Epigenetic drugs: A novel anti-aging strategy?

Frontiers in Genetics

Volumn 3, Issue OCT, 2012, Pages

  Vaiserman, A M ^a   Pasyukova, E G ^b  

^a INSTITUTE OF GERONTOLOGY   (Ukraine)

^b INSTITUTE OF MOLECULAR GENETICS   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84876125887     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2012.00224     Document Type: Article

References (37)

1. Abel, T., and Zukin, R. S. (2008). Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders. Curr. Opin. Pharmacol. 8, 57-64.
2. Akimova, T., Beier, U. H., Liu, Y., Wang, L., and Hancock, W. W. (2012). Histone/protein deacety-lases and T-cell immune responses. Blood 119, 2443-2451.
3. Berdasco, M., and Esteller, M. (2012). Hot topics in epigenetic mechanisms of aging: 2011. Aging Cell 11, 181-186.
4. Boumber, Y., and Issa, J. P. (2011). Epigenetics in cancer: what's the future? Oncology (Williston Park) 25, 220-226, 228.
5. Cantley, M. D., Bartold, P. M., Fairlie, D. P., Rainsford, K. D., and Haynes, D. R. (2012). Histone deacety-lase inhibitors as suppressors of bone destruction in inflammatory diseases. J. Pharm. Pharmacol. 64, 763-774.
6. Carafa, V., Nebbioso, A., and Altucci, L. (2012). Sirtuins and disease: the road ahead. Front. Pharmacol. 3:4. doi: 10.3389/fphar.2012.00004
7. Cochemé, H. M., and Murphy, M. P. (2010). Can antioxidants be effective therapeutics? Curr. Opin. Investig. Drugs 11, 426-431.
8. Dayangaç-Erden, D., Bora, G., Ayhan, P., Kocaefe, C., Dalkara, S., Yelekçi, K., et al. (2009). Histone deacetylase inhibition activity and molecular docking of (e)-resveratrol: its therapeutic potential in spinal muscular atrophy. Chem. Biol Drug Des. 73, 355-364.
9. de Oliveira, R. M., Sarkander, J., Kazantsev, A. G., and Outeiro, T. F. (2012). SIRT2 as a therapeutic target for age-related disorders. Front. Pharmacol. 3:82. doi: 10.3389/fphar.2012.00082
10. Gryder, B. E., Sodji, Q. H., and Oyelere, A. K. (2012). Targeted cancer therapy: giving histone deacetylase inhibitors all they need to succeed. Future Med. Chem. 4, 505-524.
11. Huber, K., and Superti-Furga, G. (2011). After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders. Bioorg. Med. Chem. 19,3616-3624.
12. Jerome-Morais, A., Diamond, A. M., and Wright, M. E. (2011). Dietary supplements and human health: for better or for worse? Mol Nutr. Food Res. 55, 122-135.
13. Kang, H.-L., Benzer, S., and Min, K.-T. (2002). Life extension in Drosophila by feeding a drug. Proc. Natl. Acad. Sci. U.S.A. 99, 838-843.
14. Kapoor, V. K., Dureja, J., and Chadha, R. (2009). Synthetic drugs with anti-ageing effects. Drug Discov. Today 14, 899-904.
15. Karagiannis, T. C., and Maulik, N. (2012). Factors influencing epigenetic mechanisms and related diseases. Antioxid. Redox Signal. 17, 192-194.
16. Kourtis, N., and Tavernarakis, N. (2011). Cellular stress response pathways and ageing: intricate molecular relationships. EMBO J. 30, 2520-2531.
17. Lamba, V., and Ghosh, I. (2012). New directions in targeting protein kinases: focusing upon true allosteric and bivalent inhibitors. Curr. Pharm. Des. 18,2936-2945.
18. Lee, C. K., Klopp, R. G., Weindruch, R., and Prolla, T. A. (1999). Gene expression profile of aging and its retardation by caloric restriction. Science 285, 1390-1393.
19. Lee, S. J., Krauthauser, C., Maduskuie, V., Fawcett, P. T., Olson, J. M., and Rajasekaran, S. A. (2011). Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo. BMC Cancer 11:144. doi: 10.1186/1471-2407-11-144
20. Leggatt, G. R., and Gabrielli, B. (2012). Histone deacetylase inhibitors in the generation of the anti-tumour immune response. Immunol. Cell Biol. 90, 33-38.
21. Licciardi, P. V., and Karagiannis, T. C. (2012). Regulation of immune responses by histone deacetylase inhibitors. ISRN Hematol. 2012, 690901.
22. Mahajan, S. S., Leko, V., Simon, J. A., and Bedalov, A. (2011). Sirtuin modulators. Handb. Exp. Pharmacol. 206,241-255.
23. Mai, A. (2010). Small-molecule chromatin-modifying agents: therapeutic applications. Epigenomics 2, 307-324.
24. Olshansky, S. J., Hayflick, L., and Carnes, B. A. (2002). No truth to the fountain of youth. Sci. Am. 286, 92-95.
25. Price, N. L., Gomes, A. P., Ling, A. J., Duarte, F. V., Martin-Montalvo, A., North, B. J., et al. (2012). HDAC inhibitors for the treatment of cutaneous T-cell lymphomas. Future Med. Chem. 4, 471-486.
26. Reuter, S., Gupta, S. C., Park, B., Goel, A., and Aggarwal, B. B. (2011). Epigenetic changes induced by curcumin and other natural compounds. Genes Nutr. 6, 93-108.
27. Roger, T., Lugrin, J., Le Roy, D., Goy, G., Mombelli, M., Koessler, T., et al. (2011). Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection. Blood 117, 1205-1217.
28. Sananbenesi, F., and Fischer, A. (2009). The epigenetic bottleneck of neurodegenerative and psychiatric diseases. Biol. Chem. 390, 1145-1153.
29. Sato, A. (2012). Vorinostat approved in Japan for treatment of cutaneous T-cell lymphomas: status and prospects. Onco Targets Ther. 5, 67-75.
30. Satoh, A., Stein, L., and Imai, S. (2011). The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity. Handb. Exp. Pharmacol. 206, 125-162.
31. Seroude, L., Brummel, T., Kapahi, P., and Benzer, S. (2002). Spatio-temporal analysis of gene expression during aging in Drosophila melanogaster. Aging Cell 1,47-56.
32. Tao, D., Lu, J., Sun, H., Zhao, Y. M., Yuan, Z. G., Li, X. X., et al. (2004). Trichostatin A extends the lifespan of Drosophila melanogaster by elevating hsp22 expression. Acta Biochim. Biophys. Sin. 36, 618-622.
33. Vaiserman, A.M. (2011). Hormesis and epigenetics: is there a link? AgeingRes. Rev. 10, 413-421.
34. Vaiserman, A. M., Kolyada, A. K., Koshel, N. M., Simonenko, A. V., and Pasyukova, E. G. (2012). Effect of the histone deacetylase inhibitor sodium butyrate on the viability and life span in Drosophila melanogaster. Adv. Gerontol. 25, 126-131. [In Russian].
35. Vermeulen, C. J., and Loeschcke, V (2007). Longevity and the stress response in Drosophila. Exp. Gerontol. 42, 153-159.
36. Xu, K., Dai, X. L., Huang, H. C., and Jiang, Z. F. (2011). Targeting HDACs: a promising therapy for Alzheimer's disease. Oxid. Med. Cell. Longev. 2011, 143269.
37. Zhao, Y., Sun, H., Lu, J., Li, X., Chen, X., Tao, D., et al. (2005). Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors. J. Exp. Biol. 208, 697-705.