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Volumn 62, Issue 6, 2013, Pages 1913-1922

VASP increases hepatic fatty acid oxidation by activating AMPK in mice

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACETYL COENZYME A CARBOXYLASE; FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIPID; SILDENAFIL; TRIACYLGLYCEROL; VASODILATOR STIMULATED PHOSPHOPROTEIN; VERY LOW DENSITY LIPOPROTEIN;

EID: 84876175674     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-0325     Document Type: Article
Times cited : (25)

References (48)
  • 1
    • 0345374579 scopus 로고    scopus 로고
    • Minireview: Weapons of Lean Body Mass Destruction: The Role of Ectopic Lipids in the Metabolic Syndrome
    • DOI 10.1210/en.2003-0870
    • Unger RH. Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology 2003;144:5159-5165 (Pubitemid 37476041)
    • (2003) Endocrinology , vol.144 , Issue.12 , pp. 5159-5165
    • Unger, R.H.1
  • 2
    • 57649214103 scopus 로고    scopus 로고
    • Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)
    • Musso G, Gambino R, Cassader M. Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Prog Lipid Res 2009;48:1-26
    • (2009) Prog Lipid Res , vol.48 , pp. 1-26
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 3
    • 40549135297 scopus 로고    scopus 로고
    • Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: Lessons from genetically engineered mice
    • DOI 10.1172/JCI34275
    • Postic C, Girard J. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest 2008;118:829-838 (Pubitemid 351364588)
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.3 , pp. 829-838
    • Postic, C.1    Girard, J.2
  • 4
    • 63849085094 scopus 로고    scopus 로고
    • Targeting the AMPK pathway for the treatment of Type 2 diabetes
    • Viollet B, Lantier L, Devin-Leclerc J, et al. Targeting the AMPK pathway for the treatment of Type 2 diabetes. Front Biosci 2009;14:3380-3400
    • (2009) Front Biosci , vol.14 , pp. 3380-3400
    • Viollet, B.1    Lantier, L.2    Devin-Leclerc, J.3
  • 5
    • 0025329901 scopus 로고
    • Protein disulfide isomerase is a component of the microsomal triglyceride transfer protein complex
    • Wetterau JR, Combs KA, Spinner SN, Joiner BJ. Protein disulfide isomerase is a component of the microsomal triglyceride transfer protein complex. J Biol Chem 1990;265:9800-9807
    • (1990) J Biol Chem , vol.265 , pp. 9800-9807
    • Wetterau, J.R.1    Combs, K.A.2    Spinner, S.N.3    Joiner, B.J.4
  • 6
    • 0035716449 scopus 로고    scopus 로고
    • 2000 George Lyman Duff memorial lecture: Atherosclerosis is a liver disease of the heart
    • Davis RA, Hui TY. 2000 George Lyman Duff Memorial Lecture: atherosclerosis is a liver disease of the heart. Arterioscler Thromb Vasc Biol 2001;21:887-898 (Pubitemid 34168642)
    • (2001) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.21 , Issue.6 , pp. 887-898
    • Davis, R.A.1    Hui, T.Y.2
  • 7
    • 0037124084 scopus 로고    scopus 로고
    • Complexity in the secretory pathway: The assembly and secretion of apolipoprotein B-containing lipoproteins
    • DOI 10.1074/jbc.R100068200
    • Fisher EA, Ginsberg HN. Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins. J Biol Chem 2002;277:17377-17380 (Pubitemid 34967535)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.20 , pp. 17377-17380
    • Fisher, E.A.1    Ginsberg, H.N.2
  • 9
    • 0034665266 scopus 로고    scopus 로고
    • Dual epitope recognition by the VASP EVH1 domain modulates polyproline ligand specificity and binding affinity
    • Ball LJ, Kühne R, Hoffmann B, et al. Dual epitope recognition by the VASP EVH1 domain modulates polyproline ligand specificity and binding affinity. EMBO J 2000;19:4903-4914
    • (2000) EMBO J , vol.19 , pp. 4903-4914
    • Ball, L.J.1    Kühne, R.2    Hoffmann, B.3
  • 10
    • 0034705291 scopus 로고    scopus 로고
    • Putting on the brakes: A negative regulatory function for Ena/VASP proteins in cell migration
    • Machesky LM. Putting on the brakes: a negative regulatory function for Ena/VASP proteins in cell migration. Cell 2000;101:685-688
    • (2000) Cell , vol.101 , pp. 685-688
    • Machesky, L.M.1
  • 11
    • 80755168919 scopus 로고    scopus 로고
    • Endothelial NO/cGMP/VASP signaling attenuates Kupffer cell activation and hepatic insulin resistance induced by high-fat feeding
    • Tateya S, Rizzo NO, Handa P, et al. Endothelial NO/cGMP/VASP signaling attenuates Kupffer cell activation and hepatic insulin resistance induced by high-fat feeding. Diabetes 2011;60:2792-2801
    • (2011) Diabetes , vol.60 , pp. 2792-2801
    • Tateya, S.1    Rizzo, N.O.2    Handa, P.3
  • 13
    • 77955266904 scopus 로고    scopus 로고
    • AMPK activation represses the human gene promoter of the cardiac isoform of acetyl-CoA carboxylase: Role of nuclear respiratory factor-1
    • Adam T, Opie LH, Essop MF. AMPK activation represses the human gene promoter of the cardiac isoform of acetyl-CoA carboxylase: Role of nuclear respiratory factor-1. Biochem Biophys Res Commun 2010;398:495-499
    • (2010) Biochem Biophys Res Commun , vol.398 , pp. 495-499
    • Adam, T.1    Opie, L.H.2    Essop, M.F.3
  • 15
    • 55449100538 scopus 로고    scopus 로고
    • Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance
    • Kim F, Pham M, Maloney E, et al. Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance. Arterioscler Thromb Vasc Biol 2008;28:1982-1988
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1982-1988
    • Kim, F.1    Pham, M.2    Maloney, E.3
  • 18
    • 33745216724 scopus 로고    scopus 로고
    • MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    • Kanda H, Tateya S, Tamori Y, et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 2006;116:1494-1505
    • (2006) J Clin Invest , vol.116 , pp. 1494-1505
    • Kanda, H.1    Tateya, S.2    Tamori, Y.3
  • 19
    • 79953306432 scopus 로고    scopus 로고
    • 2 release from human arterial smooth muscle cells
    • 2 release from human arterial smooth muscle cells. J Lipid Res 2011;52:782-793
    • (2011) J Lipid Res , vol.52 , pp. 782-793
    • Golej, D.L.1    Askari, B.2    Kramer, F.3
  • 20
    • 0037036115 scopus 로고    scopus 로고
    • Nuclear activators and coactivators in mammalian mitochondrial biogenesis
    • DOI 10.1016/S0167-4781(02)00343-3, PII S0167478102003433
    • Scarpulla RC. Nuclear activators and coactivators in mammalian mitochondrial biogenesis. Biochim Biophys Acta 2002;1576:1-14 (Pubitemid 34597079)
    • (2002) Biochimica et Biophysica Acta - Gene Structure and Expression , vol.1576 , Issue.1-2 , pp. 1-14
    • Scarpulla, R.C.1
  • 21
    • 77952849224 scopus 로고    scopus 로고
    • Palmitate induces insulin resistance without significant intracellular triglyceride accumulation in HepG2 cells
    • Lee JY, Cho HK, Kwon YH. Palmitate induces insulin resistance without significant intracellular triglyceride accumulation in HepG2 cells. Metabolism 2010;59:927-934
    • (2010) Metabolism , vol.59 , pp. 927-934
    • Lee, J.Y.1    Cho, H.K.2    Kwon, Y.H.3
  • 22
    • 42049114034 scopus 로고    scopus 로고
    • Transcriptional paradigms in mammalian mitochondrial biogenesis and function
    • DOI 10.1152/physrev.00025.2007
    • Scarpulla RC. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev 2008;88:611-638 (Pubitemid 351520089)
    • (2008) Physiological Reviews , vol.88 , Issue.2 , pp. 611-638
    • Scarpulla, R.C.1
  • 23
    • 77957349477 scopus 로고    scopus 로고
    • AMP-activated protein kinase and its downstream transcriptional pathways
    • Cantó C, Auwerx J. AMP-activated protein kinase and its downstream transcriptional pathways. Cell Mol Life Sci 2010;67:3407-3423
    • (2010) Cell Mol Life Sci , vol.67 , pp. 3407-3423
    • Cantó, C.1    Auwerx, J.2
  • 25
    • 10644297079 scopus 로고    scopus 로고
    • Kinase-independent transcriptional co-activation of peroxisome proliferator-activated receptor alpha by AMP-activated protein kinase
    • DOI 10.1042/BJ20040955
    • Bronner M, Hertz R, Bar-Tana J. Kinase-independent transcriptional coactivation of peroxisome proliferator-activated receptor alpha by AMP-activated protein kinase. Biochem J 2004;384:295-305 (Pubitemid 39656242)
    • (2004) Biochemical Journal , vol.384 , Issue.2 , pp. 295-305
    • Bronner, M.1    Hertz, R.2    Bar-Tana, J.3
  • 26
    • 54849431792 scopus 로고    scopus 로고
    • The glucagon receptor is required for the adaptive metabolic response to fasting
    • Longuet C, Sinclair EM, Maida A, et al. The glucagon receptor is required for the adaptive metabolic response to fasting. Cell Metab 2008;8:359-371
    • (2008) Cell Metab , vol.8 , pp. 359-371
    • Longuet, C.1    Sinclair, E.M.2    Maida, A.3
  • 27
    • 0030047184 scopus 로고    scopus 로고
    • Identification of a peroxisome proliferator-responsive element upstream of the human peroxisomal fatty acyl coenzyme A oxidase gene
    • DOI 10.1074/jbc.271.4.2147
    • Varanasi U, Chu R, Huang Q, Castellon R, Yeldandi AV, Reddy JK. Identification of a peroxisome proliferator-responsive element upstream of the human peroxisomal fatty acyl coenzyme A oxidase gene. J Biol Chem 1996;271:2147-2155 (Pubitemid 26047804)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.4 , pp. 2147-2155
    • Varanasi, U.1    Chu, R.2    Huang, Q.3    Castellon, R.4    Yeldandi, A.V.5    Reddy, J.K.6
  • 28
    • 67651102871 scopus 로고    scopus 로고
    • The role of PPARalpha in lipid metabolism and obesity: Focusing on the effects of estrogen on PPARalpha actions
    • Yoon M. The role of PPARalpha in lipid metabolism and obesity: focusing on the effects of estrogen on PPARalpha actions. Pharmacol Res 2009;60:151-159
    • (2009) Pharmacol Res , vol.60 , pp. 151-159
    • Yoon, M.1
  • 29
    • 25844432311 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency
    • DOI 10.1074/jbc.M507621200
    • Koves TR, Li P, An J, et al. Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem 2005;280:33588-33598 (Pubitemid 41397160)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.39 , pp. 33588-33598
    • Koves, T.R.1    Li, P.2    An, J.3    Akimoto, T.4    Slentz, D.5    Ilkayeva, O.6    Dohm, G.L.7    Yan, Z.8    Newgard, C.B.9    Muoio, D.M.10
  • 30
    • 33845922351 scopus 로고    scopus 로고
    • Coordinate transcriptional repression of liver fatty acid-binding protein and microsomal triglyceride transfer protein blocks hepatic very low density lipoprotein secretion without hepatosteatosis
    • DOI 10.1074/jbc.M607148200
    • Spann NJ, Kang S, Li AC, et al. Coordinate transcriptional repression of liver fatty acid-binding protein and microsomal triglyceride transfer protein blocks hepatic very low density lipoprotein secretion without hepatosteatosis. J Biol Chem 2006;281:33066-33077 (Pubitemid 46036689)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.44 , pp. 33066-33077
    • Spann, N.J.1    Kang, S.2    Li, A.C.3    Chen, A.Z.4    Newberry, E.P.5    Davidson, N.O.6    Hui, S.T.Y.7    Davis, R.A.8
  • 31
    • 42749100308 scopus 로고    scopus 로고
    • PPARs in the control of uncoupling proteins gene expression
    • Villarroya F, Iglesias R, Giralt M. PPARs in the control of uncoupling proteins gene expression. PPAR Res 2007;2007:74364
    • (2007) PPAR Res , vol.2007 , pp. 74364
    • Villarroya, F.1    Iglesias, R.2    Giralt, M.3
  • 33
    • 51249103805 scopus 로고    scopus 로고
    • Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients
    • Boon H, Bosselaar M, Praet SF, et al. Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients. Diabetologia 2008;51:1893-1900
    • (2008) Diabetologia , vol.51 , pp. 1893-1900
    • Boon, H.1    Bosselaar, M.2    Praet, S.F.3
  • 34
    • 0034711470 scopus 로고    scopus 로고
    • Vasodilator-stimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide/cGMP signaling and endothelial dysfunction
    • Oelze M, Mollnau H, Hoffmann N, et al. Vasodilator-stimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide/cGMP signaling and endothelial dysfunction. Circ Res 2000;87:999-1005
    • (2000) Circ Res , vol.87 , pp. 999-1005
    • Oelze, M.1    Mollnau, H.2    Hoffmann, N.3
  • 35
    • 34047094881 scopus 로고    scopus 로고
    • Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice
    • DOI 10.2337/db06-0883
    • Ayala JE, Bracy DP, Julien BM, Rottman JN, Fueger PT, Wasserman DH. Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice. Diabetes 2007;56:1025-1033 (Pubitemid 46525081)
    • (2007) Diabetes , vol.56 , Issue.4 , pp. 1025-1033
    • Ayala, J.E.1    Bracy, D.P.2    Julien, B.M.3    Rottman, J.N.4    Fueger, P.T.5    Wasserman, D.H.6
  • 36
    • 55549135363 scopus 로고    scopus 로고
    • Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cells
    • Zhang J, Xie Z, Dong Y, Wang S, Liu C, Zou MH. Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cells. J Biol Chem 2008;283:27452-27461
    • (2008) J Biol Chem , vol.283 , pp. 27452-27461
    • Zhang, J.1    Xie, Z.2    Dong, Y.3    Wang, S.4    Liu, C.5    Zou, M.H.6
  • 37
    • 36549040859 scopus 로고    scopus 로고
    • The selectivity of protein kinase inhibitors: A further update
    • Bain J, Plater L, Elliott M, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J 2007;408:297-315
    • (2007) Biochem J , vol.408 , pp. 297-315
    • Bain, J.1    Plater, L.2    Elliott, M.3
  • 38
    • 51249095379 scopus 로고    scopus 로고
    • Can patients with type 2 diabetes be treated with 5′-AMP-activated protein kinase activators?
    • Winder WW. Can patients with type 2 diabetes be treated with 5′-AMP-activated protein kinase activators? Diabetologia 2008;51:1761-1764
    • (2008) Diabetologia , vol.51 , pp. 1761-1764
    • Winder, W.W.1
  • 39
    • 65349177200 scopus 로고    scopus 로고
    • AMPK: An emerging drug target for diabetes and the metabolic syndrome
    • Zhang BB, Zhou G, Li C. AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab 2009;9:407-416
    • (2009) Cell Metab , vol.9 , pp. 407-416
    • Zhang, B.B.1    Zhou, G.2    Li, C.3
  • 40
    • 0032699670 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    • Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest 1999;103:1489-1498
    • (1999) J Clin Invest , vol.103 , pp. 1489-1498
    • Kersten, S.1    Seydoux, J.2    Peters, J.M.3    Gonzalez, F.J.4    Desvergne, B.5    Wahli, W.6
  • 41
    • 0033594980 scopus 로고    scopus 로고
    • A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: The PPARalpha-null mouse as a model of fatty acid oxidation disorders
    • DOI 10.1073/pnas.96.13.7473
    • Leone TC, Weinheimer CJ, Kelly DP. A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci USA 1999;96:7473-7478 (Pubitemid 29299686)
    • (1999) Proceedings of the National Academy of Sciences of the United States of America , vol.96 , Issue.13 , pp. 7473-7478
    • Leone, T.C.1    Weinheimer, C.J.2    Kelly, D.P.3
  • 42
    • 79959956336 scopus 로고    scopus 로고
    • AMP-activated protein kinase inhibits NF-κB signaling and inflammation: Impact on healthspan and lifespan
    • (Berl)
    • Salminen A, Hyttinen JM, Kaarniranta K. AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan. J Mol Med (Berl) 2011;89:667-676
    • (2011) J Mol Med , vol.89 , pp. 667-676
    • Salminen, A.1    Hyttinen, J.M.2    Kaarniranta, K.3
  • 43
    • 77953517927 scopus 로고    scopus 로고
    • Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1
    • Yang Z, Kahn BB, Shi H, Xue BZ. Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. J Biol Chem 2010;285:19051-19059
    • (2010) J Biol Chem , vol.285 , pp. 19051-19059
    • Yang, Z.1    Kahn, B.B.2    Shi, H.3    Xue, B.Z.4
  • 44
    • 81755166370 scopus 로고    scopus 로고
    • Reduced vascular nitric oxide-cGMP signaling contributes to adipose tissue inflammation during high-fat feeding
    • Handa P, Tateya S, Rizzo NO, et al. Reduced vascular nitric oxide-cGMP signaling contributes to adipose tissue inflammation during high-fat feeding. Arterioscler Thromb Vasc Biol 2011;31:2827-2835
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 2827-2835
    • Handa, P.1    Tateya, S.2    Rizzo, N.O.3
  • 45
    • 0037333221 scopus 로고    scopus 로고
    • Involvement of nitric oxide/cyclic GMP signaling pathway in the regulation of fatty acid metabolism in rat hepatocytes
    • DOI 10.1016/S0006-2952(02)01623-4
    • García-Villafranca J, Guillén A, Castro J. Involvement of nitric oxide/cyclic GMP signaling pathway in the regulation of fatty acid metabolism in rat hepatocytes. Biochem Pharmacol 2003;65:807-812 (Pubitemid 36293697)
    • (2003) Biochemical Pharmacology , vol.65 , Issue.5 , pp. 807-812
    • Garcia-Villafranca, J.1    Guillen, A.2    Castro, J.3
  • 47
    • 77449117735 scopus 로고    scopus 로고
    • Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance
    • Huang W, Metlakunta A, Dedousis N, et al. Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance. Diabetes 2010;59:347-357
    • (2010) Diabetes , vol.59 , pp. 347-357
    • Huang, W.1    Metlakunta, A.2    Dedousis, N.3
  • 48
    • 77952092350 scopus 로고    scopus 로고
    • Nitric oxide increases cyclic GMP levels, AMP-activated protein kinase (AMPK)alpha1-specific activity and glucose transport in human skeletal muscle
    • Deshmukh AS, Long YC, de Castro Barbosa T, et al. Nitric oxide increases cyclic GMP levels, AMP-activated protein kinase (AMPK)alpha1-specific activity and glucose transport in human skeletal muscle. Diabetologia 2010;53:1142-1150
    • (2010) Diabetologia , vol.53 , pp. 1142-1150
    • Deshmukh, A.S.1    Long, Y.C.2    De Castro Barbosa, T.3


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