Salubrinal reduces expression and activity of MMP13 in chondrocytes

Osteoarthritis and Cartilage

Volumn 21, Issue 5, 2013, Pages 764-772

  Hamamura, K ^a   Lin, C C ^a   Yokota, H ^a,b  

^a Indiana University Purdue University Indianapolis   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

IL1 ; MMP13; NF B; Salubrinal; TNF

Indexed keywords

COLLAGENASE 3; GELATINASE A; I KAPPA B; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 2ALPHA; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; SALUBRINAL; SMALL INTERFERING RNA; STROMELYSIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; TUNICAMYCIN;

ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

CELL DEATH; CELLS, CULTURED; CHONDROCYTES; CINNAMATES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-2; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE SILENCING; HUMANS; INTERLEUKIN-1BETA; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE INHIBITORS; MATRIX METALLOPROTEINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RNA, MESSENGER; THIOUREA; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA; TUNICAMYCIN; UP-REGULATION;

EID: 84875896177     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2013.02.657     Document Type: Article

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