A novel semisynthesized small molecule icaritin reduces incidence of steroid-associated osteonecrosis with inhibition of both thrombosis and lipid-deposition in a dose-dependent manner

Bone

Volumn 44, Issue 2, 2009, Pages 345-356

  Zhang, Ge ^a   Qin, Ling ^a   Sheng, Hui ^a   Wang, Xin Luan ^a,b   Wang, Yi Xiang ^a   Yeung, David Ka Wai ^a   Griffith, James F ^a   Yao, Xin Sheng ^b   Xie, Xin Hui ^a   Li, Zi Rong ^c   Lee, Kwong Man ^a   Leung, Kwok Sui ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c Sino Japan Friendship Hospital   (China)

Author keywords

Dynamic MRI based perfusion function; Extravascular lipid deposition; Icaritin; Intravascular thrombosis; MicroCT based angiography; Steroid associated osteonecrosis

Indexed keywords

FLAVONOID; ICARITIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STEROID; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; BLOOD SAMPLING; BONE MARROW; BONE NECROSIS; CONTROLLED STUDY; ENDOTHELIUM INJURY; FEMUR; FIBRINOLYSIS; HISTOLOGY; IMMUNOREACTIVITY; IN VITRO STUDY; LIPID STORAGE; LIPID TRANSPORT; LIVER CELL DAMAGE; MALE; MESENCHYMAL STEM CELL; MICRO-COMPUTED TOMOGRAPHY; MICROANGIOGRAPHY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATIVE STRESS; PROTEIN EXPRESSION; RABBIT; THROMBOSIS; VASCULARIZATION; WESTERN BLOTTING;

ANGIOGRAPHY; ANIMALS; BLOOD VESSELS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; LIPID METABOLISM; MAGNETIC RESONANCE IMAGING; MALE; OSTEONECROSIS; PARTICLE SIZE; PERFUSION; RABBITS; STEROIDS; THROMBOSIS; TREATMENT OUTCOME; VASCULAR ENDOTHELIAL GROWTH FACTOR A; X-RAY MICROTOMOGRAPHY;

EID: 58249112772     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2008.10.035     Document Type: Article

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