PKG II Inhibits EGF/EGFR-Induced Migration of Gastric Cancer Cells

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Jiang, Lu ^a   Lan, Ting ^a   Chen, Yongchang ^a   Sang, Jianrong ^a   Li, Yueying ^a   Wu, Min ^a   Tao, Yan ^a   Wang, Ying ^a   Qian, Hai ^a   Gu, Luo ^b  

^a JIANGSU UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP DEPENDENT PROTEIN KINASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C GAMMA1; RAC1 PROTEIN; RAS PROTEIN;

ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL CULTURE; CANCER INHIBITION; CELL FRACTIONATION; CELL MIGRATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MIGRATION INHIBITION; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; STOMACH CANCER; WESTERN BLOTTING;

CELL LINE; CELL LINE, TUMOR; CELL MOVEMENT; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASE TYPE II; EPIDERMAL GROWTH FACTOR; HUMANS; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; THIONUCLEOTIDES;

EID: 84876178102     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0061674     Document Type: Article

References (32)

1. Cook AL, Haynes JM, (2004) Protein kinase G II-mediated proliferative effects in human cultured prostatic stromal cells. Cell Signal 16: 253-261.
2. Swartling FJ, Ferletta M, Kastemar M, Weiss WA, Westermark B, (2009) Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines. Oncogene 28: 3121-3131.
3. Fallahian F, Karami-Tehrani F, Salami S, (2011) Cyclic GMP induced apoptosis via protein kinase G in oestrogen receptor-positive and-negative breast cancer cell lines. FEBS Journal 278: 3360-3369.
4. Yang SQ, Chen YC, Wang Y, Tao Y, (2008) Expression of cGMP dependent protein kinase II in cancer cell lines was obviously decreased. J Jiangsu Univ (Medicine edition) 1: 5-7.
5. Chen YC, Ren F, Sang JR, Tao Y, Xu WR, (2010) Type II cGMP-dependent protein kinase inhibits proliferation of the gastric cancer cell line BGC-823. Molecular Medicine Reports 3: 361-366.
6. Wu Y, Chen YC, Qu R, Lan T, Sang JR, (2012) Type II cGMP-dependent protein kinase inhibits EGF-triggered signal transduction of the MAPK/ERK-mediated pathway in gastric cancer cells. Oncology reports 27: 553-558.
7. Morandell S, Stasyk T, Skvortsov S, Ascher S, Huber LA, (2008) Quantitative proteomics and phosphoproteomics reveal novel insights into complexity and dynamics fo the EGFR signaling network. Proteomics 8: 4383-4401.
8. Wieduwilt MJ, Moasser MM, (2008) The epidermal growth factor receptor family: biology driving targeted therapeutics. Cell Mol Life Sci 65: 1566-1584.
9. Rooij J, Bos JL, (1997) Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene 14: 623-625.
10. Orstavik S, Natarajan V, Tasken K, Jahnsen T, Sandberg M, (1997) Characterization of the human gene encoding the type I alpha and type I beta cGMP-dependent protein kinase (PRKG1). Genomics 42: 311-318.
11. Orstavik S, Solberg R, Tasken K, Nordahl M, Altherr MR, et al. (1996) Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase. Biochem Biophys Res Commun 220: 759-765.
12. Hou Y, Gupta N, Schoenlein P, Wong E, Martindale R, et al. (2006) An anti-tumor role for cGMP-dependent protein kinase. Cancer Lett 240: 60-68.
13. Gamm DM, Francis SH, Angelotti TP, Corbin JD, Uhler MD, (1995) The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms. J Biol Chem 270: 27380-27388.
14. Hofmann F, (2005) The biology of cyclic GMP-dependent protein kinases. J Biol Chem 280: 1-4.
15. Nie HG, Chen L, Han DY, Li J, Song WF, et al. (2009) Regulation of epithelial sodium channels by cGMP/PKG II. J Physiol 587: 2663-2676.
16. Rangaswami H, Marathe N, Zhuang S, Chen Y, Yeh JC, et al. (2009) Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction. J Biol Chem 284: 14796-14808.
17. Rangaswami H, Schwappacher R, Marathe N, Zhuang S, Casteel DE, et al. (2010) Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts. Sci Signal 3: ra91.
18. Wells A, (1999) EGF receptor, Int J Biochem Cell Biol. 31: 637-643.
19. Olayioye MA, Neve RM, Lane HA, Hynes NE, (2000) The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J 19: 3159-3167.
20. Yarden Y (2001) The EGFR family and its ligands in human cancer: signalling mechanisms and therapeutic opportunities. Eur J Cancer (Suppl 4): S3-S8.
21. Ray RM, Vaidya RJ, Johnson LR, (2007) MEK/ERK regulates adherens junctions and migration through Rac1. Cell Motil Cytoskeleton (64): 143-156.
22. Xie ZJ, Peng J, Pennypacker SD, Chen Y, (2010) Critical role for the catalytic activity of phospholipase C-γ1 in epidermal growth factor-induced cell migration. BBRC 399: 425-428.
23. Hu ZZ, Du J, Yang L, Zhu YC, Yang Y, et al. (2012) GEP100/Arf6 Is Required for Epidermal Growth Factor-Induced ERK/Rac1 Signaling and Cell Migration in Human Hepatoma HepG2 Cells. PLoS ONE 7: e38777.
24. Nogami M, Yamazaki M, Watanabe H, Okabayashi Y, Kido Y, et al. (2003) Requirement of autophosphorylated tyrosine 992 of EGF receptor and its docking protein phospholipase C gamma 1 for membrane ruffle formation. FEBS Lett 536: 71-76.
25. Normanno N, Bianco C, De Luca A, Maiello MR, Salomon DS, (2003) Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment. Endocr Relat Cancer 10: 1-21.
26. Sharma SV, Bell DW, Settleman J, Haber DA, (2007) Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer 7: 169-181.
27. Hu T, Li C, (2010) Convergence between Wnt-β-catenin and EGFR signaling in cancer. Molecular Cancer 9: 236-243.
28. Krishnan S, Rao RD, James CD, Sarkaria JN, (2003) Combination of epidermal growth factor receptor targeted therapy with radiation therapy for malignant gliomas. Front Biosci 8: e1-13.
29. Merla A and Goel S (2012) Novel Drugs Targeting the Epidermal Growth Factor Receptor and Its Downstream Pathways in the Treatment of Colorectal Cancer: A Systematic Review. Chemotherapy Research and Practice Volume 2012, Article ID 387172.
30. Quatrale AE, Porcelli L, Silvestris N, Colucci G, Angelo A, et al. (2011) EGFR tyrosine kinases inhibitors in cancer treatment: in vitro and in vivo evidence. Front Biosci 16: 1962-1972.
31. Lin CR, Chen WS, Lazar CS, Carpenter CD, Gill GN, et al. (1986) Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms.Cell. 44: 839-848.
32. Theroux SJ, Stanley K, Campbell DA, Davis RJ, (1992) Mutational removal of the major site of serine phosphorylation of the epidermal growth factor receptor causes potentiation of signal transduction role of receptor down-regulation. Mol Endocrinol 6: 1849-1857.