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Volumn 16, Issue 7, 2008, Pages 3959-3968
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The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds
a
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Author keywords
Anticancer; Bisanthrapyrazole; Bisintercalating; Cardiotoxic; Cytotoxicity; DNA; DNA binding; Docking; K562 cells; Molecular modeling; Topoisomerase II
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Indexed keywords
ANTINEOPLASTIC AGENT;
BIS[2 [[2 (7 CHLORO 6 OXO 6H DIBENZO[CD,G]INDAZOL 2 YL) ETHYL]METHYLAMINO]ETHYL]PIMELATE;
BIS[2 [[2 (7 CHLORO 6 OXO 6H DIBENZO[CD,G]INDAZOL 2 YL)ETHYL]METHYLAMINO]ETHYL]ADIPATE DIHYDROCHLORIDE;
BIS[2 [[2 (7 CHLORO 6 OXO 6H DIBENZO[CD,G]INDAZOL 2 YL)ETHYL]METHYLAMINO]ETHYL]GLUTARATE;
BIS[2 [[2 (7 CHLORO 6 OXO 6H DIBENZO[CD,G]INDAZOL 2 YL)ETHYL]METHYLAMINO]ETHYL]MALONATE;
BIS[2 [[2 (7 CHLORO 6 OXO 6H DIBENZO[CD,G]INDAZOL 2 YL)ETHYL]METHYLAMINO]ETHYL]SUCCINATE;
DNA TOPOISOMERASE (ATP HYDROLYSING);
DOUBLE STRANDED DNA;
DOXORUBICIN;
LOSOXANTRONE;
MITOXANTRONE;
OXANTHRAZOLE;
UNCLASSIFIED DRUG;
ARTICLE;
CANCER INHIBITION;
CELL GROWTH;
DRUG DESIGN;
DRUG DNA BINDING;
DRUG SCREENING;
DRUG STRUCTURE;
DRUG SYNTHESIS;
ENZYME ACTIVITY;
ENZYME INHIBITION;
HUMAN;
HUMAN CELL;
ANTHRACYCLINES;
ANTIGENS, NEOPLASM;
ANTINEOPLASTIC AGENTS;
CELL LINE;
CELL SURVIVAL;
DNA;
DNA TOPOISOMERASES, TYPE II, EUKARYOTIC;
DNA-BINDING PROTEINS;
DRUG DESIGN;
ENZYME INHIBITORS;
HUMANS;
MODELS, MOLECULAR;
MOLECULAR STRUCTURE;
NEOPLASMS;
NUCLEIC ACID DENATURATION;
PLASMIDS;
PROTEIN BINDING;
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;
TEMPERATURE;
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EID: 41649115185
PISSN: 09680896
EISSN: None
Source Type: Journal
DOI: 10.1016/j.bmc.2008.01.033 Document Type: Article |
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Times cited : (17)
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References (30)
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