Different mechanisms contribute to motor cortex hyperexcitability in amyotrophic lateral sclerosis

Clinical Neurophysiology

Volumn 113, Issue 11, 2002, Pages 1688-1697

  Zanette, Giampietro ^a,b   Tamburin, Stefano ^a   Manganotti, Paolo ^a   Refatti, Nicola ^a   Forgione, Antonio ^a   Rizzuto, Nicola ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY HOSPITAL OF VERONA   (Italy)

Author keywords

Amyotrophic lateral sclerosis; Intracortical inhibition; Motor cortex hyperexcitability; Transcranial magnetic stimulation

Indexed keywords

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BRAIN CORTEX; BRAIN FUNCTION; CLINICAL FEATURE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DISEASE DURATION; EVOKED MUSCLE RESPONSE; FEMALE; HUMAN; HYPERACTIVITY; INHIBITION KINETICS; MAJOR CLINICAL STUDY; MALE; MEMBRANE STEADY POTENTIAL; MOTOR CORTEX; MOTOR DYSFUNCTION; MOTOR SYSTEM; PERCEPTIVE THRESHOLD; PRIORITY JOURNAL; TRANSCRANIAL MAGNETIC STIMULATION;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; DISEASE PROGRESSION; ELECTROMYOGRAPHY; EVOKED POTENTIALS, MOTOR; FEMALE; HAND; HUMANS; MALE; MIDDLE AGED; MOTOR CORTEX; MOTOR NEURONS; PSYCHOMOTOR PERFORMANCE; PYRAMIDAL TRACTS; RECRUITMENT, NEUROPHYSIOLOGICAL;

EID: 0036848084     PISSN: 13882457     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-2457(02)00288-2     Document Type: Article

References (48)

1. Bensimon G., Lacomblez L., Meininger V., ALS/Riluzole Study Group . A controlled trial of riluzole in amyotrophic lateral sclerosis. N Engl J Med. 330:1994;585-591.
2. Brooks B.R., Bushara K., Khan A.L., et al. Functional magnetic resonance imaging (fMRI) clinical studies in ALS-paradigms, problems and promises. ALS. 1:(Suppl 2):2000;S23-S32.
3. Brouwer B., Ashby P. Corticospinal projections to upper and lower limb spinal motoneurons in man. Electroenceph clin Neurophysiol. 76:1990;509-519.
4. Brouwer B., Ashby P. Corticospinal projections to lower limb motoneurons in man. Exp Brain Res. 89:1992;649-654.
5. Caramia M.D., Palmieri M.G., Desiato M.T., et al. Pharmacological reversal of cortical hyperexcitability in patients with ALS. Neurology. 54:2000;58-64.
6. Chen R., Samii A., Caños M., Wassermann E.M., Hallett M. Effects of phenytoin on cortical excitability in humans. Neurology. 49:1997;881-883.
7. Chen R., Tam A., Butefisch C., et al. Intracortical inhibition and facilitation in different representations of the human motor cortex. J Neurophysiol. 80:1998;2870-2881.
8. Desiato M.T., Caramia M.D. Towards a neurophysiological marker of amyotrophic lateral sclerosis as revealed by changes in cortical excitability. Electroenceph clin Neurophysiol. 105:1997;1-7.
9. Devanne H., Lavoie B.A., Capaday C. Input-output properties and gain changes in the human corticospinal pathway. Exp Brain Res. 114:1997;329-338.
10. Eisen A., Weber M. The motor cortex and amyotrophic lateral sclerosis. Muscle Nerve. 24:2001;564-573.
11. Eisen A., Swash M. Clinical neurophysiology of ALS. Clin Neurophysiol. 112:2001;2190-2201.
12. Eisen A., Shytbel W., Murphy K., Hoirch M. Cortical magnetic stimulation in amyotrophic lateral sclerosis. Muscle Nerve. 13:1990;146-151.
13. Eisen A., Pant B., Stewart H. Cortical excitability in amyotrophic lateral sclerosis: a clue to pathogenesis. Can J Neurol Sci. 20:1993;11-16.
14. Eisen A., Entezari-Taher M., Stewart H. Cortical projections to spinal motoneurons: changes with aging and amyotrophic lateral sclerosis. Neurology. 46:1996;1396-1404.
15. El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis . Subcommittee on motor neuron disease/amyotrophic lateral sclerosis of the World Federation of Neurology Research Group on Neuromuscular Disease and the El-Escorial 'Clinical limits of amyotrophic lateral sclerosis' workshop contributors. J Neurol Sci. 124:(Suppl):1994;96-107.
16. Galea M.P., Darian-Smith I. Multiple corticospinal neuron populations in the macaque monkey are specified by their unique cortical origin, spinal terminations, and connections. Cereb Cortex. 4:1994;166-194.
17. Hallett M. Transcranial magnetic stimulation. Negative effects. Adv Neurol. 67:1995;107-114.
18. Hanajima R., Ugawa Y., Terao Y., Ogata K., Kanazawa I. Ipsilateral cortico-cortical inhibition of the motor cortex in various neurological disorders. J Neurol Sci. 140:1996;109-116.
19. Hess C.W., Mills K.R., Murray N.M.F. Responses in small hand muscles from magnetic stimulation of the human brain. J Physiol (Lond). 388:1987;397-419.
20. Ikoma K., Samii A., Mercuri B., Wassermann E.M., Hallett M. Abnormal cortical motor excitability in dystonia. Neurology. 46:1996;1371-1376.
21. Kew J.J., Leigh P.N., Playford E.D., Passingham R.E., Goldstein L.H., Frackowiak R.S., Brooks D.J. Cortical function in amyotrophic lateral sclerosis. A positron emission tomography study. Brain. 116:1993;655-680.
22. Kohara N., Kaji R., Kojima Y., et al. Abnormal excitability of the corticospinal pathway in patients with amyotrophic lateral sclerosis: a single motor unit study using transcranial magnetic stimulation. Electroenceph clin Neurophysiol. 101:1996;32-41.
23. Kujirai T., Caramia M.D., Rothwell J.C., et al. Corticortical inhibition in human motor cortex. J Physiol (Lond). 471:1993;501-519.
24. Miller R.G., Moore D., Young L.A., et al. Placebo-controlled trial of gabapentin in patients with amyotrophic lateral sclerosis. Neurology. 47:1996;1383-1388.
25. Mills K.R. Motor neuron disease. Studies of the corticospinal excitation of single motor neurons by magnetic brain stimulation. Brain. 118:1995;971-982.
26. Mills K.R. Corticomotoneuronal PSTH studies. Muscle Nerve. 22:1999;297-298.
27. Mills K.R., Nithi K.A. Corticomotor threshold is reduced in early sporadic amyotrophic lateral sclerosis. Muscle Nerve. 20:1997;1137-1141.
28. Nakajima M., Eisen A., McCarthy R., Olney R.K., Aminoff M.J. Reduced corticomotoneuronal excitatory postsynaptic potentials (EPSPs) with normal Ia afferent EPSPs in amyotrophic lateral sclerosis. Neurology. 47:1996;1555-1561.
29. Nakamura H., Kitagawa H., Kawaguchi Y., Tsuji H. Intracortical facilitation and inhibition after transcranial magnetic stimulation in conscious humans. J Physiol (Lond). 498:1997;817-823.
30. Nihei K., McKee A.C., Kowall N.W. Patterns of neuronal degeneration in the motor cortex of amyotrophic lateral sclerosis patients. Acta Neuropathol (Berl). 86:(1):1993;55-64.
31. Palmer E., Ashby P. Corticospinal projections to upper limb motoneurones in humans. J Physiol (Lond). 448:1992;397-412.
32. Prout A.J., Eisen A. The cortical silent period and amyotrophic lateral sclerosis. Muscle Nerve. 17:1994;217-223.
33. Ridding M.C., Rothwell J.C. Stimulus/response curves as a method of measuring motor cortical excitability in man. Electroenceph clin Neurophysiol. 105:(5):1997;340-344.
34. Ridding M.C., Taylor J.L., Rothwell J.C. The effect of voluntary contraction on cortico-cortical inhibition in human motor cortex. J Physiol (Lond). 487:1995;541-548.
35. Rossini P., Barker A., Berardelli A., et al. Non invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of IFCN committee. Electroenceph clin Neurophysiol. 91:1994;79-92.
36. Rothman K.J. No adjustments are needed for multiple comparisons. Epidemiology. 1:1990;43-46.
37. Rothstein J.D. Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis. Adv Neurol. 68:1995;7-20.
38. Rowland L.P., Shneider N.A. Amyotrophic lateral sclerosis. N Engl J Med. 344:(22):2001;1688-1700.
39. Salerno A., Georgesco M. Double magnetic stimulation of the motor cortex in amyotrophic lateral sclerosis. Electroenceph clin Neurophysiol. 107:1998;133-139.
40. Stefan K., Kunesch E., Benecke R., Classen J. Effects of riluzohe on cortical excitability in patients with amyotrophic lateral sclerosis. Ann Neurol. 49:2001;537-540.
41. Triggs W.J., Menkes D., Onorato J., et al. Transcranial magnetic stimulation identifies upper motor neuron involvement in motor neuron disease. Neurology. 53:1999;605-611.
42. Valls-Solé J., Pascual-Leone A., Brazil-Neto N.J., Cammarota A., McShane L., Hallett M. Abnormal facilitation of the response to transcranial magnetic stimulation in patients with Parkinson's disease. Neurology. 44:1994;735-741.
43. Weber M., Eisen A., Nakajima M. Corticomotoneuronal activity in ALS. Changes in the peristimulus time histogram over time. Clin Neurophysiol. 111:2000;169-177.
44. Yokota T., Yoshino A., Inaba A., Saito Y. Double cortical stimulation in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 61:1996;596-600.
45. Zeman S., Lloyd C., Meldrum B., Leigh P.N. Excitatory aminoacids, free radicals and the pathogenesis of motor neuron disease. Neuropathol Appl Neurobiol. 20:1994;219-231.
46. Ziemann U., Lönnecker S., Steinhoff B.J., Paulus W. Effects of antiepileptic drugs on motor cortex excitability in humans: a trancranial magnetic stimulation study. Ann Neurol. 40:1996;367-378.
47. Ziemann U., Rothwell J.C., Ridding M.C. Interaction between intracortical inhibition and facilitation in human motor cortex. J Physiol (Lond). 496:1996;873-881.
48. Ziemann U., Winter M., Reimers C.D., Reimers K., Tergau F., Paulus W. Impaired motor cortex inhibition in patients with amyotrophic lateral sclerosis. Evidence from paired transcranial magnetic stimulation. Neurology. 49:1997;1292-1298.