Gadolinium chloride augments tumor-specific imaging of targeted quantum dots in vivo

ACS Nano

Volumn 4, Issue 7, 2010, Pages 4131-4141

  Diagaradjane, Parmeswaran ^a   Deorukhkar, Amit ^a   Gelovani, Juri G ^a   Maru, Dipen M ^a   Krishnan, Sunil ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

gadolinium chloride; imaging; Kupffer cell; nanoparticle; quantum dots

Indexed keywords

BIOMEDICAL APPLICATIONS; COMPARTMENTAL MODELING; ENDOTHELIAL SYSTEMS; IMAGING; IN-VIVO; KUPFFER CELLS; PRE-TREATMENT; QUANTUM DOT; RATE PARAMETERS;

CHLORINE COMPOUNDS; GADOLINIUM; IMAGE QUALITY; MACROPHAGES; SEMICONDUCTOR QUANTUM DOTS; TUMORS;

NANOPARTICLES;

EPIDERMAL GROWTH FACTOR RECEPTOR; GADOLINIUM; GADOLINIUM CHLORIDE; QUANTUM DOT;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; DRUG EFFECT; HALF LIFE TIME; HUMAN; KUPFFER CELL; LIVER; MALE; METABOLISM; METHODOLOGY; MOLECULAR IMAGING; MOLECULAR PROBE; MOUSE; NEOPLASM; PATHOLOGY; REPRODUCIBILITY; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; GADOLINIUM; HALF-LIFE; HUMANS; KUPFFER CELLS; LIVER; MALE; MICE; MODELS, BIOLOGICAL; MOLECULAR IMAGING; MOLECULAR PROBES; NEOPLASMS; QUANTUM DOTS; RECEPTOR, EPIDERMAL GROWTH FACTOR; REPRODUCIBILITY OF RESULTS;

EID: 77955536814     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn901919w     Document Type: Article

References (62)

1. Fass, L. Imaging and Cancer: A Review Mol. Oncol. 2008, 2, 115-152
2. Debbage, P.; Jaschke, W. Molecular Imaging with Nanoparticles: Giant Roles for Dwarf Actors Histochem. Cell Biol. 2008, 130, 845-875
3. Zhang, H.; Yee, D.; Wang, C. Quantum Dots for Cancer Diagnosis and Therapy: Biological and Clinical Perspectives Nanomedicine 2008, 3, 83-91
4. Bruchez, M., Jr.; Moronne, M.; Gin, P.; Weiss, S.; Alivisatos, A. P. Semiconductor Nanocrystals as Fluorescent Biological Labels Science 1998, 281, 2013-2016
5. Alivisatos, P. The Use of Nanocrystals in Biological Detection Nat. Biotechnol. 2004, 22, 47-52
6. Ballou, B.; Lagerholm, B. C.; Ernst, L. A.; Bruchez, M. P.; Waggoner, A. S. Noninvasive Imaging of Quantum Dots in Mice Bioconjugate Chem. 2004, 15, 79-86
7. Michalet, X.; Pinaud, F. F.; Bentolila, L. A.; Tsay, J. M.; Doose, S.; Li, J. J.; Sundaresan, G.; Wu, A. M.; Gambhir, S. S.; Weiss, S. Quantum Dots for Live Cells, In Vivo Imaging, and Diagnostics Science 2005, 307, 538-544
8. Akerman, M. E.; Chan, W. C.; Laakkonen, P.; Bhatia, S. N.; Ruoslahti, E. Nanocrystal Targeting In Vivo Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 12617-12621
9. Papagiannaros, A.; Levchenko, T.; Hartner, W.; Mongayt, D.; Torchilin, V. Quantum Dots Encapsulated in Phospholipid Micelles for Imaging and Quantification of Tumors in the Near-Infrared Region Nanomedicine 2009, 5, 216-224
10. Mulder, W. J.; Castermans, K.; van Beijnum, J. R.; Oude Egbrink, M. G.; Chin, P. T.; Fayad, Z. A.; Lowik, C. W.; Kaijzel, E. L.; Que, I.; Storm, G.; Strijkers, G. J.; Griffioen, A. W.; Nicolay, K. Molecular Imaging of Tumor Angiogenesis Using Alphavbeta3-Integrin Targeted Multimodal Quantum Dots Angiogenesis 2009, 12, 17-24
11. Chen, K.; Li, Z. B.; Wang, H.; Cai, W.; Chen, X. Dual-Modality Optical and Positron Emission Tomography Imaging of Vascular Endothelial Growth Factor Receptor on Tumor Vasculature Using Quantum Dots Eur. J. Nucl. Med. Mol. Imaging 2008, 35, 2235-2244
12. Smith, B. R.; Cheng, Z.; De, A.; Koh, A. L.; Sinclair, R.; Gambhir, S. S. Real-Time Intravital Imaging of Rgd-Quantum Dot Binding to Luminal Endothelium in Mouse Tumor Neovasculature Nano Lett. 2008, 8, 2599-2606
13. Cai, W.; Shin, D. W.; Chen, K.; Gheysens, O.; Cao, Q.; Wang, S. X.; Gambhir, S. S.; Chen, X. Peptide-Labeled Near-Infrared Quantum Dots for Imaging Tumor Vasculature in Living Subjects Nano Lett. 2006, 6, 669-676
14. Morgan, N. Y.;, ish, S.; Chen, W.; Chernomordik, V.; Russo, A.; Smith, P. D.; Gandjbakhche, A. Real Time In Vivo Non-invasive Optical Imaging Using near-Infrared Fluorescent Quantum Dots Acad. Radiol. 2005, 12, 313-323
15. Robe, A.; Pic, E.; Lassalle, H. P.; Bezdetnaya, L.; Guillemin, F.; Marchal, F. Quantum Dots in Axillary Lymph Node Mapping: Biodistribution Study in Healthy Mice BMC Cancer 2008, 8, 111
16. Takeda, M.; Tada, H.; Higuchi, H.; Kobayashi, Y.; Kobayashi, M.; Sakurai, Y.; Ishida, T.; Ohuchi, N. In Vivo Single Molecular Imaging and Sentinel Node Navigation by Nanotechnology for Molecular Targeting Drug-Delivery Systems and Tailor-Made Medicine Breast Cancer 2008, 15, 145-152
17. Kim, S.; Lim, Y. T.; Soltesz, E. G.; De Grand, A. M.; Lee, J.; Nakayama, A.; Parker, J. A.; Mihaljevic, T.; Laurence, R. G.; Dor, D. M.; Cohn, L. H.; Bawendi, M. G.; Frangioni, J. V. Near-Infrared Fluorescent Type II Quantum Dots for Sentinel Lymph Node Mapping Nat. Biotechnol. 2004, 22, 93-97
18. Soltesz, E. G.; Kim, S.; Laurence, R. G.; DeGrand, A. M.; Parungo, C. P.; Dor, D. M.; Cohn, L. H.; Bawendi, M. G.; Frangioni, J. V.; Mihaljevic, T. Intraoperative Sentinel Lymph Node Mapping of the Lung Using Near-Infrared Fluorescent Quantum Dots Ann. Thorac. Surg. 2005, 79, 269-277 discussion 269-277
19. Soltesz, E. G.; Kim, S.; Kim, S. W.; Laurence, R. G.; De Grand, A. M.; Parungo, C. P.; Cohn, L. H.; Bawendi, M. G.; Frangioni, J. V. Sentinel Lymph Node Mapping of the Gastrointestinal Tract by Using Invisible Light Ann. Surg. Oncol. 2006, 13, 386-396
20. Parungo, C. P.; Ohnishi, S.; Kim, S. W.; Kim, S.; Laurence, R. G.; Soltesz, E. G.; Chen, F. Y.; Colson, Y. L.; Cohn, L. H.; Bawendi, M. G.; Frangioni, J. V. Intraoperative Identification of Esophageal Sentinel Lymph Nodes with Near-Infrared Fluorescence Imaging J. Thorac. Cardiovasc. Surg. 2005, 129, 844-850
21. Ballou, B.; Ernst, L. A.; Andreko, S.; Harper, T.; Fitzpatrick, J. A.; Waggoner, A. S.; Bruchez, M. P. Sentinel Lymph Node Imaging Using Quantum Dots in Mouse Tumor Models Bioconjugate Chem. 2007, 18, 389-396
22. Diagaradjane, P.; Orenstein-Cardona, J. M.; Colon-Casasnovas, N. E.; Deorukhkar, A.; Shentu, S.; Kuno, N.; Schwartz, D. L.; Gelovani, J. G.; Krishnan, S. Imaging Epidermal Growth Factor Receptor Expression In Vivo: Pharmacokinetic and Biodistribution Characterization of a Bioconjugated Quantum Dot Nanoprobe Clin. Cancer Res. 2008, 14, 731-741
23. Gao, X.; Cui, Y.; Levenson, R. M.; Chung, L. W.; Nie, S. In Vivo Cancer Targeting and Imaging with Semiconductor Quantum Dots Nat. Biotechnol. 2004, 22, 969-976
24. Lidke, D. S.; Nagy, P.; Heintzmann, R.; Arndt-Jovin, D. J.; Post, J. N.; Grecco, H. E.; Jares-Erijman, E. A.; Jovin, T. M. Quantum Dot Ligands Provide New Insights into Erbb/Her Receptor-Mediated Signal Transduction Nat. Biotechnol. 2004, 22, 198-203
25. Barat, B.; Sirk, S. J.; McCabe, K. E.; Li, J.; Lepin, E. J.; Remenyi, R.; Koh, A. L.; Olafsen, T.; Gambhir, S. S.; Weiss, S.; Wu, A. M., Cys-Diabody Quantum Dot Conjugates (ImmunoQdots) for Cancer Marker Detection. Bioconjugate Chem. 2009, 20, 1474-1481.
26. Shi, C.; Zhu, Y.; Xie, Z.; Qian, W.; Hsieh, C. L.; Nie, S.; Su, Y.; Zhau, H. E.; Chung, L. W. Visualizing Human Prostate Cancer Cells in Mouse Skeleton Using Bioconjugated Near-Infrared Fluorescent Quantum Dots Urology 2009, 74, 446-451
27. Wang, J.; Yong, W. H.; Sun, Y.; Vernier, P. T.; Koeffler, H. P.; Gundersen, M. A.; Marcu, L. Receptor-Targeted Quantum Dots: Fluorescent Probes for Brain Tumor Diagnosis J. Biomed. Opt. 2007, 12, 044021
28. Wu, X.; Liu, H.; Liu, J.; Haley, K. N.; Treadway, J. A.; Larson, J. P.; Ge, N.; Peale, F.; Bruchez, M. P. Immunofluorescent Labeling of Cancer Marker Her2 and Other Cellular Targets with Semiconductor Quantum Dots Nat. Biotechnol. 2003, 21, 41-46
29. Sen, D.; Deerinck, T. J.; Ellisman, M. H.; Parker, I.; Cahalan, M. D. Quantum Dots for Tracking Dendritic Cells and Priming an Immune Response In Vitro and In Vivo PLoS One 2008, 3 e3290
30. Schipper, M. L.; Cheng, Z.; Lee, S. W.; Bentolila, L. A.; Iyer, G.; Rao, J.; Chen, X.; Wu, A. M.; Weiss, S.; Gambhir, S. S. Micropet-Based Biodistribution of Quantum Dots in Living Mice J. Nucl. Med. 2007, 48, 1511-1518
31. Lewinski, N.; Colvin, V.; Drezek, R. Cytotoxicity of Nanoparticles Small 2008, 4, 26-49
32. Hardman, R. A Toxicologic Review of Quantum Dots: Toxicity Depends on Physicochemical and Environmental Factors Environ. Health Perspect. 2006, 114, 165-172
33. Harris, J. M.; Chess, R. B. Effect of Pegylation on Pharmaceuticals Nat. Rev. Drug Discovery 2003, 2, 214-221
34. Greenwald, R. B. PEG Drugs: An Overview J. Controlled Release 2001, 74, 159-171
35. Brigger, I.; Dubernet, C.; Couvreur, P. Nanoparticles in Cancer Therapy and Diagnosis Adv. Drug Delivery Rev. 2002, 54, 631-651
36. Proffitt, R. T.; Williams, L. E.; Presant, C. A.; Tin, G. W.; Uliana, J. A.; Gamble, R. C.; Baldeschwieler, J. D. Liposomal Blockade of the Reticuloendothelial System: Improved Tumor Imaging with Small Unilamellar Vesicles Science 1983, 220, 502-505
37. Hamori, C. J.; Lasic, D. D.; Vreman, H. J.; Stevenson, D. K. Targeting Zinc Protoporphyrin Liposomes to the Spleen Using Reticuloendothelial Blockade with Blank Liposomes Pediatr. Res. 1993, 34, 1-5
38. Gregoriadis, G.; Neerunjun, D. E. Control of the Rate of Hepatic Uptake and Catabolism of Liposome-Entrapped Proteins Injected into Rats. Possible Therapeutic Applications Eur. J. Biochem. 1974, 47, 179-185
39. Souhami, R. L.; Patel, H. M.; Ryman, B. E. The Effect of Reticuloendothelial Blockade on the Blood Clearance and Tissue Distribution of Liposomes Biochim. Biophys. Acta 1981, 674, 354-371
40. Gregoriadis, G.; Neerunjun, D. E.; Hunt, R. Fate of a Liposome-Associated Agent Injected into Normal and Tumour-Bearing Rodents. Attempts To Improve Localization in Tumour Tissues Life Sci. 1977, 21, 357-369 (Pubitemid 8191972)
41. Husztik, E.; Lazar, G.; Parducz, A. Electron Microscopic Study of Kupffer-Cell Phagocytosis Blockade Induced by Gadolinium Chloride Br. J. Exp. Pathol. 1980, 61, 624-630
42. Iimuro, Y.; Yamamoto, M.; Kohno, H.; Itakura, J.; Fujii, H.; Matsumoto, Y. Blockade of Liver Macrophages by Gadolinium Chloride Reduces Lethality in Endotoxemic Rats - Analysis of Mechanisms of Lethality in Endotoxemia J. Leukocyte Biol. 1994, 55, 723-728
43. Abraham, S.; Szabo, A.; Kaszaki, J.; Varga, R.; Eder, K.; Duda, E.; Lazar, G.; Tiszlavicz, L.; Boros, M.; Lazar, G., Jr. Kupffer Cell Blockade Improves the Endotoxin-Induced Microcirculatory Inflammatory Response in Obstructive Jaundice Shock 2008, 30, 69-74
44. Usynin, I. F.; Khar'kovsky, A. V.; Balitskaya, N. I.; Panin, L. E. Gadolinium Chloride-Induced Kupffer Cell Blockade Increases Uptake of Oxidized Low-Density Lipoproteins by Rat Heart and Aorta Biochemistry (Moscow) 1999, 64, 620-624
45. Ding, H.; Tong, J.; Wu, S. C.; Yin, D. K.; Yuan, X. F.; Wu, J. Y.; Chen, J.; Shi, G. G. Modulation of Kupffer Cells on Hepatic Drug Metabolism World J. Gastroenterol. 2004, 10, 1325-1328
46. Ruttinger, D.; Vollmar, B.; Wanner, G. A.; Messmer, K. In Vivo Assessment of Hepatic Alterations Following Gadolinium Chloride-Induced Kupffer Cell Blockade J. Hepatol. 1996, 25, 960-967
47. Lazar, G., Jr.; Lazar, G.; Kaszaki, J.; Olah, J.; Kiss, I.; Husztik, E. Inhibition of Anaphylactic Shock by Gadolinium Chloride-Induced Kupffer Cell Blockade Agents Actions 1994, 41, C97-C98
48. Giakoustidis, D. E.; Iliadis, S.; Tsantilas, D.; Papageorgiou, G.; Kontos, N.; Kostopoulou, E.; Botsoglou, N. A.; Gerasimidis, T.; Dimitriadou, A. Blockade of Kupffer Cells by Gadolinium Chloride Reduces Lipid Peroxidation and Protects Liver from Ischemia/Reperfusion Injury Hepatogastroenterology 2003, 50, 1587-1592
49. Spencer, A.; Wilson, S.; Harpur, E. Gadolinium Chloride Toxicity in the Mouse Hum. Exp. Toxicol. 1998, 17, 633-637
50. Maeda, H.; Fang, J.; Inutsuka, T.; Kitamoto, Y. Vascular Permeability Enhancement in Solid Tumor: Various Factors, Mechanisms Involved and Its Implications Int. Immunopharmacol. 2003, 3, 319-328
51. Smith, A. M.; Duan, H.; Mohs, A. M.; Nie, S. Bioconjugated Quantum Dots for In Vivo Molecular and Cellular Imaging Adv. Drug Delivery Rev. 2008, 60, 1226-1240
52. Faure, A. C.; Dufort, S.; Josserand, V.; Perriat, P.; Coll, J. L.; Roux, S.; Tillement, O. Control of the In Vivo Biodistribution of Hybrid Nanoparticles with Different Poly(ethylene glycol) Coatings Small 2009, 5, 2565-2575
53. van Schooneveld, M. M.; Vucic, E.; Koole, R.; Zhou, Y.; Stocks, J.; Cormode, D. P.; Tang, C. Y.; Gordon, R. E.; Nicolay, K.; Meijerink, A.; Fayad, Z. A.; Mulder, W. J. Improved Biocompatibility and Pharmacokinetics of Silica Nanoparticles by Means of a Lipid Coating: A Multimodality Investigation Nano Lett. 2008, 8, 2517-2525
54. Li, S. D.; Huang, L. Pharmacokinetics and Biodistribution of Nanoparticles Mol. Pharmaceutics 2008, 5, 496-504
55. Bailey, R. E.; Smith, A. M.; Nie, S. M. Quantum Dots in Biology and Medicine Physica E 2004, 25, 1-12
56. Clift, M. J.; Rothen-Rutishauser, B.; Brown, D. M.; Duffin, R.; Donaldson, K.; Proudfoot, L.; Guy, K.; Stone, V. The Impact of Different Nanoparticle Surface Chemistry and Size on Uptake and Toxicity in a Murine Macrophage Cell Line Toxicol. Appl. Pharmacol. 2008, 232, 418-427
57. Patel, K. R.; Li, M. P.; Baldeschwieler, J. D. Suppression of Liver Uptake of Liposomes by Dextran Sulfate 500 Proc. Natl. Acad. Sci. U.S.A. 1983, 80, 6518-6522
58. Choi, H. S.; Liu, W.; Misra, P.; Tanaka, E.; Zimmer, J. P.; Itty Ipe, B.; Bawendi, M. G.; Frangioni, J. V. Renal Clearance of Quantum Dots Nat. Biotechnol. 2007, 25, 1165-1170
59. Lim, Y. T.; Kim, S.; Nakayama, A.; Stott, N. E.; Bawendi, M. G.; Frangioni, J. V. Selection of Quantum Dot Wavelengths for Biomedical Assays and Imaging Mol. Imaging 2003, 2, 50-64
60. Krohn, N.; Kapoor, S.; Enami, Y.; Follenzi, A.; Bandi, S.; Joseph, B.; Gupta, S. Hepatocyte Transplantation-Induced Liver Inflammation Is Driven by Cytokines-Chemokines Associated with Neutrophils and Kupffer Cells Gastroenterology 2009, 136, 1806-1817
61. Chung, K. Y.; Jeong, G. Y.; Choi, K. B.; Sung, S. H.; Kim, Y. S. Prevention of Primary Nonfunction after Canine Liver Allotransplantation: The Effect of Gadolinium Chloride Transplant Proc. 2004, 36, 1928-1930
62. von Frankenberg, M.; Golling, M.; Mehrabi, A.; Nentwich, H.; Klar, E.; Kraus, T. W. Donor Pretreatment with Gadolinium Chloride Improves Early Graft Function and Survival after Porcine Liver Transplantation Transplant Int. 2003, 16, 806-813