Expression of proton-coupled oligopeptide transporter (POTs) in prostate of mice and patients with benign prostatic hyperplasia (BPH) and prostate cancer (PCa)

Prostate

Volumn 73, Issue 3, 2013, Pages 287-295

  Sun, Dongli ^a   Tan, Fuqing ^b   Fang, Danbo ^b   Wang, Yuqing ^a   Zeng, Su ^a   Jiang, Huidi ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

BPH; inflammation; PCa; PepT2; PHT2

Indexed keywords

GAMMA INTERFERON; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 6; MEMBRANE PROTEIN; MESSENGER RNA; PEPTIDE TRANSPORTER 1; PEPTIDE TRANSPORTER 2; PROTEIN PHT1; PROTEIN PHT2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG ABSORPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE EPITHELIUM; PROSTATE HYPERTROPHY; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; WESTERN BLOTTING;

ANIMALS; CARRIER PROTEINS; CELL LINE; CELL LINE, TUMOR; EPITHELIAL CELLS; HUMANS; MALE; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED ICR; MODELS, ANIMAL; NERVE TISSUE PROTEINS; PROSTATE; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; RNA, MESSENGER; SYMPORTERS;

EID: 84872811746     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.22568     Document Type: Article

References (34)

1. Ganapathy ME, Brandsch M, Prasad PD, Ganapathy V, Leibach FH,. differental recognition of beta-lactam antibiotics by intestinal and renal peptide transporters, PepT-1 and PepT-2. J Biol Chem 1995; 270 (43): 25672-25677.
2. +/peptide transporters revisited. J Pharmacol Exp Ther 2008; 327 (2): 432-441.
3. Saito H, Terada T, Okuda M, Sasaki S, Inui K,. Molecular cloning and tissue distribution of rat peptide transporter PEPT2. Biochim Biophys Acta 1996; 1280 (2): 173-177.
4. Ganapathy ME, Huang W, Wang H, Ganapathy V, Leibach FH,. Valacycloviv: A substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. Biochem Biophys Res Commun 1998; 246 (2): 470-475.
5. Novotny A, Xiang J, Stummer W, Teuscher NS, Smith DE, Keep RF,. Mechanisms of 5-aminolevulinic acid uptake at the choroid plexus. J Neurochem 2000; 75 (1): 321-328.
6. Fei YJ, Kanai Y, Nussberger S, Ganapathy V, Leibach FH, Romero MF, Singh SK, Boron WF, Hediger MA,. Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 1994; 368 (6471): 563-566.
7. Boll M, Herget M, Wagener M, Weber WM, Markovich D, Biber J, Clauss W, Murer H, Daniel H,. Expression cloning and functional characterization of the kidney cortex high-affinity proton-coupled peptide transporter. Proc Natl Acad Sci USA 1996; 93 (1): 284-289.
8. Berger UV, Hediger MA,. Distribution of peptide transporter PEPT2 mRNA in the rat nervous system. Anat Embryol 1999; 199 (5): 439-449.
9. Teuscher NS, Novotny A, Keep RF, Smith DE,. Functional evidence for presence of PEPT2 in rat choroid plexus: Studies with glycylsarcosine. J Pharmacol Exp Ther 2000; 294 (2): 494-499.
10. Shen H, Smith DE, Keep RF, Xiang JM, Brosius FC,. Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus. J Biol Chem 2003; 278 (7): 4786-4791.
11. Groneberg DA, Nickolaus M, Springer J, Doring F, Daniel H, Fischer A,. Localization of the peptide transporter PEPT2 in the lung-Implications for pulmonary oligopeptide uptake. Am J Pathol 2001; 158 (2): 707-714.
12. Groneberg DA, Doring F, Theis S, Nickolaus M, Fischer A, Daniel H,. Peptide transport in the mammary gland: Expression and distribution of PEPT2 mRNA and protein. Am J Physiol Endocrinol Metab 2002; 282 (5): E1172-E1179.
13. Bahadduri PM, D'Souza VM, Pinsonneault JK, Sadee W, Bao SY, Knoell DL, Swaan PW,. Functional characterization of the peptide transporter PEPT2 in primary cultures of human upper airway epithelium. Am J Respir Cell Mol Biol 2005; 32 (4): 319-325.
14. Botka CW, Wittig TW, Graul RC, Nielsen CU, Higaki K, Amidon GL, Sadee W,. Human proton/oligopeptide transporter (POT) genes: Identification of putative human genes using bioinformatics. AAPS PharmSci 2000; 2 (2): art. no.-16.
15. Yamashita T, Shimada S, Guo W, Sato K, Kohmura E, Hayakawa T, Takagi T, Tohyama M,. Cloning and functional expression of a brain peptide/histidine transporter. J Biol Chem 1997; 272 (15): 10205-10211.
16. Sakata K, Yamashita T, Maeda M, Moriyama Y, Shimada S, Tohyama M,. Cloning of a lymphatic peptide/histidine transporter. Biochem J 2001; 356 (Pt 1): 53-60.
17. Sasawatari S, Okamura T, Kasumi E, Tanaka-Furuyama K, Yanobu-Takanashi R, Shirasawa S, Kato N, Toyama-Sorimachi N,. The solute carrier family 15A4 regulates TLR9 and NOD1 functions in the innate immune system and promotes colitis in mice. Gastroenterology 2011; 140 (5): 1513-1525.
18. Talluri RS, Samanta SK, Gaudana R, Mitra AK,. Synthesis, metabolism and cellular permeability of enzymatically stable dipeptide prodrugs of acyclovir. Int J Pharm 2008; 361 (1-2): 118-124.
19. Quarcoo D, Fischer TC, Heppt W, Lauenstein HD, Pilzner C, Welte T, Groneberg DA,. Expression, localisation and functional implications of the transporter protein PEPT2 in the upper respiratory tract. Respiration 2009; 77 (4): 440-446.
20. Romano A, Barca A, Kottra G, Daniel H, Storelli C, Verri T,. Functional expression of SLC15 peptide transporters in rat thyroid follicular cells. Mol Cell Endocrinol 2010; 315 (1-2): 174-181.
21. Agu R, Cowley E, Shao D, Macdonald C, Kirkpatrick D, Renton K, Massoud E,. Proton-coupled oligopeptide transporter (POT) family expression in human nasal epithelium and their drug transport potential. Mol Pharm 2011; 8 (3): 664-672.
22. Siegel R, Naishadham D, Jemal A,. Cancer Statistics, 2012. Ca-Cancer J Clin 2012; 62 (1): 10-29.
23. Morgan ET, Goralski KB, Piquette-Miller M, Renton KW, Robertson GR, Chaluvadi MR, Charles KA, Clarke SJ, Kacevska M, Liddle C, Richardson TA, Sharma R, Sinal CJ,. Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer. Drug Metab Dispos 2008; 36 (2): 205-216.
24. Vavricka SR, Musch MW, Fujiya M, Kles K, Chang L, Eloranta JJ, Kullak-Ublick GA, Drabik K, Merlin D, Chang EB,. Tumor necrosis factor-alpha and interferon-gamma increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine. Pflugers Arch 2006; 452 (1): 71-80.
25. Merlin D, Si-Tahar M, Sitaraman SV, Eastburn K, Williams I, Liu X, Hediger MA, Madara JL,. Colonic epithelial hPepT1 expression occurs in inflammatory bowel disease: Transport of bacterial peptides influences expression of MHC class 1 molecules. Gastroenterology 2001; 120 (7): 1666-1679.
26. De Nunzio C, Kramer G, Marberger M, Montironi R, Nelson W, Schroder F, Sciarra A, Tubaro A,. The controversial relationship between benign prostatic hyperplasia and prostate cancer: The role of inflammation. Eur Urol 2011; 60 (1): 106-117.
27. De Marzo AM, Platz EA, Sutcliffe S, Xu JF, Gronberg H, Drake CG, Nakai Y, Isaacs WB, Nelson WG,. Inflammation in prostate carcinogenesis. Nat Rev Cancer 2007; 7 (4): 256-269.
28. Ocheltree SM, Shen H, Hu Y, Keep RF, Smith DE,. Role and relevance of peptide transporter 2 (PEPT2) in the kidney and choroid plexus: In vivo studies with glycylsarcosine in wild-type and PEPT2 knockout mice. J Pharmacol Exp Ther 2005; 315 (1): 240-247.
29. Hayward SW, Cunha GR,. The prostate: Development and physiology. Radiol Clin North Am 2000; 38 (1): 1-14.
30. Wong YC, Wang XH, Ling MT,. Prostate development and carcinogenesis. Int Rev Cytol 2003; 227: 65-130.
31. Desouki MM, Geradts J, Milon B, Franklin RB, Costello LC,. hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands. Mol Cancer 2007; 6: 37.
32. Luo JH, Yu YP, Cieply K, Lin F, Deflavia P, Dhir R, Finkelstein S, Michalopoulos G, Becich M,. Gene expression analysis of prostate cancers. Mol Carcinogen 2002; 33 (1): 25-35.
33. Luo J, Duggan DJ, Chen YD, Sauvageot J, Ewing CM, Bittner ML, Trent JM, Isaacs WB,. Human prostate cancer and benign prostatic hyperplasia: Molecular dissection by gene expression profiling. Cancer Res 2001; 61 (12): 4683-4688.
34. Alcaraz A, Hammerer P, Tubaro A, Schroder FH, Castro R,. Is there evidence of a relationship between benign prostatic hyperplasia and prostate cancer? Findings of a literature review. Eur Urol 2009; 55 (4): 864-875.