Icaritin exhibits anti-inflammatory effects in the mouse peritoneal macrophages and peritonitis model

International Immunopharmacology

Volumn 16, Issue 1, 2013, Pages 41-49

  Lai, Xinqiang ^a   Ye, Yanxia ^a   Sun, Chenghong ^b   Huang, Xiuyan ^a   Tang, Xiangao ^c   Zeng, Xiangfeng ^a   Yin, Pinghe ^a   Zeng, Yaoying ^a  

^a JINAN UNIVERSITY   (China)

^b Shandong New Time Pharmaceutical Co Ltd   (China)

^c National Engineering Laboratory for Regenerative Implantable Medical Devices   (China)

Author keywords

Anti inflammatory; Icaritin; JNK; p38; Peritoneal macrophages; Peritonitis

Indexed keywords

ANTIINFLAMMATORY AGENT; CD11B ANTIGEN; CD69 ANTIGEN; FLAVONOID; ICARITIN; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZYMOSAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXTRACELLULAR CALCIUM; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MORTALITY; MOUSE; NONHUMAN; PERITONEAL CAVITY; PERITONEUM EXUDATE; PERITONEUM MACROPHAGE; PERITONITIS; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CALCIUM; CELL SURVIVAL; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; FLAVONOIDS; LECTINS, C-TYPE; LEUKOCYTE COUNT; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE; PERITONITIS; PHAGOCYTOSIS;

EID: 84875957599     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2013.03.025     Document Type: Article

References (33)

1. L.P. Cousens, J.S. Orange, H.C. Su, and C.A. Biron Interferon-alpha/beta inhibition of interleukin 12 and interferon-gamma production in vitro and endogenously during viral infection Proc Natl Acad Sci U S A 94 1997 634 639
2. A.F. McGettrick, and L.A.J. O'Neill Regulators of TLR4 Signaling by Endotoxins Endotoxins: Structure, Function and Recognition 2010 153 171
3. J.-H. Jeng, H.-L. Wu, B.-R. Lin, W.-H. Lan, H.-H. Chang, and Y.-S. Ho Antiplatelet effect of sanguinarine is correlated to calcium mobilization, thromboxane and cAMP production Atherosclerosis 191 2007 250 258
4. X. Niu, W. Xing, W. Li, T. Fan, H. Hu, and Y. Li Isofraxidin exhibited anti-inflammatory effects in vivo and inhibited TNF-alpha production in LPS-induced mouse peritoneal macrophages in vitro via the MAPK pathway Int Immunopharmacol 14 2012 164 171
5. L.C. Ye, and J.M. Chen Advances in study on pharmacological effects of Epimedium Zhongguo Zhong Yao Za Zhi 26 2001 293 295
6. J.J. Liu, S.P. Li, and Y.T. Wang Optimization for quantitative determination of four flavonoids in Epimedium by capillary zone electrophoresis coupled with diode array detection using central composite design J Chromatogr A 1103 2006 344 349
7. L. Li, and L. Wang Progress of pharmacological research on icariin Zhongguo Zhong Yao Za Zhi 33 2008 2727 2732
8. J. Liu, H. Ye, and Y. Lou Determination of rat urinary metabolites of icariin in vivo and estrogenic activities of its metabolites on MCF-7 cells Pharmazie 60 2005 120 125
9. F. Qiu, Y.J. Chen, Y.H. Kano, and X.S. Yao Metabolism of orally administered icariin in rats Acta Pharmacol Sin 34 1999 4
10. J.-S. Tong, Q.-H. Zhang, X. Huang, X.-Q. Fu, S.-T. Qi, and Y.-P. Wang Icaritin causes sustained ERK1/2 activation and induces apoptosis in human endometrial cancer cells PLoS One 2011 6
11. Y. Guo, X. Zhang, J. Meng, and Z.-Y. Wang An anticancer agent icaritin induces sustained activation of the extracellular signal-regulated kinase (ERK) pathway and inhibits growth of breast cancer cells Eur J Pharmacol 658 2011 114 122
12. X. Huang, D. Zhu, and Y. Lou A novel anticancer agent, icaritin, induced cell growth inhibition, G(1) arrest and mitochondrial transmembrane potential drop in human prostate carcinoma PC-3 cells Eur J Pharmacol 564 2007 26 36
13. J.F. Zhu, Z.J. Li, G. sen Zhang, K. Meng, W.Y. Kuang, and J. Li Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3/AKT signalings PLoS One 2011 6
14. G. Zhang, L. Qin, H. Sheng, X.-L. Wang, Y.-X. Wang, and D.K.-W. Yeung A novel semisynthesized small molecule icaritin reduces incidence of steroid-associated osteonecrosis with inhibition of both thrombosis and lipid-deposition in a dose-dependent manner Bone 44 2009 345 356
15. X. Li, Y. Hu, L. He, S. Wang, H. Zhou, and S. Liu Icaritin inhibits T cell activation and prolongs skin allograft survival in mice Int Immunopharmacol 13 2012 1 7
16. M.N. Ajuebor, A.M. Das, L. Virag, R.J. Flower, C. Szabo, and M. Perretti Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL-10 J Immunol 162 1999 1685 1691 (Baltimore, Md: 1950)
17. A. El-Mahmoudy, H. Matsuyama, M.A. Borgan, Y. Shimizu, M.G. El-Sayed, and N. Minamoto Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages Int Immunopharmacol 2 2002 1603 1611
18. Y. Ye, X. Huang, Y. Zhang, X. Lai, X. Wu, and X. Zeng Calcium influx blocked by SK&F 96365 modulates the LPS plus IFN-gamma-induced inflammatory response in murine peritoneal macrophages Int Immunopharmacol 12 2012 384 393
19. Z. Fang, F. Xing, C. Bronner, Z. Teng, and Z. Guo ICBP90 mediates the ERK1/2 signaling to regulate the proliferation of Jurkat T cells Cell Immunol 257 2009 80 87
20. R. Marzio, E. Jirillo, A. Ransijn, J. Mauel, and S.B. Corradin Expression and function of the early activation antigen CD69 in murine macrophages J Leukoc Biol 62 1997 349 355
21. R.S. Lewis Calcium signaling mechanisms in T lymphocytes Annu Rev Immunol 19 2001 497 521
22. A.B. Parekh, and J.W. Putney Jr. Store-operated calcium channels Physiol Rev 85 2005 757 810
23. M. Prakriya, and R.S. Lewis CRAC channels: activation, permeation, and the search for a molecular identity Cell Calcium 33 2003 311 321
24. K. Fehsel, K.D. Kroncke, K.L. Meyer, H. Huber, V. Wahn, and V. Kolb-Bachofen Nitric oxide induces apoptosis in mouse thymocytes J Immunol 155 1995 2858 2865 (Baltimore, Md: 1950)
25. C. Thiemermann, C. Szabo, J.A. Mitchell, and J.R. Vane Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide Proc Natl Acad Sci U S A 90 1993 267 271
26. J.M. Cavaillon Cytokines and macrophages Biomed Pharmacother Biomedecine & pharmacotherapie 48 1994 445 453
27. T.F. Bachiega, J.P. de Sousa, J.K. Bastos, and J.M. Sforcin Clove and eugenol in noncytotoxic concentrations exert immunomodulatory/anti-inflammatory action on cytokine production by murine macrophages J Pharm Pharmacol 64 2012 610 616
28. E. Kolaczkowska, B. Arnold, and G. Opdenakker Gelatinase B/MMP-9 as an inflammatory marker enzyme in mouse zymosan peritonitis: comparison of phase-specific and cell-specific production by mast cells, macrophages and neutrophils Immunobiology 213 2008 109 124
29. E. Kolaczkowska, W. Grzybek, N. van Rooijen, H. Piccard, B. Plytycz, and B. Arnold Neutrophil elastase activity compensates for a genetic lack of matrix metalloproteinase-9 (MMP-9) in leukocyte infiltration in a model of experimental peritonitis J Leukoc Biol 85 2009 374 381
30. E. Kolaczkowska, R. Seljelid, and B. Plytycz Role of mast cells in zymosan-induced peritoneal inflammation in Balb/c and mast cell-deficient WBB6F1 mice J Leukoc Biol 69 2001 33 42
31. E. Kolaczkowska, S. Shahzidi, R. Seljelid, N. van Rooijen, and B. Plytycz Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes Inflammation 26 2002 61 71
32. M.N. Ajuebor, A.M. Das, L. Virag, C. Szabo, and M. Perretti Regulation of macrophage inflammatory protein-1 alpha expression and function by endogenous interleukin-10 in a model of acute inflammation Biochem Biophys Res Commun 255 1999 279 282
33. M.N. Ajuebor, L. Virag, R.J. Flower, M. Perretti, and C. Szabo Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan-induced inflammation Immunology 95 1998 625 630