The kinetics of cytokine gene expression in the thyroids of mice developing granulomatous experimental autoimmune thyroiditis

Journal of Autoimmunity

Volumn 11, Issue 6, 1998, Pages 581-589

  Tang, Haiwen ^a   Sharp, Gordon C ^a   Chen, Kemin ^a   Braley Mullen, Helen ^a,b  

^a University of Missouri   (United States)

^b DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

Autoimmunity; CD8+ T cells; Cytokine; In vivo animal models; Th1 Th2

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; EXPERIMENTAL MODEL; GENE EXPRESSION; GRANULOMATOSIS; HASHIMOTO DISEASE; HELPER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0032417347     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1998.0247     Document Type: Article

References (47)

1. Charreire J. Immune mechanisms in autoimmune thyroiditis. Adv. Immunol. 46:1989;263-334.
2. Braley-Mullen H., Johnson M., Sharp G.C., Kyriakos M. Induction of experimental autoimmune thyroiditis (EAT) in mice within vitro. Cell. Immunol. 93:1985;132-143.
3. Braley-Mullen H., Sharp G.C., Bickel J.T., Kyriakos M. Induction of severe granulomatous experimental autoimmune thyroiditis in mice by effector cells activated in the presence of anti-interleukin 2 receptor antibody. J. Exp. Med. 173:1991;899-912.
4. Braley-Mullen H., Sharp G.C., Tang H., Kyriakos M., Bickel J.T. IL-12 promotes activation of effector cells that induce a severe destructive granulomatous form of experimental autoimmune thyroiditis. Am. J. Pathol. 152:1998;1347-1358.
5. +. Cell. Immunol. 153:1994;492-504.
6. Stull S.J., Sharp G.C., Kyriakos M., Bickel J.T., Braley-Mullen H. Induction of granulomatous experimental autoimmune thyroiditis in mice within vitro. J. Immunol. 149:1992;2219-2226.
7. Tang H., Sharp G.C., Peterson K.E., Braley-Mullen H. Induction of granulomatous experimental autoimmune thyroiditis in IL-4 gene disrupted mice. J. Immunol. 160:1998;155-162.
8. Tang H., Sharp G.C., Peterson K.E., Braley-Mullen H. IFN-γ deficient mice develop severe granulomatous experimental autoimmune thyroiditis with eosinophil infiltration in thyroids. J. Immunol. 160:1998;5105-5112.
9. Chensue S.W., Ruth J.H., Warmington K., Lincoln P., Kunkel S.L. In vivo. J. Immunol. 155:1995;3546-3551.
10. Chensue S.W., Warmington K., Ruth J., Lincoln P., Kuo M.C., Kunkel S.L. Cytokine responses during mycobacterial and schistosomal antigen-induced pulmonary granuloma formation. Production of Th1 and Th2 cytokines and relative contribution of tumor necrosis factor. Am. J. Pathol. 145:1994;1105-1113.
11. Grzych J.M., Pearce E., Cheever A., Caulada Z.A., Caspar P., Heiny S., Lewis F., Sher A. Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni. J. Immunol. 146:1991;1322-1327.
12. Wynn T.A., Eltoum I., Cheeve A.W., Lewis F.A., Gause W.C., Sher A. Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni. J. Immunol. 151:1993;1430-1440.
13. Steinman L. A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: A tale of smart bombs and the infantry. Proc. Natl. Acad Sci. USA. 93:1996;2253-2256.
14. Brocke S., Gijbels K., Allegretta M., Ferber I., Piercy C., Blankenstein T., Martin R., Utz U., Karin N., Mitchell D., Veromaa T., Waisman A., Gaur A., Conlon P., Ling N., Fairchild P.J., Wraith D.C., O'Garra A., Fathman C.G., Steinman L. Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature. 379:1996;343-346.
15. Tang H., Braley-Mullen H. Intravenous administration of deaggregated mouse thyroglobulin suppresses induction of experimental autoimmune thyroiditis and expression of both Th1 and Th2 cytokines. Int. Immunol. 5:1997;679-687.
16. Mosmann T.R., Coffman R.L. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann. Rev. Immunol. 7:1989;145-173.
17. Snapper C.M., Mond J.J. Toward a comprehensive view of immunoglobulin class switching. Immunol. Today. 14:1993;15-17.
18. Wesselingh S.L., Levine B., Fox R. J., Choi S., Griffin D.E. Intracerebral cytokine mRNA expression during fatal and non-fatal alphavirus encephalitis suggests a predominant type 2 T cell response. J. Immunol. 152:1994;1289-1297.
19. Kennedy M.K., Torrance D.S., Picha K.S., Mohler K.M. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149:1992;2496-2505.
20. Weiner H.L. Oral tolerance: immune mechanisms and treatment of autoimmune disease. Immunol. Today. 18:1997;335-343.
21. Zitron I.M., Reddy B.P., Gould K.E., Stepaniak J.A., Swanborg R.H. Regulation of cytokine gene expression in experimental autoimmune encephalomyelitis. J. Neurosci. Res. 46:1996;438-444.
22. Trinchieri G. Interleukin 12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Ann. Rev. Immunol. 13:1995;251-276.
23. Abbas A.K., Murphy K.M., Sher A. Functional diversity of helper T lymphocytes. Nature. 383:1996;787-793.
24. McKnight A.J., Zimmer G.J., Fogelman I., Wolf S.F., Abbas A.K. Effect of IL-12 on helper T cell-dependent immune responsesin vivo. J. Immunol. 152:1994;2172-2179.
25. Wynn T.A., Jankovic D., Hieny S., Cheever A.W., Sher A. IL-12 enhances vaccine-induced immunity toSchistosoma mansoni. J. Immunol. 154:1995;4701-4709.
26. Leonard J.P., Waldburger K.E., Goldman S.J. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. J. Exp. Med. 181:1995;381-386.
27. Trembleau S., Penna G., Bosi E., Mortara A., Gately M.K., Adorini L. Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J. Exp. Med. 181:1995;817-821.
28. Karin N., Binah O., Grabie N., Mitchell D.J., Felzen B., Solomon M.D., Conlon P., Gaur A., Ling N., Steinman L. Short peptide-based tolerogens without self-antigenic or pathogenic activity reverse autoimmune disease. J. Immunol. 160:1998;5188-5194.
29. Stull S.J., Kyriakos M., Sharp G.C., Braley-Mullen H. Prevention and reversal of experimental autoimmune thyroiditis (EAT) in mice by administration of anti-L3T4 monoclonal antibody at different stages of disease development. Cell. Immunol. 177:1988;188-195.
30. McMurray R.W., Sharp G.C., Braley-Mullen H. Intrathyroidal cell phenotype in murine lymphocytic and granulomatous experimental autoimmune thyroiditis. Autoimmunity. 18:1994;93-102.
31. +. Scand. J. Immunol. 32:1990;433-440.
32. Roura-Mir C., Catalfamo M., Sospedra M., Alcalde L., Pujol-Borrell R., Jaraquemada D. Single-cell analysis of intrathyroidal lymphocytes shows differential cytokine expression in Hashimoto's and Graves' disease. Eur. J. Immunol. 12:1997;3290-3302.
33. Barton K., McLauchlan M.T., Calder V.L., Lightman S. The kinetics of cytokine mRNA expression in the retina during experimental autoimmune uveoretinitis. Cell. Immunol. 164:1995;133-140.
34. +. J. Autoimmunity. 3:1996;331-339.
35. Rizzo L.V., Xu H., Chan C-C., Wiggert B., Caspi R.R. IL-10 has a protective role in experimental autoimmune uveoretinitis. Int. Immunol. 10:1998;807-814.
36. Joosten L., Lubberts E., Durez P., Helsen M., Jacobs M.J., Goldman M., van den Berg W. Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis. Protective effect of interleukin-4 and interleukin-10 treatment on cartilage destruction. Arthritis Rheum. 40: 1997;249-260.
37. Bai X.F., Zhu G.X., Zhang G.X., Kaponides G., Hojeberg B., van der Meide P.H., Link H. IL-10 suppresses experimental autoimmune neuritis and down-regulates Th1-type cytokine responses. Clin. Exp. Immunopathol. 83: 1997;117-126.
38. +. Nature. 389: 1997;737-742.
39. Mignon-Godefroy K., Rott O., Brazillet M-P., Charreire J. Curative and protective effects of IL-10 in experimental autoimmune thyroiditis (EAT). Evidence for IL-10-enhanced cell death in EAT. J. Immunol. 154: 1995;6634-6643.
40. +. Clin. Exp. Immunol. 97: 1994;212-218.
41. ++. Immunol. Invest. 25: 1996;341-353.
42. -/-. Science. 256: 1992;1210-1213.
43. +. Science. 256: 1992;1213-1215.
44. +in vivo. J. Immunol. 151: 1993;1391-1400.
45. ++. J. Immunol. 127: 1981;363-367.
46. Imahori S.C., Vladutiu A.O. Autoimmune granulomatous thyroiditis in inbred mice: resemblance to subacute (de Quervain's) thyroiditis in man. Proc. Soc. Exp. Biol. Med. 173: 1983;408-416.
47. Imahori S.C., Vladutiu A.O. Evolution and host-dependent lesions in autoimmune thyroiditis: experimental study in inbred mice. Clin. Immunol. Immunopathol. 33: 1984;87-98.