Metabolic impact of nigella sativa extracts on experimental menopause induced rats

Journal of Applied Pharmaceutical Science

Volumn 1, Issue 9, 2011, Pages 38-42

  Parhizkar, Saadat ^a,b   Latiff, Latiffah A ^b   Rahman, Sabariah A ^b   Hanachi, Parichehr ^c   Dollah, Mohammad Aziz ^b  

^a YASUJ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Universiti Putra   (Malaysia)

^c ALZAHRA UNIVERSITY   (Iran)

Author keywords

Menopause; Metabolic syndrome; Nigella sativa; Ovariectomy

Indexed keywords

EID: 84875830755     PISSN: None     EISSN: 22313354     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Ali, B.H. and Blunden, G. Pharmacological and toxicological peroperties of Nigella Sativa. Journal of Phytotherapy Research. 2003;17(4):299-305.
2. Alsaif, M.A. Effect of Nigella sativa oil on impaired glucose tolerance and insulin insensitivity induced by high-fat-diet and turpentine induced-trauma. Pakistan Journal of Biological Sciences. 2008; 11(8):1093-1098.
3. Aqel, M. The relaxing effect of the volatile oil of Nigella sativa seeds on vascular smooth muscle. Dirasat Series B, Pure Applied Sciences. 1992; 19(2): 91-100.
4. Araujo, L.B.F., Soares, J.M., Simoes, R.S. Ricardo Santos, S., Calió, P.L., Ricardo Oliveira-Filho, M., Simões, M.J., Haidar, M.A. and Baracat, E.C. Effect of conjugated equine estrogens and tamoxifen administration on thyroid gland histomorphology of the rat. Clinics, 2006; 61: 321-326.
5. Bamosa, A.O., Ali, B.A., Sawayan, S.A. Effect of oral ingestion of Nigella Sativa seed on some blood parameters. Saudi Pharmaceutical Journal. 1997;5: 126-129.
6. El Dakhakhny, M., Mady, N.L., Halim, M.A. Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats. Arzneimittelforschung, 2000; 50(9); 832-6.
7. Genazzani, A. R., Stomati, M., Bernardi, F.,Luisi S., Casarosa, E., Puccetti, S., Genazzani, A.D., Palumbo, M. and Luisi, M. Conjugated equine estrogens reverse the effects of aging on central and peripheral allopregnanolone and beta-endorphin levels in female rats. Fertility and Sterility, 2004; 81(1): 757-766.
8. Hajdu, A., Chappel, C. I. and Rona, G. The influence of estrogens on scorbutic bone lesions in guinea-pigs. Cellular and Molecular Life Sciences. 1965; 21(8): 466-467.
9. Hanafy, M.S. and Hatem, M.E. Studies on the anti-microbial activity of the Nigella Sativa seed (Black Cumin). Journal of Ethnopharmacology. 1991; 34: 275-278.
10. Hawsawi, Z.A., Ali, B.A., Bamosa, A.O. Effect of Nigella sativa (Black seed) and thymoquinone on blood glucose in Albino rats. Annals of Saudi Medicine. 2001; 21 ( 3-4), 242-244.
11. Hernández-Ceruelos, A., Madrigal-Bujaidar, E. and de la Cruz, C. Inhibitory effect of chamomile essential oil on the sister chromatid exchanges induced by daunorubicin and methyl methanesulfonate in mouse bone marrow. Toxicology letters, 2002; 135(1-2):103-110.
12. Houcher, Z., Boudiaf, Kh., Benboubetra, M. and Houcher, B. Effects of Methanolic Extract and Commercial Oil of Nigella sativa L. on Blood Glucose and Antioxidant Capacity in Alloxan-Induced Diabetic Rats. Pteridines. 2007; 18:8-18.
13. Houghton, P.J., Zarka, R., Heras, B. and Hoult, J.R. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Medica. 1995; 61: 33-36.
14. Kanter, M., Meral, I.,Yener, Z., Ozbek, H. and Demir, H. Partial regeneration/ proliferation of the beta-cells in the islets of Langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats. Tohoku Journal of Experimental Medicine. 2003;201: 213-219.
15. Labhal, A., Settaf, A., Bennani-Kabchi, N., Cherrah, Y., Slaoui, A., Hassar, M. Action anti-obésité, hypocholestérolémiante et hypotriglycéridémiante de Nigella sativa chez le Psammomys obesus. Caducée. 1997; 27: 26-28.
16. Labhal, A., Settaf, A., Zalagh, F., Cherrah, Y., Hassar, M., Slaoui, A. Propriétés anti-diabétiques des graines de Nigella sativa chez le Meriones shawi obese et diabétique. Espérance Médicale, 1999; 47: 72- 74.
17. Le, P.M., Benhaddou-Andaloussi, A., Settaf, A., Cherrah, Y. and Haddad, P.S. The petroleum ether extract of Nigella sativa exerts lipid lowering action in the rats. Journal of Ethnopharmacology. 2004;94(2-3): 251-9.
18. Meddah, B., Ducroc, R., Faouzi, M.E.A., Eto, B., Mahraoui, L., Benhaddou-Andaloussi, A., Martineau, L.Ch., Cherrah, Y. and Haddad, P.S. Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. Journal of Ethnopharmacology, 2009;121(3); 419-424.
19. Oropeza, M.V., Orozco, S., Ponce, H. and Campos, M.G. Tofupill lacks peripheral estrogen-like actions in the rat reproductive tract. Reproductive Toxicology, 2005; 20: 261-266.
20. Parhizkar, S., Rashid I and Latiffah AL. Incision Choice in Laparatomy: a Comparison of Two Incision Techniques in Ovariectomy of Rats. World Journal of Applied Sciences. 2008; 4 (4): 537-540.
21. Parhizkar, S., Latiffah, A. L., Sabariah, A.R., Dollah, M.A. Preventive effect of Nigella sativa on metabolic syndrome in Menopause Induced Rats. Journal of Medicinal Plant Research. 2011b ;5(8);1478- 1484.
22. Saadat Parhizkar, Latiffah Abdul Latiff, Sabariah Abdul Rahman, Mohammad Aziz Dollah, Hanachi Parichehr. Assessing estrogenic activity of Nigella sativa in ovariectomized rats using vaginal cornification assay. African Journal of Pharmacy and Pharmacology. 2011a ; 5(2):137 - 142.
23. Schwartsmann, G. , Ratain, M.J., Cragg, G.M. , Wong, J.E., Saijo, N., Parkinson, D.R., Fujiwara, Y., Pazdur, R., Newman, D.J., Dagher, R. and Di Leone, L. Anticancer Drug Discovery and Development throughout the World. Journal of Clinical Oncology, 2002; 20(18S): 47s- 59s.
24. Settaf, A., Berrada, Y., Haddad, P.S., Cherrah, Y., Hassar, M. and Slaoui, A. (2000). Volatile oil of Nigella sativa lowers plasma lipids and insulin in obese hyperlipidemic sand rats (Psammomys obesus), 6th International Congress on Ethnopharmacology: P2A/36.
25. Turkdogan, M.K., Agaoglu, Z., Yener, Z., Sekeroglu, R., Akkan, H.A. and. Avci, M.E. The role of antioxidant vitamins (C and E), selenium and Nigella sativa in the prevention of liver fibrosis and cirrhosis in rabbits: new hopes. Dtsch Tierarztl Wochenschr, 2001; 108: 71-73.
26. Zaoui, A., Cherrah, Y., Lacaille-Dubois, M.A., Settaf, A., Amarouch, H. and Hassar, M. Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat. Therapie, 2000; 55: 379- 382.
27. Zaoui, A., Cherrah, Y., Mahassini, N., Alaoui, K., Amarouch, H. and Hassar, M. Acute and chronic toxicity of Nigella sativa fixed oil. Phytomedicin, 2002; 9: 69-74.