Transungual drug delivery: An overview

Journal of Applied Pharmaceutical Science

Volumn 2, Issue 1, 2012, Pages 203-209

  Rajendra, Vivek B ^a   Baro, Anjana ^a   Kumari, Abha ^a   Dhamecha, Dinesh L ^b   Lahoti, Swaroop R ^c   Shelke, Santosh D ^d  

^a Jaywantrao Sawant College of Pharmacy and Research   (India)

^b Genba Sopanrao Moze College of Pharmacy   (India)

^c Y B CHAVAN COLLEGE OF PHARMACY   (India)

^d Yash Institute of Pharmacy   (India)

Author keywords

Nail; Nail plate; Transungual delivery

Indexed keywords

EID: 84875907002     PISSN: None     EISSN: 22313354     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Baden, H.P., Goldsmith, L.A., Fleming, B. A comparative study of the physicochemical properties of human keratinised tissues. Biochim. Biophys. Acta 1973: 322; 269-278.
2. Baran, R. Dermatology of topical anti-fungal preparations in nail tissue. In: Gabard, B., Elsner, P., Surber, C., Treffel, P. (Eds.), Dermatology of Topical Preparations. Springer, London, 2000: pp. 281-295.
3. Baran, R. Amorolfine nail lacquer. A new Transungual Delivery System for nail mycoses. J. Am. Med. Assoc. Southeast Asia 1993: 9 (Suppl. 4); 5-6.
4. Baran, R., Hay, R.J., Garduno, J.I. Review of antifungal therapy and the severity index for assessing onychomycosis: part I. J. Dermatolog. Treat. 2000:19; 72-81.
5. Bean, W.B. Nail growth. Thirty five years of observation. Arch. Intern. Med. 1980: 140; 73-76
6. Behl, P.N. Abrasion in the treatment of nail disorders. Indian J. Dermatol. 1973: 18; 77-79.
7. Bronaugh, R.L., Maibach, H.I., 2005. Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methodology. Taylor & Francis, Boca Raton.
8. Brown, M.B, Khengar, R.H., Turner, R.B., Forbes, B., Traynor, M.J., Evans, C.R., Jones, S.A. Overcoming the nail barrier: a systematic investigation of ungula chemical penetration enhancement. Int. J. Pharm. 2009: 370; 61-67.
9. Dawber, R.P.R., De Berker, D., Baran, R. Science of the nail apparatus. In: Baran, R., Dawber, R.P.R. (Eds.), Diseases of the Nails and their Management, 2nd Ed. Blackwell Scientific Publications, London,1994: pp. 1-34.
10. De Berker, D.A.R., Baran, R., Dawber, R.P.R. Infections involving the nail unit. In: Handbook of Diseases of the Nails and their Management. Blackwell Science Ltd, Oxford, 1973: pp. 53-63.
11. Del Rosso, J.Q., Basuk, P.J., Scher, R.K., Ricci, A.R. Dermatologic diseases of the nail unit. In: Scher, R.K., Daniel, C.R. (Eds.), Nails: Therapy, Diagnosis, Surgery, 2nd Ed. WB Saunders, Philadelphia. 1973; pp. 172-200.
12. Di Chiacchio, N., Kadunc, B.V., De Almeida, A.R., Madeira, C.L. Nail abrasion. J. Cosmet. Dermatol. 2003: 2; 150-152.
13. Donnelly, R.F., Mccarron, P.A., Lightowler, J.M., Woolfson, A.D. Bioadhesive patch-based delivery of 5-aminolevulinic acid to the nail for photodynamic therapy of onychomycosis. J. Control. Release. 2005: 103; 381-392.
14. Elewski, B.E., Charif, M.A., Daniel, C.R. III, 1997. Onychomycosis. In: Scher, R.K., Daniel, C.R. (Eds.), Nails: Therapy, Diagnosis, Surgery, 2nd Ed. WB Saunders, Philadelphia, pp. 151-162.
15. Fleckman, P. Basic science of the nail unit. In: Scher, R.K., Daniel, C.R. (Eds.), Nails: Therapy, Diagnosis, Surgery, 2nd Ed. WB Saunders, Philadelphia. 1997: pp. 37-54.
16. Geoghegan, B., Roberts, D.F., Sampford, M.R. A possible climatic effect on nail growth. J. Appl. Physiol. 1958:13;135-138.
17. Gilchrist, M., Dudley Buxton, L.H. The relation of fingernail growth to nutritional status. J. Anat. 1938: 73; 575-582.
18. Gradisar, H., Friedrich, J., Krizaj, I., Jerala, R. Similarities and specificities of fungal keratinolytic proteases: comparison of keratinases of Paecilomyces marquandii and Doratomyces microsporus to some known proteases. Appl. Environ. Microbiol. 2005: 71; 3420-3426.
19. Gupta, A.K., Scher, R.K. Oral antifungal agents for onychomycosis. Lancet. 1998: 351; 541-542.
20. Hamilton, J.B., Terada, H., Mestler, G.E. Studies of growth throughout the lifespan in Japanese: growth and size of nails and their relationship to age, sex, heredity and other factors. J. Gerontol. 1995: 10; 401-415.
21. Hao, J., Li, S.K. Transungual iontophoretic transport of polar neutral and positively charged model permeants: effects of electrophoresis and electroosmosis. J. Pharm. Sci. 2008: 97: 893-905.
22. Hui, X., Baker, S.J., Wester, R.C., Barbadillo, S., Cashmore, A.K., Sanders, V., Hold, K.M., Akama, T., Zhang, Y.K., Plattner, J.J., Maibach, H.I. In vitro penetration of a novel oxaborole antifungal (AN2690) into the human nail plate. J. Pharm. Sci. 2007: 96; 2622-2631.
23. Hui, X., Chan, T.C., Barbadillo, S., Lee, C., Maibach, H.I., Wester, R.C. Enhanced econazole penetration into human nail by 2-n-nonyl-1,3-dioxolane. J. Pharm. Sci. 2003: 92; 142-148.
24. Hui, X., Wester, R.C., Barbadillo, S., Lee, C., Patel, B., Wortzmman, M., Gans, E.H., Maibach, H.I. Ciclopirox delivery into the human nail plate. J. Pharm. Sci. 2004: 93; 2545-2548
25. Hettinger, D.F., Valinsky, M.S. Treatment of onychomycosis with nail avulsion and topical ketoconazole. J. Am. Podiatr. Med. Assoc. 1991: 81; 28-32.
26. Hewitt, D., Hillman, R.W. Relation between rate of nail growth in pregnant women and estimated previous general growth rate. Am. J. Clin. Nutr. 1966: 19; 436-439.
27. Karrell, M.L. Laser Apparatus for Making Holes and Etchings. 1999: USPTO, USA.
28. Kassan, D.G., Lynch, A.M., Stiller, M.J. Physical enhancement of dermatologic drug delivery: iontophoresis and phonophoresis. J. Am. Acad. Dermatol. 1996: 34 (4); 657-666.
29. Kobayashi, Y., Miyamoto, M., Sugibayashi, K., Morimoto, Y. Enhancing effect of N-acetyl-l-cysteine or 2-mercaptoethanol on the in vitro permeation of 5- fluorouracil or tolnaftate through the human nail plate. Chem. Pharm. Bull. (Tokyo) 1998: 46; 1797-1802.
30. Landherr, G., Braun-Falco, O., Hofmann, C., Plewig, G., Galosi, A. Fingernail growth in patients with psoriasis receiving puva-therapy. Hautarzt 1982: 33; 210-213.
31. LeGros Clark, W.E., Buxton, L.H.D. Studies in nail growth. Br. J. Dermatol. 1938: 50; 221-229.
32. Malhotra, G.G., Zatz, J.L. Investigation of nail permeation enhancement by chemical modification using water as a probe. J. Pharm. Sci. 2002: 91; 312-323.
33. Maltezos, G., Scherer, A. Treatment of Toenail Fungus. 2005: USPTO, USA.
34. Mertin, D., Lippold, B.C. In vitro permeability of the human nail and of a keratin membrane from bovine hooves: influence of the partition coefficient octanol/water and the water solubility of drugs on their permeability and maximum flux. J. Pharm. Pharmacol. 1997: 49; 30-34.
35. Mididoddi, P.K., Prodduturi, S., Repka, M.A. Influence of tartaric acid on the bioadhesion and mechanical properties of hot-melt extruded hydroxypropyl cellulose films for the human nail. Drug Dev. Ind. Pharm. 2006: 32; 1059-1066.
36. Mohorcic, M., Torkar, A., Friedrich, J., Kristl, J., Murdan, S. An investigation into keratinolytic enzymes to enhance ungual drug delivery. Int. J. Pharm. 2007: 332; 196-201.
37. Murdan, S.1st meeting on topical drug delivery to the nail. Expert. Opin. Drug Deliv. 2007: 4; 453-455.
38. Murdan, S. Enhancing the nail permeability of topically applied drugs. Expert. Opin. Drug Deliv. 2008: 5; 1267-1282
39. Murthy, S.N., Wiskirchen, D.E., Bowers, C.P. Iontophoretic drug delivery across human nail. J. Pharm. Sci. 2007: 96; 305-311.
40. Myoung, Y., Choi, H.K. Permeation of ciclopirox across porcine hoof membrane: effect of pressure sensitive adhesives and vehicles. Eur. J. Pharm. Sci. 2003: 20; 319-325.
41. Quintanar-Guerrero, D., Ganem-Quintanar, A., Tapia-Olguin, P., Kalia, Y.N., Buri, P. The effect of keratolytic agents on the permeability of three imidazole antimycotic drugs through the human nail. Drug Dev. Ind. Pharm. 1998: 24; 685-690.
42. Repka, M.A., Mididoddi, P.K., Stodghill, S.P. Influence of human nail etching for the assessment of topical onychomycosis therapies. Int. J. Pharm. 2004: 282; 95-106.
43. Sibinga, M.S. Observations on growth of fingernails in health and disease. Pediatrics 1959: 24; 225-233.
44. Walters, K.A., Flynn, G.L., Marvel, J.R. Penetration of the human nail plate: the effects of vehicle pH on the permeation of miconazole. J. Pharm. Pharmacol. 1985:37; 498-499.
45. Wang, J.C.T., Sun, Y. Human nail and its topical treatment: brief review of current research and development of topical antifungal drug delivery for onychomycosis treatment. J. Cosmet. Sci. 1998: 71-76.