Regenerating i messenger RNA and protein expression in the failing human testis: A potential molecular prognostic marker of seminoma

Human Pathology

Volumn 42, Issue 12, 2011, Pages 1841-1848

  Mauro, Virginie ^a   Volle, David H ^a   Chevallier, Daniel ^b   Haudebourg, Juliette ^b   Sénégas Balas, Françoise ^a   Pointis, Georges ^a  

^a INSERM   (France)

^b PASTEUR HOSPITAL   (France)

Author keywords

Azoospermia; Marker; Reg I; Seminoma; Testis

Indexed keywords

ALKALINE PHOSPHATASE; MESSENGER RNA; REGENERATING I PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; AZOOSPERMIA; CLINICAL ARTICLE; CONTROLLED STUDY; GERM CELL; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; MALE; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEMINIFEROUS TUBULE; SEMINOMA; SERTOLI CELL; SPERMATOGENESIS; TESTIS BIOPSY; WESTERN BLOTTING;

ADULT; AZOOSPERMIA; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LITHOSTATHINE; MALE; MIDDLE AGED; PROGNOSIS; RNA, MESSENGER; SEMINOMA; TESTICULAR NEOPLASMS; TESTIS; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION; YOUNG ADULT;

EID: 80955165978     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2010.05.033     Document Type: Article

References (38)

1. Kinoshita Y., Ishihara S., Kadowaki Y., Fukui H., and Chiba T. Reg protein is a unique growth factor of gastric mucosal cells J Gastroenterol 39 2004 507 513 (Pubitemid 38996891)
2. Zhang Y.W., Ding L.S., and Lai M.D. Reg gene family and human diseases World J Gastroenterol 9 2003 2635 2641
3. Iovanna J.L., and Dagorn J.C. The multifunctional family of secreted proteins containing a C-type lectin-like domain linked to a short N-terminal peptide Biochim Biophys Acta 1723 2005 8 18 (Pubitemid 40744667)
4. Zhang Y.W., Ding L.S., and Lai M.D. Reg gene family and human diseases World J Gastroenterol 12 2003 2635 2641
5. Takehara A., Eguchi H., and Ohigashi H. Novel tumor marker REG4 detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4 Cancer Sci 11 2006 1191 1197 (Pubitemid 44430644)
6. Mitani Y., Oue N., and Matsumura S. Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy Oncogene 26 2007 4383 4393 (Pubitemid 47014457)
7. Nata K., Liu Y., and Xu L. Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III Gene 340 2004 161 170 (Pubitemid 39360242)
8. Hayashi T., Matsubara A., and Ohara S. Immunohistochemical analysis of Reg IV in urogenital organs: frequent expression of Reg IV in prostate cancer and potential utility as serum tumor marker Oncol Rep 21 2009 95 100
9. Ohara S., Oue N., and Matsubara A. Reg IV is an independent prognostic factor for relapse in patients with clinically localized prostate cancer Cancer Sci 99 2008 1570 1577
10. Bray F., Richiardi L., Ekbom A., Pukkala E., Cuninkova M., and Moller H. Trends in testicular cancer incidence and mortality in 22 European countries: continuing increases in incidence and declines in mortality Int J Cancer 118 2006 3099 3111
11. Mauro V., Carette D., and Chevallier D. Reg I protein in healthy and seminoma human testis Histol Histopathol 23 2008 1195 1203
12. Van de Geijn G.J., Hersmus R., and Looijenga L.H. Recent developments in testicular germ cell tumor research Birth Defects Res C Embryo Today 87 2009 96 113
13. Fukui H., Fujii S., and Takeda J. Expression of Reg I protein in human gastric cancers Digestion 69 2004 177 184 (Pubitemid 38813027)
14. Dhar D.K., Udagawa J., and Ishihara S. Expression of regenerating gene I in gastric adenocarcinomas: correlation with tumor differentiation status and patient survival Cancer 100 2004 1130 1136 (Pubitemid 38325939)
15. Rechreche H., Montalto G., and Mallo G.V. Pap, reg I alpha and reg I beta mRNAs are concomitantly up-regulated during human colorectal carcinogenesis Int J Cancer 81 1999 688 694 (Pubitemid 29214374)
16. Sekikawa A., Fukui H., and Fujii S. Possible role of REG I alpha protein in ulcerative colitis and colitic cancer Gut 54 2005 1437 1444 (Pubitemid 41375201)
17. Harada K., Zen Y., and Kanemori Y. Human REG I gene is up-regulated in intrahepatic cholangiocarcinoma and its precursor lesions Hepatology 33 2001 1036 1042 (Pubitemid 32378199)
18. Skakkebaek N.E., Rajpert-De Meyts E., and Main K.M. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects Hum Reprod 16 2001 972 978 (Pubitemid 32451837)
19. Bernard-Perrone F., Renaud W., and Guy-Crotte O. Expression of the Reg I protein during cell growth and differentiation of two colon carcinoma cells J Histochem Cytochem 47 1999 863 870 (Pubitemid 29310077)
20. Lange P.H., Millan J.L., Stigbrand T., Vessella R.L., Ruoslahti E., and Fishman W.H. Placental alkaline phosphatase as a tumour marker for seminoma Cancer Res 42 1982 3244 3247 (Pubitemid 12041086)
21. Bergmann M., and Kliesch S. The distribution pattern of cytokeratin and vimentin immunoreactivity in testicular biopsies of infertile men Anat Embryol 190 1994 515 520 (Pubitemid 24359590)
22. Raman J.D., Nobert C.F., and Goldstein M. Increased incidence of testicular cancer in men presenting with infertility and abnormal semen analysis J Urol 174 2005 1819 1822 (Pubitemid 41546950)
23. Walsh T., Croughan M., Schembri M., Chan J., and Turek P. Increased risk of testicular germ cell cancer among infertile men MD Arch Intern Med 169 2009 351 356
24. Peng X., Zeng X., Peng S., Deng D., and Zhang J. The association risk of male subfertility and testicular cancer: a systematic review PLoS One e5591 2009 4
25. Hotaling J.M., and Walsh T.J. Male infertility: a risk factor for testicular cancer Nat Rev Urol 10 2009 550 556
26. Lawrance I.C., Fiocchi C., and Chakravarti S. Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes Hum Mol Genet 10 2001 445 456 (Pubitemid 32181667)
27. Dieckgraefe B.K., Crimmins D.L., and Landt V. Expression of the regenerating gene family in inflammatory bowel disease mucosa: Reg Ialpha upregulation, processing, and antiapoptotic activity J Investig Med 50 2002 421 434 (Pubitemid 35278683)
28. Kiji T., Dohi Y., Takasawa S., Okamoto H., Nonomura A., and Taniguchi S. Activation of regenerating gene Reg in rat and human hearts in response to acute stress Am J Physiol Heart Circ Physiol 289 2005 277 284
29. Terazono K., Yamamoto H., and Takasawa S. A novel gene activated in regenerating islets J Biol Chem 263 1988 2111 2114 (Pubitemid 18060259)
30. Zenilman M.E., Magnuson T.H., Swinson K., Egan J., Perfetti R., and Shuldiner A.R. Pancreatic thread protein is mitogenic to pancreatic-derived cells in culture Gastroenterology 110 1996 1208 1214 (Pubitemid 26113761)
31. Oue N., Kuniyasu H., and Noguchi T. Serum concentration of Reg IV in patients with colorectal cancer: overexpression and high serum levels of Reg IV are associated with liver metastasis Oncology 72 2007 371 380 (Pubitemid 351238152)
32. Sasahira T., Oue N., and Kirita T. Reg IV expression is associated with cell growth and prognosis of adenoid cystic carcinoma in the salivary gland Histopathology 53 2008 667 675 (Pubitemid 352768720)
33. Neuvians T.J., Gashaw I., and Sauer C.G. Standardization strategy for quantitative PCR in human seminoma and normal testis J Biotechnol 117 2005 163 171 (Pubitemid 40488706)
34. Słowikowska-Hilczer J., Walczak-Jedrzejowska R., and Kula K. Immunohistochemical diagnosis of preinvasive germ cell cancer of the testis Folia Histochem Cytobiol 39 2001 67 72 (Pubitemid 32377379)
35. Brehm R., Marks A., Rey R., Kliesch S., Bergmann M., and Steger K. Altered expression of connexins 26 and 43 in Sertoli cells in seminiferous tubules infiltrated with carcinoma-in-situ or seminoma J Pathol 197 2002 647 653
36. Richiardi L., Bellocco R., and Adami H.O. Testicular cancer incidence in eight northern European countries: secular and recent trends Cancer Epidemiol Biomarkers Prev 12 2004 2157 2166 (Pubitemid 40054312)
37. Favilla V., Cimino S., Madonia M., and Morgia G. New advances in clinical biomarkers in testis cancer.New advances in clinical biomarkers in testis cancer Front Biosci 1 2010 456 477
38. Trigo J.M., Tabernero J.M., and Paz-Ares L. Tumor markers at the time of recurrence in patients with germ cell tumors Cancer 1 2000 162 168 (Pubitemid 30027692)