Synthesis and structure-activity relationships of carboxylic acid derivatives of pyridoxal as P2X receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 9, 2013, Pages 2643-2650

  Jung, Kwan Young ^a   Cho, Joong Heui ^a   Lee, Jung Sun ^a   Kim, Hyo Jun ^a   Kim, Yong Chul ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

Antagonists; P2X1 receptor; P2X3 receptor; Pyridine carboxylic acids; Structure activity relationships; Two electrode voltage clamp

Indexed keywords

3 (2 CARBOXYETHYL) 2 [(2,5 DISULFOPHENYL)DIAZENYL] 5 HYDROXY 6 METHYLISONICOTINIC ACID; 3 (2 CARBOXYETHYL) 2 [(4 CARBOXYPHENYL)DIAZENYL] 5 HYDROXY 6 METHYLISONICOTINIC ACID; 3 (2 CARBOXYETHYL) 5 HYDROXY 6 METHYL 2 [(4 SULFOPHENYL)DIAZENYL]ISONICOTINIC ACID; 3 (4 FORMYL 5 HYDROXY 6 METHYLPYRIDIN 3 YL)PROPANOIC ACID; 3 [4 FORMYL 5 HYDROXY 6 METHYL 2 [(4 SULFOPHENYL)DIAZENYL]PYRIDIN 3 YL]PROPANOIC ACID; 3[2 [(2,5 DISULFOPHENYL)DIAZENYL] 4 FORMYL 5 HYDROXY 6 METHYLPYRIDIN 3 YL]PROPANOIC ACID; 4 [[3 (2 CARBOXYETHYL) 4 FORMYL 5 HYDROXY 6 METHYLPYRIDIN 2 YL]DIAZENYL]BENZOIC ACID; 5 (2 CARBOXYETHYL) 3 HYDROXY 2 METHYLISONICOTINIC ACID; ALDEHYDE; CARBOXYLIC ACID DERIVATIVE; LYSINE; PHOSPHATE; PHOSPHORIC ACID; PURINERGIC P2X RECEPTOR ANTAGONIST; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2X3 RECEPTOR; PYRIDOXAL 5 PHOSPHATE; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; OOCYTE; RECEPTOR BINDING; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION; VOLTAGE CLAMP; XENOPUS;

CARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR STRUCTURE; PURINERGIC P2X RECEPTOR ANTAGONISTS; PYRIDOXAL; RECEPTORS, PURINERGIC P2X3; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84876132913     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.073     Document Type: Article

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