 versus 500 units of vitamin D3, sun exposure and surrounding factors in breastfed infants. Arch Dis Child. 2011 ; 96 (1). 91-95
57. Ponnapakkam T, Bradford E, Gensure R. A treatment trial of vitamin D supplementation in breast-fed infants: universal supplementation is not necessary for rickets prevention in southern Louisiana. Clin Pediatr (Phila). 2010 ; 49 (11). 1053-1060
58. Kim MJ, Na B, No SJ, et al. Nutritional status of vitamin D and the effect of vitamin D supplementation in Korean breast-fed infants. J Korean Med Sci. 2010 ; 25 (1). 83-89
59. Madar AA, Klepp KI, Meyer HE. Effect of free vitamin D(2) drops on serum 25-hydroxyvitamin D in infants with immigrant origin: a cluster randomized controlled trial. Eur J Clin Nutr. 2009 ; 63 (4). 478-484
60. Saadi HF, Dawodu A, Afandi BO, Zayed R, Benedict S, Nagelkerke N. Efficacy of daily and monthly high-dose calciferol in vitamin D-deficient nulliparous and lactating women. Am J Clin Nutr. 2007 ; 85 (6). 1565-1571
61. Al-Mustafa ZH, Al-Madan M, Al-Majid HJ, Al-Muslem S, Al-Ateeq S, Al-Ali AK. Vitamin D deficiency and rickets in the eastern province of Saudi Arabia. Ann Trop Paediatr. 2007 ; 27 (1). 63-67
62. Lovelady CA, Stephenson KG, Kuppler KM, Williams JP. The effects of dieting on food and nutrient intake of lactating women. J Am Diet Assoc. 2006 ; 106 (6). 908-912
63. Lorini R, Minicucci L, Napoli F, et al. Screening for type 1 diabetes genetic risk in newborns of continental Italy. primary prevention (prevefin Italy): preliminary data. Acta Biomed. 2005 ; 76: 31-35
64. Gartner LM, Greer FR. Prevention of rickets and vitamin D deficiency: new guidelines for vitamin D intake. Pediatrics. 2003 ; 111 (4)(pt 1). 908-910
65. Picaud JC, Boucher P, Lapillonne A, et al. Influence of dietary cholesterol on vitamin D metabolism in formula-fed preterm neonates. J Pediatr Gastroenterol Nutr. 2002 ; 35 (2). 180-184
66. Gessner BD, Plotnik J, Muth PT. 25-hydroxyvitamin D levels among healthy children in Alaska. J Pediatr. 2003 ; 143 (4). 434-437
67. Thomas MK, Lloyd-Jones DM, Thadhani RI, et al. Hypovitaminosis D in medical inpatients. N Engl J Med. 1998 ; 338 (12). 777-783
68. De-Regil LM, Palacios C, Ansary A, Kulier R, Pena-Rosas JP. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev. 2012 ; 2: CD008873
69. Centers for Disease Control and Prevention. http://www.cdc.gov/ breastfeeding/data/reportcard.htm#Rise. Updated 2012. Accessed August 2012.
70. Agricultural Research Service. USDA National Nutrient Database for Standard Reference [release 25]. Washington, DC: US Department of Agriculture; 2012. http://www.ars.usda.gov/ba/bhnrc/ndl. Accessed August 1, 2012.