The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects

Atherosclerosis

Volumn 216, Issue 1, 2011, Pages 157-160

  Sharma, Rajani ^a   Prudente, Sabrina ^b   Andreozzi, Francesco ^c   Powers, Christine ^a   Mannino, Gaia ^c   Bacci, Simonetta ^b   Gervino, Ernest V ^d,e   Hauser, Thomas H ^d,e   Succurro, Elena ^c   Mercuri, Luana ^b   Goheen, Elizabeth H ^a   Shah, Hetal ^a,e   Trischitta, Vincenzo ^b,f   Sesti, Giorgio ^c   Doria, Alessandro ^a,e,g  

^a JOSLIN DIABETES CENTER   (United States)

^b CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f SAPIENZA UNIVERSITY OF ROME   (Italy)

^g HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Coronary artery disease; Insulin resistance; Polymorphisms; Type 2 diabetes

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN RECEPTOR SUBSTRATE 1; TRIACYLGLYCEROL;

ARTICLE; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CORONARY ARTERY DISEASE; GENE LOCUS; GENETIC ASSOCIATION; HUMAN; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL;

BIOLOGICAL MARKERS; BODY MASS INDEX; BOSTON; CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; CHOLESTEROL, HDL; CORONARY ARTERY DISEASE; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERTENSION; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; ITALY; LOGISTIC MODELS; MALE; ODDS RATIO; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK ASSESSMENT; RISK FACTORS; TRIGLYCERIDES;

EID: 79955535484     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2011.01.022     Document Type: Article

References (16)

1. Lange L.A., Bowden D.W., Langefeld C.D., et al. Heritability of carotid artery intima-medial thickness in type 2 diabetes. Stroke 2002, 33:1876-1881.
2. Marenberg M.E., Risch N., Berkman L.F., Floderus B., De Faire U. Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med 1994, 330:1041-1046.
3. Rutter M.K., Meigs J.B., Sullivan L.M., D'Agostino R.B., Wilson P.W. Insulin resistance, the metabolic syndrome, and incident cardiovascular events in the Framingham Offspring Study. Diabetes 2005, 54:3252-3257.
4. Poulsen P., Kyvik K.O., Vaag A., Beck-Nielsen H. Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance - a population-based twin study. Diabetologia 1999, 42:139-145.
5. Stern M.P. Diabetes and cardiovascular disease. The 'common soil' hypothesis. Diabetes 1995, 44:369-374.
6. Rung J., Cauchi S., Albrechtsen A., et al. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet 2009, 41:1110-1115.
7. Kahn C.R., White M.F., Shoelson S.E., et al. The insulin receptor and its substrate: molecular determinants of early events in insulin action. Recent Prog Horm Res 1993, 48:291-339.
8. Samani N.J., Erdmann J., Hall A.S., et al. Genomewide association analysis of coronary artery disease. N Engl J Med 2007, 357:443-453.
9. Teslovich T.M., Musunuru K., Smith A.V., et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010, 466:707-713.
10. Kathiresan S., Voight B.F., Purcell S., et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet 2009, 41:334-341.
11. Doria A., Wojcik J., Xu R., et al. Interaction between poor glycemic control and 9p21 locus on risk of coronary artery disease in type 2 diabetes. JAMA 2008, 300:2389-2397.
12. Soccio T., Zhang Y.Y., Bacci S., et al. Common haplotypes at the adiponectin receptor 1 (ADIPOR1) locus are associated with increased risk of coronary artery disease in type 2 diabetes. Diabetes 2006, 55:2763-2770.
13. Tian C., Plenge R.M., Ransom M., et al. Analysis and application of European genetic substructure using 300K SNP information. PLoS Genet 2008, 4:e4.
14. Shai I., Rimm E.B., Hankinson S.E., et al. Multivariate assessment of lipid parameters as predictors of coronary heart disease among postmenopausal women: potential implications for clinical guidelines. Circulation 2004, 110:2824-2830.
15. Taniguchi C.M., Emanuelli B., Kahn C.R. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 2006, 7:85-96.
16. Dupuis J., Langenberg C., Prokopenko I., et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010, 42:105-116.