Nicotinamide inhibits the lysosomal cathepsin b-like protease and kills African trypanosomes

Journal of Biological Chemistry

Volumn 288, Issue 15, 2013, Pages 10548-10557

  Juan D Unciti Broceta, ^a   Jose MacEira ^a   Sonia Morales, ^a   Angelica Garcia Perez ^a   Manuel E Munoz Torres ^b   Garcia Salcedo, Jose A ^a  

^a Granada Health Research Institute ibs GRANADA   (Spain)

^b INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AFRICAN TRYPANOSOMES; ANTI-MICROBIAL ACTIVITY; INHIBITORY EFFECT; SOLUBLE COMPOUNDS; TRYPANOSOMATIDS; VITAMIN B3;

BIOCHEMISTRY; BIOLOGY;

AMIDES;

ANTITRYPANOSOMAL AGENT; CATHEPSIN B; CATHEPSIN B INHIBITOR; NICOTINAMIDE;

AFRICAN TRYPANOSOMIASIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOKINESIS; DRUG EFFICACY; DRUG MECHANISM; ENDOCYTOSIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LYSOSOME; MAMMAL CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TREATMENT RESPONSE; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

CATHEPSIN B; ENDOCYTOSIS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LYSOSOMES; NIACINAMIDE; PROTEIN TRANSPORT; PROTOZOAN PROTEINS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN; VITAMIN B COMPLEX;

TRYPANOSOMATIDAE;

EID: 84876211355     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.449207     Document Type: Article

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