The anti-mitotic drug griseofulvin induces apoptosis of human germ cell tumor cells through a connexin 43-dependent molecular mechanism

Apoptosis

Volumn 18, Issue 4, 2013, Pages 480-491

  Mauro, V ^a,b   Carette, D ^a,b   Pontier Bres, R ^a,b   Dompierre, J ^c   Czerucka, D ^a,b   Segretain, D ^c,d   Gilleron, J ^a,c   Pointis, G ^a,b  

^a CENTRE MÉDITERRANÉEN DE MÉDECINE MOLÉCULAIRE C3M   (France)

^b UNIVERSITÉ CÔTE D'AZUR   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

Author keywords

Caspase; Cell death; Connexin 43; Griseofulvin; Nuclear effect

Indexed keywords

CASPASE 3; CASPASE 9; CONNEXIN 43; GRISEOFULVIN; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CHANNEL GATING; CONTROLLED STUDY; CYTOPLASM; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; GAP JUNCTION; GERM CELL TUMOR; HUMAN; HUMAN CELL; IC 50; IMMUNOLOCALIZATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

ANTIMITOTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CONNEXIN 43; GRISEOFULVIN; HUMANS; MICROTUBULES; MITOCHONDRIA; NEOPLASMS, GERM CELL AND EMBRYONAL; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; TUBULIN;

MUS;

EID: 84876014421     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-012-0800-8     Document Type: Article

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