Alterations in Connexin26 expression during colorectal carcinogenesis

Oncology

Volumn 68, Issue 2-3, 2005, Pages 217-222

  Kanczuga Koda, Luiza ^a   Sulkowski, Stanislaw ^a   Koda, Mariusz ^a   Sulkowska, Mariola ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Adenoma; Carcinogenesis; Colorectal cancer; Connexin26

Indexed keywords

CONNEXIN 26; MEMBRANE PROTEIN; GAP JUNCTION PROTEIN;

ADENOMA; ADULT; AGED; ARTICLE; CARCINOGENESIS; COLON MUCOSA; COLORECTAL CARCINOMA; CONTROLLED STUDY; CYTOPLASM; EPITHELIUM; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE EPITHELIUM; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING; TISSUE SECTION; TUMOR CELL; TUMOR LOCALIZATION; CELL COMMUNICATION; CELL JUNCTION; COLORECTAL TUMOR; GENE EXPRESSION REGULATION; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADULT; AGED; AGED, 80 AND OVER; CELL COMMUNICATION; COLORECTAL NEOPLASMS; CONNEXINS; CYTOPLASM; FEMALE; GAP JUNCTIONS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED;

EID: 16344383162     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000086777     Document Type: Article

References (25)

1. Willecke K, Eiberger J, Degen J, Eckardt D, Romualdi A, Guldenagel M, Deutsch U, Sohl G: Structural and functional diversity of connexin genes in the mouse and human genome. Biol Chem 2002;383:725-737.
2. Krutovskikh VA, Piccoli C, Yamasaki H: Gap junction intercellular communication propagates cell death in cancerous cells. Oncogene 2002;21:1989-1999.
3. Trosko JE, Chang CC: Mechanism of up-regulated gap junctional intercellular communication during chemoprevention and chemotherapy of cancer. Mutat Res 2001;480-481:219-229.
4. Wilgenbus KK, Kirkpatrick CJ, Knuechel R, Willecke K, Traub O: Expression of Cx26, Cx32 and Cx43 gap junction proteins in normal and neoplastic human tissues. Int J Cancer 1992;51:522-529.
5. Trosko JE, Ruch RJ: Cell-cell communication in carcinogenesis. Front Biosci 1998;3:208-236.
6. Yamasaki H, Naus CC: Role of connexin genes in growth control. Carcinogenesis 1996;17:1199-1213.
7. Naus CCG: Gap junctions and tumour progression. Can J Physiol Pharmacol 2002;80:136-141.
8. Huang RP, Fan Y, Hossain MZ, Peng A, Zeng ZL, Boynton AL: Reversion of the neoplastic phenotype of human glioblastoma cells by connexin43 (Cx43). Cancer Res 1998;58:5089-5096.
9. Giepmans BN, Moolenaar WH: The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein. Curr Biol 1998;8:931-934.
10. Loo LW, Kanemitsu MY, Lau AF: In vivo association of pp60v-src and the gap-junction protein connexin43 in v-src-transformed fibroblasts. Mol Carcinog 1999;25:187-195.
11. Dubina MV, Iatckii NA, Popov DE, Vasil'ev SV, Krutovskikh VA: Connexin43, but not connexin32, is mutated at advanced stages of human sporadic colon cancer. Oncogene 2002;21:4992-4996.
12. Koda M, Sulkowski S, Garofalo C, Kanczuga-Koda L, Sulkowska M: Expression of the insulin-like growth factor-I receptor in primary breast cancer and lymph node metastases: Correlations with estrogen receptors alpha and beta. Horm Metab Res 2003;35:794-801.
13. Falk MM: Biosynthesis and structural composition of gap junction intercellular membrane channels. Eur J Cell Biol 2000;79:564-574.
14. Evans WH, Martin PE: Gap junctions: Structure and function (review). Mol Membr Biol 2002;19:121-136.
15. Jamieson S, Going JJ, D'Arcy R, George WD: Expression of gap junction proteins connexin26 and connexin43 in normal human breast and in breast tumours. J Pathol 1998;184:37-43.
16. Laird DW, Fistouris P, Batist G, Alpert L, Huynh HT, Carystinos GD, Alaoui-Jamali MA: Deficiency of connexin43 gap junctions is an independent marker for breast tumors. Cancer Res 1999;59:4104-4110.
17. Umhauer S, Ruch RJ, Fanning J: Gap junctional intercellular communication and connexin43 expression in ovarian carcinoma. Am J Obstet Gynecol 2000;182:999-1000.
18. Gee J, Tanaka M, Grossman HB: Connexin26 is abnormally expressed in bladder cancer. J Urol 2003;169:1135-1137.
19. Krutovskikh VA, Troyanovsky SM, Piccoli C, Tsuda H, Asamoto M, Yamasaki H: Differential effect of subcellular localization of communication impairing gap junction protein connexin43 on tumor cell growth in vivo. Oncogene 2000;19:505-513.
20. Defamie N, Mograbi B, Roger C, Cronier L, Malassine A, Brucker-Davis F, Fenichel P, Segretain D, Pointis G: Disruption of gap junctional intercellular communication by lindane is associated with aberrant localization of connexin43 and zonula occludens-1 in 42GPA9 Sertoli cells. Carcinogenesis 2001;22:1537-1542.
21. Olbina G, Eckhart W: Mutations in the second extracellular region of connexin43 prevent localization to the plasma membrane, but do not affect its ability to suppress cell growth. Mol Cancer Res 2003;1:690-700.
22. Ito A, Katoh F, Kataoka TR, Okada M, Tsubota N, Asada H, Yoshikawa K, Maeda S, Kitamura Y, Yamasaki H, Nojima H: A role for heterologous gap junctions between melanoma and endothelial cells in metastasis. J Clin Invest 2000;105:1189-1197.
23. Saunders MM, Seraj MJ, Li Z, Zhou Z, Winter CR, Welch DR, Donahue HJ: Breast cancer metastatic potential correlates with a breakdown in homospecific and heterospecific gap junctional intercellular communication. Cancer Res 2001;61:1765-1767.
24. King TJ, Fukushima LH, Hieber AD, Shimabukuro KA, Sakr WA, Bertram JS: Reduced levels of connexin43 in cervical dysplasia: Inducible expression in a cervical carcinoma cell line decreases neoplastic potential with implications for tumor progression. Carcinogenesis 2000;21:1097-1109.
25. Habermann H, Ray V, Habermann W, Prins GS: Alterations in gap junction protein expression in human benign prostatic hyperplasia and prostate cancer. J Urol 2001;166:2267-2272.