Pharmacological effects of a novel isosorbide-based butyrylcholinesterase inhibitor

Chemico-Biological Interactions

Volumn 175, Issue 1-3, 2008, Pages 231-234

  Khan, D ^a   Gilmer, J F ^a   Carolan, C G ^a   Gaynor, J M ^a   Ryder, S A ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Butyrylcholinesterase; Carboxylesterase; Hydrolysis; Inhibition

Indexed keywords

CARBOXYLESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DONEPEZIL; GALANTAMINE; ISOSORBIDE 2 BENZYLCARBAMATE 5 BENZOATE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CHOLINESTERASE INHIBITION; DRUG DEGRADATION; DRUG EFFECT; DRUG METABOLISM; DRUG PENETRATION; DRUG STABILITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROLYSIS; MOUSE; NONHUMAN; PHARMACODYNAMICS; PLASMA; SINGLE DRUG DOSE;

ANIMALS; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ISOSORBIDE; MALE; MICE; MICE, INBRED C57BL;

MUS;

EID: 50649088600     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.05.024     Document Type: Article

References (13)

1. Giacobini E. Butryrlcholinesterase: Its Function and Inhibitors (2003), Taylor & Francis Ltd., London
2. Darvesh S., Hopkins D.A., and Geula C. Neurobiology of butyrylcholinesterase. Nat. Rev. Neurosci. 4 (2003) 131-138
3. Silver A. The Biology of Cholinesterases (1974), Elsevier, Amsterdam
4. Perry E.K., Tomlinson B.E., Blessed G., Bergmann K., Gibson P.H., and Perry R.H. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. Brit. Med. J. 2 (1978) 1457-1459
5. Mesulam M.M., and Geula C. Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia. Ann. Neurol. 36 (1994) 722-727
6. Gilmer J.F., Lally M.N., Gardiner P., Dillon G., Gaynor J.M., and Reidy S. Novel isosorbide-based substrates for human butyrylcholinesterase. Chem. Biol. Interact. 157/158 (2005) 317-319
7. Ellman G.L., Courtney K.D., Andres Jr. V., and Feather-Stone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7 (1961) 88-95
8. Chatonnet A., and Lockridge O. Comparison of butyrylcholinesterase and acetylcholinesterase. Biochem. J. 260 (1989) 625-634
9. Li B., Sedlacek M., Manoharan I., Boopathy R., Duysen E.G., Masson P., and Lockridge O. Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma. Biochem. Pharmacol. 70 (2005) 1673-1684
10. Satoh T., and Hosokawa M. Structure, function and regulation of carboxylesterases. Chem. Biol. Interact. 162 (2006) 195-211
11. Taketani M., Shii M., Ohura K., Ninomiya S., and Imai T. Carboxylesterase in the liver and small intestine of experimental animals and human. Life Sci. 81 (2007) 924-932
12. Giacobini E. Cholinergic function and Alzheimer's disease. Int. J. Geriatr. Psychiatr. 18 Suppl. 1 (2003) S1-S5
13. Greig N.H., Utsuki T., Ingram D.K., Wang Y., Pepeu G., Scali C., Yu Q.S., Mamczarz J., Holloway H.W., Giordano T., Chen D., Furukawa K., Sambamurti K., Brossi A., and Lahiri D.K. Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 17213-17218