Agonistic Anti-CD40 induces thyrocyte proliferation and promotes thyroid autoimmunity by increasing CD40 expression on thyroid epithelial cells

Journal of Immunology

Volumn 190, Issue 8, 2013, Pages 3928-3938

  Kayes, Timothy ^a   Fang, Yujiang ^a   Yu, Shiguang ^b   Downey, Edward ^a   Wang, Shufang ^a   Braley Mullen, Helen ^a  

^a University of Missouri   (United States)

^b ARKANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIBODY; CD40 ANTIGEN; GAMMA INTERFERON; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE THYROIDITIS; BONE MARROW; CELL PROLIFERATION; CHIMERA; CONTROLLED STUDY; CYTOKINE PRODUCTION; EPITHELIUM CELL; FIBROSIS; HYPERTHYROIDISM; INFLAMMATION; LYMPHOID CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYROID CELL;

ANIMALS; ANTIBODIES; ANTIGENS, CD40; AUTOIMMUNITY; CELL PROLIFERATION; EPITHELIAL CELLS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, INBRED DBA; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; PRIMARY CELL CULTURE; THYROID GLAND;

EID: 84876009063     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1202929     Document Type: Article

References (38)

1. Kobawala, T. P., G. H. Patel, D. R. Gajjar, K. N. Patel, P. B. Thakor, U. B. Parekh, K. M. Patel, S. N. Shukla, and P. M. Shah. 2011. Clinical utility of serum interleukin-8 and interferon-alpha in thyroid diseases. J. Thyroid Res. 2011: 270149.
2. Asa, S. L. 2004. My approach to oncocytic tumours of the thyroid. J. Clin. Pathol. 57: 225-232.
3. DeMay, R. M. 2000. Follicular lesions of the thyroid. W(h)ither follicular carcinoma? Am. J. Clin. Pathol. 114: 681-683.
4. Derwahl, M., and H. Studer. 2002. Hyperplasia versus adenoma in endocrine tissues: are they different? Trends Endocrinol. Metab. 13: 23-28.
5. -/- mice. Oncogene 20: 3235-3246.
6. Yu, S., G. C. Sharp, and H. Braley-Mullen. 2002. Dual roles for IFN-gamma, but not for IL-4, in spontaneous autoimmune thyroiditis in NOD.H-2h4 mice. J. Immunol. 169: 3999-4007.
7. Yu, S., Y. Fang, T. Sharav, G. C. Sharp, and H. Braley-Mullen. 2011. CD8+ T cells induce thyroid epithelial cell hyperplasia and fibrosis. J. Immunol. 186: 2655-2662.
8. Yu, S., G. C. Sharp, and H. Braley-Mullen. 2006. Thyroid epithelial cell hy-perplasia in IFN-gamma deficient NOD.H-2h4 mice. Clin. Immunol. 118: 92-100.
9. -/-) mice by down-regulation of p21 and p27 via AKT pathway. Am. J. Pathol. 180: 650-660.
10. Yu, S., G. C. Sharp, and H. Braley-Mullen. 2008. TGF-beta promotes thyroid epithelial cell hyperplasia and fibrosis in IFN-gamma-deficient NOD.H-2h4 mice. J. Immunol. 181: 2238-2245.
11. Bennett, S. R., F. R. Carbone, F. Karamalis, R. A. Flavell, J. F. Miller, and W. R. Heath. 1998. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 393: 478-480.
12. French, R. R., H. T. Chan, A. L. Tutt, and M. J. Glennie. 1999. CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help. Nat. Med. 5: 548-553.
13. Uhlig, H. H., B. S. McKenzie, S. Hue, C. Thompson, B. Joyce-Shaikh, R. Stepankova, N. Robinson, S. Buonocore, H. Tlaskalova-Hogenova, D. J. Cua, and F. Powrie. 2006. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 25: 309-318.
14. Shameli, A., X. Clemente-Casares, J. Wang, and P. Santamaria. 2011. Development of memory-like autoregulatory CD8+ T cells is CD4+ T cell dependent. J. Immunol. 187: 2859-2866.
15. Baker, R. L., D. H. Wagner, Jr., and K. Haskins. 2008. CD40 on NOD CD4 T cells contributes to their activation and pathogenicity. J. Autoimmun. 31: 385-392.
16. Barbe-Tuana, F. M., D. Klein, H. Ichii, D. M. Berman, L. Coffey, N. S. Kenyon, C. Ricordi, and R. L. Pastori. 2006. CD40-CD40 ligand interaction activates proinflammatory pathways in pancreatic islets. Diabetes 55: 2437-2445.
17. Peters, A. L., L. L. Stunz, and G. A. Bishop. 2009. CD40 and autoimmunity: the dark side of a great activator. Semin. Immunol. 21: 293-300.
18. Ponomarev, E. D., L. P. Shriver, and B. N. Dittel. 2006. CD40 expression by microglial cells is required for their completion of a two-step activation process during central nervous system autoimmune inflammation. J. Immunol. 176: 1402-1410.
19. Smith, T. J., D. Sciaky, R. P. Phipps, and T. A. Jennings. 1999. CD40 expression in human thyroid tissue: evidence for involvement of multiple cell types in autoimmune and neoplastic diseases. Thyroid 9: 749-755.
20. Grewal, I. S., and R. A. Flavell. 1998. CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 16: 111-135.
21. Huber, A. K., F. D. Finkelman, C. W. Li, E. Concepcion, E. Smith, E. Jacobson, R. Latif, M. Keddache, W. Zhang, and Y. Tomer. 2012. Genetically driven target tissue overexpression of CD40: a novel mechanism in autoimmune disease. J. Immunol. 189: 3043-3053.
22. Metcalfe, R. A., R. S. McIntosh, F. Marelli-Berg, G. Lombardi, R. Lechler, and A. P. Weetman. 1998. Detection of CD40 on human thyroid follicular cells: analysis of expression and function. J. Clin. Endocrinol. Metab. 83: 1268-1274.
23. Beatty, G. L., E. G. Chiorean, M. P. Fishman, B. Saboury, U. R. Teitelbaum, W. Sun, R. D. Huhn, W. Song, D. Li, L. L. Sharp, et al. 2011. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 331: 1612-1616.
24. Khalil, M., and R. H. Vonderheide. 2007. Anti-CD40 agonist antibodies: preclinical and clinical experience. Update Cancer Ther. 2: 61-65.
25. Khong, A., D. J. Nelson, A. K. Nowak, R. A. Lake, and B. W. Robinson. 2012. The use of agonistic anti-CD40 therapy in treatments for cancer. Int. Rev. Immunol. 31: 246-266.
26. Murugaiyan, G., S. Martin, and B. Saha. 2007. CD40-induced countercurrent conduits for tumor escape or elimination? Trends Immunol. 28: 467-473.
27. Inoue, Y., T. Kaifu, A. Sugahara-Tobinai, A. Nakamura, J. Miyazaki, and T. Takai. 2007. Activating Fc gamma receptors participate in the development of autoimmune diabetes in NOD mice. J. Immunol. 179: 764-774.
28. Tang, H., G. C. Sharp, K. Chen, and H. Braley-Mullen. 1998. The kinetics of cytokine gene expression in the thyroids of mice developing granulomatous experimental autoimmune thyroiditis. J. Autoimmun. 11: 581-589.
29. Yu, S., G. C. Sharp, and H. Braley-Mullen. 2006. Thyrocytes responding to IFN-gamma are essential for development of lymphocytic spontaneous autoimmune thyroiditis and inhibition of thyrocyte hyperplasia. J. Immunol. 176: 1259-1265.
30. Li, F., and J. V. Ravetch. 2011. Inhibitory Fcγ receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies. Science 333: 1030-1034.
31. Yip, I., X. P. Pang, L. Berg, and J. M. Hershman. 1995. Antitumor actions of interferon-gamma and interleukin-1 beta on human papillary thyroid carcinoma cell lines. J. Clin. Endocrinol. Metab. 80: 1664-1669.
32. White, A. L., H. T. Chan, A. Roghanian, R. R. French, C. I. Mockridge, A. L. Tutt, S. V. Dixon, D. Ajona, J. S. Verbeek, A. Al-Shamkhani, et al. 2011. Interaction with FcgRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody. J. Immunol. 187: 1754-1763.
33. Estienne, V., C. Duthoit, M. Reichert, A. Praetor, P. Carayon, W. Hunziker, and J. Ruf. 2002. Androgen-dependent expression of FcgRIIB2 by thyrocytes from patients with autoimmune Graves' disease: a possible molecular clue for sex dependence of autoimmune disease. FASEB J. 16: 1087-1092.
34. Correze, C., J. P. Blondeau, and M. Pomerance. 2005. p38 mitogen-activated protein kinase contributes to cell cycle regulation by cAMP in FRTL-5 thyroid cells. Eur. J. Endocrinol. 153: 123-133.
35. McLachlan, S. M., J. Taverne, M. C. Atherton, A. Cooke, S. Middleton, C. A. Pegg, F. Clark, and B. Rees Smith. 1990. Cytokines, thyroid autoantibody synthesis and thyroid cell survival in culture. Clin. Exp. Immunol. 79: 175-181.
36. Tomer, Y., E. Concepcion, and D. A. Greenberg. 2002. A C/T single-nucleotide polymorphism in the region of the CD40 gene is associated with Graves' disease. Thyroid 12: 1129-1135.
37. Becher, B., B. G. Durell, A. V. Miga, W. F. Hickey, and R. J. Noelle. 2001. The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system. J. Exp. Med. 193: 967-974.
38. Roth, E., J. Schwartzkopff, and H. Pircher. 2002. CD40 ligation in the presence of self-reactive CD8 T cells leads to severe immunopathology. J. Immunol. 168: 5124-5129.