UV-Vis scan-based quality control of assay-ready plates for improved data integrity

European Pharmaceutical Review

Volumn 16, Issue 2, 2011, Pages

  Smith, Gary K ^a   Leesnitzer, M Anthony ^a   Wright, Lois L ^a   Popa Burke, Iona ^a   Miller, Luke ^b   Gomez, Melissa ^b   Scherer, Iris ^b  

^a Trevor Casserly ^*  (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYL SULFOXIDE;

ANALYTICAL ERROR; ARTICLE; ASSAY; BIOASSAY; CHEMOLUMINESCENCE; DEGRADATION; FREEZE THAWING; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRECIPITATION; QUALITY CONTROL; SCREENING; STRUCTURE ACTIVITY RELATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET SPECTROSCOPY;

EID: 84876216663     PISSN: 13608606     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Article

References (23)

1. Janzen WP, Popa-Burke I: Advances in Improving the Quality and Flexibility of Compound Management. J. Biomol. Screen. 2009, in press
2. Macarron R: Critical review of HTS in drug discovery. Drug Discovery Today 2006; 11(7-8): 277-279
3. Mayr LM, Fuerst P: The Future of High-Throughput Screening. J. Biomol. Screening 2008; 13(6): 443-448
4. Snowden MA, Green DVS: The impact of diversity-based, high-throughput screening on drug discovery: "Chance favours the prepared mind". Curr. Op. Drug Disc. & Dev. 2008; 11(4): 553-558
5. Makarenkov V, Zentili P, Kevorkov D, Gagarin A, Malo N, Nadon R: An efficient method for the detection and elimination of systematic error in high-throughput screening. Bioinformatics 2007; 23(13): 1648-1657
6. Taylor PB, Ashman S, Baddeley SM, Bartram SL, Battle CD, Bond BC, Clements YM, Gaul NJ, McAllister WE, Mostacero JA, Ramon F, Wilson JM, Hertzberg RP, Pope AJ, Macarron R: A Standard Operating Procedure for Assessing liquid Handler Performance in High-Throughput Screening. J. Biomol. Screen. 2002; 7(6): 554-569
7. Quintero C, Rosenstein C, Hughes B, Middleton R, Kariv I: Quality Control Procedures for Dose-Response Curve Generation Using Nanoliter Dispense Technologies. J. Biomol. Screen. 2007; 12(6): 891-899
8. Popa-Burke I, Lupotsky B, Boyer J, Gannon W, Hughes R, Kadwill P, Lyerly D, Nichols J, Nixon E, Rimmer D, Saiz-Nicolas I, Sanfiz-Pinton B, Holland S: Establishing Quality Assurance Criteria for Serial Diution Operations on Liquid Handling Equipment. J. Biomol. Screen. 2009, in press
9. Comley J: Compound Management in pursuit of sample integrity. Drug Disc. World 2005; 6(2): 59-78
10. Ripka WC, Barker G, Krakover J: High-throughput purification of compound libraries. Drug Disc. Today 2001; 6(9): 471-477
11. Isbell JJ, Zhou Y, Guintu C, Rynd M, Jiang S, Petrov D, Micklash K, Mainquist J, Ek J, Chang J, Weselak M, Backes BJ, Brailsford A, Shave D: Purifying the Masses: Integrating Prepurification Quality Control, Highthroughput LC/MS Purification, and Compound Plating to Feed High- Throughput Screening. J. Comb. Chem. 2005; 7: 210-217
12. Schaffrath M, von Roedern E, Hamley P, Stilz HU: High- Throughput Purification of Single Compounds and Libraries. J. Comb. Chem. 2007; 7: 546-553
13. Guintu C, Kwok M, Hanlon JJ, Spalding TA, Wolff K, Yin H, Kuhen K, Sasher K, Calvin Pl, Jiang S, Zhou Y, Isbell JJ: Just-in- Time Purification: An Effective Solution for Cherry-Picking and Purifying Active Compounds from Large Legacy Libraries. J Biomol. Screening 2006; 11: 933-939
14. Yurek DA, Branch DL, Kuo MS: Development of a System to Evaluate Compound Identity, Purity, and Concentration in a Single Experiment and Its Applications in Quality Assessment of Combinatorial Libraries and Screening Hits. J. Comb. Chem. 2002; 4: 138-148
15. Popa-Burke IG, Issakova O, Arroway JD, Bernasconi P, Chen M, Coudurier L, Galasinski S, Janzen WP, Lagasca D, Liu D, Lewis RS, Mohney RP, Sepetov N, Sparkman DA, Hodge CN: Streamlined System for Purifying and Quantifying a Diverse Library of Compounds and the Effect of Compound Concentration Measurements on the Accurate Interpretation of Biological Assay Results. Anal. Chem. 2004; 76: 7278-7287
16. Letot E, Koch G, Falchetto R, Bovermann G, Oberer L, Roth HJ: Quality Control in Combinatorial Chemistry: Determinations of Amounts and Comparison of the "Purity" of LC-MS-Purified Samples by NMR, LC-UV and CLND. J. Comb. Chem. 2005, 7: 364-371
17. Schopfer U, Engeloch C, Stanek J, Girod M, Schuffenhauer A, Jacoby E, Acklin P: The Novartis Compound Archive - From Concept to Reality. Combi. Chem. HTS 2005; 8: 513-519
18. Houston JG, Banks MN, Binnie A, Brenner S, O'Connell J, Petrillo EW: Case study: impact of technology investment on lead discovery at Bristol-Myers Squibb, 1998-2006. Drug Disc. Today 2008; 13(1/2): 44-51
19. Yasgar A, Shinn P, Jadhav A, Auld D, Michael S, Zheng W, Austin CP, Inglese J, Simeonov A: Compound Management for Quantitative High-Throughput Screening. J Assoc. Lab. Autom. 2008; 13: 79-89
20. Koppitz M, Brailsford A, Wenz M: Maximizing Automation in LC/MS High-Throughput Analysis and Purification. J. Comb. Chem. 2005; 7: 714-720
21. Ari N, Westling L, Isbell J: Cherry-picking in an Orchard: Unattended LC/MS Analysis from an Autosampler with >32,000 Samples Online. J. Biomol. Screen. 2006; 11(3): 318-322
22. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S: The Protein Kinase Complement of the Human Genome. Science 2002; 298: 1916-1934
23. Biondi, RM, Cheung, PC, Casamayor, A, Deak, M, Currie, RA and Alessi, DR: Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA. EMBO J. 2000; 19, 979-988