Eicosapentaenoic and docosahexaenoic acid supplementations reduce platelet aggregation and hemostatic markers differentially in men and women

Journal of Nutrition

Volumn 143, Issue 4, 2013, Pages 457-463

  Phang, Melinda ^a   Lincz, Lisa F ^b   Garg, Manohar L ^a  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b CALVARY MATER NEWCASTLE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; ESTRADIOL; FATTY ACID; ICOSAPENTAENOIC ACID; PADGEM PROTEIN; PLACEBO; PLASMINOGEN ACTIVATOR INHIBITOR 1; TESTOSTERONE; THROMBOXANE B2; VON WILLEBRAND FACTOR;

ADULT; ARTICLE; CARDIOVASCULAR RISK; COHORT ANALYSIS; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ERYTHROCYTE COUNT; ESTRADIOL BLOOD LEVEL; FATTY ACID BLOOD LEVEL; FEMALE; HEMATOCRIT; HEMOSTASIS; HUMAN; IMMUNOASSAY; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; TESTOSTERONE BLOOD LEVEL; THROMBOCYTE; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT;

ADULT; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; DOUBLE-BLIND METHOD; EICOSAPENTAENOIC ACID; ERYTHROCYTE COUNT; ESTRADIOL; FATTY ACIDS; FEMALE; HEMATOCRIT; HEMOSTASIS; HUMANS; MALE; PLACEBOS; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLATELET AGGREGATION; PLATELET COUNT; SEX FACTORS; TESTOSTERONE;

EID: 84875773019     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.112.171249     Document Type: Article

References (55)

1. Kantha SS. Dietary effects of fish oils on human health: a review of recent studies. Yale J Biol Med. 1987;60:37-44.
2. Rodvien R, Mielke CH Jr. Role of platelets in hemostasis and thrombosis. West J Med. 1976;125:181-6.
3. Myers DD Jr, Henke PK, Wrobleski SK, Hawley AE, Farris DM, Chapman AM, Knipp BS, Thanaporn P, Schaub RG, Greenfield LG, et al. P-selectin inhibition enhances thrombus resolution and decreases vein wall fibrosis in a rat model. J Vasc Surg. 2002;36:928-38.
4. Kohler HP, Grant PJ. Plasminogen-activator inhibitor type 1 and coronary artery disease. N Engl J Med. 2000;342:1792-801.
5. Bruno MJ, Koeppe RE II, Andersen OS. Docosahexaenoic acid alters bilayer elastic properties. Proc Natl Acad Sci USA. 2007;104:9638-43.
6. Calder PC. Polyunsaturated fatty acids and inflammatory processes: new twists in an old tale. Biochimie. 2009;91:791-5.
7. Mori TA, Beilin LJ, Burke V, Morris J, Ritchie J. Interactions between dietary fat, fish, and fish oils and their effects on platelet function in men at risk of cardiovascular disease. Arterioscler Thromb Vasc Biol. 1997;17:279-86.
8. Scheurlen M, Kirchner M, Clemens MR, Jaschonek K. Fish oil preparations rich in docosahexaenoic acid modify platelet responsiveness to prostaglandin-endoperoxide/thromboxane A2 receptor agonists. Biochem Pharmacol. 1993;46:245-9.
9. von Schacky C, Fischer S, Weber PC. Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans. J Clin Invest. 1985;76:1626-31.
10. Sanders TA, Naismith DJ, Haines AP, Vickers M. Cod-liver oil, platelet fatty acids, and bleeding time. Lancet. 1980;1:1189.
11. Saga T, Aoyama T, Takekoshi T. Changes in platelet count and mean volume of platelet after administration of icosapentaenoic acid ethylester, and factors that may affect those changes. Nippon Ronen Igakkai Zasshi. 1994;31:538-47.
12. Shahar E, Folsom AR, Wu KK, Dennis BH, Shimakawa T, Conlan MG, Davis CE, Williams OD. Associations of fish intake and dietary n-3 polyunsaturated fatty acids with a hypocoagulable profile. The Atherosclerosis Risk in Communities (ARIC) Study. Arterioscler Thromb. 1993;13:1205-12.
13. Agren JJ, Vaisanen S, Hanninen O, Muller AD, Hornstra G. Hemostatic factors and platelet aggregation after a fish-enriched diet or fish oil or docosahexaenoic acid supplementation. Prostaglandins Leukot Essent Fatty Acids. 1997;57:419-21.
14. Park Y, HarrisW. EPA, but not DHA, decreases mean platelet volume in normal subjects. Lipids. 2002;37:941-6.
15. Nelson GJ, Schmidt PS, Bartolini GL, Kelley DS, Kyle D. The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. Lipids. 1997;32: 1129-36.
16. Archer SL, Green D, Chamberlain M, Dyer AR, Liu K. Association of dietary fish and n-3 fatty acid intake with hemostatic factors in the coronary artery risk development in young adults (CARDIA) study. Arterioscler Thromb Vasc Biol. 1998;18:1119-23.
17. Johansen O, Seljeflot I, Hostmark AT, Arnesen H. The effect of supplementation with omega-3 fatty acids on soluble markers of endothelial function in patients with coronary heart disease. Arterioscler Thromb Vasc Biol. 1999;19:1681-6.
18. Marckmann P, Bladbjerg EM, Jespersen J. Dietary fish oil (4 g daily) and cardiovascular risk markers in healthy men. Arterioscler Thromb Vasc Biol. 1997;17:3384-91.
19. Din JN, Harding SA, Valerio CJ, Sarma J, Lyall K, Riemersma RA, Newby DE, Flapan AD. Dietary intervention with oil rich fish reduces platelet-monocyte aggregation in man. Atherosclerosis. 2008;197: 290-6.
20. Davies MJ. The current status of myocardial disarray in hypertrophic cardiomyopathy. Br Heart J. 1984;51:361-3.
21. Eschen O, Christensen JH, De Caterina R, Schmidt EB. Soluble adhesion molecules in healthy subjects: a dose-response study using n-3 fatty acids. Nutr Metab Cardiovasc Dis. 2004;14:180-5.
22. Fox K, Alonso Garcia MA, Ardissino D, Buszman P, Camici PG, Crea F, Daly C, De Backer G, Hjemdahl P, Lopez-Sendon J, et al. Guidelines on the management of stable angina pectoris: executive summary. G Ital Cardiol (Rome). 2006;7:535-83.
23. Burdge GC, Jones AE, Wootton SA. Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men. Br J Nutr. 2002;88:355-63.
24. Burdge GC, Wootton SA. Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr. 2002;88:411-20.
25. Phang M, Garg ML, Sinclair AJ. Inhibition of platelet aggregation by omega-3 polyunsaturated fatty acids is gender specific: redefining platelet response to fish oils. Prostaglandins Leukot Essent Fatty Acids. 2009;81:35-40.
26. Phang M, Sinclair AJ, Lincz LF, Garg ML. Gender-specific inhibition of platelet aggregation following omega-3 fatty acid supplementation. Nutr Metab Cardiovasc Dis. 2012;22:109-14.
27. Phang M, Lincz L, Seldon M, Garg ML. Acute supplementation with eicosapentaenoic acid reduces platelet microparticle activity in healthy subjects. J Nutr Biochem. 2012;23:1128-33.
28. Cardinal DC, Flower RJ. The electronic aggregrometer: a novel device for assessing platelet behaviour in blood. J Pharmacol Methods. 1980; 3:135-58.
29. Lepage G, Roy CC. Direct transesterification of all classes of lipids in a one-step reaction. J Lipid Res. 1986;27:114-20.
30. Conquer JA, Holub BJ. Supplementation with an algae source of docosahexaenoic acid increases (n-3) fatty acid status and alters selected risk factors for heart disease in vegetarian subjects. J Nutr. 1996; 126:3032-9.
31. Giltay EJ, Gooren LJ, Toorians AW, Katan MB, Zock PL. Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. Am J Clin Nutr. 2004;80:1167-74.
32. Ajayi AA, Mathur R, Halushka PV. Testosterone increases human platelet thromboxane A2 receptor density and aggregation responses. Circulation. 1995;91:2742-7.
33. Bakewell L, Burdge GC, Calder PC. Polyunsaturated fatty acid concentrations in young men and women consuming their habitual diets. Br J Nutr. 2006;96:93-9.
34. Skeaff CM, Hodson L, McKenzie JE. Dietary-induced changes in fatty acid composition of human plasma, platelet, and erythrocyte lipids follow a similar time course. J Nutr. 2006;136:565-9.
35. Cheryk LA, Conquer JA, Holub BJ, Gentry PA. Docosahexaenoic acid and docosapentanoic acid incorporation into human platelets after 24 and 72 hours: inhibitory effects on platelet reactivity. Platelets. 1999; 10:203-11.
36. Galloway JH, Cartwright IJ, Woodcock BE, Greaves M, Russell RG, Preston FE. Effects of dietary fish oil supplementation on the fatty acid composition of the human platelet membrane: demonstration of selectivity in the incorporation of eicosapentaenoic acid into membrane phospholipid pools. Clin Sci (Lond). 1985;68:449-54.
37. von Schacky C, Weber PC. Metabolism and effects on platelet function of the purified eicosapentaenoic and docosahexaenoic acids in humans. J Clin Invest. 1985;76:2446-50.
38. De Caterina R, Liao JK, Libby P. Fatty acid modulation of endothelial activation. Am J Clin Nutr. 2000;71:S213-23.
39. Palabrica T, Lobb R, Furie BC, Aronovitz M, Benjamin C, Hsu YM, Sajer SA, Furie B. Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. Nature. 1992; 359:848-51.
40. Ruggeri ZM. The role of von Willebrand factor in thrombus formation. Thromb Res. 2007;120:S5-9.
41. Vaughan DE. PAI-1 antagonists: the promise and the peril. Trans Am Clin Climatol Assoc. 2011;122:312-25.
42. Collen D, Lijnen HR. Basic and clinical aspects of fibrinolysis and thrombolysis. Blood. 1991;78:3114-24.
43. Aso Y. Plasminogen activator inhibitor (PAI)-1 in vascular inflammation and thrombosis. Front Biosci. 2007;12:2957-66.
44. Fumeron F, Brigant L, Ollivier V, de Prost D, Driss F, Darcet P, Bard JM, Parra HJ, Fruchart JC, Apfelbaum M, et al. n-3 polyunsaturated fatty acids raise low-density lipoproteins, high-density lipoprotein 2, and plasminogen-activator inhibitor in healthy young men. Am J Clin Nutr. 1991;54:118-22.
45. Barcelli U, Glas-Greenwalt P, Pollak VE. Enhancing effect of dietary supplementation with omega-3 fatty acids on plasma fibrinolysis in normal subjects. Thromb Res. 1985;39:307-12.
46. Eritsland J, Arnesen H, Gronseth K, Fjeld NB, Abdelnoor M. Effect of dietary supplementation with n-3 fatty acids on coronary artery bypass graft patency. Am J Cardiol. 1996;77:31-6.
47. Henry M, Tregouet DA, Alessi MC, Aillaud MF, Visvikis S, Siest G, Tiret L, Juhan-Vague I. Metabolic determinants are much more important than genetic polymorphisms in determining the PAI-1 activity and antigen plasma concentrations: a family study with part of the Stanislas Cohort. Arterioscler Thromb Vasc Biol. 1998;18:84-91.
48. Hansen J, Grimsgaard S, Nordoy A, Bonaa KH. Dietary supplementation with highly purified eicosapentaenoic acid and docosahexaenoic acid does not influence PAI-1 activity. Thromb Res. 2000;98:123-32.
49. Asselbergs FW, Williams SM, Hebert PR, Coffey CS, Hillege HL, Navis G, Vaughan DE, van Gilst WH, Moore JH. Gender-specific correlations of plasminogen activator inhibitor-1 and tissue plasminogen activator levels with cardiovascular disease-related traits. J Thromb Haemost. 2007;5:313-20.
50. Toft I, Bonaa KH, Ingebretsen OC, Nordoy A, Birkeland KI, Jenssen T. Gender differences in the relationships between plasma plasminogen activator inhibitor-1 activity and factors linked to the insulin resistance syndrome in essential hypertension. Arterioscler Thromb Vasc Biol. 1997;17:553-9.
51. Rubak P, Villadsen K, Hvas AM. Reference intervals for platelet aggregation assessed by multiple electrode platelet aggregometry. Thromb Res. 2012;130:420-3.
52. Melamed N, Yogev Y, Bouganim T, Altman E, Calatzis A, Glezerman M. The effect of menstrual cycle on platelet aggregation in reproductive-age women. Platelets. 2010;21:343-7.
53. Haque SF, Matsubayashi H, Izumi S, Sugi T, Arai T, Kondo A, Makino T. Sex difference in platelet aggregation detected by new aggregometry using light scattering. Endocr J. 2001;48:33-41.
54. Ridker PM, Cook NR, Lee IM, Gordon D, Gaziano JM, Manson JE, Hennekens CH, Buring JE. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med. 2005;352:1293-304.
55. Iso H, Rexrode KM, Stampfer MJ, Manson JE, Colditz GA, Speizer FE, Hennekens CH, Willett WC. Intake of fish and omega-3 fatty acids and risk of stroke in women. JAMA. 2001;285:304-12.