메뉴 건너뛰기




Volumn 64, Issue 1, 2013, Pages 115-123

Evaluation of apoptotic activity of newcondensed pyrazole derivatives

Author keywords

Apoptosis; Caspase; Cytotoxic activity; DNA intercalators; Poly ADP ribose polymerase; Pyrazole derivatives

Indexed keywords

CASPASE 8; CASPASE 9; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; PYRAZOLE DERIVATIVE; TOSIND; TOSPYRQUIN; UNCLASSIFIED DRUG;

EID: 84875769611     PISSN: 08675910     EISSN: 18991505     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (29)

References (47)
  • 1
    • 42449123761 scopus 로고    scopus 로고
    • Expansion and evolution of cell death programmes
    • Degterev A, Yuan J. Expansion and evolution of cell death programmes. Nature Rev Mol Cell Biol 2008; 9: 378-390.
    • (2008) Nature Rev Mol Cell Biol , vol.9 , pp. 378-390
    • Degterev, A.1    Yuan, J.2
  • 2
    • 79952708318 scopus 로고    scopus 로고
    • Caspase-8 and Bid: Caught in the act between death receptors and mitochondria
    • Kantari C, Walczak H. Caspase-8 and Bid: caught in the act between death receptors and mitochondria. Biochim Biophys Acta 2011; 1813: 558-563.
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 558-563
    • Kantari, C.1    Walczak, H.2
  • 3
    • 84861652703 scopus 로고    scopus 로고
    • The central role of initiator caspase-9 in apoptosis signal transduction and the regulation of its activation and activity on the apoptosome
    • Wurstle ML, Laussmann MA, Rehm M. The central role of initiator caspase-9 in apoptosis signal transduction and the regulation of its activation and activity on the apoptosome. Exp Cell Res 2012; 318: 1213-1220.
    • (2012) Exp Cell Res , vol.318 , pp. 1213-1220
    • Wurstle, M.L.1    Laussmann, M.A.2    Rehm, M.3
  • 4
    • 0035853130 scopus 로고    scopus 로고
    • Solution structure of the antiapoptotic protein bcl-2
    • Petros AM, Medek A, Nettesheim D G, et al. Solution structure of the antiapoptotic protein bcl-2. Proc Natl Acad Sci USA 2001; 98: 3012-3017.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3012-3017
    • Petros, A.M.1    Medek, A.2    Nettesheim, D.G.3
  • 5
    • 84861862161 scopus 로고    scopus 로고
    • Photodynamic therapy in melanoma - an update
    • Baldea I, Filip AG. Photodynamic therapy in melanoma - an update. J Physiol Pharmacol 2012; 63; 109-118.
    • (2012) J Physiol Pharmacol , vol.63 , pp. 109-118
    • Baldea, I.1    Filip, A.G.2
  • 6
    • 20444486559 scopus 로고    scopus 로고
    • An inhibitor of Bcl-2 family proteins induces regression of solid tumours
    • Oltersdorf T, Elmore SW, Shoemaker AR, et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005; 435: 677-681.
    • (2005) Nature , vol.435 , pp. 677-681
    • Oltersdorf, T.1    Elmore, S.W.2    Shoemaker, A.R.3
  • 7
    • 57749110500 scopus 로고    scopus 로고
    • Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors
    • Porter J, Payne A, de Candole B, et al. Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors. Bioorg Med Chem Lett 2009; 19: 230-233.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 230-233
    • Porter, J.1    Payne, A.2    de Candole, B.3
  • 8
    • 54049096626 scopus 로고    scopus 로고
    • One-pot synthesis and antibacterial activities of pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine-dione derivatives
    • Bazgir A, Khanaposhtani MM, Soorki AA. One-pot synthesis and antibacterial activities of pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine-dione derivatives. Bioorg Med Chem Lett 2008; 18: 5800-5803.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 5800-5803
    • Bazgir, A.1    Khanaposhtani, M.M.2    Soorki, A.A.3
  • 9
    • 48449100032 scopus 로고    scopus 로고
    • Synthesis and antiviral evaluation of some new pyrazole and fused pyrazolopyrimidine derivatives
    • Rashad AE, Hegab MI, Abel-Megeid RE, Micky JA, Abdel-Megeid FM. Synthesis and antiviral evaluation of some new pyrazole and fused pyrazolopyrimidine derivatives. Bioorg Med Chem 2008; 16: 7102-7106.
    • (2008) Bioorg Med Chem , vol.16 , pp. 7102-7106
    • Rashad, A.E.1    Hegab, M.I.2    Abel-Megeid, R.E.3    Micky, J.A.4    Abdel-Megeid, F.M.5
  • 10
    • 55449128000 scopus 로고    scopus 로고
    • Substituted pyrazolo[3,4-d]pyrimidines: Microwave assisted, solvent free synthesis and biological evaluation
    • Oliveira-Campos AMF, Sivasubramanian A, Rodrigues L, et al. Substituted pyrazolo[3,4-d]pyrimidines: microwave assisted, solvent free synthesis and biological evaluation. Helvetica Chim Acta 2008; 91: 472-478.
    • (2008) Helvetica Chim Acta , vol.91 , pp. 472-478
    • Oliveira-Campos, A.M.F.1    Sivasubramanian, A.2    Rodrigues, L.3
  • 11
    • 62649107149 scopus 로고    scopus 로고
    • Synthesis and COX inhibition of 7-R1-8-R2-1-ethyl-3,4-dimeth yl-4, 10 - dih ydr o-1 H- pyr a z ol o[3,4-c][1,5] benzodiazocine-5,11-diones
    • Migliara O, Raffa D, Plescia S, Cusimano M G, Carbone A. Synthesis and COX inhibition of 7-R1-8-R2-1-ethyl-3,4-dimeth yl-4, 10 - dih ydr o-1 H- pyr a z ol o[3,4-c][1,5] benzodiazocine-5,11-diones. ARKIVOC 2009; 2: 1-10.
    • (2009) ARKIVOC , vol.2 , pp. 1-10
    • Migliara, O.1    Raffa, D.2    Plescia, S.3    Cusimano, M.G.4    Carbone, A.5
  • 12
    • 80051703065 scopus 로고    scopus 로고
    • Present and future of immunosuppressive therapy in kidney transplantation
    • Ponticelli C. Present and future of immunosuppressive therapy in kidney transplantation. Transplant Proc 2011; 43: 2439-2440.
    • (2011) Transplant Proc , vol.43 , pp. 2439-2440
    • Ponticelli, C.1
  • 13
    • 0026167668 scopus 로고
    • Anthrapyrazoles: True successors to the anthracyclines?
    • Judson IR. Anthrapyrazoles: true successors to the anthracyclines? Anticancer Drugs 1991; 2: 223-231.
    • (1991) Anticancer Drugs , vol.2 , pp. 223-231
    • Judson, I.R.1
  • 15
    • 0025345173 scopus 로고
    • Photosensitization by selected anticancer agents
    • Reszka K, Hartley JA, Lown JW. Photosensitization by selected anticancer agents. Biophys Chem 1990; 35: 313-323.
    • (1990) Biophys Chem , vol.35 , pp. 313-323
    • Reszka, K.1    Hartley, J.A.2    Lown, J.W.3
  • 16
    • 0036784064 scopus 로고    scopus 로고
    • Inhibition of DNA topoisomerases II and/or I by pyrazolo[1,5-?]indole derivatives and their growth inhibitory activities
    • Umemura K, Mizushima T, Katayama M, Kiryu Y, Yamoro T, Andoh T. Inhibition of DNA topoisomerases II and/or I by pyrazolo[1,5-?]indole derivatives and their growth inhibitory activities. Mol Pharmacol 2002; 62: 873-880.
    • (2002) Mol Pharmacol , vol.62 , pp. 873-880
    • Umemura, K.1    Mizushima, T.2    Katayama, M.3    Kiryu, Y.4    Yamoro, T.5    Andoh, T.6
  • 17
    • 41649115185 scopus 로고    scopus 로고
    • The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds
    • Hasinoff BB, Liang H, Wu X, et al. The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds. Bioorg Med Chem 2008; 16: 3959-3968.
    • (2008) Bioorg Med Chem , vol.16 , pp. 3959-3968
    • Hasinoff, B.B.1    Liang, H.2    Wu, X.3
  • 18
    • 37549056566 scopus 로고    scopus 로고
    • DNA as a target for anticancer compounds: Methods to determine the mode of binding and the mechanism of action
    • Palchaudhuri R, Hergenrother PJ. DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action. Curr Opin Biotechnol 2007; 18: 497-503.
    • (2007) Curr Opin Biotechnol , vol.18 , pp. 497-503
    • Palchaudhuri, R.1    Hergenrother, P.J.2
  • 19
    • 77951206607 scopus 로고    scopus 로고
    • 3,5-Diaryl-1H-pyrazole as a molecular scaffold for the synthesis of apoptosis-inducing agents
    • Shaw AY, Liau HH, Lu PJ, et al. 3,5-Diaryl-1H-pyrazole as a molecular scaffold for the synthesis of apoptosis-inducing agents. Bioorg Med Chem 2010; 18: 3270-3278.
    • (2010) Bioorg Med Chem , vol.18 , pp. 3270-3278
    • Shaw, A.Y.1    Liau, H.H.2    Lu, P.J.3
  • 20
    • 11844291970 scopus 로고    scopus 로고
    • The search of DNA-intercalators as antitumoral drugs: What it worked and what did not work
    • Martinez R, Chacon-Garcia L. The search of DNA-intercalators as antitumoral drugs: what it worked and what did not work. Curr Med Chem 2005; 12: 127-151.
    • (2005) Curr Med Chem , vol.12 , pp. 127-151
    • Martinez, R.1    Chacon-Garcia, L.2
  • 21
    • 0032826587 scopus 로고    scopus 로고
    • Current status of pyrazoloacridine as an anticancer agent
    • Adjei AA. Current status of pyrazoloacridine as an anticancer agent. Invest New Drugs 1999; 17: 43-48.
    • (1999) Invest New Drugs , vol.17 , pp. 43-48
    • Adjei, A.A.1
  • 22
    • 84894624826 scopus 로고    scopus 로고
    • Abhijit C. 2-Pyrazoline: A pharmacologically active moiety
    • Dipankar B, Hirakmoy C, Asish B, Abhijit C. 2-Pyrazoline: a pharmacologically active moiety. Int Res J Pharm App Sci 2011; 1: 68-80.
    • (2011) Int Res J Pharm App Sci , vol.1 , pp. 68-80
    • Dipankar, B.1    Hirakmoy, C.2    Asish, B.3
  • 23
    • 2942522534 scopus 로고    scopus 로고
    • 3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead Finding
    • Pevarello P, Brasca MG, Amici R, et al. 3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead Finding. J Med Chem 2004; 47: 3367-3380.
    • (2004) J Med Chem , vol.47 , pp. 3367-3380
    • Pevarello, P.1    Brasca, M.G.2    Amici, R.3
  • 24
    • 43249100853 scopus 로고    scopus 로고
    • Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase
    • Spreafico A, Schenone S, Serchi T, et al. Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase. FASEB J 2008; 22: 1560-1571.
    • (2008) FASEB J , vol.22 , pp. 1560-1571
    • Spreafico, A.1    Schenone, S.2    Serchi, T.3
  • 25
    • 19444372159 scopus 로고    scopus 로고
    • Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. III. Synthesis and antitumor activity of 3-phenylpiperazinyl-1-trans-propenes
    • Naito H, Ohsuki S, Atsumi R, et al. Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. III. Synthesis and antitumor activity of 3-phenylpiperazinyl-1-trans-propenes. Chem Pharm Bull 2005; 53: 153-163.
    • (2005) Chem Pharm Bull , vol.53 , pp. 153-163
    • Naito, H.1    Ohsuki, S.2    Atsumi, R.3
  • 26
    • 33748196958 scopus 로고    scopus 로고
    • Celecoxib for the prevention of sporadic colorectal adenomas
    • Bertagnolli M, Eagle C, Zauber A, et al. Celecoxib for the prevention of sporadic colorectal adenomas. New Eng J Med 2006; 355: 873-884.
    • (2006) New Eng J Med , vol.355 , pp. 873-884
    • Bertagnolli, M.1    Eagle, C.2    Zauber, A.3
  • 28
    • 84986938950 scopus 로고
    • A facile synthesis of 3-sulfonyl-substituted indole derivatives
    • Wojciechowski K, Makosza M. A facile synthesis of 3-sulfonyl-substituted indole derivatives. Synthesis 1986; 8: 651-653.
    • (1986) Synthesis , vol.8 , pp. 651-653
    • Wojciechowski, K.1    Makosza, M.2
  • 29
    • 60649119113 scopus 로고    scopus 로고
    • Signal transduction of constitutively active protein kinase C epsilon
    • Garczarczyk D, Toton E, Biedermann V, et al. Signal transduction of constitutively active protein kinase C epsilon. Cell Signal 2009; 21: 745-752.
    • (2009) Cell Signal , vol.21 , pp. 745-752
    • Garczarczyk, D.1    Toton, E.2    Biedermann, V.3
  • 30
    • 0037237879 scopus 로고    scopus 로고
    • Recommendations for conducting the in vivo alkaline comet assay
    • Hartmann A, Agurell E, Beevers C, et al. Recommendations for conducting the in vivo alkaline comet assay. Mutagenesis 2003; 18: 45-51.
    • (2003) Mutagenesis , vol.18 , pp. 45-51
    • Hartmann, A.1    Agurell, E.2    Beevers, C.3
  • 31
    • 8544283254 scopus 로고    scopus 로고
    • The comet assay for DNA damage and repair: Principles, applications, and limitations
    • Collins AR. The comet assay for DNA damage and repair: principles, applications, and limitations. Mol Biotechnol 2004; 26: 249-261.
    • (2004) Mol Biotechnol , vol.26 , pp. 249-261
    • Collins, A.R.1
  • 32
    • 0033765386 scopus 로고    scopus 로고
    • A phase I and pharmacologic evaluation of the DNA intercalator CI-958 in patients with advanced solid tumors
    • Dees EC, Whitfield LR, Grove WR, Rummel S, Grochow LB, Donehower RC. A phase I and pharmacologic evaluation of the DNA intercalator CI-958 in patients with advanced solid tumors. Clin Cancer Res 2000; 6: 3885-3894.
    • (2000) Clin Cancer Res , vol.6 , pp. 3885-3894
    • Dees, E.C.1    Whitfield, L.R.2    Grove, W.R.3    Rummel, S.4    Grochow, L.B.5    Donehower, R.C.6
  • 33
    • 0033566690 scopus 로고    scopus 로고
    • Potent antitumor activity of MS-247, a novel DNA minor groove binder, evaluated by an in vitro and in vivo human cancer cell line panel
    • Yamori T, Matsunaga A, Sato S, et al. Potent antitumor activity of MS-247, a novel DNA minor groove binder, evaluated by an in vitro and in vivo human cancer cell line panel. Cancer Res 1999; 59: 4042-4049.
    • (1999) Cancer Res , vol.59 , pp. 4042-4049
    • Yamori, T.1    Matsunaga, A.2    Sato, S.3
  • 34
    • 23044433522 scopus 로고    scopus 로고
    • YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits endothelial cell functions induced by angiogenic factors in vitro and angiogenesis in vivo models
    • Pan SL, Guh JH, Peng CY, et al. YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits endothelial cell functions induced by angiogenic factors in vitro and angiogenesis in vivo models. J Pharmacol Exp Ther 2005; 31: 35-42.
    • (2005) J Pharmacol Exp Ther , vol.31 , pp. 35-42
    • Pan, S.L.1    Guh, J.H.2    Peng, C.Y.3
  • 35
    • 37349002494 scopus 로고    scopus 로고
    • Anticancer mechanisms of YC-1 in human lung cancer cell line, NCI-H226
    • Chen CJ, Hsu MH, Huang LJ, et al. Anticancer mechanisms of YC-1 in human lung cancer cell line, NCI-H226. Biochem Pharmacol 2008; 75: 360-368.
    • (2008) Biochem Pharmacol , vol.75 , pp. 360-368
    • Chen, C.J.1    Hsu, M.H.2    Huang, L.J.3
  • 36
    • 14344254896 scopus 로고    scopus 로고
    • 1 in human hepatocellular carcinoma cells
    • Wang SW, Pan SL, Guh JH, et al. YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells. J Pharmacol Exp Ther 2005; 312: 917-925.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 917-925
    • Wang, S.W.1    Pan, S.L.2    Guh, J.H.3
  • 38
    • 0033179760 scopus 로고    scopus 로고
    • BCL-2 family members and the mitochondria in apoptosis
    • Gross A, McDonnell JM, Korsmeyer SJ. BCL-2 family members and the mitochondria in apoptosis. Genes Dev 1999; 13: 1899-1911.
    • (1999) Genes Dev , vol.13 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 39
    • 55949092244 scopus 로고    scopus 로고
    • Apoptosis induction by Bcl-2 proteins independent of the BH3 domain
    • Hossini AM, Eberle J. Apoptosis induction by Bcl-2 proteins independent of the BH3 domain. Biochem Pharmacol 2008; 76: 1612-1619.
    • (2008) Biochem Pharmacol , vol.76 , pp. 1612-1619
    • Hossini, A.M.1    Eberle, J.2
  • 40
    • 0027255417 scopus 로고
    • Specific cleavage of PARP: An early marker of chemotherapy-induced apoptosis
    • Kaufmann FC, Desnoyer S, Taviano Y, Davison NE, Poirier G G. Specific cleavage of PARP: an early marker of chemotherapy-induced apoptosis. Cancer Res 1993; 53: 3976-3985.
    • (1993) Cancer Res , vol.53 , pp. 3976-3985
    • Kaufmann, F.C.1    Desnoyer, S.2    Taviano, Y.3    Davison, N.E.4    Poirier, G.G.5
  • 41
    • 0031298259 scopus 로고    scopus 로고
    • Cleavage of poly(ADP-ribose) polymerase: A sensitive parameter to study cell death
    • Duriez PJ, Shah GM. Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death. Biochem Cell Biol 1997; 75: 337-349.
    • (1997) Biochem Cell Biol , vol.75 , pp. 337-349
    • Duriez, P.J.1    Shah, G.M.2
  • 42
    • 51449092007 scopus 로고    scopus 로고
    • Molecular mechanism of protection against chemically and g-radiation induced apoptosis in human colon cancer calls
    • Pierzchalski P, Krawiec A, Gawelko J, Pawlik WW, Konturek SJ, Gonciarz M. Molecular mechanism of protection against chemically and g-radiation induced apoptosis in human colon cancer calls. J Physiol Pharmacol 2008; 59: 191-202.
    • (2008) J Physiol Pharmacol , vol.59 , pp. 191-202
    • Pierzchalski, P.1    Krawiec, A.2    Gawelko, J.3    Pawlik, W.W.4    Konturek, S.J.5    Gonciarz, M.6
  • 43
    • 27644518437 scopus 로고    scopus 로고
    • YC-1 suppresses constitutive nuclear factor-kB activation and induces apoptosis in human prostate cancer cells
    • Huang YT, Pan SL, Guh JH, et al. YC-1 suppresses constitutive nuclear factor-kB activation and induces apoptosis in human prostate cancer cells. Mol Cancer Ther 2005; 4: 1628-1635.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1628-1635
    • Huang, Y.T.1    Pan, S.L.2    Guh, J.H.3
  • 44
    • 68949114187 scopus 로고    scopus 로고
    • Synthesis of novel pyrazole carboxamide derivatives and discovery of modulators for apoptosis or autophagy in A549 lung cancer cells
    • Ding XL, Zhang HY, Qi L, Zhao BX, Lv HS, Miao JY. Synthesis of novel pyrazole carboxamide derivatives and discovery of modulators for apoptosis or autophagy in A549 lung cancer cells. Bioorg Med Chem Lett 2009; 19: 5325-5328.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 5325-5328
    • Ding, X.L.1    Zhang, H.Y.2    Qi, L.3    Zhao, B.X.4    Lv, H.S.5    Miao, J.Y.6
  • 45
    • 77954501379 scopus 로고    scopus 로고
    • Effect of hydrogen peroxide of bacterial origin on apoptosis and necrosis of gut mucosa epithelial cells as a possible pathomechanism of inflammatory bowel disease and cancer
    • Strus M, Janczyk A, Gonet-Surowka A, et al. Effect of hydrogen peroxide of bacterial origin on apoptosis and necrosis of gut mucosa epithelial cells as a possible pathomechanism of inflammatory bowel disease and cancer. J Physiol Pharmacol 2009; 60: 55-60.
    • (2009) J Physiol Pharmacol , vol.60 , pp. 55-60
    • Strus, M.1    Janczyk, A.2    Gonet-Surowka, A.3
  • 46
    • 0028971176 scopus 로고
    • Evidence for a G2 checkpoint in p53-independent apoptosis induction by X-irradiation
    • Han Z, Chatterjee D, He DM, et al. Evidence for a G2 checkpoint in p53-independent apoptosis induction by X-irradiation. Mol Cell Biol 1995; 15: 5849-5857.
    • (1995) Mol Cell Biol , vol.15 , pp. 5849-5857
    • Han, Z.1    Chatterjee, D.2    He, D.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.