Antioxidant and weight loss effects of pomegranate molasses

Journal of Applied Pharmaceutical Science

Volumn 2, Issue 6, 2012, Pages 45-50

  Chalfoun Mounayar, A ^a   Nemr, R ^b   Yared, P ^a   Khairallah, S ^a   Chahine, R ^a  

^a LEBANESE UNIVERSITY   (Lebanon)

^b MAIMONIDES MEDICAL CENTER   (United States)

Author keywords

Antioxidants; Free radicals; Pomegranate; Weight loss

Indexed keywords

EID: 84876054612     PISSN: None     EISSN: 22313354     Source Type: Journal    
DOI: 10.7324/JAPS.2012.2602     Document Type: Article

References (25)

1. Aviram M., Dornfeld L., Rosenblat M. Pomegranate juice consumption reduces oxidative stress, atherogenic modification to LDL, and platelet aggregation : studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am J Clinical Nutrition. 2000; 71: 1062-1076.
2. Aviram M., Rosenblat M., Bisgaier C.L., Newton R.S., Primo-Parmo S.L., La Du B.N. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase. J Clin Invest. 1998; 101:1581-90.
3. Aviram M., Rosenblat M., Gaitini D. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr. 2004; 23: 423-433
4. Binsack R., Boersma B.J., Patel R.P., Kirk M., White C.R., Darley-Usmar V., et al. Enhanced antioxidant activity after chlorination of quercetin by hypochlorous acid. Alcohol Clin Exp Res. 2001; 25: 434-443.
5. Brambilla D., Mancuso C., Scuderi M.R., Bosco P., Cantarella G., Lempereur L., et al. The role of antioxidant supplement in immune system, neoplastic, and neurodegenerative disorders: a point of view for an assessment of the risk/benefit profile. Nutrition Journal 2008; 7: 29-35.
6. Cerda B., Ceron J.J., Tomas-Barberan F.A., Espin J.C., Repeated oral administration of high doses of the pomegranate ellagitannin punicalagin to rats for 37 days is not toxic. J Agric Food Chem. 2003; 51: 3493-3501.
7. Chahine R., Mateescu M.A., Roger S., Yamaguchi N., De Champlain J., Nadeau R. Protective effects of ceruloplasmin against electrolysis-induced oxygen free radicals in rat heart. Canadian Journal of Physiology and Pharmacology 1991 ; 69: 1459-1464.
8. Chidambara Murthy K.N., Jayaprakasha G.K., Singh R.P. Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo models. J Agric Food Chem. 2002; 50: 4791-4795.
9. El-Nemr S.E., Ismail I.A., Ragab M. Chemical composition of juice and seeds of pomegranate fruit. Food/Nahrung 1990; 34: 601-606.
10. Gil M.I., Tomas-Barberan F.A., Hess-Pierce B., Holcroft D.M., Kader AA. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem. 2000; 48: 4581-4589.
11. Jurenka J. Therapeutic Applications of Pomegranate (Punica granatum L.): A Review. Alternative Medicine Review 2008; 13: 128-144.
12. Korkina L.G., Afanas'ev I.B. Antioxidant and chelating properties of flavonoids. Adv Pharmacol. 1997; 38: 151-163.
13. Lecours S., Chahine R., Rochette L., Nadeau R. Production of oxygen free radicals during electrolysis in rat heart. Free Radicals Biol Med. 1998; 24: 573-579.
14. Mateescu M.A., Chahine R., Roger S., Atanasiu R., Yamaguchi N., Lalumiére G., et al. Protection of myocardial tissue against deleterious effects of oxygen free radicals by ceruloplasmin. Arzneimittel-forschung 1995 ; 45 : 476-480.
15. Middleton E.Jr., Kandaswami C Theoharides T. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev. 2000; 52: 673-751.
16. Negi P.S., Jayaprakasha G.K., Jena B.S. Antioxidant and antimutagenic activities of Pomegranate peel extracts. Food Chemistry 2003; 80, 393-397.
17. Nijveldt R.J., Van Nood E., Van Hoorn D.E., Boelens P.G.,Van Norren K., Van Leeuwen P.A.. Flavonoids: a review of probabl. e mechanisms of action and potential applications. Am J Clin Nutr. 2001; 74: 418-425.
18. Pannala A.S., Rice-Evans C.A., Halliwell B., Singh S. Inhibition of peroxynitrite-mediated tyrosine nitration by catechin polyphenols. Biochem Biophys Res Commun. 1997; 232: 164-168.
19. Porrini M., Riso P. Factors influencing the bioavailability of antioxidants in foods: A critical appraisal. Nutr. Metab. Cardiovasc Dis. 2008. 18: 647-650.
20. Rosenblat M., Volkova N., Coleman R., Aviram M., Pomegranate byproduct administration to apolipoprotein e-deficient mice attenuates atherosclerosis development as a result of decreased macrophage oxidative stress and reduced cellular uptake of oxidized lowdensity lipoprotein. J Agric Food Chem. 2006; 54: 1928-1935.
21. Schubert S.Y., Lansky E.P., Neeman I. Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids. J Ethnopharmacol 1999; 66: 11-17.
22. Singelton V.R., Orthifer R., Lamuela-Raventos R.M. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods in Enzymology 1999; 299: 152-178.
23. Singh R.P., Murthy K.N.C., Jayaprakasha G.K. Studies on antioxidant activity of pomegranate (Punica granatum) peel and seed extracts using in vitro models. J Agric Food Chem. 2002; 50: 81-86.
24. Vidal A., Fallarero A., Pena B.R., Medina M.E., Gra B., Rivera F., et al. Studies on the toxicity of Punica granatum L. (Punicaceae) whole fruit extracts. J Ethnopharmacol. 2003 ; 89: 295-300.
25. Visioli F., de La Lastra C.A., Andres-Lacueva C., Aviram M., Calhau C., Cassano A., et al. Polyphenols and Human Health: A Prospectus. Critical Reviews in Food Science and Nutrition 2011; 51: 524-546.