Nutrition and ageing: Knowledge, gaps and research priorities

Proceedings of the Nutrition Society

Volumn 72, Issue 2, 2013, Pages 246-250

  Mathers, John C ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Biology of ageing; Healthy ageing phenotype; Intervention studies

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; SIRTUIN; SOMATOMEDIN C;

AGING; ARTICLE; BEHAVIOR CHANGE; CELL FUNCTION; DEMENTIA; DIET; DIET RESTRICTION; DISABILITY; DNA REPAIR; EATING; HUMAN; LIFE EXPECTANCY; LIFESPAN; METABOLIC STRESS; NONHUMAN; NUTRITION; OUTCOME ASSESSMENT; PARKINSON DISEASE; PHENOTYPE; RESEARCH PRIORITY;

AGING; DIET; HUMANS; NUTRITIONAL STATUS; RESEARCH;

EID: 84876105690     PISSN: 00296651     EISSN: 14752719     Source Type: Journal    
DOI: 10.1017/S0029665112003023     Document Type: Article

References (50)

1. Christensen K, Doblhammer G, Rau R et al. (2009) Ageing populations: the challenges ahead. Lancet 374, 1196-1208.
2. Centers for Disease Control (2011) Ten great public health achievements - worldwide, 2001-2010. MMWR Morb Mortal Wkly Rep 60, 814-818.
3. Vaupel JW (2010) Biodemography of human ageing. Nature 464, 536-542.
4. Leon DA (2011) Trends in European life expectancy: a salutary view. Int J Epidemiol 40, 271-277.
5. McCartney G, Collins C, Walsh D et al. (2012) Why the Scots die younger: synthesizing the evidence. Public Health 126, 459-470.
6. Marmot M, Allen J, Goldblatt P et al. (2010) Fair Society, Healthy Lives: The Marmot Review; Strategic Review of Health Inequalities in England Post-2010. Available at http:// www.instituteofhealthequity.org/projects/fair- society-healthylives- the-marmot-review.
7. Slagboom PE, Beekman M, Passtoors WM et al. (2011) Genomics of human longevity. Philos Trans R Soc Lond B Biol Sci 366, 35-42.
8. Wheeler HE & Kim SK (2011) Genetics and genomics of human ageing. Philos Trans R Soc Lond B Biol Sci 366, 43-50.
9. Jacobsen R, Martinussen T, Christiansen L et al. (2010) Increased effect of the ApoE gene on survival at advanced age in healthy and long-lived Danes: two nationwide cohort studies. Aging Cell 9, 1004-1009.
10. Deelen J, Beekman M, Uh HW et al. (2011) Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell 10, 686-698.
11. Bertram L, McQueen MB, Mullin K et al. (2007) Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet 39, 17-23.
12. Kirkwood TB (2008) A systematic look at an old problem. Nature 451, 644-647.
13. Langie SA, Lara J & Mathers JC (2012) Early determinants of the ageing trajectory. Best Pract Res Clin Endocrinol Metab 26, 613-626.
14. Li W & Vijg J (2012) Measuring genome instability in aging - a mini-review. Gerontology 58, 129-138.
15. Gorbunova V, Seluanov A, Mao Z et al. (2007) Changes in DNA repair during aging. Nucleic Acids Res 35, 7466- 7474.
16. Langie SA, Cameron KM, Waldron KJ et al. (2011) Measuring DNA repair incision activity of mouse tissue extracts towards singlet oxygen-induced DNA damage: a cometbased in vitro repair assay. Mutagenesis 26, 461-471.
17. Greaves LC, Barron MJ, Plusa S et al. (2010) Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts. Exp Gerontol 45, 573-579.
18. Nooteboom M, Johnson R, Taylor RW et al. (2010) Ageassociated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts. Aging Cell 9, 96-99.
19. Li X-J & Li S (2011) Proteasomal dysfunction in aging and Huntington disease. Neurobiol Dis 43, 4-8.
20. Martinez-Vicente M & Cuervo AM (2007) Autophagy and neurodegeneration: when the cleaning crew goes on strike. Lancet Neurol 6, 352-361.
21. Pannese E (2011) Morphological changes in nerve cells during normal aging. Brain Struct Funct 216, 85-89.
22. Deschenes MR (2011) Motor unit and neuromuscular junction remodeling with aging. Curr Aging Sci 4, 209-220.
23. Jeyapalan JC, Ferreira M, Sedivy JM et al. (2007) Accumulation of senescent cells in mitotic tissue of aging primates. Mech Ageing Dev 128, 36-44.
24. Campisi J (2011) Cellular senescence: putting the paradoxes in perspective. Curr Opin Genet Dev 21, 107-112.
25. Bahar R, Hartmann CH, Rodriguez KA et al. (2006) Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature 441, 1011-1014.
26. Mathers JC & Ford D (2009) Nutrition, epigenetics, and aging. In Nutrients and epigenetics, pp. 175-206 [S-W Choi and S Friso, editors]. Boca Raton: CRC Press.
27. Mathers JC (2008) Session 2: personalised nutrition. Epigenomics: a basis for understanding individual differences? Proc Nutr Soc 67, 390-394.
28. Mathers JC, Strathdee G & Relton CL (2010) Induction of epigenetic alterations by dietary and other environmental factors. Adv Genet 71, 3-39.
29. Johnstone SE & Baylin SB (2010) Stress and the epigenetic landscape: a link to the pathobiology of human diseases? Nat Rev Genet 11, 806-812.
30. Bishop NA, Lu T & Yankner BA (2010) Neural mechanisms of ageing and cognitive decline. Nature 464, 529-535.
31. Speakman JR & Mitchell SE (2011) Caloric restriction. Mol Aspects Med 32, 159-221.
32. Swindell WR (2012) Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype- dependent effects on lifespan. Ageing Res Rev 11, 254-270.
33. Colman RJ, Anderson RM, Johnson SC et al. (2009) Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325, 201-204.
34. Mattison JA, Roth GS, Beasley TM et al. (2012) Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 489, 318-321.
35. Whitlock G, Lewington S, Sherliker P et al. (2009) Body mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 373, 1083-1096.
36. Sun Q, Townsend MK, Okereke OI et al. (2009) Adiposity and weight change in mid-life in relation to healthy survival after age 70 in women: prospective cohort study. Br Med J 339, b3796.
37. Zhong LM, Zong Y, Sun L et al. (2012) Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells. PLoS ONE 7, e32195.
38. Zhu X, Liu Q, Wang M et al. (2011) Activation of Sirt1 by resveratrol inhibits TNF-alpha induced inflammation in fibroblasts. PLoS ONE 6, e27081.
39. Hector KL, Lagisz M & Nakagawa S (2012) The effect of resveratrol on longevity across species: a meta-analysis. Biol Lett 8, 790-793.
40. Brookmeyer R, Johnson E, Ziegler-Graham K et al. (2007) Forecasting the global burden of Alzheimer's disease. Alzheimers Dement 3, 186-191.
41. Jonsson T, Atwal JK, Steinberg S et al. (2012) A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 488, 96-99.
42. Reitz C, Brayne C & Mayeux R (2011) Epidemiology of Alzheimer disease. Nat Rev Neurol 7, 137-152.
43. Handschin C & Spiegelman BM (2008) The role of exercise and PGC1alpha in inflammation and chronic disease. Nature 454, 463-469.
44. Trichopoulou A, Orfanos P, Norat T et al. (2005) Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study. Br Med J 330, 991.
45. Sofi F, Abbate R, Gensini GF et al. (2010) Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. Am J Clin Nutr 92, 1189-1196.
46. Smith AD, Smith SM, de Jager CA et al. (2010) Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS ONE 5, e12244.
47. Mathers JC, Stanner S, Thompson R et al. (2009) Healthy Ageing: the Role of Nutrition and Lifestyle: the Report of a British Nutrition Foundation Task Force. Chichester, West Sussex; Ames, Iowa: Published by Blackwell for the British Nutrition Foundation.
48. CRD (2012) PROSPERO. http://www.crd.york.ac.uk/ PROSPERO/
49. Martin-Ruiz C, Jagger C, Kingston A et al. (2011) Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85 + study. Mech Ageing Dev 132, 496- 502.
50. Franco OH, Karnik K, Osborne G et al. (2009) Changing course in ageing research: the healthy ageing phenotype. Maturitas 63, 13-19.