Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 6, 2012, Pages 1961-1966

  Garcia Marcos, Mikel ^a   Kietrsunthorn, Patrick S ^a   Pavlova, Yelena ^b   Adia, Michelle A ^a   Ghosh, Pradipta ^b   Farquhar, Marilyn G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Hill coefficient; Switch like; Trimeric G proteins; Ultrasensitivity

Indexed keywords

G ALPHA INTERACTING VESICLE ASSOCIATED PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ARTICLE; CELL FUNCTION; CELL LINE; CELL MIGRATION; ENZYME ACTIVATION; IN VIVO STUDY; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MOTIF; SIGNAL TRANSDUCTION; STIMULUS; STRESS FIBER;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CELL MOVEMENT; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HELA CELLS; HUMANS; INSULIN; LYSOPHOSPHOLIPIDS; MICROFILAMENT PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STRESS FIBERS; VESICULAR TRANSPORT PROTEINS;

GREAT ISLAND VIRUS;

EID: 84857128930     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1120538109     Document Type: Article

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