The IRS1 rs2943641 variant and risk of future cancer among morbidly obese individuals

Journal of Clinical Endocrinology and Metabolism

Volumn 98, Issue 4, 2013, Pages

  Maglio, Cristina ^a   Ericson, Ulrika ^b   Burza, Maria Antonella ^a   Mancina, Rosellina Margherita ^a,c   Pirazzi, Carlo ^a   Assarsson, Johanna Andersson ^a   Sjöholm, Kajsa ^a   Baroni, Marco Giorgio ^d   Svensson, Per Arne ^a   Montalcini, Tiziana ^c   Pujia, Arturo ^c   Sjöström, Lars ^a   Wiklund, Olov ^a   Carlsson, Lena M S ^a   Boren, Jan ^a   Orho Melander, Marju ^b   Romeo, Stefano ^a,c  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^d UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; BARIATRIC SURGERY; BODY MASS; CANCER INCIDENCE; CANCER RISK; COHORT ANALYSIS; CONTROLLED STUDY; DIET THERAPY; FOLLOW UP; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; INSULIN RESISTANCE; IRS1 GENE; MALE; META ANALYSIS (TOPIC); OBESITY; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; BARIATRIC SURGERY; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; INCIDENCE; INSULIN RECEPTOR SUBSTRATE PROTEINS; MALE; MIDDLE AGED; NEOPLASMS; OBESITY, MORBID; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; RISK FACTORS;

EID: 84876221523     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-2831     Document Type: Article

References (21)

1. Finucane MM, Stevens GA, Cowan M.J., et al; Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index). National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet. 2011; 377:557-567.
2. Must A, Spadano J, Coakley E.H., Field AE, Colditz G, Dietz WH The disease burden associated with overweight and obesity. JAMA. 1999; 282:1523-1529.
3. Frasca F, Pandini G, Sciacca L., et al The roleofinsulin receptors and IGF-I receptors in cancer and other diseases. Arch Physiol BioChem. 2008; 114:23-37.
4. Sjöström L, Gummesson A, Sjöström CD, et al; Swedish Obese Subjects Study. Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial. Lancet Oncol. 2009; 10:653-662.
5. Ruiter R, Visser LE, van Herk-Sukel MP, et al. Lower risk of cancer in patients on metformin in comparison with those on sulfonylurea derivatives: results from a large population-based follow-up study. Diabetes Care. 2012; 35:119-124.
6. Sun XJ, Rothenberg P, Kahn C.R., et al Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature. 1991; 352:73-77.
7. Rung J, Cauchi S, Albrechtsen A., et al Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulin-emia. Nat Genet. 2009; 41:1110-1115.
8. Yiannakouris N, Cooper JA, Shah S, et al IRS1 gene variants, dys-glycaemic metabolic changes and type-2 diabetes risk. Nutr Metab Cardiovasc Dis. 2012; 22:1024-1030.
9. Sharma R, Prudente S, Andreozzi F., et al The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects. Atherosclerosis. 2011; 216:157-160.
10. Qi Q, Bray GA, Smith S.R., Hu FB, Sacks FM, Qi L. Insulin receptor substrate 1 gene variation modifies insulin resistance response to weight-loss diets in a 2-year randomized trial: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) Trial. Circulation. 2011; 124:563-571.
11. Kilpeläinen T.O., Zillikens MC, Stančákova A, et al. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet. 2011; 43:753-760.
12. Teslovich TM, Musunuru K, Smith A.V., et al Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010; 466: 707-713.
13. Sjostrom L, Narbro K, Sjostrom C.D., et al Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007; 357:741-752.
14. Manjer J, Carlsson S, Elmståhl S, et al The Malmö Diet and Cancer Study: representativity, cancer incidence and mortality in participants and non-participants. Eur J Cancer PRev. 2001; 10:489-499.
15. Palmer CN, Maglio C, Pirazzi C., et al Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant. PLoS One. 2012; 7:e39362.
16. Burza MA, Pirazzi C, Maglio C., et al PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals. Dig Liver Dis. 2012; 44:1037-1041.
17. Manning AK, Hivert MF, Scott R.A., et al; Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium; Multiple Tissue Human Expression Resource (MUTHER) Consortium. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet. 2012; 44:659-669.
18. World Health Organization. 2000 Obesity: preventing and managing the global epidemic. Report of a WHO consultation. WHO Tech Rep Ser 894. Geneva, Switzerland: World Health Organization; 2000.
19. White MF. IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab. 2002; 283:E413-E422.
20. Chang Q, Li Y, White M.F., Fletcher JA, Xiao S. Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: therapeutic implications. Cancer Res. 2002; 62:6035-6038.
21. Wu X, Williams KJ NOX4 pathway as a source of selective insulin resistance and responsiveness. Arterioscler Thromb Vasc Biol. 2012; 32:1236-1245.