메뉴 건너뛰기




Volumn 154, Issue 4, 2013, Pages 1528-1539

Dexamethasone-mediated changes in adipose triacylglycerol metabolism are exaggerated, not diminished, in the absence of a functional GR dimerization domain

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; INSULIN; MUSCLE PROTEIN; TRIACYLGLYCEROL;

EID: 84875859581     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-1047     Document Type: Article
Times cited : (10)

References (54)
  • 2
    • 0031780131 scopus 로고    scopus 로고
    • Systemic corticosteroid therapy-side effects and their management
    • Stanbury RM, Graham EM. Systemic corticosteroid therapy-side effects and their management. Br J Ophthalmol. 1998;82:704-708.
    • (1998) Br J Ophthalmol , vol.82 , pp. 704-708
    • Stanbury, R.M.1    Graham, E.M.2
  • 3
    • 0022393794 scopus 로고
    • Primary structure and expression of a functional human glucocorticoid receptor cDNA
    • Hollenberg SM, Weinberger C, Ong ES, et al. Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature. 1985;318:635-641.
    • (1985) Nature , vol.318 , pp. 635-641
    • Hollenberg, S.M.1    Weinberger, C.2    Ong, E.S.3
  • 5
    • 14644429018 scopus 로고    scopus 로고
    • Optimised glucocorticoid therapy: The sharpening of an old spear
    • Buttgereit F, Burmester GR, Lipworth BJ. Optimised glucocorticoid therapy: the sharpening of an old spear. Lancet. 2005;365:801-803.
    • (2005) Lancet , vol.365 , pp. 801-803
    • Buttgereit, F.1    Burmester, G.R.2    Lipworth, B.J.3
  • 6
    • 18844450441 scopus 로고    scopus 로고
    • The search for safer glucocorticoid receptor ligands
    • Rosen J, Miner JN. The search for safer glucocorticoid receptor ligands. Endocr Rev. 2005;26:452-464.
    • (2005) Endocr Rev , vol.26 , pp. 452-464
    • Rosen, J.1    Miner, J.N.2
  • 7
    • 34547887674 scopus 로고    scopus 로고
    • Selective glucocorticoid receptor agonists (SEGRAs): Novel ligands with an improved therapeutic index
    • Schacke H, Berger M, Rehwinkel H, Asadullah K. Selective glucocorticoid receptor agonists (SEGRAs): novel ligands with an improved therapeutic index. Mol Cell Endocrinol. 2007;275:109-117.
    • (2007) Mol Cell Endocrinol , vol.275 , pp. 109-117
    • Schacke, H.1    Berger, M.2    Rehwinkel, H.3    Asadullah, K.4
  • 9
    • 0028831128 scopus 로고
    • Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors
    • Scheinman R, Gualberto A, Jewell C, Cidlowski J, Baldwin A Jr. Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors. Mol Cell Biol. 1995; 15:943-953.
    • (1995) Mol Cell Biol , vol.15 , pp. 943-953
    • Scheinman, R.1    Gualberto, A.2    Jewell, C.3    Cidlowski, J.4    Baldwin Jr., A.5
  • 10
    • 0028107237 scopus 로고
    • Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor
    • Ray A, Prefontaine KE. Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc Natl Acad Sci U S A. 1994;91: 752-756.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 752-756
    • Ray, A.1    Prefontaine, K.E.2
  • 11
    • 0025188132 scopus 로고
    • Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction
    • Yang-Yen HF, Chambard JC, Sun YL, et al. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell. 1990;62:1205-1215.
    • (1990) Cell , vol.62 , pp. 1205-1215
    • Yang-Yen, H.F.1    Chambard, J.C.2    Sun, Y.L.3
  • 13
    • 0027058940 scopus 로고
    • The basic region of AP-1 specifies glucocorticoid receptor activity at a composite response element
    • Miner JN, Yamamoto KR. The basic region of AP-1 specifies glucocorticoid receptor activity at a composite response element. Genes Dev. 1992;6:2491-2501.
    • (1992) Genes Dev , vol.6 , pp. 2491-2501
    • Miner, J.N.1    Yamamoto, K.R.2
  • 14
    • 0034665748 scopus 로고    scopus 로고
    • The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain
    • Nissen RM, Yamamoto KR. The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain. Genes Dev. 2000;14: 2314-2329.
    • (2000) Genes Dev , vol.14 , pp. 2314-2329
    • Nissen, R.M.1    Yamamoto, K.R.2
  • 15
    • 77952950546 scopus 로고    scopus 로고
    • Selective glucocorticoid receptor modulators
    • De Bosscher K. Selective glucocorticoid receptor modulators. J Steroid Biochem Mol Biol. 2010;120:96-104.
    • (2010) J Steroid Biochem Mol Biol , vol.120 , pp. 96-104
    • De Bosscher, K.1
  • 16
    • 0036810356 scopus 로고    scopus 로고
    • Mechanisms involved in the side effects of glucocorticoids
    • Schäcke H, Döcke WD, Asadullah K. Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther. 2002;96:23-43.
    • (2002) Pharmacol Ther , vol.96 , pp. 23-43
    • Schäcke, H.1    Döcke, W.D.2    Asadullah, K.3
  • 17
    • 27644492383 scopus 로고    scopus 로고
    • A fully dissociated compound of plant origin for inflammatory gene repression
    • De Bosscher K, Vanden Berghe W, Beck IM, et al. A fully dissociated compound of plant origin for inflammatory gene repression. Proc Natl Acad Sci U S A. 2005;102:15827-15832.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 15827-15832
    • De Bosscher, K.1    Vanden Berghe, W.2    Beck, I.M.3
  • 18
    • 34547872354 scopus 로고    scopus 로고
    • Glucocorticoid receptor action in beneficial and side effects of steroid therapy: Lessons from conditional knockout mice
    • Kleiman A, Tuckermann JP. Glucocorticoid receptor action in beneficial and side effects of steroid therapy: lessons from conditional knockout mice. Mol Cell Endocrinol. 2007;275:98-108.
    • (2007) Mol Cell Endocrinol , vol.275 , pp. 98-108
    • Kleiman, A.1    Tuckermann, J.P.2
  • 19
    • 0036685418 scopus 로고    scopus 로고
    • Designer glucocorticoids
    • Miner JN. Designer glucocorticoids. Biochem Pharmacol. 2002;64: 355-361.
    • (2002) Biochem Pharmacol , vol.64 , pp. 355-361
    • Miner, J.N.1
  • 20
    • 0347719371 scopus 로고    scopus 로고
    • Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects
    • Schacke H, Schottelius A, Docke WD, et al. Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects. Proc Natl Acad Sci U S A. 2004;101:227-232.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 227-232
    • Schacke, H.1    Schottelius, A.2    Docke, W.D.3
  • 21
    • 0027934108 scopus 로고
    • A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1
    • Heck S, Kullmann M, Gast A, et al. A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J. 1994;13:4087-4095.
    • (1994) EMBO J , vol.13 , pp. 4087-4095
    • Heck, S.1    Kullmann, M.2    Gast, A.3
  • 22
    • 18144444807 scopus 로고    scopus 로고
    • DNA binding of the glucocorticoid receptor is not essential for survival
    • Reichardt HM, Kaestner KH, Tuckermann J, et al. DNA binding of the glucocorticoid receptor is not essential for survival. Cell. 1998; 93:531-541.
    • (1998) Cell , vol.93 , pp. 531-541
    • Reichardt, H.M.1    Kaestner, K.H.2    Tuckermann, J.3
  • 23
    • 0037126620 scopus 로고    scopus 로고
    • Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor
    • Reichardt HM, Tuckermann JP, Gottlicher M, et al. Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor. EMBO J. 2001;20:7168-7173.
    • (2001) EMBO J , vol.20 , pp. 7168-7173
    • Reichardt, H.M.1    Tuckermann, J.P.2    Gottlicher, M.3
  • 24
    • 77953063043 scopus 로고    scopus 로고
    • Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor
    • Frijters R, Fleuren W, Toonen EJ, et al. Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor. BMC Genomics. 11:359.
    • BMC Genomics , vol.11 , pp. 359
    • Frijters, R.1    Fleuren, W.2    Toonen, E.J.3
  • 25
    • 77956277161 scopus 로고    scopus 로고
    • Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor
    • Rauch A, Seitz S, Baschant U, et al. Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell Metab. 11:517-531.
    • Cell Metab , vol.11 , pp. 517-531
    • Rauch, A.1    Seitz, S.2    Baschant, U.3
  • 26
    • 56049123409 scopus 로고    scopus 로고
    • The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene
    • Waddell DS, Baehr LM, van den Brandt J, et al. The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene. Am J Physiol. 2008;295:E785-E797.
    • (2008) Am J Physiol , vol.295
    • Waddell, D.S.1    Baehr, L.M.2    Van Den Brandt, J.3
  • 28
    • 77949706528 scopus 로고    scopus 로고
    • Differential in vivo effects on target pathways of a novel arylpyrazole glucocorticoid receptor modulator compared with prednisolone
    • Roohk DJ, Varady KA, Turner SM, et al. Differential in vivo effects on target pathways of a novel arylpyrazole glucocorticoid receptor modulator compared with prednisolone. J Pharmacol Exp Ther. 333:281-289.
    • J Pharmacol Exp Ther , vol.333 , pp. 281-289
    • Roohk, D.J.1    Varady, K.A.2    Turner, S.M.3
  • 29
    • 0037840686 scopus 로고    scopus 로고
    • Measurement of mitochondrial DNA synthesis in vivo using a stable isotope-mass spectrometric technique
    • Collins ML, Eng S, Hoh R, Hellerstein MK. Measurement of mitochondrial DNA synthesis in vivo using a stable isotope-mass spectrometric technique. J Appl Physiol. 2003;94:2203-2211.
    • (2003) J Appl Physiol , vol.94 , pp. 2203-2211
    • Collins, M.L.1    Eng, S.2    Hoh, R.3    Hellerstein, M.K.4
  • 32
    • 33646106593 scopus 로고    scopus 로고
    • Measurement of protein turnover rates by heavy water labeling of nonessential amino acids
    • Busch R, Kim YK, Neese RA, et al. Measurement of protein turnover rates by heavy water labeling of nonessential amino acids. Biochim Biophys Acta. 2006;1760:730-744.
    • (2006) Biochim Biophys Acta , vol.1760 , pp. 730-744
    • Busch, R.1    Kim, Y.K.2    Neese, R.A.3
  • 33
    • 0025796935 scopus 로고
    • Measurement of de novo hepatic lipogenesis in humans using stable isotopes
    • Hellerstein MK, Christiansen M, Kaempfer S, et al. Measurement of de novo hepatic lipogenesis in humans using stable isotopes. J Clin Invest. 1991;87:1841-1852.
    • (1991) J Clin Invest , vol.87 , pp. 1841-1852
    • Hellerstein, M.K.1    Christiansen, M.2    Kaempfer, S.3
  • 34
    • 0027377603 scopus 로고
    • Model for measuring absolute rates of hepatic de novo lipogenesis and reesterification of free fatty acids
    • Hellerstein MK, Neese RA, Schwarz JM. Model for measuring absolute rates of hepatic de novo lipogenesis and reesterification of free fatty acids. Am J Physiol. 1993;265:E814-E820.
    • (1993) Am J Physiol , vol.265
    • Hellerstein, M.K.1    Neese, R.A.2    Schwarz, J.M.3
  • 35
    • 34047210437 scopus 로고    scopus 로고
    • Dissociation between adipose tissue fluxes and lipogenic gene expression in ob/ob mice
    • Turner SM, Roy S, Sul HS, et al. Dissociation between adipose tissue fluxes and lipogenic gene expression in ob/ob mice. Am J Physiol. 2007;292:E1101-E1109.
    • (2007) Am J Physiol , vol.292
    • Turner, S.M.1    Roy, S.2    Sul, H.S.3
  • 37
    • 0035892726 scopus 로고    scopus 로고
    • Advances in the stable isotopemass spectrometric measurement of DNA synthesis and cell proliferation
    • Neese RA, Siler SQ, Cesar D, et al. Advances in the stable isotopemass spectrometric measurement of DNA synthesis and cell proliferation. Anal Biochem. 2001;298:189-195.
    • (2001) Anal Biochem , vol.298 , pp. 189-195
    • Neese, R.A.1    Siler, S.Q.2    Cesar, D.3
  • 38
    • 0033038503 scopus 로고    scopus 로고
    • Mass isotopomer distribution analysis at eight years: Theoretical, analytic, and experimental considerations
    • Hellerstein MK, Neese RA. Mass isotopomer distribution analysis at eight years: theoretical, analytic, and experimental considerations. Am J Physiol. 1999;276:E1146-E1170.
    • (1999) Am J Physiol , vol.276
    • Hellerstein, M.K.1    Neese, R.A.2
  • 39
    • 34547629031 scopus 로고    scopus 로고
    • Dose effects of modified alternate-day fasting regimens on in vivo cell proliferation and plasma insulin-like growth factor-1 in mice
    • Varady KA, Roohk DJ, Hellerstein MK. Dose effects of modified alternate-day fasting regimens on in vivo cell proliferation and plasma insulin-like growth factor-1 in mice. J Appl Physiol. 2007; 103:547-551.
    • (2007) J Appl Physiol , vol.103 , pp. 547-551
    • Varady, K.A.1    Roohk, D.J.2    Hellerstein, M.K.3
  • 40
    • 34948907445 scopus 로고    scopus 로고
    • Effects of modified alternate-day fasting regimens on adipocyte size, triglyceride metabolism, and plasma adiponectin levels in mice
    • Varady KA, Roohk DJ, Loe YC, McEvoy-Hein BK, HellersteinMK. Effects of modified alternate-day fasting regimens on adipocyte size, triglyceride metabolism, and plasma adiponectin levels in mice. J Lipid Res. 2007;48:2212-2219.
    • (2007) J Lipid Res , vol.48 , pp. 2212-2219
    • Varady, K.A.1    Roohk, D.J.2    Loe, Y.C.3    McEvoy-Hein, B.K.4    Hellerstein, M.K.5
  • 41
    • 42149152638 scopus 로고    scopus 로고
    • Time course and dynamics of adipose tissue development in obese and lean Zucker rat pups
    • Pouteau E, Turner S, Aprikian O, et al. Time course and dynamics of adipose tissue development in obese and lean Zucker rat pups. Int J Obes (Lond). 2008;32:648-657.
    • (2008) Int J Obes (Lond) , vol.32 , pp. 648-657
    • Pouteau, E.1    Turner, S.2    Aprikian, O.3
  • 42
    • 0033569441 scopus 로고    scopus 로고
    • Metabolic adaptations to dietary fat malabsorption in chylomicron-deficient mice
    • Jung HR, Turner SM, Neese RA, Young SG, Hellerstein MK. Metabolic adaptations to dietary fat malabsorption in chylomicron-deficient mice. Biochem J. 1999;343(Pt 2):473-478.
    • (1999) Biochem J , vol.343 , Issue.PART 2 , pp. 473-478
    • Jung, H.R.1    Turner, S.M.2    Neese, R.A.3    Young, S.G.4    Hellerstein, M.K.5
  • 43
    • 78650882261 scopus 로고    scopus 로고
    • Genome-wide analysis of glucocorticoid receptor binding regions in adipocytes reveal gene network involved in triglyceride homeostasis
    • Yu CY, Mayba O, Lee JV, et al. Genome-wide analysis of glucocorticoid receptor binding regions in adipocytes reveal gene network involved in triglyceride homeostasis. PLoS One. 5:e15188.
    • PLoS One , vol.5
    • Yu, C.Y.1    Mayba, O.2    Lee, J.V.3
  • 44
    • 34247628439 scopus 로고    scopus 로고
    • Whole-body glycolysis measured by the deuterated-glucose disposal test correlates highly with insulin resistance in vivo
    • Beysen C, Murphy EJ, McLaughlin T, et al. Whole-body glycolysis measured by the deuterated-glucose disposal test correlates highly with insulin resistance in vivo. Diabetes Care. 2007;30:1143-1149.
    • (2007) Diabetes Care , vol.30 , pp. 1143-1149
    • Beysen, C.1    Murphy, E.J.2    McLaughlin, T.3
  • 45
    • 0035005804 scopus 로고    scopus 로고
    • Dexamethasone inhibits the stimulation of muscle protein synthesis and PHAS-I and p70 S6-kinase phosphorylation
    • Long W, Wei L, Barrett EJ. Dexamethasone inhibits the stimulation of muscle protein synthesis and PHAS-I and p70 S6-kinase phosphorylation. Am J Physiol. 2001;280:E570-E575.
    • (2001) Am J Physiol , vol.280
    • Long, W.1    Wei, L.2    Barrett, E.J.3
  • 47
    • 0020521619 scopus 로고
    • Time course of the effect of catabolic doses of corticosterone on protein turnover in rat skeletal muscle and liver
    • Odedra BR, Bates PC, Millward DJ. Time course of the effect of catabolic doses of corticosterone on protein turnover in rat skeletal muscle and liver. Biochem J. 1983;214:617-627.
    • (1983) Biochem J , vol.214 , pp. 617-627
    • Odedra, B.R.1    Bates, P.C.2    Millward, D.J.3
  • 48
  • 49
    • 0022551936 scopus 로고
    • Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid-dependent mechanism
    • May RC, Kelly RA, Mitch WE. Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid-dependent mechanism. J Clin Invest. 1986;77:614-621.
    • (1986) J Clin Invest , vol.77 , pp. 614-621
    • May, R.C.1    Kelly, R.A.2    Mitch, W.E.3
  • 50
    • 0035156842 scopus 로고    scopus 로고
    • Molecular mechanisms regulating protein turnover in muscle
    • Price SR, Du J, Bailey JL, Mitch WE. Molecular Mechanisms Regulating Protein Turnover in Muscle. Am J Kidney Dis. 2001;37: S112-S114.
    • (2001) Am J Kidney Dis , vol.37
    • Price, S.R.1    Du, J.2    Bailey, J.L.3    Mitch, W.E.4
  • 51
    • 0030051797 scopus 로고    scopus 로고
    • Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids
    • Tiao G, Fagan J, Roegner V, et al. Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids. J Clin Invest. 1996;97:339-348.
    • (1996) J Clin Invest , vol.97 , pp. 339-348
    • Tiao, G.1    Fagan, J.2    Roegner, V.3
  • 52
    • 0027460118 scopus 로고
    • Glucocorticoids activate the ATP-ubiquitindependent proteolytic system in skeletal muscle during fasting
    • Wing SS, Goldberg AL. Glucocorticoids activate the ATP-ubiquitindependent proteolytic system in skeletal muscle during fasting. Am J Physiol. 1993;264:E668-E676.
    • (1993) Am J Physiol , vol.264
    • Wing, S.S.1    Goldberg, A.L.2
  • 53
    • 0030866606 scopus 로고    scopus 로고
    • Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets
    • Lambillotte C, Gilon P, Henquin JC. Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets. J Clin Invest. 1997;99:414-423.
    • (1997) J Clin Invest , vol.99 , pp. 414-423
    • Lambillotte, C.1    Gilon, P.2    Henquin, J.C.3
  • 54
    • 0345564849 scopus 로고    scopus 로고
    • Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor
    • Rogatsky I, Wang JC, Derynck MK, et al. Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor. Proc Natl Acad Sci U S A. 2003;100:13845-13850.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 13845-13850
    • Rogatsky, I.1    Wang, J.C.2    Derynck, M.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.