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Volumn 118, Issue 4, 2013, Pages 838-845

Enhanced antitumor effect of YM872 and AG1296 combination treatment on human glioblastoma xenograft models

Author keywords

Akt; AMPAR; Glioblastoma; Oncology; Platelet derived growth factor receptor; Xenograft model

Indexed keywords

6,7 DIMETHOXY 2 PHENYLQUINOXALINE; CHLORPHENIRAMINE MALEATE PLUS PHENYLEPHRINE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE B; STEM CELL FACTOR; VIMENTIN; ZONAMPANEL;

EID: 84875863362     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/2012.11.JNS12362     Document Type: Article
Times cited : (7)

References (41)
  • 1
    • 0031913246 scopus 로고    scopus 로고
    • Mechanism of activation and function of protein kinase B
    • Alessi DR, Cohen P: Mechanism of activation and function of protein kinase B. Curr Opin Genet Dev 8:55-62, 1998
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 55-62
    • Alessi, D.R.1    Cohen, P.2
  • 2
    • 33748051406 scopus 로고    scopus 로고
    • Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
    • Bao S, Wu Q, Sathornsumetee S, Hao Y, Li Z, Hjelmeland AB, et al: Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res 66:7843-7848, 2006
    • (2006) Cancer Res , vol.66 , pp. 7843-7848
    • Bao, S.1    Wu, Q.2    Sathornsumetee, S.3    Hao, Y.4    Li, Z.5    Hjelmeland, A.B.6
  • 3
    • 0026755385 scopus 로고
    • Recombinant human stem cell factor stimulates growth of a human glioblastoma cell line expressing c-kit protooncogene
    • Berdel WE, de Vos S, Maurer J, Oberberg D, von Marschall Z, Schroeder JK, et al: Recombinant human stem cell factor stimulates growth of a human glioblastoma cell line expressing c-kit protooncogene. Cancer Res 52:3498-3502, 1992
    • (1992) Cancer Res , vol.52 , pp. 3498-3502
    • Berdel, W.E.1    De Vos, S.2    Maurer, J.3    Oberberg, D.4    Von Marschall, Z.5    Schroeder, J.K.6
  • 4
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • Blume-Jensen P, Hunter T: Oncogenic kinase signalling. Nature 411:355-365, 2001
    • (2001) Nature , vol.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 5
    • 34250718676 scopus 로고    scopus 로고
    • Isolation and culture of adult neurons and neurospheres
    • Brewer GJ, Torricelli JR: Isolation and culture of adult neurons and neurospheres. Nat Protoc 2:1490-1498, 2007
    • (2007) Nat Protoc , vol.2 , pp. 1490-1498
    • Brewer, G.J.1    Torricelli, J.R.2
  • 6
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P: Angiogenesis in health and disease. Nat Med 9: 653-660, 2003
    • (2003) Nat Med , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 7
    • 0038615946 scopus 로고    scopus 로고
    • Analysis of the phosphatidylinositol 3′-kinase signaling pathway in glioblastoma patients in vivo
    • Choe G, Horvath S, Cloughesy TF, Crosby K, Seligson D, Palotie A, et al: Analysis of the phosphatidylinositol 3′-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res 63:2742-2746, 2003
    • (2003) Cancer Res , vol.63 , pp. 2742-2746
    • Choe, G.1    Horvath, S.2    Cloughesy, T.F.3    Crosby, K.4    Seligson, D.5    Palotie, A.6
  • 8
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • Cully M, You H, Levine AJ, Mak TW: Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 6:184-192, 2006
    • (2006) Nat Rev Cancer , vol.6 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 9
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta SR, Brunet A, Greenberg ME: Cellular survival: a play in three Akts. Genes Dev 13:2905-2927, 1999
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 10
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, et al: Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241, 1997
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6
  • 11
    • 43149104379 scopus 로고    scopus 로고
    • Knockdown of GluR1 expression by RNA interference inhibits glioma proliferation
    • de Groot JF, Piao Y, Lu L, Fuller GN, Yung WK: Knockdown of GluR1 expression by RNA interference inhibits glioma proliferation. J Neurooncol 88:121-133, 2008
    • (2008) J Neurooncol , vol.88 , pp. 121-133
    • De Groot, J.F.1    Piao, Y.2    Lu, L.3    Fuller, G.N.4    Yung, W.K.5
  • 13
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, et al: Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 344:1031-1037, 2001
    • (2001) N Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3    Peng, B.4    Buchdunger, E.5    Ford, J.M.6
  • 14
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • Engelman JA, Luo J, Cantley LC: The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 7:606-619, 2006
    • (2006) Nat Rev Genet , vol.7 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 15
    • 34648821254 scopus 로고    scopus 로고
    • Making a tumour's bed: Glioblastoma stem cells and the vascular niche
    • Gilbertson RJ, Rich JN: Making a tumour's bed: glioblastoma stem cells and the vascular niche. Nat Rev Cancer 7:733-736, 2007
    • (2007) Nat Rev Cancer , vol.7 , pp. 733-736
    • Gilbertson, R.J.1    Rich, J.N.2
  • 16
    • 70249128040 scopus 로고    scopus 로고
    • Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: A multicenter phase II trial
    • Grossman SA, Ye X, Chamberlain M, Mikkelsen T, Batchelor T, Desideri S, et al: Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter phase II trial. J Clin Oncol 27:4155-4161, 2009
    • (2009) J Clin Oncol , vol.27 , pp. 4155-4161
    • Grossman, S.A.1    Ye, X.2    Chamberlain, M.3    Mikkelsen, T.4    Batchelor, T.5    Desideri, S.6
  • 17
    • 0028911678 scopus 로고
    • Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop
    • Guha A, Dashner K, Black PM, Wagner JA, Stiles CD: Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop. Int J Cancer 60:168-173, 1995
    • (1995) Int J Cancer , vol.60 , pp. 168-173
    • Guha, A.1    Dashner, K.2    Black, P.M.3    Wagner, J.A.4    Stiles, C.D.5
  • 18
    • 0026772431 scopus 로고
    • Platelet-derived growth factor and its receptors in human glioma tissue: Expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops
    • Hermanson M, Funa K, Hartman M, Claesson-Welsh L, Heldin CH, Westermark B, et al: Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. Cancer Res 52:3213-3219, 1992
    • (1992) Cancer Res , vol.52 , pp. 3213-3219
    • Hermanson, M.1    Funa, K.2    Hartman, M.3    Claesson-Welsh, L.4    Heldin, C.H.5    Westermark, B.6
  • 19
    • 0035256772 scopus 로고    scopus 로고
    • Gliomagenesis: Genetic alterations and mouse models
    • Holland EC: Gliomagenesis: genetic alterations and mouse models. Nat Rev Genet 2:120-129, 2001
    • (2001) Nat Rev Genet , vol.2 , pp. 120-129
    • Holland, E.C.1
  • 20
    • 0034020459 scopus 로고    scopus 로고
    • Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
    • Holland EC, Celestino J, Dai C, Schaefer L, Sawaya RE, Fuller GN: Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat Genet 25:55-57, 2000
    • (2000) Nat Genet , vol.25 , pp. 55-57
    • Holland, E.C.1    Celestino, J.2    Dai, C.3    Schaefer, L.4    Sawaya, R.E.5    Fuller, G.N.6
  • 22
    • 0036732391 scopus 로고    scopus 로고
    • Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells
    • Ishiuchi S, Tsuzuki K, Yoshida Y, Yamada N, Hagimura N, Okado H, et al: Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells. Nat Med 8:971-978, 2002
    • (2002) Nat Med , vol.8 , pp. 971-978
    • Ishiuchi, S.1    Tsuzuki, K.2    Yoshida, Y.3    Yamada, N.4    Hagimura, N.5    Okado, H.6
  • 23
    • 34547438107 scopus 로고    scopus 로고
    • Ca2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation
    • Ishiuchi S, Yoshida Y, Sugawara K, Aihara M, Ohtani T, Watanabe T, et al: Ca2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation. J Neurosci 27:7987-8001, 2007
    • (2007) J Neurosci , vol.27 , pp. 7987-8001
    • Ishiuchi, S.1    Yoshida, Y.2    Sugawara, K.3    Aihara, M.4    Ohtani, T.5    Watanabe, T.6
  • 24
    • 26044467362 scopus 로고    scopus 로고
    • Amplification of genes encoding KIT, PDGFRalpha and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme
    • Joensuu H, Puputti M, Sihto H, Tynninen O, Nupponen NN: Amplification of genes encoding KIT, PDGFRalpha and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme. J Pathol 207:224-231, 2005
    • (2005) J Pathol , vol.207 , pp. 224-231
    • Joensuu, H.1    Puputti, M.2    Sihto, H.3    Tynninen, O.4    Nupponen, N.N.5
  • 25
    • 0028091564 scopus 로고
    • Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation
    • Kovalenko M, Gazit A, Böhmer A, Rorsman C, Rönnstrand L, Heldin CH, et al: Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation. Cancer Res 54:6106-6114, 1994
    • (1994) Cancer Res , vol.54 , pp. 6106-6114
    • Kovalenko, M.1    Gazit, A.2    Böhmer, A.3    Rorsman, C.4    Rönnstrand, L.5    Heldin, C.H.6
  • 26
    • 0030059969 scopus 로고    scopus 로고
    • Microvessel density is a prognostic indicator for patients with astroglial brain tumors
    • Leon SP, Folkerth RD, Black PM: Microvessel density is a prognostic indicator for patients with astroglial brain tumors. Cancer 77:362-372, 1996
    • (1996) Cancer , vol.77 , pp. 362-372
    • Leon, S.P.1    Folkerth, R.D.2    Black, P.M.3
  • 27
    • 0036645057 scopus 로고    scopus 로고
    • Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: Evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors
    • Lokker NA, Sullivan CM, Hollenbach SJ, Israel MA, Giese NA: Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Cancer Res 62:3729-3735, 2002
    • (2002) Cancer Res , vol.62 , pp. 3729-3735
    • Lokker, N.A.1    Sullivan, C.M.2    Hollenbach, S.J.3    Israel, M.A.4    Giese, N.A.5
  • 28
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • Maehama T, Dixon JE: The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273:13375-13378, 1998
    • (1998) J Biol Chem , vol.273 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 30
    • 53749096014 scopus 로고    scopus 로고
    • Phase II study of imatinib in patients with recurrent gliomas of various histologies: A European Organisation for Research and Treatment of Cancer Brain Tumor Group Study
    • Raymond E, Brandes AA, Dittrich C, Fumoleau P, Coudert B, Clement PM, et al: Phase II study of imatinib in patients with recurrent gliomas of various histologies: a European Organisation for Research and Treatment of Cancer Brain Tumor Group Study. J Clin Oncol 26:4659-4665, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 4659-4665
    • Raymond, E.1    Brandes, A.A.2    Dittrich, C.3    Fumoleau, P.4    Coudert, B.5    Clement, P.M.6
  • 31
    • 0037186924 scopus 로고    scopus 로고
    • Imatinib mesylate - A new oral targeted therapy
    • Savage DG, Antman KH: Imatinib mesylate - a new oral targeted therapy. N Engl J Med 346:683-693, 2002
    • (2002) N Engl J Med , vol.346 , pp. 683-693
    • Savage, D.G.1    Antman, K.H.2
  • 32
    • 0031667548 scopus 로고    scopus 로고
    • YM872, a highly water-soluble AMPA receptor antagonist, preserves the hemodynamic penumbra and reduces brain injury after permanent focal ischemia in rats
    • Shimizu-Sasamata M, Kano T, Rogowska J, Wolf GL, Moskowitz MA, Lo EH: YM872, a highly water-soluble AMPA receptor antagonist, preserves the hemodynamic penumbra and reduces brain injury after permanent focal ischemia in rats. Stroke 29:2141-2148, 1998
    • (1998) Stroke , vol.29 , pp. 2141-2148
    • Shimizu-Sasamata, M.1    Kano, T.2    Rogowska, J.3    Wolf, G.L.4    Moskowitz, M.A.5    Lo, E.H.6
  • 33
    • 35348822482 scopus 로고    scopus 로고
    • Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
    • Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, et al: Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science 318:287-290, 2007
    • (2007) Science , vol.318 , pp. 287-290
    • Stommel, J.M.1    Kimmelman, A.C.2    Ying, H.3    Nabioullin, R.4    Ponugoti, A.H.5    Wiedemeyer, R.6
  • 36
    • 0032879415 scopus 로고    scopus 로고
    • Tumour vascularity and proliferation: Clear evidence of a close relationship
    • Weidner N: Tumour vascularity and proliferation: clear evidence of a close relationship. J Pathol 189:297-299, 1999
    • (1999) J Pathol , vol.189 , pp. 297-299
    • Weidner, N.1
  • 37
    • 0031993988 scopus 로고    scopus 로고
    • Tumoural vascularity as a prognostic factor in cancer patients: The evidence continues to grow
    • Weidner N: Tumoural vascularity as a prognostic factor in cancer patients: the evidence continues to grow. J Pathol 184: 119-122, 1998
    • (1998) J Pathol , vol.184 , pp. 119-122
    • Weidner, N.1
  • 38
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen PY, Kesari S: Malignant gliomas in adults. N Engl J Med 359:492-507, 2008
    • (2008) N Engl J Med , vol.359 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 39
    • 33748376520 scopus 로고    scopus 로고
    • Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08
    • Wen PY, Yung WK, Lamborn KR, Dahia PL, Wang Y, Peng B, et al: Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08. Clin Cancer Res 12:4899-4907, 2006
    • (2006) Clin Cancer Res , vol.12 , pp. 4899-4907
    • Wen, P.Y.1    Yung, W.K.2    Lamborn, K.R.3    Dahia, P.L.4    Wang, Y.5    Peng, B.6
  • 40
    • 0034176579 scopus 로고    scopus 로고
    • The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
    • Williams MR, Arthur JS, Balendran A, van der Kaay J, Poli V, Cohen P, et al: The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr Biol 10:439-448, 2000
    • (2000) Curr Biol , vol.10 , pp. 439-448
    • Williams, M.R.1    Arthur, J.S.2    Balendran, A.3    Van Der Kaay, J.4    Poli, V.5    Cohen, P.6
  • 41
    • 33645794516 scopus 로고    scopus 로고
    • Serum-dependence of AMPA receptor-mediated proliferation in glioma cells
    • Yoshida Y, Tsuzuki K, Ishiuchi S, Ozawa S: Serum-dependence of AMPA receptor-mediated proliferation in glioma cells. Pathol Int 56:262-271, 2006
    • (2006) Pathol Int , vol.56 , pp. 262-271
    • Yoshida, Y.1    Tsuzuki, K.2    Ishiuchi, S.3    Ozawa, S.4


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