Enhancing effect of N-acetyl-L-cysteine or 2-mercaptoethanol on the in vitro permeation of 5-fluorouracil or tolnaftate through the human nail plate

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 11, 1998, Pages 1797-1802

  Kobayashi, Yoichi ^a   Miyamoto, Misao ^b   Sugibayashi, Kenji ^a   Morimoto, Yasunori ^a  

^a JOSAI UNIVERSITY   (Japan)

^b NISSAN CHEMICAL INDUSTRIES LTD   (Japan)

Author keywords

5 fluorouracil; Acetylcysteine; Mercaptoethanol; Nail; Nail permeation; Permeation enhancer; Tolnaftate

Indexed keywords

ACETYLCYSTEINE; FLUOROURACIL; MERCAPTOETHANOL; TOLNAFTATE;

ADULT; ARTICLE; DRUG PENETRATION; DRUG POTENTIATION; DRUG UPTAKE; FINGER NAIL; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; SKIN PENETRATION; TOPICAL DRUG ADMINISTRATION;

EID: 0031730650     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.1797     Document Type: Article

References (21)

1. Piepponen T., Blomqvist K., Brandt H., Havu V., Hollmen A., Kohtamäki K., Lehtonen L., Turjanmaa K., J. Antimicrobial Chemotherapy, 29, 195-205 (1992).
2. Villars V. V., Jones T. C., Br. J. Derm., 126 (Suppl. 39), 61-69 (1992).
3. Wilson J. W., Plunkett O. A., Univ. Calif. Press, Berkeley, 1962, pp. 231-251.
4. Walters K. A., Flynn G. L., Marvel J. R., J. Pharm. Pharmacol., 35, 28-33 (1983).
5. Walters K. A., Flynn G. L., Marvel J. R., J. Pharm. Pharmacol., 37, 771-775 (1985).
6. Okumura M., Nakamori Y., Yoshida Y., Drug Des. Del., 6, 137-148 (1990).
7. Morimoto Y., Sugibayashi K., Kobayashi D., Shoji H., Yamazaki J., Kimura M., Int. J. Pharm., 91, 9-14 (1993).
8. Kobayashi D., Matsuzawa T., Sugibayashi K., Morimoto Y., Kobayashi M., Kimura M., Biol. Pharm. Bull., 16, 254-258 (1993).
9. Nakamura H., Pongpaibul Y., Hayashi T., Sugibayashi K., Morimoto Y., Int., J. Pharm., 141, 71-80 (1996).
10. Nakamura H., Kobayashi Y., Sugibayashi K., Morimoto Y., Drug Delively System, 12, 101-106 (1997).
11. Mertin D., Lippold B. C., J. Pharm. Pharmacol., 49, 241-245 (1997).
12. Hoogdalem E. J., Hoven W. E., Terpstra I. J., Zijtveld J., Verschoor J. S. C., Visser J. N., Eur. J. Pharm. Sci., 5, 119-127 (1997).
13. Yamazaki K., Tanaka M., J. Soc. Cosmet. Chem. Japan, 25, 144-161 (1991).
14. Kitahara T., Ogawa H., J. Dermatological Sci., 2, 402-406 (1991).
15. Yamauchi K., Fragrance J., 5, 62-67 (1993).
16. Mertin D., Lippold B. C., J. Pharm. Pharmacol., 49, 30-34 (1997).
17. Fritsch H., Stettendorf S., Hegemann L., Dermatology, 185, 32-36 (1992).
18. Walters K. A., Flynn G. L., Int. J. Cos. Sci., 5, 231-246 (1983).
19. Hirose T., Momota H., Kitajima T., Okura S., Matsuda T., Motoyoshi K., J. Soc. Cosmet. Chem. Japan, 24, 98-105 (1990).
20. Spruit D., Am. Perf. & Cosm., 87, 57-58 (1972).
21. Spearman R. I. C., "The Physiology of the Nail." Vol. 5. ed. by Jarrett A., Academic Press, London, 1978, pp. 1810-1855.