Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors

Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2001, Pages 340-349

  Kim, Y C ^a   Brown, S G ^b   Harden, T K ^c   Boyer, J L ^c   Dubyak, G ^d   King, B F ^b   Burnstock, G ^b   Jacobson, K A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b ROYAL FREE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOLIPASE C; PURINE P2X RECEPTOR; PURINE P2Y RECEPTOR; PYRIDOXAL 5 PHOSPHATE; PYRIDOXAL 5' PHOSPHATE 6 AZOPHENYL 2',5' DISULFONATE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; IC 50; ION CURRENT; NONHUMAN; OOCYTE; RAT; RECEPTOR INTRINSIC ACTIVITY; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; OOCYTES; PATCH-CLAMP TECHNIQUES; PYRIDOXAL PHOSPHATE; RATS; RECEPTORS, PURINERGIC P2; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 0035253859     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9904203     Document Type: Article

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