Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 15, 2013, Pages 5963-5968

  Gupta, Amit ^a   Toscano, Sarah ^b   Trivedi, Deepti ^b   Jones, David R ^c   Mathre, Swarna ^a   Clarke, Jonathan H ^d   Divecha, Nullin ^c   Raghu, Padinjat ^a,b  

^a TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

^b BABRAHAM INSTITUTE   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 5 PHOSPHATE 4 KINASE; PHOSPHOTRANSFERASE; TARGET OF RAPAMYCIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; CELL SIZE; CONTROLLED STUDY; DROSOPHILA; LARVAL DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WEIGHT REDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CELL PROLIFERATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN INTERACTION DOMAINS AND MOTIFS; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; TOR SERINE-THREONINE KINASES;

EID: 84876023059     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1219333110     Document Type: Article

References (31)

1. Church RB, Robertson FW (1966) Biochemical analysis of genetic differences in the growth of Drosophila. Genet Res 7(3):383-407.
2. Mirth CK, Riddiford LM (2007) Size assessment and growth control: How adult size is determined in insects. Bioessays 29(4):344-355.
3. Edgar BA (2006) How flies get their size: Genetics meets physiology. Nat Rev Genet 7(12):907-916.
4. Engelman JA, Luo J, Cantley LC (2006) The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 7(8):606-619.
5. Backer JM (2008) The regulation and function of Class III PI3Ks: Novel roles for Vps34. Biochem J 410(1):1-17.
6. Nobukuni T, et al. (2005) Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci USA 102(40):14238-14243.
7. Hinchliffe KA, Ciruela A, Irvine RF (1998) PIPkins1, their substrates and their products: new functions for old enzymes. Biochim Biophys Acta 1436(1-2):87-104.
8. Rameh LE, Tolias KF, Duckworth BC, Cantley LC (1997) A new pathway for synthesis of phosphatidylinositol-4, 5-bisphosphate. Nature 390(6656):192-196.
9. Zhang X, et al. (1997) Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules. J Biol Chem 272(28):17756-17761.
10. van den Bout I, Divecha N (2009) PIP5K-driven PtdIns (4, 5) P2 synthesis: Regulation and cellular functions. J Cell Sci 122(Pt 21):3837-3850.
11. Homma K, et al. (1998) Phosphatidylinositol-4-phosphate 5-kinase localized on the plasma membrane is essential for yeast cell morphogenesis. J Biol Chem 273(25):15779-15786.
12. Kunz J, Fuelling A, Kolbe L, Anderson RA (2002) Stereo-specific substrate recognition by phosphatidylinositol phosphate kinases is swapped by changing a single amino acid residue. J Biol Chem 277(7):5611-5619.
13. Kunz J, et al. (2000) The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity. Mol Cell 5(1):1-11.
14. Clarke JH, Wang M, Irvine RF (2010) Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases. Adv Enzyme Regul 50(1):12-18.
15. Ciruela A, Hinchliffe KA, Divecha N, Irvine RF (2000) Nuclear targeting of the beta isoform of type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its alpha-helix 7. Biochem J 346(Pt 3):587-591.
16. Jones DR, et al. (2006) Nuclear PtdIns5P as a transducer of stress signaling: An in vivo role for PIP4Kbeta. Mol Cell 23(5):685-695.
17. Carricaburu V, et al. (2003) The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3, 4, 5-trisphosphate degradation. Proc Natl Acad Sci USA 100(17):9867-9872.
18. Lamia KA, et al. (2004) Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/-mice. Mol Cell Biol 24(11):5080-5087.
19. Clarke JH, Emson PC, Irvine RF (2008) Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron. Am J Physiol Renal Physiol 295(5):F1422-F1430.
20. Rao VD, Misra S, Boronenkov IV, Anderson RA, Hurley JH (1998) Structure of type IIbeta phosphatidylinositol phosphate kinase: A protein kinase fold flattened for interfacial phosphorylation. Cell 94(6):829-839.
21. Morris JB, Hinchliffe KA, Ciruela A, Letcher AJ, Irvine RF (2000) Thrombin stimulation of platelets causes an increase in phosphatidylinositol 5-phosphate revealed by mass assay. FEBS Lett 475(1):57-60.
22. Montagne J, et al. (1999) Drosophila S6 kinase: A regulator of cell size. Science 285(5436):2126-2129.
23. Proud CG (2009) mTORC1 signalling and mRNA translation. Biochem Soc Trans 37(Pt 1):227-231.
24. Loewith R, et al. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10(3):457-468.
25. Zhang H, Stallock JP, Ng JC, Reinhard C, Neufeld TP (2000) Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev 14(21):2712-2724.
26. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307(5712):1098-1101.
27. Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J (2005) Rheb binds and regulates the mTOR kinase. Curr Biol 15(8):702-713.
28. Ikeya T, Galic M, Belawat P, Nairz K, Hafen E (2002) Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila. Curr Biol 12(15):1293-1300.
29. Sarkes D, Rameh LE (2010) A novel HPLC-based approach makes possible the spatial characterization of cellular PtdIns5P and other phosphoinositides. Biochem J 428(3):375-384.
30. Gozani O, et al. (2003) The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell 114(1):99-111.
31. Ramel D, et al. (2009) PtdIns5P protects Akt from dephosphorylation through PP2A inhibition. Biochem Biophys Res Commun 387(1):127-131.