Improving the immunostimulatory potency of diethanolamine-containing lipid A mimics

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 8, 2013, Pages 2199-2209

  Lewicky, Jordan D ^a   Ulanova, Marina ^a   Jiang, Zi Hua ^a  

^a LAKEHEAD UNIVERSITY   (Canada)

Author keywords

Glycolipid; Immunostimulant; Lipid A; Toll like receptor 4

Indexed keywords

CARBOXYLIC ACID; DIETHANOLAMINE DERIVATIVE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPID A DERIVATIVE; MOLECULAR SCAFFOLD; N (2 PHOSPHONOETHYL) N [2 [2 DEOXY 4 O PHOSPHONO 3 O (3 TETRADECANOYLOXYTETRADECANOYL) 2 (3 TETRADECANOYLOXYTETRADECANAMIDO) BETA GLUCOPYRANOSYLOXY]ETHYL] 3 TETRADECANOYLOXYTETRADECANAMIDE; N (CARBOXYMETHYL) N [2 [2 DEOXY 4 O PHOSPHONO 3 O (3 TETRADECANOYLOXYTETRADECANOYL) 2 (3 TETRADECANOYLOXYTETRADECANAMIDO) BETA GLUCOPYRANOSYLOXY]ETHYL] 3 TETRADECANOYLOXYTETRADECANAMIDE; PHOSPHATE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG TARGETING; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; MONOCYTE; SYNTHESIS;

ADJUVANTS, IMMUNOLOGIC; BIOMIMETIC MATERIALS; CELL LINE; ETHANOLAMINES; HUMANS; LIPID A; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

BACTERIA (MICROORGANISMS); IVA; NEGIBACTERIA;

EID: 84875753050     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.02.024     Document Type: Article

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