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Volumn 8, Issue 4, 2013, Pages

Dissecting the Dynamics of HIV-1 Protein Sequence Diversity

Author keywords

[No Author keywords available]

Indexed keywords

GAG PROTEIN; HLA ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; NEF PROTEIN; PROTEOME; T LYMPHOCYTE RECEPTOR; VIRUS ENVELOPE PROTEIN;

EID: 84875955713     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059994     Document Type: Article
Times cited : (14)

References (64)
  • 1
    • 0017038871 scopus 로고
    • The proportion of revertant and mutant phage in a growing population, as a function of mutation and growth rate
    • Batschelet E, Domingo E, Weissmann C, (1976) The proportion of revertant and mutant phage in a growing population, as a function of mutation and growth rate. Gene 1: 27-32.
    • (1976) Gene , vol.1 , pp. 27-32
    • Batschelet, E.1    Domingo, E.2    Weissmann, C.3
  • 2
    • 0027222068 scopus 로고
    • Viral quasispecies
    • Eigen M, (1993) Viral quasispecies. Sci Am 269: 42-49.
    • (1993) Sci Am , vol.269 , pp. 42-49
    • Eigen, M.1
  • 5
    • 77957658175 scopus 로고    scopus 로고
    • Quasispecies theory and the behavior of RNA viruses
    • Lauring AS, Andino R, (2010) Quasispecies theory and the behavior of RNA viruses. PLoS Pathog 6: e1001005.
    • (2010) PLoS Pathog , vol.6
    • Lauring, A.S.1    Andino, R.2
  • 6
    • 0027787423 scopus 로고
    • The fastest genome evolution ever described: HIV variation in situ
    • Wain-Hobson S, (1993) The fastest genome evolution ever described: HIV variation in situ. Curr Opin Genet Dev 3: 878-883.
    • (1993) Curr Opin Genet Dev , vol.3 , pp. 878-883
    • Wain-Hobson, S.1
  • 8
    • 0033977268 scopus 로고    scopus 로고
    • High rate of recombination throughout the human immunodeficiency virus type 1 genome
    • Jetzt AE, Yu H, Klarmann GJ, Ron Y, Preston BD, et al. (2000) High rate of recombination throughout the human immunodeficiency virus type 1 genome. J Virol 74: 1234-1240.
    • (2000) J Virol , vol.74 , pp. 1234-1240
    • Jetzt, A.E.1    Yu, H.2    Klarmann, G.J.3    Ron, Y.4    Preston, B.D.5
  • 11
    • 84857959077 scopus 로고    scopus 로고
    • Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response
    • Troyer RM, McNevin J, Liu Y, Zhang SC, Krizan RW, et al. (2009) Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response. PLoS Pathog 5: e1000365.
    • (2009) PLoS Pathog , vol.5
    • Troyer, R.M.1    McNevin, J.2    Liu, Y.3    Zhang, S.C.4    Krizan, R.W.5
  • 12
    • 77956820495 scopus 로고    scopus 로고
    • Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication
    • Abram ME, Ferris AL, Shao W, Alvord WG, Hughes SH, (2010) Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication. J Virol 84: 9864-9878.
    • (2010) J Virol , vol.84 , pp. 9864-9878
    • Abram, M.E.1    Ferris, A.L.2    Shao, W.3    Alvord, W.G.4    Hughes, S.H.5
  • 14
    • 76749115071 scopus 로고    scopus 로고
    • HIV-1 vaccine development after STEP
    • Barouch DH, Korber B, (2010) HIV-1 vaccine development after STEP. Annu Rev Med 61: 153-167.
    • (2010) Annu Rev Med , vol.61 , pp. 153-167
    • Barouch, D.H.1    Korber, B.2
  • 15
    • 55849141268 scopus 로고    scopus 로고
    • Viral sequence diversity: challenges for AIDS vaccine designs
    • McBurney SP, Ross TM, (2008) Viral sequence diversity: challenges for AIDS vaccine designs. Expert Rev Vaccines 7: 1405-1417.
    • (2008) Expert Rev Vaccines , vol.7 , pp. 1405-1417
    • McBurney, S.P.1    Ross, T.M.2
  • 16
    • 44049108744 scopus 로고    scopus 로고
    • Toward an AIDS vaccine
    • Walker BD, Burton DR, (2008) Toward an AIDS vaccine. Science 320: 760-764.
    • (2008) Science , vol.320 , pp. 760-764
    • Walker, B.D.1    Burton, D.R.2
  • 18
    • 0028922319 scopus 로고
    • Chemistry of peptides associated with MHC class I and class II molecules
    • Rammensee HG, (1995) Chemistry of peptides associated with MHC class I and class II molecules. Curr Opin Immunol 7: 85-96.
    • (1995) Curr Opin Immunol , vol.7 , pp. 85-96
    • Rammensee, H.G.1
  • 19
  • 20
    • 77953701383 scopus 로고    scopus 로고
    • Control of HIV-1 replication in elite suppressors
    • Blankson JN, (2010) Control of HIV-1 replication in elite suppressors. Discovery medicine 9: 261-266.
    • (2010) Discovery Medicine , vol.9 , pp. 261-266
    • Blankson, J.N.1
  • 21
    • 84864020166 scopus 로고    scopus 로고
    • Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses
    • Ndhlovu ZM, Proudfoot J, Cesa K, Alvino DM, McMullen A, et al. (2012) Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses. Journal of virology 86: 6959-6969.
    • (2012) Journal of Virology , vol.86 , pp. 6959-6969
    • Ndhlovu, Z.M.1    Proudfoot, J.2    Cesa, K.3    Alvino, D.M.4    McMullen, A.5
  • 23
  • 24
    • 79957618772 scopus 로고    scopus 로고
    • Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
    • Hansen SG, Ford JC, Lewis MS, Ventura AB, Hughes CM, et al. (2011) Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature 473: 523-527.
    • (2011) Nature , vol.473 , pp. 523-527
    • Hansen, S.G.1    Ford, J.C.2    Lewis, M.S.3    Ventura, A.B.4    Hughes, C.M.5
  • 25
    • 61949216736 scopus 로고    scopus 로고
    • Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge
    • Hansen SG, Vieville C, Whizin N, Coyne-Johnson L, Siess DC, et al. (2009) Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge. Nature medicine 15: 293-299.
    • (2009) Nature Medicine , vol.15 , pp. 293-299
    • Hansen, S.G.1    Vieville, C.2    Whizin, N.3    Coyne-Johnson, L.4    Siess, D.C.5
  • 26
    • 53749089460 scopus 로고    scopus 로고
    • Gag-specific cytotoxic T-lymphocyte-based control of primary simian immunodeficiency virus replication in a vaccine trial
    • Kawada M, Tsukamoto T, Yamamoto H, Iwamoto N, Kurihara K, et al. (2008) Gag-specific cytotoxic T-lymphocyte-based control of primary simian immunodeficiency virus replication in a vaccine trial. Journal of virology 82: 10199-10206.
    • (2008) Journal of Virology , vol.82 , pp. 10199-10206
    • Kawada, M.1    Tsukamoto, T.2    Yamamoto, H.3    Iwamoto, N.4    Kurihara, K.5
  • 27
    • 69449106633 scopus 로고    scopus 로고
    • Impact of cytotoxic-T-lymphocyte memory induction without virus-specific CD4+ T-Cell help on control of a simian immunodeficiency virus challenge in rhesus macaques
    • Tsukamoto T, Takeda A, Yamamoto T, Yamamoto H, Kawada M, et al. (2009) Impact of cytotoxic-T-lymphocyte memory induction without virus-specific CD4+ T-Cell help on control of a simian immunodeficiency virus challenge in rhesus macaques. Journal of virology 83: 9339-9346.
    • (2009) Journal of Virology , vol.83 , pp. 9339-9346
    • Tsukamoto, T.1    Takeda, A.2    Yamamoto, T.3    Yamamoto, H.4    Kawada, M.5
  • 32
    • 43149084860 scopus 로고    scopus 로고
    • Evolutionarily conserved protein sequences of influenza a viruses, avian and human, as vaccine targets
    • Heiny AT, Miotto O, Srinivasan KN, Khan AM, Zhang GL, et al. (2007) Evolutionarily conserved protein sequences of influenza a viruses, avian and human, as vaccine targets. PLoS One 2: e1190.
    • (2007) PLoS One , vol.2
    • Heiny, A.T.1    Miotto, O.2    Srinivasan, K.N.3    Khan, A.M.4    Zhang, G.L.5
  • 33
    • 84887818315 scopus 로고    scopus 로고
    • HIV-1 Subtype and Circulating Recombinant Form (CRF) Reference Sequences, 2005. The Human Retroviruses and AIDS 2005 Compendium
    • Leitner T, Korber B, Daniels M, Calef C, Foley B (2005) HIV-1 Subtype and Circulating Recombinant Form (CRF) Reference Sequences, 2005. The Human Retroviruses and AIDS 2005 Compendium. Los Alamos: Los Alamos National Laboratory.
    • (2005) Los Alamos: Los Alamos National Laboratory
    • Leitner, T.1    Korber, B.2    Daniels, M.3    Calef, C.4    Foley, B.5
  • 34
    • 0023214763 scopus 로고
    • Molecular evolution and phylogeny of the human AIDS viruses LAV, HTLV-III, and ARV
    • Yokoyama S, Gojobori T, (1987) Molecular evolution and phylogeny of the human AIDS viruses LAV, HTLV-III, and ARV. Journal of molecular evolution 24: 330-336.
    • (1987) Journal of Molecular Evolution , vol.24 , pp. 330-336
    • Yokoyama, S.1    Gojobori, T.2
  • 35
    • 42449090264 scopus 로고    scopus 로고
    • PROMALS3D: a tool for multiple protein sequence and structure alignments
    • Pei J, Kim BH, Grishin NV, (2008) PROMALS3D: a tool for multiple protein sequence and structure alignments. Nucleic Acids Res 36: 2295-2300.
    • (2008) Nucleic Acids Res , vol.36 , pp. 2295-2300
    • Pei, J.1    Kim, B.H.2    Grishin, N.V.3
  • 36
    • 0027968068 scopus 로고
    • CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
    • Thompson JD, Higgins DG, Gibson TJ, (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22: 4673-4680.
    • (1994) Nucleic Acids Res , vol.22 , pp. 4673-4680
    • Thompson, J.D.1    Higgins, D.G.2    Gibson, T.J.3
  • 37
    • 0038391401 scopus 로고    scopus 로고
    • RASCAL: rapid scanning and correction of multiple sequence alignments
    • Thompson JD, Thierry JC, Poch O, (2003) RASCAL: rapid scanning and correction of multiple sequence alignments. Bioinformatics 19: 1155-1161.
    • (2003) Bioinformatics , vol.19 , pp. 1155-1161
    • Thompson, J.D.1    Thierry, J.C.2    Poch, O.3
  • 38
  • 39
    • 77955001673 scopus 로고    scopus 로고
    • Recovery of replication-competent residual HIV-1 from plasma of a patient receiving prolonged, suppressive highly active antiretroviral therapy
    • Sahu GK, Sarria JC, Cloyd MW, (2010) Recovery of replication-competent residual HIV-1 from plasma of a patient receiving prolonged, suppressive highly active antiretroviral therapy. J Virol 84: 8348-8352.
    • (2010) J Virol , vol.84 , pp. 8348-8352
    • Sahu, G.K.1    Sarria, J.C.2    Cloyd, M.W.3
  • 40
    • 33947400235 scopus 로고    scopus 로고
    • Large-scale analysis of antigenic diversity of T-cell epitopes in dengue virus
    • Khan AM, Heiny AT, Lee KX, Srinivasan KN, Tan TW, et al. (2006) Large-scale analysis of antigenic diversity of T-cell epitopes in dengue virus. BMC Bioinformatics 7 (Suppl 5): S4.
    • (2006) BMC Bioinformatics , vol.7 , Issue.SUPPL. 5
    • Khan, A.M.1    Heiny, A.T.2    Lee, K.X.3    Srinivasan, K.N.4    Tan, T.W.5
  • 41
    • 34248397523 scopus 로고    scopus 로고
    • A systematic bioinformatics approach for selection of epitope-based vaccine targets
    • Khan AM, Miotto O, Heiny AT, Salmon J, Srinivasan KN, et al. (2006) A systematic bioinformatics approach for selection of epitope-based vaccine targets. Cell Immunol 244: 141-147.
    • (2006) Cell Immunol , vol.244 , pp. 141-147
    • Khan, A.M.1    Miotto, O.2    Heiny, A.T.3    Salmon, J.4    Srinivasan, K.N.5
  • 42
    • 0032825083 scopus 로고    scopus 로고
    • Computational binding assays of antigenic peptides
    • Brusic V, Zeleznikow J, (1999) Computational binding assays of antigenic peptides. Letters in Peptide Science 6: 313-324.
    • (1999) Letters in Peptide Science , vol.6 , pp. 313-324
    • Brusic, V.1    Zeleznikow, J.2
  • 43
    • 84856043672 scopus 로고
    • A mathematical theory of communication
    • Shannon CE (1948) A mathematical theory of communication. Bell System Technical Journal 27: 379-423 and 623-656.
    • (1948) Bell System Technical Journal , vol.27
    • Shannon, C.E.1
  • 44
    • 43149095780 scopus 로고    scopus 로고
    • Identification of human-to-human transmissibility factors in PB2 proteins of influenza A by large-scale mutual information analysis
    • Miotto O, Heiny A, Tan TW, August JT, Brusic V, (2008) Identification of human-to-human transmissibility factors in PB2 proteins of influenza A by large-scale mutual information analysis. BMC Bioinformatics 9 (Suppl 1): S18.
    • (2008) BMC Bioinformatics , vol.9 , Issue.SUPPL. 1
    • Miotto, O.1    Heiny, A.2    Tan, T.W.3    August, J.T.4    Brusic, V.5
  • 46
    • 0017667182 scopus 로고
    • The hypercycle. A principle of natural self-organization. Part A: Emergence of the hypercycle
    • Eigen M, Schuster P, (1977) The hypercycle. A principle of natural self-organization. Part A: Emergence of the hypercycle. Die Naturwissenschaften 64: 541-565.
    • (1977) Die Naturwissenschaften , vol.64 , pp. 541-565
    • Eigen, M.1    Schuster, P.2
  • 47
    • 0032581491 scopus 로고    scopus 로고
    • Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes
    • Klenerman P, Zinkernagel RM, (1998) Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes. Nature 394: 482-485.
    • (1998) Nature , vol.394 , pp. 482-485
    • Klenerman, P.1    Zinkernagel, R.M.2
  • 48
    • 0032516035 scopus 로고    scopus 로고
    • Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade
    • Purbhoo MA, Sewell AK, Klenerman P, Goulder PJ, Hilyard KL, et al. (1998) Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade. Proc Natl Acad Sci U S A 95: 4527-4532.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 4527-4532
    • Purbhoo, M.A.1    Sewell, A.K.2    Klenerman, P.3    Goulder, P.J.4    Hilyard, K.L.5
  • 49
  • 50
    • 0029006397 scopus 로고
    • The effects of natural altered peptide ligands on the whole blood cytotoxic T lymphocyte response to human immunodeficiency virus
    • Klenerman P, Meier UC, Phillips RE, McMichael AJ, (1995) The effects of natural altered peptide ligands on the whole blood cytotoxic T lymphocyte response to human immunodeficiency virus. European journal of immunology 25: 1927-1931.
    • (1995) European Journal of Immunology , vol.25 , pp. 1927-1931
    • Klenerman, P.1    Meier, U.C.2    Phillips, R.E.3    McMichael, A.J.4
  • 51
    • 0030869489 scopus 로고    scopus 로고
    • Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides
    • Sewell AK, Harcourt GC, Goulder PJ, Price DA, Phillips RE, (1997) Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides. Eur J Immunol 27: 2323-2329.
    • (1997) Eur J Immunol , vol.27 , pp. 2323-2329
    • Sewell, A.K.1    Harcourt, G.C.2    Goulder, P.J.3    Price, D.A.4    Phillips, R.E.5
  • 52
    • 0033601293 scopus 로고    scopus 로고
    • The structural basis for the increased immunogenicity of two HIV-reverse transcriptase peptide variant/class I major histocompatibility complexes
    • Kirksey TJ, Pogue-Caley RR, Frelinger JA, Collins EJ, (1999) The structural basis for the increased immunogenicity of two HIV-reverse transcriptase peptide variant/class I major histocompatibility complexes. J Biol Chem 274: 37259-37264.
    • (1999) J Biol Chem , vol.274 , pp. 37259-37264
    • Kirksey, T.J.1    Pogue-Caley, R.R.2    Frelinger, J.A.3    Collins, E.J.4
  • 53
    • 0037239977 scopus 로고    scopus 로고
    • Administration of different antigenic forms of altered peptide ligands derived from HIV-1 RTase influences their effects on T helper cell activation
    • Moschella F, Ombra MN, Del Pozzo G, Guardiola J, (2003) Administration of different antigenic forms of altered peptide ligands derived from HIV-1 RTase influences their effects on T helper cell activation. Hum Immunol 64: 1-8.
    • (2003) Hum Immunol , vol.64 , pp. 1-8
    • Moschella, F.1    Ombra, M.N.2    Del Pozzo, G.3    Guardiola, J.4
  • 54
    • 44449096577 scopus 로고    scopus 로고
    • Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells
    • Streeck H, Brumme ZL, Anastario M, Cohen KW, Jolin JS, et al. (2008) Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells. PLoS Med 5: e100.
    • (2008) PLoS Med , vol.5
    • Streeck, H.1    Brumme, Z.L.2    Anastario, M.3    Cohen, K.W.4    Jolin, J.S.5
  • 55
    • 79955962732 scopus 로고    scopus 로고
    • HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis
    • Sauce D, Larsen M, Fastenackels S, Pauchard M, Ait-Mohand H, et al. (2011) HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis. Blood 117: 5142-5151.
    • (2011) Blood , vol.117 , pp. 5142-5151
    • Sauce, D.1    Larsen, M.2    Fastenackels, S.3    Pauchard, M.4    Ait-Mohand, H.5
  • 56
    • 0033960578 scopus 로고    scopus 로고
    • T-cell receptor-mediated anergy of a human immunodeficiency virus (HIV) gp120-specific CD4(+) cytotoxic T-cell clone, induced by a natural HIV type 1 variant peptide
    • Bouhdoud L, Villain P, Merzouki A, Arella M, Couture C, (2000) T-cell receptor-mediated anergy of a human immunodeficiency virus (HIV) gp120-specific CD4(+) cytotoxic T-cell clone, induced by a natural HIV type 1 variant peptide. J Virol 74: 2121-2130.
    • (2000) J Virol , vol.74 , pp. 2121-2130
    • Bouhdoud, L.1    Villain, P.2    Merzouki, A.3    Arella, M.4    Couture, C.5
  • 57
    • 84866503033 scopus 로고    scopus 로고
    • Broad and cross-clade CD4+ T-cell responses elicited by a DNA vaccine encoding highly conserved and promiscuous HIV-1 M-group consensus peptides
    • Almeida RR, Rosa DS, Ribeiro SP, Santana VC, Kallas EG, et al. (2012) Broad and cross-clade CD4+ T-cell responses elicited by a DNA vaccine encoding highly conserved and promiscuous HIV-1 M-group consensus peptides. PLoS One 7: e45267.
    • (2012) PLoS One , vol.7
    • Almeida, R.R.1    Rosa, D.S.2    Ribeiro, S.P.3    Santana, V.C.4    Kallas, E.G.5
  • 58
    • 33747041588 scopus 로고    scopus 로고
    • Ancestral and consensus envelope immunogens for HIV-1 subtype C. Virology
    • Kothe DL, Li Y, Decker JM, Bibollet-Ruche F, Zammit KP, et al. (2006) Ancestral and consensus envelope immunogens for HIV-1 subtype C. Virology. 352: 438-449.
    • (2006) , vol.352 , pp. 438-449
    • Kothe, D.L.1    Li, Y.2    Decker, J.M.3    Bibollet-Ruche, F.4    Zammit, K.P.5
  • 60
    • 23644454804 scopus 로고    scopus 로고
    • Development of a synthetic consensus sequence scrambled antigen HIV-1 vaccine designed for global use
    • Thomson SA, Jaramillo AB, Shoobridge M, Dunstan KJ, Everett B, et al. (2005) Development of a synthetic consensus sequence scrambled antigen HIV-1 vaccine designed for global use. Vaccine 23: 4647-4657.
    • (2005) Vaccine , vol.23 , pp. 4647-4657
    • Thomson, S.A.1    Jaramillo, A.B.2    Shoobridge, M.3    Dunstan, K.J.4    Everett, B.5
  • 61
    • 29844453771 scopus 로고    scopus 로고
    • Cross-clade protection induced by human immunodeficiency virus-1 DNA immunogens expressing consensus sequences of multiple genes and epitopes from subtypes A, B, C, and FGH
    • Malm M, Rollman E, Ustav M, Hinkula J, Krohn K, et al. (2005) Cross-clade protection induced by human immunodeficiency virus-1 DNA immunogens expressing consensus sequences of multiple genes and epitopes from subtypes A, B, C, and FGH. Viral immunology 18: 678-688.
    • (2005) Viral Immunology , vol.18 , pp. 678-688
    • Malm, M.1    Rollman, E.2    Ustav, M.3    Hinkula, J.4    Krohn, K.5
  • 62
    • 33846111016 scopus 로고    scopus 로고
    • Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants
    • Fischer W, Perkins S, Theiler J, Bhattacharya T, Yusim K, et al. (2007) Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants. Nat Med 13: 100-106.
    • (2007) Nat Med , vol.13 , pp. 100-106
    • Fischer, W.1    Perkins, S.2    Theiler, J.3    Bhattacharya, T.4    Yusim, K.5
  • 63
    • 77949263061 scopus 로고    scopus 로고
    • Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys
    • Barouch DH, O'Brien KL, Simmons NL, King SL, Abbink P, et al. (2010) Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys. Nat Med 16: 319-323.
    • (2010) Nat Med , vol.16 , pp. 319-323
    • Barouch, D.H.1    O'Brien, K.L.2    Simmons, N.L.3    King, S.L.4    Abbink, P.5
  • 64
    • 84869020041 scopus 로고    scopus 로고
    • Full-length HIV-1 immunogens induce greater magnitude and comparable breadth of T lymphocyte responses to conserved HIV-1 regions compared with conserved-region-only HIV-1 immunogens in rhesus monkeys
    • Stephenson KE, SanMiguel A, Simmons NL, Smith K, Lewis MG, et al. (2012) Full-length HIV-1 immunogens induce greater magnitude and comparable breadth of T lymphocyte responses to conserved HIV-1 regions compared with conserved-region-only HIV-1 immunogens in rhesus monkeys. Journal of virology 86: 11434-11440.
    • (2012) Journal of Virology , vol.86 , pp. 11434-11440
    • Stephenson, K.E.1    SanMiguel, A.2    Simmons, N.L.3    Smith, K.4    Lewis, M.G.5


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