Vitamin D metabolism in mammary gland and breast cancer

Molecular and Cellular Endocrinology

Volumn 347, Issue 1-2, 2011, Pages 55-60

  Welsh, JoEllen ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Breast cancer; CYP24A1; CYP27B1; Mammary; VDR; Vitamin D

Indexed keywords

CALCIDIOL 1 MONOOXYGENASE; CALCITRIOL; CHOLESTANETRIOL 26 MONOOXYGENASE; CUBILIN; ESTROGEN; ESTROGEN RECEPTOR; INSULIN; MEGALIN; PARATHYROID HORMONE; PROGESTERONE; PROLACTIN; SOMATOMEDIN; VITAMIN D; VITAMIN D BINDING PROTEIN; VITAMIN D RECEPTOR;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; AUTOCRINE EFFECT; BIOSYNTHESIS; BREAST CANCER; BREAST CARCINOGENESIS; BREAST CELL; CANCER INHIBITION; CANCER PREVENTION; CANCER RISK; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONCENTRATION RESPONSE; ENDOCYTOSIS; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE LOCATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; GROWTH INHIBITION; HORMONE RESPONSE; HUMAN; INTERNALIZATION; MAMMARY GLAND; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TISSUE DISTRIBUTION; TUMOR SUPPRESSOR GENE; VITAMIN D METABOLISM;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ANIMALS; BREAST NEOPLASMS; CALCITRIOL; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; HUMANS; MAMMARY GLANDS, HUMAN; MICE; RECEPTORS, CALCITRIOL; SIGNAL TRANSDUCTION; STEROID HYDROXYLASES; VITAMIN D;

EID: 82455208957     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2011.05.020     Document Type: Review

References (40)

1. Abbas S., Chang-Claude J., Linseisen J. Plasma 25-hydroxyvitamin D and premenopausal breast cancer risk in a German case-control study. Int. J. Cancer 2008, 124:250-255.
2. Agadir A., Lazzaro G., Zheng Y., Zhang X.K., Mehta R. Resistance of HBL100 human breast epithelial cells to vitamin D action. Carcinogenesis 1999, 20:577-582.
3. Bland R., Walker E.A., Hughes S.V., Stewart P.M., Hewison M. Constitutive expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in a transformed human proximal tubule cell line: evidence for direct regulation of vitamin D metabolism by calcium. Endocrinology 1999, 140:2027-2034.
4. Buras R.R., Schumaker L.M., Davoodi F., Brenner R.V., Shabahang M., Nauta R.J., Evans S.R. Vitamin D receptors in breast cancer cells. Breast Cancer Res. Treat. 1994, 31:191-202.
5. Chen P., Hu P., Xie D., Qin Y., Wang F., Wang H. Meta-analysis of vitamin D, calcium and the prevention of breast cancer. Breast Cancer Res. Treat. 2010, 121:469-477.
6. Cordes T., Diesing D., Becker S., Fischer D., Diedrich K., Friedrich M. Expression of splice variants of 1alpha-hydroxylase in MCF-7 breast cancer cells. J. Steroid Biochem. Mol. Biol. 2007, 103:326-329.
7. de Lyra E.C., da Silva I.A., Katayama M.L., Brentani M.M., Nonogaki S., Góes J.C., Folgueira M.A. 25(OH)D3 and 1,25(OH)2D3 serum concentration and breast tissue expression of 1alpha-hydroxylase, 24-hydroxylase and vitamin D receptor in women with and without breast cancer. J. Steroid Biochem. Mol. Biol. 2006, 100:184-192.
8. Diorio C., Sinotte M., Brisson J., Bérubé S., Pollak M. Vitamin D pathway polymorphisms in relation to mammographic breast density. Cancer Epidemiol. Biomarkers Prev. 2008, 17:2505-2508.
9. Elenbaas B., Spirio L., Koerner F., Fleming M.D., Zimonjic D.B., Donaher J.L., Popescu N.C., Hahn W.C., Weinberg R.A. Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev. 2001, 15:50-65.
10. Fischer D., Seifert M., Becker S., Ludders D., Cordes T., Reichrath J., Friedrich M. 25-Hydroxyvitamin D3 1alpha-hydroxylase splice variants in breast cell lines MCF-7 and MCF-10. Cancer Genomics Proteomics 2007, 4:295-300.
11. Friedrich M., Rafi L., Mitschele T., Tilgen W., Schmidt W., Reichrath J. Analysis of the vitamin D system in cervical carcinomas, breast cancer and ovarian cancer. Recent Results Cancer Res. 2003, 164:239-246.
12. Høyer-Hansen M., Bastholm L., Mathiasen I.S., Elling F., Jäättelä M. Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Cell Death Differ. 2005, 12:1297-1309.
13. Hsu J.Y., Feldman D., McNeal J.E., Peehl D.M. Reduced 1alpha-hydroxylase activity in human prostate cancer cells correlates with decreased susceptibility to 25-hydroxyvitamin D3-induced growth inhibition. Cancer Res. 2001, 61:2852-2856.
14. Huang D.C., Papavasiliou V., Rhim J.S., Horst R.L., Kremer R. Targeted disruption of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in ras-transformed keratinocytes demonstrates that locally produced 1alpha,25-dihydroxyvitamin D3 suppresses growth and induces differentiation in an autocrine fashion. Mol. Cancer Res. 2002, 1:56-67.
15. Kemmis C.M., Welsh J. Mammary epithelial cell transformation is associated with deregulation of the vitamin D pathway. J. Cell. Biochem. 2008, 105:980-988.
16. Kemmis C.M., Salvador S.M., Smith K.M., Welsh J. Human mammary epithelial cells express CYP27B1 and are growth inhibited by 25-hydroxyvitamin D-3, the major circulating form of vitamin D-3. J. Nutr. 2006, 136:887-892.
17. Lechner D., Bajna E., Adlercreutz H., Cross H.S. Genistein and 17beta-estradiol, but not equol, regulate vitamin D synthesis in human colon and breast cancer cells. Anticancer Res. 2006, 26:2597-2603.
18. Lopes N., Sousa B., Martins D., Gomes M., Vieira D., Veronese L.A., Milanezi F., Paredes J., Costa J.L., Schmitt F. Alterations in vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions. BMC Cancer 2010, 10:483.
19. Lou Y.R., Molnár F., Peräkylä M., Qiao S., Kalueff A.V., St-Arnaud R., Carlberg C., Tuohimaa P. 25-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand. J. Steroid Biochem. Mol. Biol. 2010, 18:162-170.
20. McCullough M.L., Stevens V.L., Diver W.R., Feigelson H.S., Rodriguez C., Bostick R.M., Thun M.J., Calle E.E., et al. Vitamin D pathway gene polymorphisms, calcium intake, and risk of postmenopausal breast cancer. Breast Cancer Res. 2007, 9:R9.
21. McCullough M.L., Bostick R.M., Mayo T.L. Vitamin D gene pathway polymorphisms and risk of colorectal, breast, and prostate cancer. Annu. Rev. Nutr. 2009, 29:111-132.
22. Mehta R.G., Moriarty R.M., Mehta R.R., Penmasta R., Lazzaro G., Constantinou A., Guo L. Prevention of preneoplastic mammary lesion development by a novel vitamin D analogue, 1alpha-hydroxyvitamin D5. J. Natl. Cancer Inst. 1997, 89:212-218.
23. Narvaez C.J., Welsh J. Role of mitochondria and caspases in vitamin D-mediated apoptosis of MCF-7 breast cancer cells. J. Biol. Chem. 2001, 276:9101-9107.
24. Nykjaer A., Dragun D., Walther D., Vorum H., Jacobsen C., Herz J., Melsen F., Christensen E.I., Willnow T.E. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell 1999, 96:507-515.
25. Pendas-Franco N., Gonzalez-Sancho J.M., Suarez Y., Aguilera O., Steinmeyer A., Gamallo C., Berciano M.T., Lafarga M., Munoz A. Vitamin D regulates the phenotype of human breast cancer cells. Differentiation 2007, 75:193-207.
26. Peng X., Hawthorne M., Vaishnav A., St-Arnaud R., Mehta R.G. 25-Hydroxyvitamin D3 is a natural chemopreventive agent against carcinogen induced precancerous lesions in mouse mammary gland organ culture. Breast Cancer Res. Treat. 2009, 113:31-41.
27. Peng X., Vaishnav A., Murillo G., Alimirah F., Torres K.E., Mehta R.G. Protection against cellular stress by 25-hydroxyvitamin D3 in breast epithelial cells. J. Cell. Biochem. 2010, 110:1324-1333.
28. Rowling M.J., Kemmis C.M., Taffany D.A., Welsh J. Megalin-mediated endocytosis of vitamin D binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cells. Nutrition 2006, 136:2754-2759.
29. Rozenchan P.B., Folgueira M.A., Katayama M.L., Snitcovsky I.M., Brentani M.M. Ras activation is associated with vitamin D receptor mRNA instability in HC11 mammary cells. J. Steroid Biochem. Mol. Biol. 2004, 92:89-95.
30. Segersten U., Holm P.K., Björklund P., Hessman O., Nordgren H., Binderup L., Akerström G., Hellman P., Westin G. 25-Hydroxyvitamin D3 1alpha-hydroxylase expression in breast cancer and use of non-1alpha-hydroxylated vitamin D analogue. Breast Cancer Res. 2005, 7:R980-R986.
31. Sinotte M., Diorio C., Bérubé S., Pollak M., Brisson J. Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women. Am. J. Clin. Nutr. 2009, 89:634-640.
32. Solomon C., Sebag M., White J.H., Rhim J., Kremer R. Disruption of vitamin D receptor-retinoid X receptor heterodimer formation following ras transformation of human keratinocytes. J. Biol. Chem. 1998, 273:17573-17578.
33. Stedman L., Nickel K.P., Castillo S.S., Andrade J., Burgess J.R., Teegarden D. 1,25-Dihydroxyvitamin D inhibits vitamin E succinate-induced apoptosis in C3H10T1/2 cells but not Harvey ras-transfected cells. Nutr. Cancer 2003, 45:93-100.
34. Townsend K., Evans K.N., Campbell M.J., Colston K.W., Adams J.S., Hewison M. Biological actions of extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase and implications for chemoprevention and treatment. J. Steroid Biochem. Mol. Biol. 2005, 97:103-109.
35. Townsend K., Banwell C.M., Guy M., Colston K.W., Mansi J.L., Stewart P.M., Campbell M.J., Hewison M. Autocrine metabolism of vitamin D in normal and malignant breast tissue. Clin. Cancer Res. 2005, 11:3579-3586.
36. Turunen M.M., Dunlop T.W., Carlberg C., Väisänen S. Selective use of multiple vitamin D response elements underlies the 1alpha, 25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene. Nucleic Acids Res. 2007, 5:2734-2747.
37. Willnow T.E., Nykjaer A. Cellular uptake of steroid carrier proteins - mechanisms and implications. Mol. Cell. Endocrinol. 2010, 316:93-102.
38. Yin L., Grandi N., Raum E., Haug U., Arndt V., Brenner H. Meta-analysis: serum vitamin D and breast cancer risk. Eur. J. Cancer 2010, 46:2196-2205.
39. Zinser G.M., Welsh J.E. Accelerated mammary gland development during pregnancy and delayed post-lactational involution in vitamin D3 receptor null mice. Mol. Endocrinol. 2004, 18:2208-2223.
40. Zinser G.M., Packman K., Welsh J.E. Vitamin D(3) receptor ablation alters mammary gland morphogenesis. Development 2002, 129:3067-3076.