Broad spectrum alkynyl inhibitors of T315I Bcr-Abl

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 14, 2010, Pages 4196-4200

  Deng, Xianming ^a   Lim, Sang Min ^a,b   Zhang, Jianming ^a   Gray, Nathanael S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

Kinase inhibitors; T315I Bcr Abl

Indexed keywords

ALKYNE; ALKYNYL GROUP; BCR ABL PROTEIN; HG 78501; IMATINIB; NILOTINIB; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CYTOTOXICITY; DRUG INHIBITION; MUTANT; STRUCTURE ACTIVITY RELATION; WILD TYPE;

ALKYNES; FUSION PROTEINS, BCR-ABL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77953871612     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.05.043     Document Type: Article

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20. The image was generated by using the web-based TREEspot™ software (Ambit Biosciences).