Ciclopirox delivery into the human nail plate

Journal of Pharmaceutical Sciences

Volumn 93, Issue 10, 2004, Pages 2545-2548

  Hui, Xiaoying ^a   Wester, Ronald C ^a   Barbadillo, Sherry ^a   Lee, Christine ^a   Patel, Bhiku ^b   Wortzmman, Mitchel ^b   Gans, Eugene H ^b   Maibach, Howard I ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Medicis Pharmaceutical Corporation   (United States)

Author keywords

Antifungal; Ciclopirox; Deep nail concentration; Nail; Topical formulation

Indexed keywords

CICLOPIROX; PAINT;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG PENETRATION; GEL; HUMAN; NAIL BED;

EID: 4844223491     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20159     Document Type: Article

References (4)

1. Hui X, Shainhouse JZ, Tanojo H, Anigbogu A, Markus G, Maibach HI, Wester RC. 2002. Enhanced human nail drug delivery: Nail inner drug content assayed by new unique method. J Pharm Sci 91:189-195.
2. Hui X, Barbadillo S, Lee C, Maibach HI, Wester RC. 2003. Enhanced econazole penetration into human nail by 2-N-nonyl-1,3-dioxane. J Pharm Sci 92:142-148.
3. Data from SRC PhysProp Database: http://esc. syrres.com/interkow/webprop. exe?CAS=29342-05-0.
4. Gupta AK, Kohli Y. 2003. In vitro susceptibility testing of ciclopirox, terbinafine, ketoconazole and itraconazole against dermatophytes and nondermatophytes, and in vitro evaluation of combination antifungal activity. Br J Dermatol 149:296-305.